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Volumn 28, Issue 5, 2008, Pages 746-772

Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads

Author keywords

Andrographolide; Curcumin; Glycyrrhizin; Hepatoprotective; Hypophyllanthin; Kutkoside; Neoandrographolide; Phyllanthin; Picroside; Silymarin

Indexed keywords

ANDROGRAPHOLIDE; BERBERINE; CAFESTOL; CAFFEIC ACID; CLEOME VISCOSA EXTRACT; CURCUMIN; EMODIN; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; HYPOPHYLLANTHIN; KAHWEOL; KOLAVIRON; KUTKIN; LEAD; LUPEOL; MYRISTICIN; NEOANDROGRAPHOLIDE; OLEANOLIC ACID; PARACETAMOL; PHYLLANTHIN; PLANT EXTRACT; QUERCETIN; RUBIADIN; SCHIZANDRIN B; SILYMARIN; THYMOQUINONE; TILIROSIDE; UNCLASSIFIED DRUG; URSOLIC ACID;

EID: 50249134405     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/med.20115     Document Type: Review
Times cited : (158)

References (179)
  • 1
    • 50249134274 scopus 로고    scopus 로고
    • WHO fact sheet No. 164 and 204, October 2000.
    • WHO fact sheet No. 164 and 204, October 2000.
  • 3
    • 1942470397 scopus 로고    scopus 로고
    • Review article: Current management of alcoholic liver disease
    • Tome S, Lucey MR. Review article: Current management of alcoholic liver disease. Aliment Pharmacol Ther 2004;19:707-714.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 707-714
    • Tome, S.1    Lucey, M.R.2
  • 4
    • 31144431583 scopus 로고    scopus 로고
    • Antiviral properties of Ent-labdene diterpenes of Andrographis paniculata Nees, inhibitors of herpes simplex virus type 1
    • Wiart C, Kumar K, Yusof MY, Hamimah H, Fauzi ZM, Sulaiman M. Antiviral properties of Ent-labdene diterpenes of Andrographis paniculata Nees, inhibitors of herpes simplex virus type 1. Phytother Res 2005;19:1069-1070.
    • (2005) Phytother Res , vol.19 , pp. 1069-1070
    • Wiart, C.1    Kumar, K.2    Yusof, M.Y.3    Hamimah, H.4    Fauzi, Z.M.5    Sulaiman, M.6
  • 6
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs 2001;61:2035-2063.
    • (2001) Drugs , vol.61 , pp. 2035-2063
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 7
    • 0032008339 scopus 로고    scopus 로고
    • Milk Thistle (Silybum marianum) for the therapy of liver disease
    • Flora K, Hahn M, Rosen H, Benner K. Milk Thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998;93:139-143.
    • (1998) Am J Gastroenterol , vol.93 , pp. 139-143
    • Flora, K.1    Hahn, M.2    Rosen, H.3    Benner, K.4
  • 8
    • 33947206263 scopus 로고    scopus 로고
    • Total sales of herbal supplements in United States show steady growth
    • Blumenthal M, Ferrier GKL, Cavaliere C. Total sales of herbal supplements in United States show steady growth. Herbal Gram 2006;71:64-66.
    • (2006) Herbal Gram , vol.71 , pp. 64-66
    • Blumenthal, M.1    Ferrier, G.K.L.2    Cavaliere, C.3
  • 9
    • 33749802265 scopus 로고
    • Liver therapeutic drugs from Silybum marianum
    • Chang HM, Yeung HW, Tso WW, Koo A, editors, Singapore: World Scientific Publ. Co
    • Wagner H, Seligmann O. Liver therapeutic drugs from Silybum marianum. In: Chang HM, Yeung HW, Tso WW, Koo A, editors. Advances in Chinese Medicinal Materials Research. Singapore: World Scientific Publ. Co.; 1985.
    • (1985) Advances in Chinese Medicinal Materials Research
    • Wagner, H.1    Seligmann, O.2
  • 10
    • 0034771620 scopus 로고    scopus 로고
    • Treatment of hepatitis C with milk thistle
    • Chavez ML. Treatment of hepatitis C with milk thistle? J Herb Pharmacother 2001;1:79-90.
    • (2001) J Herb Pharmacother , vol.1 , pp. 79-90
    • Chavez, M.L.1
  • 11
  • 12
    • 0030512154 scopus 로고    scopus 로고
    • Properties and medical use of flavanolignans (Silymarin) from Silybum marianum
    • Leng-Peschlow E. Properties and medical use of flavanolignans (Silymarin) from Silybum marianum. Phytother Res 1996;10 (Suppl 1):S25-S26.
    • (1996) Phytother Res , vol.10 , Issue.SUPPL. 1
    • Leng-Peschlow, E.1
  • 14
    • 33745571251 scopus 로고    scopus 로고
    • Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry
    • Lee JI, Hsu BH, Wu D, Barrett JS. Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 2006; 57-68.
    • (2006) J Chromatogr A , pp. 57-68
    • Lee, J.I.1    Hsu, B.H.2    Wu, D.3    Barrett, J.S.4
  • 15
    • 50249096263 scopus 로고    scopus 로고
    • Blumenthal M Sr, editor. Herbal medicine: Expanded commission E monographs. 1st edition. Newton, MA: Integrative Med Commun; 2000. pp 257-263.
    • Blumenthal M Sr, editor. Herbal medicine: Expanded commission E monographs. 1st edition. Newton, MA: Integrative Med Commun; 2000. pp 257-263.
  • 18
    • 0025645646 scopus 로고
    • Pharmacokinetic studies in IdB 1016, a silybinphosphatiddylcholine complex, in healthy human subjects
    • Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E. Pharmacokinetic studies in IdB 1016, a silybinphosphatiddylcholine complex, in healthy human subjects. Eur J Drug Metab Pharmacokinet 1990;15:333-338.
    • (1990) Eur J Drug Metab Pharmacokinet , vol.15 , pp. 333-338
    • Barzaghi, N.1    Crema, F.2    Gatti, G.3    Pifferi, G.4    Perucca, E.5
  • 19
    • 0025091687 scopus 로고
    • Silybin kinetics in patients with liver cirrhosis: A comparative study of a silybin-phosphatidylcholine complex and silymarin
    • Orlando R, Fragasso A, Lampertico M, et al. Silybin kinetics in patients with liver cirrhosis: A comparative study of a silybin-phosphatidylcholine complex and silymarin. Med Sci Res 1990;18:861-863.
    • (1990) Med Sci Res , vol.18 , pp. 861-863
    • Orlando, R.1    Fragasso, A.2    Lampertico, M.3
  • 20
    • 0018825608 scopus 로고
    • Studies on elimination of silymarin in cholecystectomized patients. I. Biliary and renal elimination after a single oral dose
    • Flory PJ, Krug G, Lorenz D, Mennicke WH. Studies on elimination of silymarin in cholecystectomized patients. I. Biliary and renal elimination after a single oral dose. Planta Med 1980;38:227-237.
    • (1980) Planta Med , vol.38 , pp. 227-237
    • Flory, P.J.1    Krug, G.2    Lorenz, D.3    Mennicke, W.H.4
  • 21
    • 0026776782 scopus 로고
    • Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients
    • Schandalik R, Gatti G, Perucca E. Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. Arzneimittelforschung 1992;42:964-968.
    • (1992) Arzneimittelforschung , vol.42 , pp. 964-968
    • Schandalik, R.1    Gatti, G.2    Perucca, E.3
  • 22
    • 0027282741 scopus 로고
    • A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB1016) in chronic active hepatitis
    • Buzzelli G, Moscarella S, Giusti A, Duchini A, Marena C, Lampertico M. A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB1016) in chronic active hepatitis. Int J Clin Pharmacol Ther Toxicol 1993;31(9):456-460.
    • (1993) Int J Clin Pharmacol Ther Toxicol , vol.31 , Issue.9 , pp. 456-460
    • Buzzelli, G.1    Moscarella, S.2    Giusti, A.3    Duchini, A.4    Marena, C.5    Lampertico, M.6
  • 23
    • 0018154755 scopus 로고
    • Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis, carried out at two medical centres
    • Magliulo E, Gagliardi B, Fiori GP. Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis, carried out at two medical centres. Med Klin 1978;73(28-29):1060-1065.
