Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.

Phytotherapy Research

Volumn 20, Issue 10, 2006, Pages 831-839

  Singh, B ^a   Chandan, B K ^a   Sharma, N ^a   Bhardwaj, V ^a   Satti, N K ^a   Gupta, V N ^a   Gupta, B D ^a   Suri, K A ^a   Suri, O P ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

CCl4; Galactosamine; Hepatoprotective activity; Hepatotoxicity; Indigofera tinctoria; Indigotin; Paracetamol; Preventive and restorative; trans tetracos 15 enoic acid (TCA)

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; PARACETAMOL; PLANT EXTRACT; SILYMARIN; TRANS TETRACOS 15 ENOIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; FEMALE; IN VIVO STUDY; INDIGOFERA; LD 50; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT;

ACETAMINOPHEN; ANIMALS; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; FATTY ACIDS, MONOUNSATURATED; FEMALE; HEXOBARBITAL; HYPNOTICS AND SEDATIVES; INDIGOFERA; INERT GAS NARCOSIS; LIVER DISEASES; MALE; MICE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARALYSIS; PHYTOTHERAPY; PROTECTIVE AGENTS; RATS; RATS, WISTAR; ZOXAZOLAMINE;

INDIGOFERA TINCTORIA;

EID: 33750200222     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1856     Document Type: Article

References (19)

1. Anand KK, Singh B, Saxena A, Chandan BK, Gupta VN, Bhardwaj V. 1997. 3,4,5 Trihydroxybenzoic acid (gallic acid), the pre-dominant hepatoprotective principle from the fruits of Terminalia belerica - bioassay guided activity. Pharmacol Res 36: 315-321.
2. Dunnett CW. 1964. New tables for multiple comparisons with control. Biometrics 20: 484-494.
3. Edmondson HA, Peters RL. 1985. Liver. In Anderson's Pathology International Student Edition, 8th edn, Kissane JM (ed.). C.V. Mosby: St Louis, 2: 1096-1212.
4. Ghosh MN. 1984. Statistical analysis. In Fundamentals of Experimental Pharmacology, 2nd edn. Scientific Book Agency: Calcutta; 177-190.
5. Kirtikar KR, Basu BD. 2000. Indigofera tinctoria Linn. In Indian Medicinal Plants, 3rd ed. Blatter E, Caicus JF, Mhaskar KS (eds). (Reprint). Sri Satguru Publications: Delhi; India; 8: 2587-2590.
6. Kumar V, Cotran RS, Robbins SL. 1992. Cell injury and adaptation. In Basic Pathology, 5th edn. Prism Books: Bangalore, India; 3-24.
7. Liang H, Jin Z. 1997. Development of medicinal chemistry in China. In Comprehensive Medicinal Chemistry, Vol. 1 Kennewell PD (ed.). Pergamon Press: Oxford; 99-125.
8. Liu J, Liu Y, Madhu C, Klaaassen CD. 1993. Protective effect of oleonolic acid on acetaminophen induced hepatotoxicity. J Pharmaco Exp Ther 266: 1607-1613.
9. 50 and its error by means of logarithmic probit graph papers. Proc Soc Exp Biol Med 57: 261-264.
10. Popper H. 1986. In Progress in Liver Disease, Popper H, Schaffner F (eds). Greene and Stratton: Orlando, 8: 659-683.
11. Raza M, Ahmad M, Gado A, Shabanah-Al QA. 2003. A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. Toxicol Pharmacol 134: 451-456.
12. Singh B, Chandan BK, Gupta DK. 2003. Adaptogenic activity of a novel, withanolide-free aqueous fraction from the root of Withania somnifera Dun. (part II). Phytother Res 17: 531-536.
13. Singh B, Saxena AK, Chandan BK et al. 2001. Hepatoprotective activity of indigtone - a bioactive fraction from Indigofera tinctoria Linn. Phytother Res 15: 294-297.
14. Sreepriya M, Devaki T, Balakrishna K, Apparanantham T. 2001. Effect of Indigofera tinctoria Linn. On liver antioxidant defense system during D-galactosamine/endotoxin-induced acute hepatitis in rodents. Indian J Exp Biol 39: 181-184.
15. Swinscow TDV. 1980. In Statistics at Square One, 6th edn. British Medical Association: London; 62-70.
16. Vogel HG. 2002. In Drug Discovery and Evaluation, Pharmacological Assay 2nd end, Vogel HG, Vogel WH (eds). Springer Verlag: Berlin, Heidelberg Germany; 942-945.
17. Wells PG, Ramji P, Ku MSW. 1986. Delayed enhancement of acetaminophen hepatoxicity by general anesthesia using diethyl ether or halothane. Fundam Appl Toxicol 6: 299-306.
18. Zimmerman HJ, Ishak KG. 1981. Hepatic injury due to drugs and toxins. In Pathology of the Liver, MacSween RNM, Anthony PP, Scheuer PJ (eds). Churchill Livingstone: New York; 335-386.
19. ZS-Nagy I. 1989. Functional consequences of free radical damage to cell membranes. In CRC Handbook of Free Radicals and Antioxidants in Biomedicine, Miquel J, Quintanilha AT, Weber H (eds). 1: CRC Press: Boca Raton; 1: 199-207.