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Volumn 27, Issue 12, 1999, Pages 1429-1433

Role of human CYP2B6 in S-mephobarbital N-demethylation

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; CYTOCHROME P450 ISOENZYME; MEPHENYTOIN; METHYLPHENOBARBITAL; N DEMETHYLASE; ORPHENADRINE;

EID: 0032726211     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (38)

References (33)
  • 1
    • 0028802138 scopus 로고
    • Isofluranechlorodifluroethene interaction in human liver microsomes: Role of cytochrome P4502b6 in potentiation of haloethene metabolism
    • Baker MT, Olson MJ, Wang Y, Ronnenberg JR, Johnson JT and Brady AN (1995) Isofluranechlorodifluroethene interaction in human liver microsomes: Role of cytochrome P4502B6 in potentiation of haloethene metabolism. Drug Metab Dispos 23:60-64.
    • (1995) Drug Metab Dispos , vol.23 , pp. 60-64
    • Baker, M.T.1    Olson, M.J.2    Wang, Y.3    Ronnenberg, J.R.4    Johnson, J.T.5    Brady, A.N.6
  • 2
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochrome P-450 2B and 3A in human liver microsomes
    • Chang TKH, Weber GF, Crespi CL and Waxman DJ (1993) Differential activation of cyclophosphamide and ifosphamide by cytochrome P-450 2B and 3A in human liver microsomes. Cancer Res 53:5629-5637.
    • (1993) Cancer Res , vol.53 , pp. 5629-5637
    • Chang, T.K.H.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 3
    • 0027366623 scopus 로고
    • Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4′-hydroxylation
    • Chiba K, Kobayashi K, Manabe K, Tani M, Kamataki T and Ishizaki T (1993a) Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4′-hydroxylation. J Pharmacol Exp Ther 266:52-59.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 52-59
    • Chiba, K.1    Kobayashi, K.2    Manabe, K.3    Tani, M.4    Kamataki, T.5    Ishizaki, T.6
  • 4
    • 0027316226 scopus 로고
    • Development and preliminary application of a simple assay of S-mephenytoin 4-hydroxylase activity in human liver microsomes
    • Chiba K, Manabe K, Kobayashi K, Takayama Y, Tani M and Ishizaki T (1993b) Development and preliminary application of a simple assay of S-mephenytoin 4-hydroxylase activity in human liver microsomes. Eur J Clin Pharmacol 44:559-562.
    • (1993) Eur J Clin Pharmacol , vol.44 , pp. 559-562
    • Chiba, K.1    Manabe, K.2    Kobayashi, K.3    Takayama, Y.4    Tani, M.5    Ishizaki, T.6
  • 5
    • 0018212813 scopus 로고
    • Preliminary observations on the pharmacokinetics of methylphenobarbitone
    • Eadie MJ, Bochner F, Hooper WD and Tyrer JH (1978) Preliminary observations on the pharmacokinetics of methylphenobarbitone. Clin Exp Neurol 15:131-144.
    • (1978) Clin Exp Neurol , vol.15 , pp. 131-144
    • Eadie, M.J.1    Bochner, F.2    Hooper, W.D.3    Tyrer, J.H.4
  • 10
    • 0032946502 scopus 로고    scopus 로고
    • Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes
    • Granvil CP, Madan A, Sharkawi M, Parkinson A, and Wainer IW (1999) Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metab Dispos 27:533-541.
    • (1999) Drug Metab Dispos , vol.27 , pp. 533-541
    • Granvil, C.P.1    Madan, A.2    Sharkawi, M.3    Parkinson, A.4    Wainer, I.W.5
  • 11
    • 0020028678 scopus 로고
    • Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecylsulfate-polyacrylamide gel electrophoresis
    • Guengerich FP, Wang P and Davidson NK (1982) Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecylsulfate-polyacrylamide gel electrophoresis. Biochemistry 21:1698-1706.
    • (1982) Biochemistry , vol.21 , pp. 1698-1706
    • Guengerich, F.P.1    Wang, P.2    Davidson, N.K.3
  • 12
    • 0029833258 scopus 로고    scopus 로고
    • Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin
    • Heyn H, White RB and Stevens JC (1996) Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. Drug Metab Dispos 24:948-954.
    • (1996) Drug Metab Dispos , vol.24 , pp. 948-954
    • Heyn, H.1    White, R.B.2    Stevens, J.C.3
  • 13
    • 0019471999 scopus 로고
    • Pharmacokinetics and bioavailability of methylphenobarbital in man
    • Hooper WD, Kunze HE and Eadie MJ (1981a) Pharmacokinetics and bioavailability of methylphenobarbital in man. Ther Drug Monit 3:39-44.
    • (1981) Ther Drug Monit , vol.3 , pp. 39-44
    • Hooper, W.D.1    Kunze, H.E.2    Eadie, M.J.3
  • 14
    • 0019402780 scopus 로고
    • Qualitative and quantitative studies of methylphenobarbital metabolism in man