    • (1978) Med Klin , vol.73 , Issue.28-29 , pp. 1060-1065
    • Magliulo, E.1    Gagliardi, B.2    Fiori, G.P.3
  • 24
    • 0017672518 scopus 로고
    • Results of two double blind studies on the effect of silymarin in chronic hepatitis
    • Kiesewetter E, Leodolter I, Thaler H. Results of two double blind studies on the effect of silymarin in chronic hepatitis. Leber Magen Darm 1977;7(5):318-323.
    • (1977) Leber Magen Darm , vol.7 , Issue.5 , pp. 318-323
    • Kiesewetter, E.1    Leodolter, I.2    Thaler, H.3
  • 25
    • 0021869764 scopus 로고
    • Silymarin protection against hepatic lipid peroxidation by acute ethanol intoxication in the rat
    • Valenzuela A, Lagos C, Schmidt K, Videla LA. Silymarin protection against hepatic lipid peroxidation by acute ethanol intoxication in the rat. Biochem Phramacol 1985;34:2209-2212.
    • (1985) Biochem Phramacol , vol.34 , pp. 2209-2212
    • Valenzuela, A.1    Lagos, C.2    Schmidt, K.3    Videla, L.A.4
  • 27
    • 0029879066 scopus 로고    scopus 로고
    • Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silybinin
    • Dehmlow C, Erhard J, de Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silybinin. Hepatol 1996;23:749-754.
    • (1996) Hepatol , vol.23 , pp. 749-754
    • Dehmlow, C.1    Erhard, J.2    de Groot, H.3
  • 28
    • 0028301966 scopus 로고
    • Hepatoprotective mechanism of silymarin: No evidence for involvement of cytochrome P 450 2 E1
    • Miguez MP, Anundi I, Sainz-Pardo LA, Lindros KO. Hepatoprotective mechanism of silymarin: No evidence for involvement of cytochrome P 450 2 E1. Chem Biol Interact 1994;91:51-63.
    • (1994) Chem Biol Interact , vol.91 , pp. 51-63
    • Miguez, M.P.1    Anundi, I.2    Sainz-Pardo, L.A.3    Lindros, K.O.4
  • 29
    • 0024218006 scopus 로고
    • Effect of free radical scavengers on superoxide dismutase (SOD) enzyme in patients with alcoholic cirrhosis
    • Feher J, Lang I, Nekam K, Muzes G, Deak G. Effect of free radical scavengers on superoxide dismutase (SOD) enzyme in patients with alcoholic cirrhosis. Acta Med Hung 1988;45:265-276.
    • (1988) Acta Med Hung , vol.45 , pp. 265-276
    • Feher, J.1    Lang, I.2    Nekam, K.3    Muzes, G.4    Deak, G.5
  • 30
    • 0034764963 scopus 로고    scopus 로고
    • Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavanolignans
    • Varga Z, Czompa A, Kakuk G, Antus S. Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavanolignans. Phytother Res 2001;15:608-612.
    • (2001) Phytother Res , vol.15 , pp. 608-612
    • Varga, Z.1    Czompa, A.2    Kakuk, G.3    Antus, S.4
  • 31
    • 0034045694 scopus 로고    scopus 로고
    • Inhibitory effects of silybinin on cytochrome P450 enzymes in human liver microsomes
    • Beckmann-Knopp S, Reitbrock S, Weyhenmeyer R, et al. Inhibitory effects of silybinin on cytochrome P450 enzymes in human liver microsomes. Pharmcol Toxicol 2000;86:250-256.
    • (2000) Pharmcol Toxicol , vol.86 , pp. 250-256
    • Beckmann-Knopp, S.1    Reitbrock, S.2    Weyhenmeyer, R.3
  • 33
    • 0032008339 scopus 로고    scopus 로고
    • Milk Thistle (Silybum marianum) for the therapy of liver disease
    • Flora K, Hahn M, Rosen H, Benner K. Milk Thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998;93:139-143.
    • (1998) Am J Gastroenterol , vol.93 , pp. 139-143
    • Flora, K.1    Hahn, M.2    Rosen, H.3    Benner, K.4
  • 34
    • 0036085857 scopus 로고    scopus 로고
    • Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages
    • Kang JS, Jeon YJ, Kim HM, Han SH, Yang KH. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 2002;320:138-144.
    • (2002) J Pharmacol Exp Ther , vol.320 , pp. 138-144
    • Kang, J.S.1    Jeon, Y.J.2    Kim, H.M.3    Han, S.H.4    Yang, K.H.5
  • 36
    • 0033106172 scopus 로고    scopus 로고
    • An adverse reaction to the herbal medication milk thistle (Silybum marianum)
    • Adverse Drug Reactions Advisory Committee
    • Adverse Drug Reactions Advisory Committee. An adverse reaction to the herbal medication milk thistle (Silybum marianum). Med J Aust 1999;170:218-219.
    • (1999) Med J Aust , vol.170 , pp. 218-219
  • 37
    • 0031960861 scopus 로고    scopus 로고
    • Effects of silymarin in alcoholic patients with cirrhosis of the liver: Results of a controlled, double blind, randomized and multicentre trial
    • Pares A, Planas R, Torres M, et al. Effects of silymarin in alcoholic patients with cirrhosis of the liver: Results of a controlled, double blind, randomized and multicentre trial. J Hepatol 1998;28:615-621.
    • (1998) J Hepatol , vol.28 , pp. 615-621
    • Pares, A.1    Planas, R.2    Torres, M.3
  • 39
    • 0027740934 scopus 로고
    • Andrographolide protects rat hepatocytes against paracetamol-induced damage
    • Visen PKS, Shukla B, Patnaik GK, Dhawan BN. Andrographolide protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol 1993;40(2):131-136.
    • (1993) J Ethnopharmacol , vol.40 , Issue.2 , pp. 131-136
    • Visen, P.K.S.1    Shukla, B.2    Patnaik, G.K.3    Dhawan, B.N.4
  • 40
    • 0025242387 scopus 로고
    • Hepatoprotective activity of andrographolide from Andrographis paniculata against carbon tetrachloride
    • Handa SS, Sharma A. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbon tetrachloride. Ind J Med Res 1990;92:276-283.
    • (1990) Ind J Med Res , vol.92 , pp. 276-283
    • Handa, S.S.1    Sharma, A.2
  • 41
    • 0025243755 scopus 로고
    • Hepatoprotective activity of andrographolide from Andrographis paniculata against galactosamine and paracetamol intoxication in rats
    • Handa SS, Sharma A. Hepatoprotective activity of andrographolide from Andrographis paniculata against galactosamine and paracetamol intoxication in rats. Ind J Med Res 1990;92:284-292.
    • (1990) Ind J Med Res , vol.92 , pp. 284-292
    • Handa, S.S.1    Sharma, A.2
  • 42
    • 0023107410 scopus 로고
    • In vitro and in vivo effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolizing enzymes
    • Choudhury BR, Haque SJ, Poddar MK. In vitro and in vivo effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolizing enzymes. Planta Med 1987;53:135-140.
    • (1987) Planta Med , vol.53 , pp. 135-140
    • Choudhury, B.R.1    Haque, S.J.2    Poddar, M.K.3
  • 43
    • 37049076522 scopus 로고
    • A Conformational Study of Diterpenoid Lactones Isolated From the Chinese Medicinal Herb Andrographis paniculata
    • Medford CJ, Chang RS, Chen GQ, Olmstead MM, Smith KM. A Conformational Study of Diterpenoid Lactones Isolated From the Chinese Medicinal Herb Andrographis paniculata. J Chem Soc Perkin Trans II 1990;2:1011-1016.
    • (1990) J Chem Soc Perkin Trans II , vol.2 , pp. 1011-1016
    • Medford, C.J.1    Chang, R.S.2    Chen, G.Q.3    Olmstead, M.M.4    Smith, K.M.5
  • 45
    • 0033852443 scopus 로고    scopus 로고
    • A rapid method for isolation of andrographolide from Andrographis paniculata Nees (Kalmegh)
    • Rajani M, Shrivastava N, Ravishankara MN. A rapid method for isolation of andrographolide from Andrographis paniculata Nees (Kalmegh). Pharm Biol 2000;38:204-209.
    • (2000) Pharm Biol , vol.38 , pp. 204-209
    • Rajani, M.1    Shrivastava, N.2    Ravishankara, M.N.3
  • 46
    • 29744433083 scopus 로고    scopus 로고
    • HPLC and HPTLC densitometric determination of andrographolides and antioxidant potential of Andrographis paniculata
    • Akowuah GA, Zhari A, Norhayati I, Mariam A. HPLC and HPTLC densitometric determination of andrographolides and antioxidant potential of Andrographis paniculata. J Food Composit Anal 2006;19:118-126.
