Prediction of cytochrome P450 2B6-substrate interactions using pharmacophore ensemble/support vector machine (PhE/SVM) approach

Medicinal Chemistry

Volumn 4, Issue 4, 2008, Pages 396-406

  Leong, Max K ^a   Chen, Tzu Hsien ^a  

^a NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Cytochrome 2B6; In silico; Pharmacophore ensemble; Plasticity; Support vector machine

Indexed keywords

1,2 DIBROMOETHANE; 3,5 DIMETHYL 2 (3 PYRIDYL) 4 THIAZOLIDINONE; 7 ETHOXYCOUMARIN; AMITRIPTYLINE; ARTEETHER; CARBAMAZEPINE; CINNARIZINE; CLOTIAZEPAM; CYCLOPHOSPHAMIDE; CYTOCHROME P450 2B6; DEXTROMETHORPHAN; DIAZEPAM; DIETHYLTOLUAMIDE; EFAVIRENZ; IFOSFAMIDE; IMIPRAMINE; KETAMINE; LIDOCAINE; LOPERAMIDE; MEPHENYTOIN; METHADONE; METHYLPHENOBARBITAL; MIDAZOLAM; PENTOXYRESORUFIN; PETHIDINE; PICLAMILAST; SELEGILINE; STYRENE; TESTOSTERONE; UNINDEXED DRUG;

ACCURACY; ARTICLE; COMPUTER MODEL; COMPUTER PREDICTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG SCREENING; HUMAN; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; SUPPORT VECTOR MACHINE; VALIDATION PROCESS;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 50049117230     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608784872226     Document Type: Article

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