메뉴 건너뛰기




Volumn 7, Issue 3, 1997, Pages 165-179

Examination of purported probes of human CYP2B6

Author keywords

7 EFC; 7 HFC; CYP2B6; Selective inhibitors; Substrate specificaty

Indexed keywords

ALPHA NAPHTHOFLAVONE; CHLORAMPHENICOL; COUMARIN DERIVATIVE; CYTOCHROME P450 ISOENZYME; DIETHYLDITHIOCARBAMIC ACID; ENZYME INHIBITOR; METHOXYCHLOR; NORMEPHENYTOIN; ORPHENADRINE;

EID: 0030822760     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199706000-00001     Document Type: Article
Times cited : (108)

References (68)
  • 1
    • 0027935778 scopus 로고
    • Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms
    • Andersson T, Miners JO, Veronese ME, Birkett DJ. Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. Br J Clin Pharmacol 1994: 38, 131-137.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 131-137
    • Andersson, T.1    Miners, J.O.2    Veronese, M.E.3    Birkett, D.J.4
  • 3
    • 0029123430 scopus 로고
    • Metabolism of highly persistent PCB congener. 2,4,5,2′,4′,5′-hexachlorobiphenyl, by human CYP2B6
    • Ariyoshi N, Oguri K, Koga N, Yoshimura H, Funae Y. Metabolism of highly persistent PCB congener. 2,4,5,2′,4′,5′-hexachlorobiphenyl, by human CYP2B6. Biochem Biophys Res Comm 1995: 212, 455-460.
    • (1995) Biochem Biophys Res Comm , vol.212 , pp. 455-460
    • Ariyoshi, N.1    Oguri, K.2    Koga, N.3    Yoshimura, H.4    Funae, Y.5
  • 4
    • 0026799461 scopus 로고
    • In vivo evidence that ethosuximide is a substrate for cytochrome P450IILA
    • Bachmann K, Chu CA, Greear V. In vivo evidence that ethosuximide is a substrate for cytochrome P450IILA. Pharmacology 1992: 45, 121-128.
    • (1992) Pharmacology , vol.45 , pp. 121-128
    • Bachmann, K.1    Chu, C.A.2    Greear, V.3
  • 8
    • 0030430033 scopus 로고    scopus 로고
    • Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalysed by human liver microsomes
    • Bourrié M, Meunier V, Berger Y, Fabre G. Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalysed by human liver microsomes. J Pharmacol Exp Ther 1996: 277, 321-332.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 321-332
    • Bourrié, M.1    Meunier, V.2    Berger, Y.3    Fabre, G.4
  • 9
    • 0024359553 scopus 로고
    • Effect of quinidine on the dextromethophan O-demethylase activity of microsomal fractions from human liver
    • Broly F, Libersa C, Lhermitte M, Bechtel P, Dupois B. Effect of quinidine on the dextromethophan O-demethylase activity of microsomal fractions from human liver. Br J Clin Pharmacol 1989: 28, 29-36.
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 29-36
    • Broly, F.1    Libersa, C.2    Lhermitte, M.3    Bechtel, P.4    Dupois, B.5
  • 10
    • 0027374515 scopus 로고
    • A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man
    • Buters JTM, Schiller CD, Chou RC. A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Biochem Pharmacol 1993: 46, 1577-1584.
    • (1993) Biochem Pharmacol , vol.46 , pp. 1577-1584
    • Buters, J.T.M.1    Schiller, C.D.2    Chou, R.C.3
  • 11
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes
    • Chang TKH, Weber GF, Crespi CL, Waxman DJ. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res 1993: 53, 5629-5637.
    • (1993) Cancer Res , vol.53 , pp. 5629-5637
    • Chang, T.K.H.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 12
    • 0028174881 scopus 로고
    • Evaluation of triacetyloleandomycin, α-napthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450
    • Chang TKH, Gonzalez FJ, Waxman DJ. Evaluation of triacetyloleandomycin, α-napthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch Biochem Biophys 1994: 311, 437-442.