    • (2006) J Food Composit Anal , vol.19 , pp. 118-126
    • Akowuah, G.A.1    Zhari, A.2    Norhayati, I.3    Mariam, A.4
  • 47
    • 0033983848 scopus 로고    scopus 로고
    • High-performance thin-layer chromatographic analysis of hepatoprotective diterpenoids from Andrographis paniculata
    • Saxena S, Jain DC, Gupta MM, Bhakuni RS, Mishra HO, Sharma RP. High-performance thin-layer chromatographic analysis of hepatoprotective diterpenoids from Andrographis paniculata. Phytochem Anal 2000;11:34-36.
    • (2000) Phytochem Anal , vol.11 , pp. 34-36
    • Saxena, S.1    Jain, D.C.2    Gupta, M.M.3    Bhakuni, R.S.4    Mishra, H.O.5    Sharma, R.P.6
  • 48
    • 0037427774 scopus 로고    scopus 로고
    • Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography
    • Du Q, Jerz G, Winterhalter PJ. Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography. J Chromatogr A 2003;984:147-151.
    • (2003) J Chromatogr A , vol.984 , pp. 147-151
    • Du, Q.1    Jerz, G.2    Winterhalter, P.J.3
  • 49
    • 33646570828 scopus 로고    scopus 로고
    • Flow injection spectrophotometric determination of andrographolide from Andrographis paniculata
    • Ruengsitagoon W, Anuntakarun K, Aromdee C. Flow injection spectrophotometric determination of andrographolide from Andrographis paniculata. Talanta 2006;69:900-905.
    • (2006) Talanta , vol.69 , pp. 900-905
    • Ruengsitagoon, W.1    Anuntakarun, K.2    Aromdee, C.3
  • 51
    • 0021241786 scopus 로고
    • Andrographolide and kalmegh (A. paniculata) extract: Effect on rat liver and serum transminase
    • Choudhury BR, Poddar MK. Andrographolide and kalmegh (A. paniculata) extract: Effect on rat liver and serum transminase. IRCS J Med Sci 1984;12:466-467.
    • (1984) IRCS J Med Sci , vol.12 , pp. 466-467
    • Choudhury, B.R.1    Poddar, M.K.2
  • 52
    • 0027740934 scopus 로고
    • Andrographolide protects rat hepatocytes against paracetamol induced damage
    • Visen PKS, Shukla B, Patnaik GK, Dhawan BN. Andrographolide protects rat hepatocytes against paracetamol induced damage. J Ethnopharmacol 1993;40(2):131-136.
    • (1993) J Ethnopharmacol , vol.40 , Issue.2 , pp. 131-136
    • Visen, P.K.S.1    Shukla, B.2    Patnaik, G.K.3    Dhawan, B.N.4
  • 53
    • 0029013861 scopus 로고    scopus 로고
    • Kapoor NK, Chander R, Srivastava V, Tandon JS. Antihepatotoxic activity of diterpenes of Andrographis paniculata (Kal-Megh) against Plasmodium berghei-induced hepatic damage in Mastomys natalensis. Int J Phramacog 1995;33(2):135-138.
    • Kapoor NK, Chander R, Srivastava V, Tandon JS. Antihepatotoxic activity of diterpenes of Andrographis paniculata (Kal-Megh) against Plasmodium berghei-induced hepatic damage in Mastomys natalensis. Int J Phramacog 1995;33(2):135-138.
  • 54
    • 0026560231 scopus 로고
    • Choleretic effect of andrographolide in rats and guinea pigs
    • Shukla B, Visen PK, Patnaik GK, Dhawan BN. Choleretic effect of andrographolide in rats and guinea pigs. Planta Med 1992;58(2):146-149.
    • (1992) Planta Med , vol.58 , Issue.2 , pp. 146-149
    • Shukla, B.1    Visen, P.K.2    Patnaik, G.K.3    Dhawan, B.N.4
  • 55
    • 0042703357 scopus 로고    scopus 로고
    • Four new andrographolide metabolites in rats
    • He X, Li J, Gao H, Qui F, Cui X, Yao X. Four new andrographolide metabolites in rats. Tetrahedron 2003;59:6603-6607.
    • (2003) Tetrahedron , vol.59 , pp. 6603-6607
    • He, X.1    Li, J.2    Gao, H.3    Qui, F.4    Cui, X.5    Yao, X.6
  • 56
    • 0027337678 scopus 로고
    • Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata
    • Kapil A, Koul IB, Banerjee SK, Gupta BD. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol 1993;46:182-185.
    • (1993) Biochem Pharmacol , vol.46 , pp. 182-185
    • Kapil, A.1    Koul, I.B.2    Banerjee, S.K.3    Gupta, B.D.4
  • 57
    • 0037205641 scopus 로고    scopus 로고
    • Mechanism of the superoxide scavenging activity of neoandrographolide - A natural product from Andrographolide paniculata Nees
    • Kamdem RE, Sang S, Ho CT. Mechanism of the superoxide scavenging activity of neoandrographolide - A natural product from Andrographolide paniculata Nees. J Agric Food Chem 2002;50:4662-4665.
    • (2002) J Agric Food Chem , vol.50 , pp. 4662-4665
    • Kamdem, R.E.1    Sang, S.2    Ho, C.T.3
  • 58
    • 0003851563 scopus 로고
    • Chang HM, But PPH, editors, Singapore: World Scientific Publishing Company;
    • Chang HM, But PPH, editors. Pharmacology and applications of Chinese Material Medica, Vol. 1-2. Singapore: World Scientific Publishing Company; 1986.
    • (1986) Pharmacology and applications of Chinese Material Medica , vol.1-2
  • 60
    • 0035668849 scopus 로고    scopus 로고
    • Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa
    • Song EK, Cho H, Kim JS, Kim NY, An NH, Kim JA, Lee SH, Kim YC. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med 2001;67:876-877.
    • (2001) Planta Med , vol.67 , pp. 876-877
    • Song, E.K.1    Cho, H.2    Kim, J.S.3    Kim, N.Y.4    An, N.H.5    Kim, J.A.6    Lee, S.H.7    Kim, Y.C.8
  • 61
    • 33947429094 scopus 로고    scopus 로고
    • NMR study of solution structure of curcumin
    • Payton F, Sandusky P, Alworth WL. NMR study of solution structure of curcumin. J Nat Prod 2007;70:143-146.
    • (2007) J Nat Prod , vol.70 , pp. 143-146
    • Payton, F.1    Sandusky, P.2    Alworth, W.L.3
  • 64
    • 0036320055 scopus 로고    scopus 로고
    • Microwave assisted extraction of curcuminoids from curcuma longa
    • Dandekar DV, Gaikar VG. Microwave assisted extraction of curcuminoids from curcuma longa. Separation Sci Technol 2002;37:2669-2690.
    • (2002) Separation Sci Technol , vol.37 , pp. 2669-2690
    • Dandekar, D.V.1    Gaikar, V.G.2
  • 65
    • 0037233649 scopus 로고    scopus 로고
    • Hydrotopic extraction of curcuminoids from turmeric
    • Dandekar DV, Gaikar VG. Hydrotopic extraction of curcuminoids from turmeric. Separation Sci Technol 2003;38:1185-1215.
    • (2003) Separation Sci Technol , vol.38 , pp. 1185-1215
    • Dandekar, D.V.1    Gaikar, V.G.2
  • 66
    • 0033841362 scopus 로고    scopus 로고
    • Preparative separation of curcuminoids from crude curcumin and turmeric powder by pH-zone refining countercurrent chromatography
    • Patel K, Krishna K, Sokoloski E, Ito Y. Preparative separation of curcuminoids from crude curcumin and turmeric powder by pH-zone refining countercurrent chromatography. J Liquid Chromatogr Relat Technol 2000;23:2209-2218.
    • (2000) J Liquid Chromatogr Relat Technol , vol.23 , pp. 2209-2218
    • Patel, K.1    Krishna, K.2    Sokoloski, E.3    Ito, Y.4
  • 68
    • 0037134941 scopus 로고    scopus 로고
    • An improved HPLC method for the determination of curcumin, demethoxy curcumin and bisdemethoxy curcumin
    • Jayaprakasha GK, JagamohanRao L, Sakariah KK. An improved HPLC method for the determination of curcumin, demethoxy curcumin and bisdemethoxy curcumin. J Agric Food Chem 2002;50:3668-3672.
