Picroliv: Hepatoprotectant immunomodulator

Drugs of the Future

Volumn 26, Issue 1, 2001, Pages 25-31

  Gupta, P P ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; KUTKIN; PLACEBO;

ADULT; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CLINICAL TRIAL; DOSE LIVER FUNCTION RELATION; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; FEMALE; HUMAN; IMMUNOMODULATION; LIVER DISEASE; LIVER FUNCTION TEST; LIVER PROTECTION; MALE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; REACTION ANALYSIS; SIDE EFFECT; TREATMENT OUTCOME; VIRUS HEPATITIS;

EID: 0035100044     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2001.026.01.603287     Document Type: Article

References (86)

1. Chemical examination of Picrorhiza kurroa. Part VI: Reinvestigation of kutkin
2. Picroside II, a new 6vanilloyl-catapol from Picrorhiza kurroa Royle and Benth
3. A curcubitacin glycoside from Picrorhiza kurroa
4. Minor iridoid and phenol glycosides of Picrorhiza kurroa
5. New curcubitacin glycoside from Picrorhiza kurroa
6. Hepatoprotective activity of kutkin, the iridoid glycoside mixture of Picrorhiza kurroa
7. A new direction in the study of carbon tetrachloride hepatotoxicity
8. Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo
9. Lipid peroxidation in fatty fiver induced by caffeine in rats
10. An alteration in fiver microsomal membrane of the rat following paracetamol overdose
11. Alcoholic drink, its production and effects
12. Commercially and traditionally important plants of Mandakini valley and Uttarakhand Himalayas
13. Natural products and plants as fiver protecting drugs
14. Effect of different extracts of kutaki (Picrorrhiza kurroa) on experimentally induced abnormalities in the liver
15. Effect of an indigenous drug kutaki (Picrorhiza kurroa) on bile flow after producing a biliary fistula in dogs
16. Jaundice of infective hepatitis A and its treatment with an indigenous drug Picrorhiza kurroa: Review of 30 cases and clinical trial
17. Effect of Picrorhiza kurroa and Eclipta alba on Na-K-ATPase in hepatic injury by hepatotoxic agents
18. Picrorhiza kurroa (kutaki) Royle ex Benth as a hepatoprotective agent. Experimental and clinical studies
19. The antihepatotoxic effect of silymarin on liver damage in rats induced by carbon tetrachloride, dgalactosamine and allyl alcohol
20. Picroliv - A new hepatoprotective agent from an Indian medicinal plant, Picrorhiza kurroa
21. Preparation of isolated rat liver cells
22. Hepatoprotective activity of picroliv isolated from Picrorhiza kurroa against thioacetamide toxicity on rat hepatocytes
23. Prevention of galactosamine induced hepatic damage by picroliv: Study on bile flow and isolated hepatocytes (ex vivo)
24. Hepatoprotective activity of active principle of Picrorhiza kurroa on rat hepatocytes against paracetamol toxicity
25. Hepatoprotective effect of picroliv against rifampicin-induced toxicity
26. Protective activity of picroliv, isolated from Picrorhiza kurroa against ethanol toxicity in isolated rat hepatocytes
27. Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats
28. Protective effect of picroliv active constituent of Picrorhiza kurroa, against oxytetracycline induced hepatic damage
29. Curative effect of picroliv on primary cultured rat hepatocytes against different hepatotoxins: An in vitro study
30. Cholerectic effect of picrofiv, the hepatoprotector principle of Picrorhiza kurroa
31. Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis
32. Reversal of thioacetamide induced cholestasis by picroliv in rodent
33. Restoration of the fiver of the white rat following partial surgical removal
34. Effect of picroliv and silymarin on fiver regeneration in rats
35. Effect of picroliv on liver regeneration in rats
36. Effect of picroliv on protein and nucleic acid synthesis
37. Effect of picroliv on antioxidant system in fiver of rats, after partial hepatectomy
38. Effect of picroliv on regeneration of liver after partial hepatectomy in rats
39. In vitro studies on the effect of certain natural products against hepatitis