    • (1994) Arch Biochem Biophys , vol.311 , pp. 437-442
    • Chang, T.K.H.1    Gonzalez, F.J.2    Waxman, D.J.3
  • 13
    • 0027366623 scopus 로고
    • Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4′-hydroxylation
    • Chiba K, Kabayashi K, Manabe K, Tani M, Kamataki T, Ishizaki T. Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4′-hydroxylation. Pharmacol Exp Ther 1993: 266, 52-59.
    • (1993) Pharmacol Exp Ther , vol.266 , pp. 52-59
    • Chiba, K.1    Kabayashi, K.2    Manabe, K.3    Tani, M.4    Kamataki, T.5    Ishizaki, T.6
  • 15
    • 0028315963 scopus 로고
    • Quantification of CYP2B7, CYP4B1 and CYPOR messenger RNAs in normal human lung and lung tumors
    • Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ. Quantification of CYP2B7, CYP4B1 and CYPOR messenger RNAs in normal human lung and lung tumors. Cancer Res 1994: 54, 1085-1091.
    • (1994) Cancer Res , vol.54 , pp. 1085-1091
    • Czerwinski, M.1    McLemore, T.L.2    Gelboin, H.V.3    Gonzalez, F.J.4
  • 16
    • 0027946075 scopus 로고
    • Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans
    • Dehal SS, Kupfer D. Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Drug Metab Dispos 1994: 22, 937-946.
    • (1994) Drug Metab Dispos , vol.22 , pp. 937-946
    • Dehal, S.S.1    Kupfer, D.2
  • 17
    • 0023919384 scopus 로고
    • A direct, highly sensitive assay for cytochrome P-450 catalyzed O-deethylation using a novel coumarin analog
    • DeLuca JG, Dysart GR, Rasnick D, Bradley MO. A direct, highly sensitive assay for cytochrome P-450 catalyzed O-deethylation using a novel coumarin analog. Biochem Pharmacol 1988: 37, 1731-1739.
    • (1988) Biochem Pharmacol , vol.37 , pp. 1731-1739
    • DeLuca, J.G.1    Dysart, G.R.2    Rasnick, D.3    Bradley, M.O.4
  • 18
    • 0029683112 scopus 로고    scopus 로고
    • Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalysing 4-hydroxylantipyrine, 3-hydroxymethyantipyrine, and norantipyrine formation
    • Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M. Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalysing 4-hydroxylantipyrine, 3-hydroxymethyantipyrine, and norantipyrine formation. Clin Pharmacol Ther 1996: 59, 613-23.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 613-623
    • Engel, G.1    Hofmann, U.2    Heidemann, H.3    Cosme, J.4    Eichelbaum, M.5
  • 20
    • 0027956791 scopus 로고
    • Characterization of dextromethorphan N-demethylation by human liver microsomes
    • Gorski JC, Jones DR, Wrighton SA, Hall SD. Characterization of dextromethorphan N-demethylation by human liver microsomes. Biochem Pharmacol 1994: 47, 173-182.
    • (1994) Biochem Pharmacol , vol.47 , pp. 173-182
    • Gorski, J.C.1    Jones, D.R.2    Wrighton, S.A.3    Hall, S.D.4
  • 21
    • 0026035519 scopus 로고
    • Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich FP, Kim D-H, Iwasaki M. Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 1991: 4, 168-179.
    • (1991) Chem Res Toxicol , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kim, D.-H.2    Iwasaki, M.3
  • 22
    • 0029833258 scopus 로고    scopus 로고
    • Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin
    • Heyn H, White, RB, Stevens JC. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. Drug Metab Dispos 1996: 24, 948-953.
    • (1996) Drug Metab Dispos , vol.24 , pp. 948-953
    • Heyn, H.1    White, R.B.2    Stevens, J.C.3
  • 23
    • 0030176193 scopus 로고    scopus 로고
    • Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential
    • Hoult JRS, M Payá. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996: 27, 713-722.