    • (2002) J Agric Food Chem , vol.50 , pp. 3668-3672
    • Jayaprakasha, G.K.1    JagamohanRao, L.2    Sakariah, K.K.3
  • 69
    • 0037419493 scopus 로고    scopus 로고
    • Curcumin in plasma and urine: Quantitation by high performance liquid chromatography
    • Health DD, Pruitt MA, Brenner DE, Rock CL. Curcumin in plasma and urine: Quantitation by high performance liquid chromatography. J Chromatogr B 2003;783:287-295.
    • (2003) J Chromatogr B , vol.783 , pp. 287-295
    • Health, D.D.1    Pruitt, M.A.2    Brenner, D.E.3    Rock, C.L.4
  • 72
    • 33645241865 scopus 로고    scopus 로고
    • Selective protection of curcumin against carbon tetrachloride- induced inactivation of hepatic cytochrome P450 isozymes in rats
    • Sugiyama T, Nagata J, Yamagishi A, Endoh K, Saitoh M, Yamada K, Yamada S, Umegaki K. Selective protection of curcumin against carbon tetrachloride- induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci 2006;78(19):2188-2193.
    • (2006) Life Sci , vol.78 , Issue.19 , pp. 2188-2193
    • Sugiyama, T.1    Nagata, J.2    Yamagishi, A.3    Endoh, K.4    Saitoh, M.5    Yamada, K.6    Yamada, S.7    Umegaki, K.8
  • 73
    • 0031826328 scopus 로고    scopus 로고
    • Effects of curcumin on lipid profile and lipid peroxidation status in experimental hepatic fibrosis
    • Akila G, Rajakrishnan V, Vishwanathan P, Rajshekaran KN, Menon VP. Effects of curcumin on lipid profile and lipid peroxidation status in experimental hepatic fibrosis. Hepatol Res 1998;11(3):147-157.
    • (1998) Hepatol Res , vol.11 , Issue.3 , pp. 147-157
    • Akila, G.1    Rajakrishnan, V.2    Vishwanathan, P.3    Rajshekaran, K.N.4    Menon, V.P.5
  • 75
    • 4544360560 scopus 로고    scopus 로고
    • Protection of liver cells from ethanol cytotoxicity by Curcumin in liver slice culture in vitro
    • Naik RS, Mujumdar AM, Ghaskabi S. Protection of liver cells from ethanol cytotoxicity by Curcumin in liver slice culture in vitro. J Ethnopharmacol 2004;95:31-37.
    • (2004) J Ethnopharmacol , vol.95 , pp. 31-37
    • Naik, R.S.1    Mujumdar, A.M.2    Ghaskabi, S.3
  • 78
    • 0033653374 scopus 로고    scopus 로고
    • Changes in the prostaglandin levels in alcohol toxicity: Effect of curcumin and N-acetylcysteine
    • Rajkrishnan V, Jayadeep A, Arun OS, Sudhakaran PR, Menon VP. Changes in the prostaglandin levels in alcohol toxicity: Effect of curcumin and N-acetylcysteine. J Nutr Biochem 2000;11:509-514.
    • (2000) J Nutr Biochem , vol.11 , pp. 509-514
    • Rajkrishnan, V.1    Jayadeep, A.2    Arun, O.S.3    Sudhakaran, P.R.4    Menon, V.P.5
  • 81
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucuronidation in mice
    • Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metabol Depos 1999;27:486-494.
    • (1999) Drug Metabol Depos , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 82
    • 0018222291 scopus 로고
    • The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione) in the rat
    • Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione) in the rat. Xenobiotica 1978;8:761-776.
    • (1978) Xenobiotica , vol.8 , pp. 761-776
    • Holder, G.M.1    Plummer, J.L.2    Ryan, A.J.3
  • 83
    • 0021815329 scopus 로고
    • Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L
    • Toda S, Miyase T, Arichi H, Tanizawa H, Takino Y. Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem Pharm Bull 1985;33:1725-1728.
    • (1985) Chem Pharm Bull , vol.33 , pp. 1725-1728
    • Toda, S.1    Miyase, T.2    Arichi, H.3    Tanizawa, H.4    Takino, Y.5
  • 85
    • 0028116672 scopus 로고
    • Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous ion
    • Pulla Reddy ACH, Lokesh BR. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous ion. Mol Cell Biochem 1994;137:1-8.
    • (1994) Mol Cell Biochem , vol.137 , pp. 1-8
    • Pulla Reddy, A.C.H.1    Lokesh, B.R.2
  • 86
    • 0029025113 scopus 로고
    • Curcumin inhibits nitrogen dioxide induced oxidation of haemoglobin
    • Unnikrishnan MK, Rao MN. Curcumin inhibits nitrogen dioxide induced oxidation of haemoglobin. Mol Cell Biochem 1995;146:35-37.
    • (1995) Mol Cell Biochem , vol.146 , pp. 35-37
    • Unnikrishnan, M.K.1    Rao, M.N.2
  • 89
    • 1442326142 scopus 로고    scopus 로고
    • Protective role of tetrahydrocurcumin against erythromycin estolate induced hepatotoxicity
    • Pari L, Murugan P. Protective role of tetrahydrocurcumin against erythromycin estolate induced hepatotoxicity. Pharmacol Res 2004;49:481-486.
    • (2004) Pharmacol Res , vol.49 , pp. 481-486
    • Pari, L.1    Murugan, P.2
  • 90
    • 0000663636 scopus 로고    scopus 로고
    • Theoretical elucidation on the antioxidant mechanism of curcumin: A DFT study
    • Sun YM, Zhang HY, Chen DZ, Liu CB. Theoretical elucidation on the antioxidant mechanism of curcumin: A DFT study. Org Lett 2002;4:2909-2911.
    • (2002) Org Lett , vol.4 , pp. 2909-2911
    • Sun, Y.M.1    Zhang, H.Y.2    Chen, D.Z.3    Liu, C.B.4
  • 91
    • 0026093041 scopus 로고
    • Pharmacology of Curcuma longa
    • Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med 1991;57(1):1-7.
    • (1991) Planta Med , vol.57 , Issue.1 , pp. 1-7
    • Ammon, H.P.1    Wahl, M.A.2
  • 92
    • 0022869536 scopus 로고
    • Natural products and plants as liver protecting drugs
    • Handa SS, Sharma A, Chakrabarti KK. Natural products and plants as liver protecting drugs. Fitoterapia 1986;57:503-512.
    • (1986) Fitoterapia , vol.57 , pp. 503-512
    • Handa, S.S.1    Sharma, A.2    Chakrabarti, K.K.3
  • 93
    • 50249087501 scopus 로고    scopus 로고
    • Aswal BS, Chandra R, Chatterjee SK, Dhawan BN, Dwivedi Y, Garg NK, Jain P, Kapoor NK, Kulshreshtha DK, Mehrotra BN, Patnaik GK, Rastogi R, Sarin JPS, Saxena KC, Sharma SC, Shukla B, Visen PKS. Ind. Patent File No. 450/de1/90
    • Aswal BS, Chandra R, Chatterjee SK, Dhawan BN, Dwivedi Y, Garg NK, Jain P, Kapoor NK, Kulshreshtha DK, Mehrotra BN, Patnaik GK, Rastogi R, Sarin JPS, Saxena KC, Sharma SC, Shukla B, Visen PKS. Ind. Patent File No. 450/de1/90.
  • 94
    • 0035100044 scopus 로고    scopus 로고
    • Gupta PP. Picroliv. Drugs Fut 2001;26(1):25-31.
    • Gupta PP. Picroliv. Drugs Fut 2001;26(1):25-31.
  • 95
    • 0343765380 scopus 로고    scopus 로고
    • Kitagawa I, Hino K, Nishimura T, Kukai E, Yoshioka I, Inouye H, Yoshida T. Picroside I: A bitter principle of Picrorrhiza kurroa. Tetrahedron Lett 1969;43:3837-3840.
    • Kitagawa I, Hino K, Nishimura T, Kukai E, Yoshioka I, Inouye H, Yoshida T. Picroside I: A bitter principle of Picrorrhiza kurroa. Tetrahedron Lett 1969;43:3837-3840.
  • 96
    • 0002368387 scopus 로고
    • Chemical examination of Picrorrhiza kurroa Benth. Part VI. Reinvestigation of kutkin
    • Singh B, Rastogi RP. Chemical examination of Picrorrhiza kurroa Benth. Part VI. Reinvestigation of kutkin. Ind J Chem 1972;10:29-31.