40. A preliminary clinical trial of Picrorhiza kurroa in bronchial asthma
41. Clinical trials of Picrorhiza kurroa as an immunoregulator
42. Effect of disodium cromoglycate and Picrorhiza kurroa root powder on sensitivity of guinea pigs to histamine and sympathomimetic amines
43. Induction of resistance to isoprenaline in guinea pigs and its modulation by disodium cromoglycate, Picrorhiza kurroa and indomethacin
44. Study of Picrorhiza kurroa (PK 300) in cases of bronchial asthma
45. Protective effect of active substance and mechanisms of action
46. Antiasthmatic effects of Picrorhiza kurroa: Androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigs
47. Anti-allergic and anti-anaphylactic activity of picroliv - A standardised iridoid glycoside fraction of Picrorhiza kurroa
48. Immunomodulating agents of plant origin. I: Preliminary screening
49. Immunomodulatory compounds from Picrorhiza kurroa: Isolation and characterization of two anti-complementary polymeric fractions from an aqueous root extract
50. Immunostimulatory activity of Picrorhiza kurroa leaf extract
51. Immunostimulant activity of picroliv, the iridoid glycoside fraction of Picrorhiza kurroa, and its protective action against Leishmania donovani infection in hamsters
52. Inhibition of hepatocarcinogenesis by picroliv
53. Hypolipidaemic activity of picroliv in albino rats
54. Protective activity of picroliv from Picrorhiza kurroa against myocardial ischemia induced by coronary ligation of isoproterenol
55. Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol
56. Picroliv, picroside-I and kutkoside from Picrorhiza kurroa are scavengers of superoxide anions
57. Effect of picroliv on gfutathione metabolism in fiver and brain of Mastomys natafensis infected with Plasmodium berghei
58. Picroliv affects γ-glutamyl cycle in liver and brain of Mastomys natalensis infected with Plasmodium berghei
59. Picroliv prevents oxidation in serum lipoprotein lipids of Mastomys coucha infected with Plasmodium berghei
60. Safety evaluation studies on a new hepatoprotective agent picroliv in rats and monkeys
61. Effect of picroliv, a hepatoprotective agent prepared from Picrorhiza kurroa on mice chromosomes
62. Safety and tolerability of picroliv in healthy human volunteers
63. Phase II clinical study of picroliv in acute viral hepatitis: A preliminary report
64. Picroliv (a new hepatoprotective agent): First clinical impression
65. Picroliv protects aflatoxin-B, acute hepatotoxicity in rats
66. Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin)
67. Effects of picroliv, the active principle of Picrorhiza kurroa, on biochemical changes in rat liver poisoned by Amanita phalloides
68. Hepatoprotective activity of picroliv against carbon tetrachloride-induced liver damage in rats
69. Hepatoprotective activity of picroliv against alcohol-carbon tetrachloride induced damage in rat
70. Antihepatotoxic properties of picroliv: An active fraction from rhizomes of Picrorhiza kurroa
71. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats
72. Picroliv protects against alcohol-induced chronic hepatotoxicity in rats
73. Protective activity of picroliv against hepatic damage induced by lanthanum chloride
74. Picroliv protects against monocrotaline-induced hepatic damage in rats
75. Prevention of paracetamol induced hepatic damage in rats by picroliv, the standardised active fraction from Picrorhiza kurroa
76. Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei
77. Rifampicin induced hepatotoxicity in rats: Protective effect of picroliv
78. Effect of picroliv on the pharmacokinetics of rifampicin in rats
79. Picroliv affords protection against thioacetamide-induced hepatic damage in rats
80. Protective effect of picroliv from Picrorhiza kurroa against Leishmania donovani infections in Mesocricetus auratus
81. Picroliv reduces the formation of lipoprotein-X in liver damage
82. In vitro effect of combinations of picroliv and andrographolide on rat hepatocytes against chemical toxins
83. Iron chelating activity of picroliv
84. Development of stable formulations of picroliv, a new hepatoprotective agent