Inhibition by Phyllanthus amarus of hepatocarcinogenesis induced by N-nitrosodiethylamine

Journal of Clinical Biochemistry and Nutrition

Volumn 24, Issue 3, 1998, Pages 133-139

  Joy, K L ^a   Kuttan, Ramadasan ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Chemoprevention; Hepatocarcinogenesis; Nitrosodiethylamine; Phyllanthus amarus

Indexed keywords

ANIMALIA; PHYLLANTHUS AMARUS; PHYLLANTHUS DEBILIS; PHYLLANTHUS NIRURI;

EID: 0031761453     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.24.133     Document Type: Article

References (21)

1. Dixit, S.P., and Achar, M.P. (1983): Bhumyamalaki (Phyllanthus niruri LINN) and jaundice in children. J. Nat. Integ. Med. Assoc., 25, 269-272.
2. Unander, D.W., Venkateswaran, P.S., Millman, I., and Blumberg, B.S. (1991): Inhibition of hepatitis B virus-dependent DNA polymerase by species of Phyllanthus; genetic and environmental effects on this activity. Brenesia, 32, 27-40.
3. 4-induced liver dysfunction. Curr. Sci., 20, 1243-1246.
4. Joy, K.L., and Kuttan, R. (1995): Anti-oxidant activity of selected plant extracts. Amala Res. Bull., 15, 68-71.
5. Bartsch, H., Hietanen, E., and Malaveille, C (1989): Carcinogenic nitrosamines: Free radical aspects of their action. Free Radical Biol. Med., 7, 637-644.
6. Preussmann, R. (1984): Occurrence and exposure to N-nitroso compounds and precursors, in N-Nitroso Compounds: Occurrence, Biological Effects and Relevance to Human Cancer, ed. by O'Neil, I.K., Von Borstel, R C., Miller, C.T., Lony, J., and Bartsch, H., IARC Scientific Publications, Lyon, pp. 3-15.
7. Narurkar, L.M., and Narurkar, M.V. (1989): Role of nicotinamide in suppression of diethylnitrosamine hepatocarcinogenesis in rats, in Chemoprevention of Cancer, ed. by Bhide, S.V., and Maru, G.B., Omega Scientific Publishers, New Delhi, pp. 162-177.
8. Ohkawa, H., Ohishi, N., and Yagi, K. (1979): Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
9. Lowry, H.D., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951): Protein measurement with Folin phenol reagent. J. Biol. Chem., 193, 265-275.
10. Bergmeyer, H.U., and Bernt, E. (1980): Colorimetric method for aspartate and alanine aminotransferases, in Practical Clinical Biochemistry, Vol. 1, 5th ed., ed. by Varley, H., Gowenlock, A.H., and Bell, M., William Heinemann Medical Books Ltd., London, pp. 741-742.
11. King, E.J., and Armstrong, A.R. (1980): Method of King and Armstrong, in Practical Clinical Bio-Chemistry, Vol. 1, 5th ed., ed. by Varley, H., Gowenlock, A.H., and Bell, M., William Heinemann Medical Books Ltd., London, pp. 897-899.
12. Habig, W.H., Pabst, M.J., and Jakoby, W.R. (1974): Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249, 7130-7139.
13. Moron, M.A., Depierre, J.W., and Mannervick, B. (1979): Levels of glutathione, glutathione reductase, and glutathione-S-transferase activities in rat liver. Biochim. Biophys. Acta, 582, 67-78.
14. Jendrassik, L., and Grof, P. (1938): Simplified photometric method for the determination of the blood bilirubin. Biochem. Z., 297, 81-89.
15. Szasz, G. (1976): Reaction rate method for γ-glutamyl transferase activity in serum. Clin. Chem., 22, 2031-2055.
16. Mazel, P. (1971): Experiments illustrating drug metabolism in vitro, in Fundamentals of Drug Metabolism and Drug Disposition, ed. by LaDu, B.N., Mandel, H.G., and Way, B.L., Williams and Wilkins, Baltimore, pp. 546-578.
17. Tate, S.S., and Meister, A. (1974): Interaction of γ-glutamyl transpeptidase with amino acids, peptides, and derivatives and analogues of glutathione. J. Biol. Chem., 23, 7593-7602.
18. Singer, B. (1976): All oxygens in nucleic acids react with carcinogenic ethylating agents. Nature (Lond 264), 333-339.
19. Ishimaru, K., Yoshimatsu, K., Kamada, H., and Shimomura, K. (1992): Phenolic constituents in tissue cultures of Phyllanthus niruri. Phytochemistry, 31, 2015-2018.
20. Agarwal, T., and Tiwari, J.S. (1991): Note on the flavonoid and other constituents of Phyllanthus genus. J. Indian Chem., Soc-68, 479-480.
21. Satynarayana, P., Subrahmanyam, P., Viswanatham, K.N., and Ward, R.S. (1988): New seco- and hydroxy-lignans from Phyllanthus niruri. J. Nat. Prod., 51, 44-49.