    • (1972) Ind J Chem , vol.10 , pp. 29-31
    • Singh, B.1    Rastogi, R.P.2
  • 97
    • 0024605421 scopus 로고
    • Quantitative determination of picroside I and kutkoside in kutkin by TLC
    • Dwivedi AK, Chaudhury M, Sarin JPS. Quantitative determination of picroside I and kutkoside in kutkin by TLC. Ind J Pharm Sci 1989;51:23-25.
    • (1989) Ind J Pharm Sci , vol.51 , pp. 23-25
    • Dwivedi, A.K.1    Chaudhury, M.2    Sarin, J.P.S.3
  • 98
    • 0024842393 scopus 로고
    • Simultaneous micro-determination of picroside-I and kutkoside in picroliv (Kutkin) by high performance liquid chromatography
    • Dwivedi AK, Chaudhury R, Seth RK, Sarin JPS. Simultaneous micro-determination of picroside-I and kutkoside in picroliv (Kutkin) by high performance liquid chromatography. Ind J Pharmac Sci 1989;51:274-275.
    • (1989) Ind J Pharmac Sci , vol.51 , pp. 274-275
    • Dwivedi, A.K.1    Chaudhury, R.2    Seth, R.K.3    Sarin, J.P.S.4
  • 99
    • 19444374103 scopus 로고    scopus 로고
    • A sensitive and selective LC-MS-MS method for simultaneous determination of picroside-I and kutkoside (active principles of herbal preparation picroliv) using solid phase extraction in rabbit plasma: Application to pharmacokinetic study
    • Vipul K, Nitin M, Gupta RC. A sensitive and selective LC-MS-MS method for simultaneous determination of picroside-I and kutkoside (active principles of herbal preparation picroliv) using solid phase extraction in rabbit plasma: Application to pharmacokinetic study. J Chromatogr B 2005;820(2):221-227.
    • (2005) J Chromatogr B , vol.820 , Issue.2 , pp. 221-227
    • Vipul, K.1    Nitin, M.2    Gupta, R.C.3
  • 100
    • 50249107502 scopus 로고    scopus 로고
    • Dhawan BN. Picroliv-A new hepatoprotective agent from an Indian medicinal plant, Picrorrhiza kurroa. Med Chem Res 1995;21:1194-1201.
    • Dhawan BN. Picroliv-A new hepatoprotective agent from an Indian medicinal plant, Picrorrhiza kurroa. Med Chem Res 1995;21:1194-1201.
  • 101
    • 0026019430 scopus 로고
    • Hepatoprotective activity of active principle of Picrorrhiza kurroa on rat hepatocytes against paracetamol toxicity
    • Visen PKS, Shukla B, Patnaik GK, Kaul S, Kapoor NK, Dhawan BN. Hepatoprotective activity of active principle of Picrorrhiza kurroa on rat hepatocytes against paracetamol toxicity. Drug Dev Res 1991;22:209.
    • (1991) Drug Dev Res , vol.22 , pp. 209
    • Visen, P.K.S.1    Shukla, B.2    Patnaik, G.K.3    Kaul, S.4    Kapoor, N.K.5    Dhawan, B.N.6
  • 102
    • 0025828055 scopus 로고
    • Prevention of paracetamol induced hepatic damage in rats by Picroliv, the standardized active fraction from Picrorrhiza kurroa
    • Dwivedi Y, Rastogi R, Garg NK, Dhawan BN. Prevention of paracetamol induced hepatic damage in rats by Picroliv, the standardized active fraction from Picrorrhiza kurroa. Phytother Res 1991;5:115-119.
    • (1991) Phytother Res , vol.5 , pp. 115-119
    • Dwivedi, Y.1    Rastogi, R.2    Garg, N.K.3    Dhawan, B.N.4
  • 104
    • 0027247365 scopus 로고
    • Anticholestatic effect of Picroliv, active hepatoprotective principle of Picrorrhiza kurroa, against carbon tetrachloride induced cholestasis
    • Saraswat B, Visen PKS, Patnaik GK, Dhawan BN. Anticholestatic effect of Picroliv, active hepatoprotective principle of Picrorrhiza kurroa, against carbon tetrachloride induced cholestasis. Ind J Exp Biol 1993;31:316-318.
    • (1993) Ind J Exp Biol , vol.31 , pp. 316-318
    • Saraswat, B.1    Visen, P.K.S.2    Patnaik, G.K.3    Dhawan, B.N.4
  • 105
    • 0026050333 scopus 로고
    • Hepatoprotective activity of Picroliv isolated from Picrorrhiza kurroa against thioacetamide toxicity on rat hepatocytes
    • Visen PKS, Shukla B, Patnaik GK, Chandra R, Singh V Kapoor NK, Dhawan BN. Hepatoprotective activity of Picroliv isolated from Picrorrhiza kurroa against thioacetamide toxicity on rat hepatocytes. Phytother Res 1991;5:224-227.
    • (1991) Phytother Res , vol.5 , pp. 224-227
    • Visen, P.K.S.1    Shukla, B.2    Patnaik, G.K.3    Chandra, R.4    Singh, V.5    Kapoor, N.K.6    Dhawan, B.N.7
  • 106
  • 107
    • 0026028811 scopus 로고
    • Picroliv affords protection against thioacetamide-induced hepatic damage in rats
    • Dwivedi Y, Rastogi R, Sharma SK, Garg NK, Dhawan BN. Picroliv affords protection against thioacetamide-induced hepatic damage in rats. Planta Med 1991;57:25-28.
    • (1991) Planta Med , vol.57 , pp. 25-28
    • Dwivedi, Y.1    Rastogi, R.2    Sharma, S.K.3    Garg, N.K.4    Dhawan, B.N.5
  • 108
    • 0026478072 scopus 로고
    • Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats
    • Dwivedi Y, Rastogi R, Garg NK, Dhawan BN. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacol Toxicol 1992;71:383-387.
    • (1992) Pharmacol Toxicol , vol.71 , pp. 383-387
    • Dwivedi, Y.1    Rastogi, R.2    Garg, N.K.3    Dhawan, B.N.4
  • 109
    • 0027459176 scopus 로고
    • Prevention of galactosamine induced hepatic damage by picroliv: Study on bile flow and isolated hepatocytes (ex vivo)
    • Visen PKS, Shukla B, Patnaik GK, Dhawan BN. Prevention of galactosamine induced hepatic damage by picroliv: Study on bile flow and isolated hepatocytes (ex vivo). Planta Med 1993;59:37-41.
    • (1993) Planta Med , vol.59 , pp. 37-41
    • Visen, P.K.S.1    Shukla, B.2    Patnaik, G.K.3    Dhawan, B.N.4
  • 110
    • 0029766991 scopus 로고    scopus 로고
    • Protective activity of Picroliv, isolated from Picrorrhiza kurroa against ethanol toxicity in isolated rat hepatocytes
    • Visen PKS, Saraswat B, Patnaik GK, Agarwal DP, Dhawan BN. Protective activity of Picroliv, isolated from Picrorrhiza kurroa against ethanol toxicity in isolated rat hepatocytes. Ind J Pharmacol 1996;28:98.
    • (1996) Ind J Pharmacol , vol.28 , pp. 98
    • Visen, P.K.S.1    Saraswat, B.2    Patnaik, G.K.3    Agarwal, D.P.4    Dhawan, B.N.5
  • 111
    • 0032994003 scopus 로고    scopus 로고
    • Ex vivo and in vivo investigations of picroliv from Picrorrhiza kurroa in an alcohol intoxication model in rats
    • Saraswat B, Visen PKS, Patnaik GK, Dhawan BN. Ex vivo and in vivo investigations of picroliv from Picrorrhiza kurroa in an alcohol intoxication model in rats. J Ethnopharmacol 1999;66:263-269.
    • (1999) J Ethnopharmacol , vol.66 , pp. 263-269
    • Saraswat, B.1    Visen, P.K.S.2    Patnaik, G.K.3    Dhawan, B.N.4
  • 113
    • 0028150761 scopus 로고
    • Rifampicin induced hepatotoxicity in rats: Protective effect of picroliv
    • Saksena S, Rastogi R, Garg NK, Dhawan BN. Rifampicin induced hepatotoxicity in rats: Protective effect of picroliv. Drug Dev Res 1994;33:46-50.
    • (1994) Drug Dev Res , vol.33 , pp. 46-50
    • Saksena, S.1    Rastogi, R.2    Garg, N.K.3    Dhawan, B.N.4
  • 114
    • 0002586956 scopus 로고
    • Jaundice of infective hepatitis A and its treatment with an indigenous drug Picrorrhiza kurroa: Review of 30 cases and clinical trial
    • Chaturvedi GN, Singh RH. Jaundice of infective hepatitis A and its treatment with an indigenous drug Picrorrhiza kurroa: Review of 30 cases and clinical trial. J Ind Med 1966;1:1.
