Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats

Journal of Ethnopharmacology

Volumn 66, Issue 3, 1999, Pages 263-269

  Saraswat, Binduja ^a   Visen, P K S ^a   Patnaik, G K ^a   Dhawan, B N ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Alcohol; Hepatoprotective; Hepatotoxicity; Picroliv

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE SALT; GLYCOGEN; KUTKIN;

ALCOHOL INTOXICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE FLOW; CHOLESTASIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MALE; MEDICINAL PLANT; NONHUMAN; ORAL DRUG ADMINISTRATION; OXYGEN CONSUMPTION; RAT;

ALANINE TRANSAMINASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE OXIDOREDUCTASES; ALKALINE PHOSPHATASE; ANIMALS; ANTIPROTOZOAL AGENTS; ASPARTATE AMINOTRANSFERASES; BILE; BILE ACIDS AND SALTS; CELLS, CULTURED; CHOLESTASIS; CINNAMATES; ETHANOL; GLYCOSIDES; LIVER; MALE; OXYGEN; RATS; VANILLIC ACID;

EID: 0032994003     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(99)00007-0     Document Type: Article

References (28)

1. Agarwal, D.P. and Goedde, H.W. (1990) 'Alcohol Metabolism, Alcohol Intolerance and Alcoholism. Biochemical and Pharmacogenetic Approaches.' Berlin: Springer-Verlag, pp. 126-144.
2. Ansari, R.A., Aswal, B.S., Chander, R., Dhawan, B.N., Garg, N.K., Kapoor, N.K., Kulshreshtha, D.K., Mahdi, H., Mehrotra, B.N., Patnaik, G.K. and Sharma. S.K. (1988) 'Hepatoprotective activity of kutkin, the iridoid glycoside mixture of Picrorhiza kurroa.' Indian J. Med. Res. 87, 401-404.
3. Chander, R., Dwivedi, Y., Rastogi, R., Sharma, S.K., Garg, N.K., Kapoor, N.K. and Dhawan, B.N. (1990) 'Evaluation of hepatoprotecive activity of Picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei.' Indian J. Med. Res. 92, 34-37.
4. Dwivedi, Y., Rastoui, R., Chander, R., Sharma, S.K., Garg, N.K. and Dhawan, B.N. (1990) 'Hepatoprotective activity of picroliv against carbon tetrachloride induced damage in rats.' Indian J. Med. Res. 92B, 195-200.
5. Erwin, H., Mosbach, H., Klenisy, E.H. and Forrest, E. (1954). 'Determination of deoxycholic and cholic acid in bile.' Arch. Biochem. Biophys. 57, 402-409.
6. Estabrook, J.E. (1967) 'Mitochondrial respiratory control: polarographic measurement of ADP-O ratios.' Methods Enzymol. 10, 41-47.
7. Folch, J.M., Lees, M. and Stanley, G.H. (1957) 'A simple method for isolation and purification of total lipids from animal tissues.' J. Biol. Chem. 222, 497-500.
8. Hawk, P.B., Oser, B.L. and Summerson, W.H. (1954) Bile and liver function. In: P.B. Hawk (Ed.), 'Practical Physiological Chemistry.' New York: McGraw-Hill, pp. 408-427.
9. Kai, O.L. (1995) 'Alcoholic liver disease: pathological aspects.' J. Hepatol. 23, 7-15.
10. Kind, P.R.N. and King, E.J. (1954) 'Estimation of plasma phosphatases by determination of hydrolysed phenol with aminoantipyrine.' J. Clin. Pathol. 7, 322-326.
11. Liber, C.S. (1984) 'Alcohol and the liver.' Hepatology 6, 1243-1260.
12. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall R.J. (1951) 'Protein measurement with the folin phenol reagent.' J. Biol. Chem. 193, 265-275.
13. Matsuzaki, S. and Lieber, C.S. (1977) 'Increased susceptibility of hepatic mitochondria to the toxicity of acetaldehyde after chronic ethanol consumption.' Biochem. Biophys. Res. Commun. 75, 1059-1065.
14. Moldeus, P., Hogberg, J. and Orrhenius, S. (1978) 'Isolation and use of liver cells.' Methods Enzymol. 52, 60-71.
15. Montgomery, R. (1957) 'Determination of glycogen.' Arch. Biochem. Biophys. 67, 378-386.
16. Plaa, G.L. (1970) Hyperbilirubinemia and cholestasis. A different form of liver injury produced in animals. Toxicology 2, 137-141.
17. Rastogi, R., Saksena, S., Garg, N.K., Kapoor, N.K., Agarwal, D.P. and Dhawan. B.M. (1996). Picroliv protects against alcohol induced chronic hepatotoxicity in rats. Planta Med. 62, 283-285.
18. Reitman, S. and Frankel S. (1957) A calorimetric method for the determination of serum glutamic oxaloactic and glutamic pyruvic transaminase. Am. J. Clin. Pathol. 28, 56-63.
19. Richen, J. and Simon, F.R. (1982) Cholestasis. In: I.M. Arias, H. Popper, D. Popper, S. Chachiter, D.A. Shafritz (Eds), 'Biology and Pathobiology.' New York: Raven Press, pp. 785-800.
20. Saksena, S., Rastogi, R., Garg, N.K. and Dhawan, B.N. (1994) 'Rifampicin induced hepatotoxicity in rats. Protective effect of picroliv.' Drug Dev. Res. 33, 46-50.
21. Salaspuro, M. (1989) The organ pathogenesis of alcoholism. In: H.W. Goedde, D.P. Agarwal (Ed.),' Alcoholism. Biomedical and Genetic Aspects.' New York: Pergamon, pp. 133-166.
22. Saraswat, B., Visen, P.K.S., Patnaik, G.K. and Dhawan, B.N. (1997) 'Hepatoprotective effect of picroliv against rifampicin induced toxicity.' Drug Dev. Res.40, 299-303.
23. Schaffner, F. and Popper, H. (1975) Causation and consequences of cholestatis: an overview In: C.A. Goresky, M.M. Fisher (Ed.), 'Jaundice,' New York: Plenum Press, pp. 329-349.
24. Schwarz, L.R., Schwenk, M. and Grein, H., (1977) 'Review: Current concepts in intrahepatic cholestasis.' Acta Hepatogastroenterol. 24, 210-215.
25. Seglen, P.O. (1975) 'Preparation of isolated rat liver cells.' Methods Cell Biol. 13, 29-83.
26. Shukla, B., Visen, P.K.S., Patnaik, G.K. and Dhawan, B.N. (1991) 'Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa.' Planta Med. 57, 29-33.
27. Visen P.K.S., Shukla, B., Patnaik, G.K. Kaul, S., Kapoor, N.K. and Dhawan, B.N. (1991) 'Hepatoprotective activity of picroliv, the active principle of Picrorhiza kurroa, on rat hepatocytes against paracetamol toxicity.' Drug Dev. Res. 22, 209-219.
28. Visen, P.K.S., Saraswat, B., Patnaik, G.K., Agarwal, D.P and Dhawan, B.N. (1996) 'Protective activity of picroliv isolated from Picrorhiza kurroa against ethanol toxicity in isolated rat hepatocytes.' Indian J. Pharmacol. 2B, 98-101.