    • (1996) Gen Pharmacol , vol.27 , pp. 713-722
    • Hoult, J.R.S.1    Payá, M.2
  • 27
    • 0030434501 scopus 로고    scopus 로고
    • Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers
    • Koyama E, Chiba K, Tani M, Ishizaki T. Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. J Pharmacol Exp Ther 1996: 278, 21-30.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 21-30
    • Koyama, E.1    Chiba, K.2    Tani, M.3    Ishizaki, T.4
  • 29
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of the bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 1970: 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 30
    • 4244115258 scopus 로고
    • Role of human NADPH: Cytochrome P-450 CYP2B gene family in the metabolism of the anticancer bioreductive drug tirapazamine (WIN 59075: SR4233)
    • Lewis AD, Walker C, Morecroft I, Henderson C, Wolf CR. Role of human NADPH: cytochrome P-450 CYP2B gene family in the metabolism of the anticancer bioreductive drug tirapazamine (WIN 59075: SR4233). Proc Am Assoc Cancer Res 1995: 36, 3581.
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 3581
    • Lewis, A.D.1    Walker, C.2    Morecroft, I.3    Henderson, C.4    Wolf, C.R.5
  • 31
    • 0026677396 scopus 로고
    • Cotinine formation by cDNA-expressed human cytochromes P450
    • McCracken NW, Cholerton S, Idle JR. Cotinine formation by cDNA-expressed human cytochromes P450. Med Sci Res 1992: 20, 877-878.
    • (1992) Med Sci Res , vol.20 , pp. 877-878
    • McCracken, N.W.1    Cholerton, S.2    Idle, J.R.3
  • 32
    • 0023901028 scopus 로고
    • A novel human cytochrome P450 gene (P450IIB):chromosomal localization and evidence for alternative splicing
    • Miles JS, Spurr NK, Gough AC, Jowett T, McLaren AW, Brook JD, Wolf CR. A novel human cytochrome P450 gene (P450IIB):chromosomal localization and evidence for alternative splicing. Nucleic Acid Res 1988: 16, 5783-5795.
    • (1988) Nucleic Acid Res , vol.16 , pp. 5783-5795
    • Miles, J.S.1    Spurr, N.K.2    Gough, A.C.3    Jowett, T.4    McLaren, A.W.5    Brook, J.D.6    Wolf, C.R.7
  • 34
    • 0025323155 scopus 로고
    • Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents
    • Murray M, Reidy GF. Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents. Pharmacol Rev 1990: 42, 82-101.
    • (1990) Pharmacol Rev , vol.42 , pp. 82-101
    • Murray, M.1    Reidy, G.F.2
  • 35
    • 0027793369 scopus 로고
    • Characterisation of human cytochrome P450 isozymes responsible for styrene metabolism
    • Sorsa M, Peltonen K, Vainio H, Hemminki K, eds. Lyon, IARC Scientific Publications No 127
    • Nakajima T, Elovaara E, Gonzalez FJ, Gelboin HV, Vainio H, Aoyama T. Characterisation of human cytochrome P450 isozymes responsible for styrene metabolism. In: Sorsa M, Peltonen K, Vainio H, Hemminki K, eds. Butadiene and styrene: Assessment of health hazards. Lyon, IARC Scientific Publications No 127, 1993: 101-108.
    • (1993) Butadiene and Styrene: Assessment of Health Hazards , pp. 101-108
    • Nakajima, T.1    Elovaara, E.2    Gonzalez, F.J.3    Gelboin, H.V.4    Vainio, H.5    Aoyama, T.6
  • 37
    • 0028858960 scopus 로고
    • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
    • Newton DJ, Wang RW, Lu AYH. Cytochrome P450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metab Dispos 1995: 23, 154-158.
    • (1995) Drug Metab Dispos , vol.23 , pp. 154-158
    • Newton, D.J.1    Wang, R.W.2    Lu, A.Y.H.3
  • 38
    • 0030056594 scopus 로고    scopus 로고
    • Spicificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
    • Ono S, Hatanaka T, Hotta H, Satoh T, Gonzalez FJ, Tsutsui M. Spicificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica 1996: 26, 681-693.