    • (1966) J Ind Med , vol.1 , pp. 1
    • Chaturvedi, G.N.1    Singh, R.H.2
  • 116
    • 0005877937 scopus 로고    scopus 로고
    • Inhibition of hepatocarcinogenesis by picroliv
    • Kumar RNV, Kuttan R. Inhibition of hepatocarcinogenesis by picroliv. Ind J Pharmacol 2000;32:135.
    • (2000) Ind J Pharmacol , vol.32 , pp. 135
    • Kumar, R.N.V.1    Kuttan, R.2
  • 117
    • 0026934785 scopus 로고
    • Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol
    • Singh V, Visen PKS, Patnaik GK, Kapoor NK, Dhawan BN. Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol. Ind J Biochem Biophys 1992;29:428-432.
    • (1992) Ind J Biochem Biophys , vol.29 , pp. 428-432
    • Singh, V.1    Visen, P.K.S.2    Patnaik, G.K.3    Kapoor, N.K.4    Dhawan, B.N.5
  • 118
    • 0026634040 scopus 로고
    • Picroliv, picroside-I and kutkoside from Picrorrhiza kurroa are scavengers of superoxide anions
    • Chander R, Kapoor NK, Dhawan BN. Picroliv, picroside-I and kutkoside from Picrorrhiza kurroa are scavengers of superoxide anions. Biochem Pharmacol 1992;44:180-183.
    • (1992) Biochem Pharmacol , vol.44 , pp. 180-183
    • Chander, R.1    Kapoor, N.K.2    Dhawan, B.N.3
  • 119
    • 0026737802 scopus 로고
    • Effect of Picroliv on glutathione metabolism in liver and brain of Mastomys natalensis infected with Plasmodium berghei
    • Chander R, Kapoor NK, Dhawan BN. Effect of Picroliv on glutathione metabolism in liver and brain of Mastomys natalensis infected with Plasmodium berghei. Ind J Exp Biol 1992;30:711-714.
    • (1992) Ind J Exp Biol , vol.30 , pp. 711-714
    • Chander, R.1    Kapoor, N.K.2    Dhawan, B.N.3
  • 121
    • 0029157121 scopus 로고
    • Effect of Picroliv on antioxidant system in liver of rats, after partial hepatectomy
    • Rastogi R, Saksena S, Garg NK, Dhawan BN. Effect of Picroliv on antioxidant system in liver of rats, after partial hepatectomy. Phytother Res 1995;9:364-367.
    • (1995) Phytother Res , vol.9 , pp. 364-367
    • Rastogi, R.1    Saksena, S.2    Garg, N.K.3    Dhawan, B.N.4
  • 122
    • 0005791472 scopus 로고
    • Safety evaluation studies on a new hepatoprotective agent picroliv in rats and monkeys
    • Sethi N, Singh RK, Sinha N, Bhatia G, Srivastava S, Roy AK. Safety evaluation studies on a new hepatoprotective agent picroliv in rats and monkeys. Biol Memoirs 1991;17:57.
    • (1991) Biol Memoirs , vol.17 , pp. 57
    • Sethi, N.1    Singh, R.K.2    Sinha, N.3    Bhatia, G.4    Srivastava, S.5    Roy, A.K.6
  • 123
    • 0005866579 scopus 로고    scopus 로고
    • Picroliv (a new hepatoprotective agent): First clinical impression
    • Gaur SPS, Asthana OP, Sircar AR. Picroliv (a new hepatoprotective agent): First clinical impression. Ind J Pharmacol 2000;32:163.
    • (2000) Ind J Pharmacol , vol.32 , pp. 163
    • Gaur, S.P.S.1    Asthana, O.P.2    Sircar, A.R.3
  • 125
    • 0000583647 scopus 로고
    • New lignans from Phyllanthus niruri Linn - The constitution of phyllanthin
    • Row LR, Srinivasulu C, Smith M, SubbaRao GSR. New lignans from Phyllanthus niruri Linn - The constitution of phyllanthin. Tetrahedron 1966;22(8):2899-2908.
    • (1966) Tetrahedron , vol.22 , Issue.8 , pp. 2899-2908
    • Row, L.R.1    Srinivasulu, C.2    Smith, M.3    SubbaRao, G.S.R.4
  • 126
    • 0042077213 scopus 로고
    • Crystalline constituents of euphorbiaceae-IV: The synthesis and absolute configuration of phyllanthin
    • Row LR, Satyanarayana P, Subba Rao GSR. Crystalline constituents of euphorbiaceae-IV: The synthesis and absolute configuration of phyllanthin. Tetrahedron 1967;23(4):1915-1918.
    • (1967) Tetrahedron , vol.23 , Issue.4 , pp. 1915-1918
    • Row, L.R.1    Satyanarayana, P.2    Subba Rao, G.S.R.3
  • 129
    • 33750725135 scopus 로고    scopus 로고
    • High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus
    • Dhalwal K, Biradar YS, Rajani M. High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus. J AOAC Int 2006;89(3):619-623.
    • (2006) J AOAC Int , vol.89 , Issue.3 , pp. 619-623
    • Dhalwal, K.1    Biradar, Y.S.2    Rajani, M.3
  • 130
    • 0003376363 scopus 로고    scopus 로고
    • Efficiency of Phyllanthus amarus treatment in acute viral hepatitis A, B and non A and non B: An open clinical trial
    • Jayaram S, Thyagaragan SP, Sumathy S, Manjula S, Malathy S, Madanagopalan N. Efficiency of Phyllanthus amarus treatment in acute viral hepatitis A, B and non A and non B: An open clinical trial. Ind J Viorol 1997;13:59-64.
    • (1997) Ind J Viorol , vol.13 , pp. 59-64
    • Jayaram, S.1    Thyagaragan, S.P.2    Sumathy, S.3    Manjula, S.4    Malathy, S.5    Madanagopalan, N.6
  • 132
    • 0029619040 scopus 로고    scopus 로고
    • Prakas A, Satyan KS, Wahi SP, Singh RP. Comparative hepatoprotective activity of three Phyllanthus species, P. urinaria, P. niruri and P. simplex, on carbon tetrachloride induced liver injury in the rat. Phytother Res 1995;9:594-596.
    • Prakas A, Satyan KS, Wahi SP, Singh RP. Comparative hepatoprotective activity of three Phyllanthus species, P. urinaria, P. niruri and P. simplex, on carbon tetrachloride induced liver injury in the rat. Phytother Res 1995;9:594-596.
  • 133
    • 33746004980 scopus 로고    scopus 로고
    • The protein fraction of Phyllanthus niruri plays a protective role against acetoaminophen induced hepatic disorder via its antioxidant properties
    • Bhattacharjee R, Sil PC. The protein fraction of Phyllanthus niruri plays a protective role against acetoaminophen induced hepatic disorder via its antioxidant properties. Phytother Res 2006;20(7):595-601.
    • (2006) Phytother Res , vol.20 , Issue.7 , pp. 595-601
    • Bhattacharjee, R.1    Sil, P.C.2
  • 134
    • 33646711154 scopus 로고    scopus 로고
    • Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride
    • Lee CY, Peng WH, Cheng HY, Chen FN, Lai MT, Chiu TH. Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride. Am J Chin Med 2006;34(3):471-482.
    • (2006) Am J Chin Med , vol.34 , Issue.3 , pp. 471-482
    • Lee, C.Y.1    Peng, W.H.2    Cheng, H.Y.3    Chen, F.N.4    Lai, M.T.5    Chiu, T.H.6
  • 135
    • 0004413356 scopus 로고
    • Bhunyamlaki (Phyllanthus niruri) and jaundice in children
    • Dixit SP, Achar MP. Bhunyamlaki (Phyllanthus niruri) and jaundice in children. J Natl Integ Med Ass 1983;25: 269-272.
    • (1983) J Natl Integ Med Ass , vol.25 , pp. 269-272
    • Dixit, S.P.1    Achar, M.P.2
  • 136
    • 0033944607 scopus 로고    scopus 로고
    • Management of chronic hepatitis B: Treatment of chronic liver diseases with traditional Chinese medicine
    • Wang BE. Management of chronic hepatitis B: Treatment of chronic liver diseases with traditional Chinese medicine. J Gastroenterol Hepatol 2000;15 (Suppl):E67-E70.