    • Hooper WD, Kunze HE and Eadie MJ (1981b) Qualitative and quantitative studies of methylphenobarbital metabolism in man. Draft Metab Dispos 9:381-385.
    • (1981) Draft Metab Dispos , vol.9 , pp. 381-385
    • Hooper, W.D.1    Kunze, H.E.2    Eadie, M.J.3
  • 15
    • 0029922646 scopus 로고    scopus 로고
    • Cytochrome P450 isoenzymes - Importance for the internist
    • Kerremans ALM (1996) Cytochrome P450 isoenzymes - Importance for the internist. Neth J Med 48:237-243.
    • (1996) Neth J Med , vol.48 , pp. 237-243
    • Kerremans, A.L.M.1
  • 16
    • 0031845066 scopus 로고    scopus 로고
    • Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6
    • Ko JW, Desta Z and Flockhart DA (1998) Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6. Drug Metab Dispos 26:775-778.
    • (1998) Drug Metab Dispos , vol.26 , pp. 775-778
    • Ko, J.W.1    Desta, Z.2    Flockhart, D.A.3
  • 19
  • 20
    • 0022212549 scopus 로고
    • Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylalion
    • Küpfer A and Branch RA (1985) Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylalion. Clin Pharmacol Ther 38:414-418.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 414-418
    • Küpfer, A.1    Branch, R.A.2
  • 21
    • 0021237993 scopus 로고
    • Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
    • Küpfer A and Preisig R (1984) Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man. Eur J Clin Pharmacol 26:753-759.
    • (1984) Eur J Clin Pharmacol , vol.26 , pp. 753-759
    • Küpfer, A.1    Preisig, R.2
  • 22
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685.
    • (1970) Nature (Lond) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 23
    • 0024547632 scopus 로고
    • Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: Implications for the assignment of substrate specificity
    • Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R and Wolf CR (1989) Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: Implications for the assignment of substrate specificity. Nucleic Acids Res 17:2907-2917.
    • (1989) Nucleic Acids Res , vol.17 , pp. 2907-2917
    • Miles, J.S.1    Bickmore, W.2    Brook, J.D.3    McLaren, A.W.4    Meehan, R.5    Wolf, C.R.6
  • 26
    • 0024319135 scopus 로고
    • Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics
    • Reidy GF, Methta I and Murray M (1989) Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics. Mol Pharmacol 35:736-743.
    • (1989) Mol Pharmacol , vol.35 , pp. 736-743
    • Reidy, G.F.1    Methta, I.2    Murray, M.3
  • 27
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers and inhibitors
    • Rendic S and Di Carlo FJ (1997) Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers and inhibitors. Drug Metab Rev 29:413-580.
    • (1997) Drug Metab Rev , vol.29 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.J.2
  • 28
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y and Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 30
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P and Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043-6046.
    • (1999) J Biol Chem , vol.274 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3    Honkakoski, P.4    Negishi, M.5
  • 31
    • 0026512675 scopus 로고
    • Phenobarbital induction of cytochrome P-450 gene expression
    • Waxman DJ and Azaroff L (1992) Phenobarbital induction of cytochrome P-450 gene expression. Biochem J 281:577-592.
    • (1992) Biochem J , vol.281 , pp. 577-592
    • Waxman, D.J.1    Azaroff, L.2
  • 32
    • 0028956887 scopus 로고
    • Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers - N-desisopropylation is mediated mainly by CYP1A2
    • Yoshimoto K, Echizen H, Chiba K, Tani M and Ishizaki T (1995) Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers - N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol 39:421-431.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 421-431
    • Yoshimoto, K.1    Echizen, H.2    Chiba, K.3    Tani, M.4    Ishizaki, T.5
  • 33
    • 0025841777 scopus 로고
    • Purification and characterization of human liver microsomal cytochrome P-450 2A6
    • Yun C-H, Shimada T and Guengerich FP (1991 ) Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol Pharmacol 40:679-685.
    • (1991) Mol Pharmacol , vol.40 , pp. 679-685
    • Yun, C.-H.1    Shimada, T.2    Guengerich, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.