    • (1996) Xenobiotica , vol.26 , pp. 681-693
    • Ono, S.1    Hatanaka, T.2    Hotta, H.3    Satoh, T.4    Gonzalez, F.J.5    Tsutsui, M.6
  • 39
    • 0028064672 scopus 로고
    • Development of a human lymphoblastoid cell line constitutively expressing human CYPIA1 cDNA: Substrate specificity with model substrates and promutagens
    • Penman BW, Chen L, Gelboin HV, Gonzalez FJ and Crespi CL. Development of a human lymphoblastoid cell line constitutively expressing human CYPIA1 cDNA: substrate specificity with model substrates and promutagens. Carcinogenesis 1994: 15, 1931-1937.
    • (1994) Carcinogenesis , vol.15 , pp. 1931-1937
    • Penman, B.W.1    Chen, L.2    Gelboin, H.V.3    Gonzalez, F.J.4    Crespi, C.L.5
  • 42
    • 0024319135 scopus 로고
    • Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isozyme-spicific complexation of cytochrome P-450 and inhibition kinetics
    • Reidy GF, Mehta I, Murray M. Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isozyme-spicific complexation of cytochrome P-450 and inhibition kinetics. Mol Pharmacol 1989: 35, 736-743.
    • (1989) Mol Pharmacol , vol.35 , pp. 736-743
    • Reidy, G.F.1    Mehta, I.2    Murray, M.3
  • 44
    • 0029891672 scopus 로고    scopus 로고
    • Metabolite complex formation of orphenadrine with cytochrome P450
    • Roos PH, Mahnke A. Metabolite complex formation of orphenadrine with cytochrome P450. Biochem Pharmacol 1996: 52, 73-84.
    • (1996) Biochem Pharmacol , vol.52 , pp. 73-84
    • Roos, P.H.1    Mahnke, A.2
  • 46
    • 0029934305 scopus 로고    scopus 로고
    • Enzyme kinetic modeling as a tool to analyze the behaviour of cytochrome P450 catalyzed reactions: Application to amitryptyline N-demethylation
    • Schmider J, Greenblatt DJ, Harmatz JS, Shader RI. Enzyme kinetic modeling as a tool to analyze the behaviour of cytochrome P450 catalyzed reactions: application to amitryptyline N-demethylation. Br J Clin Pharmacol 1996a: 41, 593-604.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 593-604
    • Schmider, J.1    Greenblatt, D.J.2    Harmatz, J.S.3    Shader, R.I.4
  • 47
    • 0030041594 scopus 로고    scopus 로고
    • Characterization of six in vitro reactions mediated by human cytochrome P450: Application to the testing of cytochrome P450-directed antibodies
    • Schmider JS, Greenblatt DJ, von Moltke LL, Harmatz JS, Duan SX, Karsov D, Shader RI. Characterization of six in vitro reactions mediated by human cytochrome P450: Application to the testing of cytochrome P450-directed antibodies. Pharmacology 1996b: 52, 125-134.
    • (1996) Pharmacology , vol.52 , pp. 125-134
    • Schmider, J.S.1    Greenblatt, D.J.2    Von Moltke, L.L.3    Harmatz, J.S.4    Duan, S.X.5    Karsov, D.6    Shader, R.I.7
  • 48
    • 0023949862 scopus 로고
    • Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by α-napthoflavone
    • Schwab GE, Raucy JL, Johnson EF. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by α-napthoflavone. Mol Pharmacol 1988: 33, 493-499.
    • (1988) Mol Pharmacol , vol.33 , pp. 493-499
    • Schwab, G.E.1    Raucy, J.L.2    Johnson, E.F.3
  • 51
    • 0028237729 scopus 로고
    • Interindividual variation in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemical: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variation in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemical: Studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994: 270, 414-423.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 53
    • 0017177127 scopus 로고
    • The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(α)pyrene
    • Stohs SJ, Grafström RC, Burke MD, Moldeus PW, Orrenius SG. The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(α)pyrene. Arch Biochem Biophys 1976: 177, 105-116.