    • (2000) J Gastroenterol Hepatol , vol.15 , Issue.SUPPL.
    • Wang, B.E.1
  • 139
    • 33947506805 scopus 로고    scopus 로고
    • Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiacea), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties
    • Bhattachrjee R, Sil PC. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiacea), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol 2007;45:817-826.
    • (2007) Food Chem Toxicol , vol.45 , pp. 817-826
    • Bhattachrjee, R.1    Sil, P.C.2
  • 140
    • 0031761453 scopus 로고    scopus 로고
    • Inhibition by Phyllanthus amarus of hepatocarcinogenesis induced by N-nitrosodiethyl amine
    • Joy KL, Kuttan R. Inhibition by Phyllanthus amarus of hepatocarcinogenesis induced by N-nitrosodiethyl amine. J Clin Biochem Nutr 1998;24:133-139.
    • (1998) J Clin Biochem Nutr , vol.24 , pp. 133-139
    • Joy, K.L.1    Kuttan, R.2
  • 141
    • 0027978627 scopus 로고
    • In vivo studies of a crude extract of Phyllanthus amarus L in modifying the genotoxicity induced in Vicia faba L by tannery effluents
    • Gowrishanker B, Vivekanandan OS. In vivo studies of a crude extract of Phyllanthus amarus L in modifying the genotoxicity induced in Vicia faba L by tannery effluents. Mutat Res 1994;322:185-192.
    • (1994) Mutat Res , vol.322 , pp. 185-192
    • Gowrishanker, B.1    Vivekanandan, O.S.2
  • 142
    • 29244456412 scopus 로고    scopus 로고
    • Some clinico-pathological changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats
    • Adedapo AA, Adegbayibi AY, Emikpe BO. Some clinico-pathological changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats. Phytother Res 2005;19:971-976.
    • (2005) Phytother Res , vol.19 , pp. 971-976
    • Adedapo, A.A.1    Adegbayibi, A.Y.2    Emikpe, B.O.3
  • 143
    • 9144237622 scopus 로고    scopus 로고
    • Use of herbal supplements for chronic liver disease
    • Levy C, Seeff LD, Lindor KD. Use of herbal supplements for chronic liver disease. Clin Gastrol Hepatol 2004;2:947-956.
    • (2004) Clin Gastrol Hepatol , vol.2 , pp. 947-956
    • Levy, C.1    Seeff, L.D.2    Lindor, K.D.3
  • 144
    • 31344435859 scopus 로고    scopus 로고
    • Simultaneous HPLC analysis with isocratic elution of glycyrrhizin and glycyrrhetic acid in licorice root and confectionery products
    • Sabbioni C, Ferranti A, Bugamelli F, Forti GC, Raggi MA. Simultaneous HPLC analysis with isocratic elution of glycyrrhizin and glycyrrhetic acid in licorice root and confectionery products. Phytochem Anal 2006;17:25-31.
    • (2006) Phytochem Anal , vol.17 , pp. 25-31
    • Sabbioni, C.1    Ferranti, A.2    Bugamelli, F.3    Forti, G.C.4    Raggi, M.A.5
  • 145
    • 0028659161 scopus 로고
    • HPLC determination of glycyrrhizin and glycyrrhetic acid in biological fluids, after licorice extract administration to humans and rats
    • Raggi MA, Bugamelli F, Nobile L, et al. HPLC determination of glycyrrhizin and glycyrrhetic acid in biological fluids, after licorice extract administration to humans and rats. Boll Chim Farm 1994;133:704-708.
    • (1994) Boll Chim Farm , vol.133 , pp. 704-708
    • Raggi, M.A.1    Bugamelli, F.2    Nobile, L.3
  • 146
    • 0031662048 scopus 로고    scopus 로고
    • Determination of glycyrrhizin in G. glabra and its extract by HPTLC
    • Chauhan SK, Singh BP, Kimothi GP, Agarwal S. Determination of glycyrrhizin in G. glabra and its extract by HPTLC. Ind J Pharm Sci 1998;60:251-252.
    • (1998) Ind J Pharm Sci , vol.60 , pp. 251-252
    • Chauhan, S.K.1    Singh, B.P.2    Kimothi, G.P.3    Agarwal, S.4
  • 148
    • 0036730869 scopus 로고    scopus 로고
    • Hepatoprotective effects of 18β-glycyrrhetinic acid on carbon tetrachloride induced liver injury: Inhibition of cytochrome P450 2E1 expression
    • Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, Kang SK, Chun HK. Hepatoprotective effects of 18β-glycyrrhetinic acid on carbon tetrachloride induced liver injury: Inhibition of cytochrome P450 2E1 expression. Pharmacol Res 2002;46(3):221-227.
    • (2002) Pharmacol Res , vol.46 , Issue.3 , pp. 221-227
    • Jeong, H.G.1    You, H.J.2    Park, S.J.3    Moon, A.R.4    Chung, Y.C.5    Kang, S.K.6    Chun, H.K.7
  • 149
    • 0036289062 scopus 로고    scopus 로고
    • Long term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma
    • Kumada H. Long term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma. Oncology 2002;62 (Suppl 1):94-100.
    • (2002) Oncology , vol.62 , Issue.SUPPL. 1 , pp. 94-100
    • Kumada, H.1
  • 150
    • 0021442659 scopus 로고
    • Clinical and laboratory observation on the effect of glycyrrhizin in acute and chronic viral hepatitis
    • Xianshi S, Huiming C, Lizhuang W, Chuanfa J, Jianhui L. Clinical and laboratory observation on the effect of glycyrrhizin in acute and chronic viral hepatitis. J Tradit Chin Med 1984;4:127-132.
    • (1984) J Tradit Chin Med , vol.4 , pp. 127-132
    • Xianshi, S.1    Huiming, C.2    Lizhuang, W.3    Chuanfa, J.4    Jianhui, L.5
  • 151
    • 0026073226 scopus 로고
    • Hydrolysis of glycyrrhizin to glycyrrhetyl monoglucuronide by lysosomal beta-D-glucuronidase of animal livers
    • Akao T, Akao T, Hattori M, Kanaoka M, Yamamoto K, Namba T, Kobashi K. Hydrolysis of glycyrrhizin to glycyrrhetyl monoglucuronide by lysosomal beta-D-glucuronidase of animal livers. Biochem Pharmacol 1991;41:1025-1029.
    • (1991) Biochem Pharmacol , vol.41 , pp. 1025-1029
    • Akao, T.1    Akao, T.2    Hattori, M.3    Kanaoka, M.4    Yamamoto, K.5    Namba, T.6    Kobashi, K.7
  • 152
    • 0028288963 scopus 로고
    • Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals
    • Krahenbtihl S, Hasler F, Krapf R. Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals. Steroids 1994;59:121-126.
    • (1994) Steroids , vol.59 , pp. 121-126
    • Krahenbtihl, S.1    Hasler, F.2    Krapf, R.3
  • 154
    • 0017332906 scopus 로고
    • Effect of eating liquorice on the renninangiotension aldosterone axis in normal subjects
    • Epstein M, Espiner E, Donald R, Hughes H. Effect of eating liquorice on the renninangiotension aldosterone axis in normal subjects. Br Med J 1977;1:488-490.
    • (1977) Br Med J , vol.1 , pp. 488-490
    • Epstein, M.1    Espiner, E.2    Donald, R.3    Hughes, H.4
  • 156
    • 0019293891 scopus 로고
    • Structure of Cleomiscosin A, a coumarino-lignoid of Cleome viscosa seeds
    • Ray AB, Chattopadhyay SK. Structure of Cleomiscosin A, a coumarino-lignoid of Cleome viscosa seeds. Tetrahedron Lett 1980;21:4477-4480.
    • (1980) Tetrahedron Lett , vol.21 , pp. 4477-4480
    • Ray, A.B.1    Chattopadhyay, S.K.2
  • 159
    • 29244491684 scopus 로고
    • Pharmacology of oleanolic acid and ursolic acid
    • Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995;49:57-68.
    • (1995) J Ethnopharmacol , vol.49 , pp. 57-68
    • Liu, J.1
  • 160
    • 0032911531 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 2E1 expression by oleanolic acid: Hepatoprotective effects against carbon tetrachloride-induced hepatic injury
    • Jeong HG. Inhibition of cytochrome P450 2E1 expression by oleanolic acid: Hepatoprotective effects against carbon tetrachloride-induced hepatic injury. Toxicol Lett 1999;105:215-222.
