Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride

American Journal of Chinese Medicine

Volumn 34, Issue 3, 2006, Pages 471-482

  Lee, Chao Ying ^a   Peng, Wen Huang ^a   Cheng, Hao Yuan ^a   Chen, Fei Na ^b   Lai, Ming Tsung ^b   Chiu, Tai Hui ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Carbon tetrachloride; Hepatoprotective effect; Phyllanthus methanolic extracts

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; EMBLICA OFFICINALIS EXTRACT; GALLIC ACID; GLUTATHIONE PEROXIDASE; LIVER PROTECTIVE AGENT; METHANOL; PHYLLANTHUS ACIDUS EXTRACT; PHYLLANTHUS AMARUS EXTRACT; PHYLLANTHUS DEBILIS EXTRACT; PHYLLANTHUS EMBERGERI EXTRACT; PHYLLANTHUS EXTRACT; PHYLLANTHUS HOOKERI EXTRACT; PHYLLANTHUS MULTIFLORUS EXTRACT; PHYLLANTHUS MYRTIFOLIUS EXTRACT; PHYLLANTHUS TENELLUS EXTRACT; PHYLLANTHUS URINARIA EXTRACT; PLANT EXTRACT; SILYMARIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE COURSE; DOSE RESPONSE; DRUG DETERMINATION; DRUG EFFICACY; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; HISTOPATHOLOGY; LIVER FUNCTION; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; MALE; NONHUMAN; PHYLLANTHUS; PHYLLANTHUS ACIDUS; PHYLLANTHUS DEBILIS; PHYLLANTHUS EMBERGERI; PHYLLANTHUS HOOKERI; PHYLLANTHUS MULTIFLORUS; PHYLLANTHUS MYRTIFOLIUS; PHYLLANTHUS TENELLUS; PHYLLANTHUS URINARIA; PLANT LEAF; RAT; TAIWAN;

ANIMALS; CARBON TETRACHLORIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIVER; MALE; PHYLLANTHUS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TAIWAN;

EID: 33646711154     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X06004004     Document Type: Article

References (20)

1. Anand, K.K., B. Singh, A.K. Saxena, B.K. Chandan, V.N. Gupta and V. Bhardwaj. 3,4,5- Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity. Pharmacol. Res. 36: 315-321, 1997.
2. Calixto, J.B., A.R.S. Santos, V. Cechinel Filho and R.A. Yunes. A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology, and therapeutic potential. Med. Res. Rev. 18: 225-258, 1998.
3. Clauson, G.A. Mechanism of carbon tetrachloride hepatotoxicity. Pathol. and Immunopathol. Res. 8: 104-112, 1989.
4. 4-induced liver injury and survival in rats. J. Ethnopharmacology 56: 159-164, 1997.
5. Guntherberg, H. and J. Rost. The true oxidized glutathione content of red blood cells obtained by new enzymic and paper chromatographic methods. Anal. Biochem. 15: 205-210, 1966.
6. Hafeman, D.G., R.A. Sunde and W.G. Hoekstra. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J. Nut. 104: 580, 1974.
7. Hielle, J.J. and C.D. Klaassen. Glucuronidation and biliary excretion of acetaminophen in rats. J. Pharmacol. Exp. Ther. 228: 407-413, 1984.
8. Lai, T.Y., Y.W. Wu, J.G. Lin and W.C. Lin. Effect of pretreatment of rats with an urinary preparation on liver injuries induced by carbon tetrachloride and α-naphthylisothiocyanate. Am. J. Chin. Med. 26: 343-351, 1998.
9. Leelarasamee, A., S. Trakkulsomboon, P. Maunwongyathi, A. Somanabandhu, P. Pidetcha, B. Matrakool, T. Lebnak, W. Ridthimat and D. Chandanayingyong. Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers. Lancet 335: 1600-1601, 1990.
10. Litchfield, J.T. and Jr. F. Wilcoxon. A Simplified methods of evaluating dose effect experiment. J. Pharmacol. Exp. Ther. 96: 99-113, 1949.
11. Lowry, O.H. N.J. Rosdbrough, A.L. Farr and R.J. Randall. Protein measurement with the folinophenol reagent. J. Biol. Chem. 193: 265-275, 1951.
12. Marklund, S. and G. Marklund. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47: 469-474, 1974.
13. Narendranathan, M., P.C. Mini and A. Remla. A trial of Phyllanthus amarus in acute viral hepatitis. J. Clin. Epidemiol. 50: 8S, 1997.
14. Oh, H., D.H. Kim, J.H. Cho and Y.C. Kim. Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. J. Ethnopharmacology 95: 421-424, 2004.
15. Rajasubramaniam, S., Saradhi and P. Pardha. Rapid multiplication of Phyllanthus fraternus: A plant with anti-hepatitis viral activity. Industrial Crops and Products 6: 35-40, 1997.
16. Sha, D.X., Y.H. Liu, L.S. Wang and S.X. Xu. Studies on the chemical constituents of common leafflower (Phyllanthus urinaria). J. Shenyang Pharm. Univ. 17: 176-178, 2000.
17. Thyagarajan, S.P., S. Subramanian, T. Thirunalasundari and P.S Venkateswaran. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet 764-766, 1988.
18. Tsai, C.C., C.T. Kao, C.T. Hsu, C.C. Lin and J.G. Lin. Evaluation of four prescriptions of traditional Chinese medicine: Syh-Mo-Yiin, Guizhi-Fuling-Wan, Shieh-Qing-Wan and Syh-Nih-Sann on experimental acute liver damage in rats. J. Ethnopharmacology 55: 213-222, 1997.
19. Venkateswaran, P.S., I. Millman and B.S. Blumberg. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitises virus: in vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 84: 274-278, 1987.
20. Yunnan Traditional Medicine Co. Yunnan Medicine Resource Blue Book, 1st ed. Beijing Science Press, pp. 286-288, 1993.