    • (1976) Arch Biochem Biophys , vol.177 , pp. 105-116
    • Stohs, S.J.1    Grafström, R.C.2    Burke, M.D.3    Moldeus, P.W.4    Orrenius, S.G.5
  • 54
    • 0029671245 scopus 로고    scopus 로고
    • 3H]methoxychlor as a probe for liver microsomal CYP2B activity: Potential for in vivo CYP2B assay
    • 3H]methoxychlor as a probe for liver microsomal CYP2B activity: potential for in vivo CYP2B assay. Anal Biochem 1996: 233, 100-107.
    • (1996) Anal Biochem , vol.233 , pp. 100-107
    • Stresser, D.M.1    Dehal, S.S.2    Kupfer, D.3
  • 57
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheet: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheet: procedure and some applications. Proc Natl Acad Sci 1979: 76, 4350-4354.
    • (1979) Proc Natl Acad Sci , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 59
    • 0029872402 scopus 로고    scopus 로고
    • Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor
    • VandenBranden M, Ring BJ, Binkley S, Wrighton SA. Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor. Pharmacogenetics 1996: 6, 81-91.
    • (1996) Pharmacogenetics , vol.6 , pp. 81-91
    • VandenBranden, M.1    Ring, B.J.2    Binkley, S.3    Wrighton, S.A.4
  • 60
    • 0016174577 scopus 로고
    • Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes
    • van der Hoeven TA Coon MJ. Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes. J Biol Chem 1974: 249, 6302-6310.
    • (1974) J Biol Chem , vol.249 , pp. 6302-6310
    • Van Der Hoeven, T.A.1    Coon, M.J.2
  • 63
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • Wrighton SA, Stevens JC. The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 1992: 22, 1-21.
    • (1992) Crit Rev Toxicol , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 65
    • 0029156695 scopus 로고
    • The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies
    • Wrighton SA, Ring BJ, VandenBranden M. The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies. Toxicologic Pathology 1995: 23, 199-208.
    • (1995) Toxicologic Pathology , vol.23 , pp. 199-208
    • Wrighton, S.A.1    Ring, B.J.2    VandenBranden, M.3
  • 66
    • 0024464027 scopus 로고
    • cDNA cloning and sequence and cDNA-directed expression of human P450IIB1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver
    • Yamano S, Nhamburo PT, Aoyama T, Meyer UA, Inaba T, Kalow W, Gelboin HV, McBride OW, Gonzalez FJ. cDNA cloning and sequence and cDNA-directed expression of human P450IIB1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemistry 1989: 28, 7340-7348.
    • (1989) Biochemistry , vol.28 , pp. 7340-7348
    • Yamano, S.1    Nhamburo, P.T.2    Aoyama, T.3    Meyer, U.A.4    Inaba, T.5    Kalow, W.6    Gelboin, H.V.7    McBride, O.W.8    Gonzalez, F.J.9
  • 67
    • 0030064194 scopus 로고    scopus 로고
    • 7-ethoxycoumarin O-deethylation catalyzed by cytochromes P4501A2 and 2E1 in human liver microsomes
    • Yamazaki H, Inoue K, Mimura M, Oda Y, Guengerich FP, Shimada T, 7-ethoxycoumarin O-deethylation catalyzed by cytochromes P4501A2 and 2E1 in human liver microsomes. Biochem Pharmacol 1996: 51, 313-319.
    • (1996) Biochem Pharmacol , vol.51 , pp. 313-319
    • Yamazaki, H.1    Inoue, K.2    Mimura, M.3    Oda, Y.4    Guengerich, F.P.5    Shimada, T.6
  • 68
    • 0025841777 scopus 로고
    • Purification and characterization of human liver microsomal cytochrome P-450 2A6
    • Yun C-H, Shimada T, Guengerich FP. Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol Pharmacol 1991: 40, 679-685.
    • (1991) Mol Pharmacol , vol.40 , pp. 679-685
    • Yun, C.-H.1    Shimada, T.2    Guengerich, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.