    • (1999) Toxicol Lett , vol.105 , pp. 215-222
    • Jeong, H.G.1
  • 162
    • 0037998238 scopus 로고    scopus 로고
    • Marek R, Seckarova p, Hulova D, Marek J, Dostal J, Sklenar V. Palmatine and berberine isolation artifacts. J Nat Prod 2003;66:481-486.
    • Marek R, Seckarova p, Hulova D, Marek J, Dostal J, Sklenar V. Palmatine and berberine isolation artifacts. J Nat Prod 2003;66:481-486.
  • 163
    • 0036460068 scopus 로고    scopus 로고
    • Inhibitory effect of berberine on tere-butyl hydroperoxide-induced oxidative damage in rat liver
    • Hwang JM, Wang CJ, Chou FP, Tseng TH, Hsieh YS, Lin WL, Chu CY. Inhibitory effect of berberine on tere-butyl hydroperoxide-induced oxidative damage in rat liver. Arch Toxicol 2002;76:664-670.
    • (2002) Arch Toxicol , vol.76 , pp. 664-670
    • Hwang, J.M.1    Wang, C.J.2    Chou, F.P.3    Tseng, T.H.4    Hsieh, Y.S.5    Lin, W.L.6    Chu, C.Y.7
  • 164
    • 0033989928 scopus 로고    scopus 로고
    • Studies on preventive and curative effects of berberine on chemical induced hepatotoxicity in rodents
    • Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical induced hepatotoxicity in rodents. Fitoterapia 2000;71(1):25-33.
    • (2000) Fitoterapia , vol.71 , Issue.1 , pp. 25-33
    • Janbaz, K.H.1    Gilani, A.H.2
  • 166
    • 0028970756 scopus 로고
    • Effect of schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity
    • Ip SP, Poom MK, Wu SS, Choe CT, Ng KH, Kong YC, Ko KM. Effect of schisandrin B on hepatic glutathione antioxidant system in mice: Protection against carbon tetrachloride toxicity. Planta Med 1995;61:398-401.
    • (1995) Planta Med , vol.61 , pp. 398-401
    • Ip, S.P.1    Poom, M.K.2    Wu, S.S.3    Choe, C.T.4    Ng, K.H.5    Kong, Y.C.6    Ko, K.M.7
  • 167
    • 34748870909 scopus 로고    scopus 로고
    • Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice
    • Lee KJ, Choi JH, Jeong HG. Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol 2007;45:2118-2125.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2118-2125
    • Lee, K.J.1    Choi, J.H.2    Jeong, H.G.3
  • 168
    • 1542436560 scopus 로고    scopus 로고
    • Quercetin, a flavonoids antioxidant, prevents and protects against ethanolinduced oxidative stress in mouse liver
    • Molina MF, Sanchez-Reus I, Iglesias I, Benedi J. Quercetin, a flavonoids antioxidant, prevents and protects against ethanolinduced oxidative stress in mouse liver. Biol Pharm Bull 2003;26:1398-1402.
    • (2003) Biol Pharm Bull , vol.26 , pp. 1398-1402
    • Molina, M.F.1    Sanchez-Reus, I.2    Iglesias, I.3    Benedi, J.4
  • 169
    • 33744935306 scopus 로고    scopus 로고
    • Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats. Comparative biochemistry and physiology: Part C
    • Preetha SP, Kanniappan M, Selvakumar E, Nagaraj M, Varalakshmi P. Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats. Comparative biochemistry and physiology: Part C. Toxicol Pharmacol 2006;143:333-339.
    • (2006) Toxicol Pharmacol , vol.143 , pp. 333-339
    • Preetha, S.P.1    Kanniappan, M.2    Selvakumar, E.3    Nagaraj, M.4    Varalakshmi, P.5
  • 170
    • 31344442801 scopus 로고    scopus 로고
    • Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn
    • Rao MMG, Rao CV, Pushpangadan P, Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 2006;103:484-490.
    • (2006) J Ethnopharmacol , vol.103 , pp. 484-490
    • Rao, M.M.G.1    Rao, C.V.2    Pushpangadan, P.3    Shirwaikar, A.4
  • 171
    • 3242748962 scopus 로고    scopus 로고
    • Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents
    • Janbaz KH, Saeed SA, Gilani AH. Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomed 2004;11:424-430.
    • (2004) Phytomed , vol.11 , pp. 424-430
    • Janbaz, K.H.1    Saeed, S.A.2    Gilani, A.H.3
  • 172
    • 0033796378 scopus 로고    scopus 로고
    • Antihepatotoxic activity of bergenin, the major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated hepatocytes
    • Kim HS, Lim HK, Chung MW, Kim YC. Antihepatotoxic activity of bergenin, the major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated hepatocytes. J Ethnopharmacol 2000;72:469-474.
    • (2000) J Ethnopharmacol , vol.72 , pp. 469-474
    • Kim, H.S.1    Lim, H.K.2    Chung, M.W.3    Kim, Y.C.4
  • 173
    • 0036152763 scopus 로고    scopus 로고
    • Hepatoprotective principles from the flowers of Tilia argentea (Linden): Structure requirements of tiliroside and mechanisms of action
    • Matsuda H, Ninomiya K, Shimoda H, Yoshikawa M. Hepatoprotective principles from the flowers of Tilia argentea (Linden): Structure requirements of tiliroside and mechanisms of action. Bioorg Med Chem 2002;10:707-712.
    • (2002) Bioorg Med Chem , vol.10 , pp. 707-712
    • Matsuda, H.1    Ninomiya, K.2    Shimoda, H.3    Yoshikawa, M.4
  • 174
    • 0023618433 scopus 로고
    • Evaluation of the antihepatotoxic activity of the biflavonoids of Garcinia kola seed
    • Iwu MM, Igboko OA, Onwuchekwa UA, Okunji CO. Evaluation of the antihepatotoxic activity of the biflavonoids of Garcinia kola seed. J Ethnopharmacol 1987;21:127-138.
    • (1987) J Ethnopharmacol , vol.21 , pp. 127-138
    • Iwu, M.M.1    Igboko, O.A.2    Onwuchekwa, U.A.3    Okunji, C.O.4
  • 175
    • 0032584004 scopus 로고    scopus 로고
    • Hepatoprotective activity of thymoquinone in isolated rat hepatocytes
    • Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 1998;95:23-29.
    • (1998) Toxicol Lett , vol.95 , pp. 23-29
    • Daba, M.H.1    Abdel-Rahman, M.S.2
  • 176
    • 0030885249 scopus 로고    scopus 로고
    • Matsude H, Murakami T, Ninomiya K, Inadzuki M, Yoshikawa M. New hepatoprotective saponins, bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri radix: Structure-requirements for the cytoprotective activity in primary cultured rat hepatocytes. Bioorg Med Chem Lett 1997;7:2193-2198.
    • Matsude H, Murakami T, Ninomiya K, Inadzuki M, Yoshikawa M. New hepatoprotective saponins, bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri radix: Structure-requirements for the cytoprotective activity in primary cultured rat hepatocytes. Bioorg Med Chem Lett 1997;7:2193-2198.
  • 178
    • 0037433524 scopus 로고    scopus 로고
    • Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/D-galactosamine-induced liver injury
    • Morita T, Jinho K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, Sugiyama K. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/D-galactosamine-induced liver injury. J Agric Food Chem 2003;51:1560-1565.
    • (2003) J Agric Food Chem , vol.51 , pp. 1560-1565
    • Morita, T.1    Jinho, K.2    Kawagishi, H.3    Arimoto, Y.4    Suganuma, H.5    Inakuma, T.6    Sugiyama, K.7
  • 179
    • 33750200222 scopus 로고    scopus 로고
    • Isolation, Structure Elucidation and In Vivo Hepatoprotective Potential of trans-Tetracos-15-enoic acid from Indigofera tinctoria Linn
    • Singh B, Chandan BK, Sharma N, Bhardwaj V, Satti NK, Gupta VN, Gupta BD, Suri KA, Suri OP. Isolation, Structure Elucidation and In Vivo Hepatoprotective Potential of trans-Tetracos-15-enoic acid from Indigofera tinctoria Linn. Phytother Res 2006;20:831-839.
    • (2006) Phytother Res , vol.20 , pp. 831-839
    • Singh, B.1    Chandan, B.K.2    Sharma, N.3    Bhardwaj, V.4    Satti, N.K.5    Gupta, V.N.6    Gupta, B.D.7    Suri, K.A.8    Suri, O.P.9


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