Human dopamine D3 and D2L receptors couple to inward rectifier potassium channels in mammalian cell lines

Molecular and Cellular Neurosciences

Volumn 12, Issue 6, 1998, Pages 390-402

  Kuzhikandathil, Eldo V ^a   Yu, Weifeng ^b   Oxford, Gerry S ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Icagen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC RECEPTOR; NEUROTRANSMITTER; PERTUSSIS TOXIN; POTASSIUM CHANNEL; SOMATOSTATIN; SOMATOSTATIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL LINE; CHO CELL; CONTROLLED STUDY; DESENSITIZATION; DOPAMINERGIC SYSTEM; HUMAN; IMMUNOBLOTTING; MAMMAL CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR OCCUPANCY; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0032419907     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1998.0722     Document Type: Article

References (36)

1. Accili D., Fishburn C. S., Drago J., Steiner H., Lachowicz J. E., Park B. H., Gauda E. B., Lee E. J., Cool M. H., Sibley D. R., Gerfen C. R., Westphal H., Fuchs S. A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Proc. Natl. Acad. Sci. USA. 93:1996;1945-1949.
2. Bouthenet M. L., Souil E., Martres M. P., Sokoloff P., Giros B., Schwartz J. C. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: Comparison with dopamine D2 receptor mRNA. Brain Res. 564:1991;203-219.
3. Burris K. D., Pacheco M. A., Filtz T. M., Kung M.-P., Kung H. F., Molinoff P. B. Lack of discrimination of agonist for D2 and D3 dopamine receptors. Neuropsychopharmacology. 12:1995;335-345.
4. Chio C. L., Lajiness M. E., Huff R. M. Activation of heterologously expressed D3 dopamine receptors: Comparison with D2 dopamine receptors. Mol. Pharmacol. 45:1994;51-60.
5. Cox B. A., Rosser M. P., Kozlowski M. R., Duwe K. M., Neve R. L., Neve K. A. Regulation and functional characterization of a rat recombinant dopamine D3 receptor. Synapse. 21:1995;1-9.
6. Freedman S. B., Patel S., Marwood R., Emms F., Seabrook G. R., Knowles M. R., McAllister G. Expression and pharmacological characterization of the human D3 receptor. J. Pharmacol. Exp. Ther. 268:1994;417-426.
7. Griffon N., Pilon C., Sautel F., Schwartz J.-C., Sokoloff P. Two intracellular signaling pathways for the dopamine D3 receptor: Opposite and synergistic interactions with cyclic AMP. J. Neurochem. 68:1997;1-9.
8. Hille B. Modulation of ion channel function by G-protein coupled receptors. Trends Neurosci. 17:1994;409-442.
9. +. FEBS Lett. 405:1997;291-298.
10. Jones S. V. P. m4 muscarinic receptor subtype activates an inwardly rectifying potassium conductance in AtT-20 cells. Neurosci. Lett. 147:1992;125-130.
11. Knoerzer T. A., Watts V. J., Nichols D. E., Mailman R. B. Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. J. Medicinal Chemistry. 38:1995;3062-3070.
12. +. Proc. Natl. Acad. Sci. USA. 92:1995;6542-6546.
13. Kozasa T., Kaziro Y., Ohtsuka T., Grigg J. J., Nakajima S., Nakajima Y. G protein specificity of the muscarine-induced increase in an inward rectifier potassium current in AtT-20 cells. Neurosci. Res. 26:1996;289-297.
14. +. J. Biol. Chem. 270:1995;28660-28667.
15. +. J. Neurosci. 16:1996;7137-7150.
16. Loechner K. J., Kream R. M., Dunlap K. Calcium currents in a pituitary cell line (AtT-20): differential roles in stimulus-secretion coupling. Endocrinology. 137:1996;1429-1437.
17. Lohse M. J. Molecular mechanisms of membrane receptor desensitization. Biochem. Biophys. Acta. 1179:1993;171-188.
18. Mackie K., Lai Y., Westenbroek R., Mitchell R. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT-20 cells transfected with rat brain cannabinoid receptor. J. Neurosci. 15:1995;6552-6561.
19. 2A3. J. Pharmacol. Exper. Therap. 274:1995;790-797.
20. McAllister G., Knowles M. R., Patel S., Marwood R., Emms F., Seabrook G. R., Graziano M., Borkowski D., Hey P. J., Freedman S. B. Characterization of a chimeric hD3/D2 dopamine receptor expressed in CHO cells. FEBS Lett. 324:1993;81-86.
21. McAllister G., Knowles M. R., Ward-Booth S. M., Sinclair H., Patel S., Marwood R., Emms F., Smith A., Seabrook G. R., Freedman S. B. Functional coupling of human D2, D3 and D4 receptors in HEK293 cells. J. Recep. Sig. Transduc. Res. 15:1995;267-281.
22. O'Hara C. M., Uhland-Smith A., O'Malley K. L., Todd R. D. Inhibition of dopamine synthesis by dopamine D2 and D3 but not D4 receptors. J. Pharmacol. Exper. Therap. 277:1996;186-192.
23. Patel Y. C., Panetta R., Escher E., Greenwood M., Srikant C. B. Expression of multiple somatostatin receptor genes in AtT-20 cells. J. Biol. Chem. 269:1994;1506-1509.
24. Rivet J.-M., Audinot V., Gobert A., Peglion J.-L., Millan M. J. Modulation of mesolimbic dopamine release by the selective dopamine D3 receptor antagonist, (+) -S 14297. Eur. J. Pharmacol. 265:1994;175-177.
25. Robinson S. W., Caron M. G. Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. Pharmacol. 52:1997;508-514.
26. Schwarz J. C., Levesque D., Martres M. P., Sokoloff P. Dopamine D3 receptor: basic and clinical aspects. Clin. Pharmacol. 16:1993;295-314.
27. Sharon D., Vorobiov D., Dascal N. Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes. J. Gen. Physiol. 109:1997;477-490.
28. Sibley D. R., Neve K. A. Regulation of dopamine receptor function and expression. The Dopamine Receptors. 1997;Humana Press, Totowa.
29. Silverman S. K., Kofuji P., Dougherty D. A., Davidson N., Lester H. A. A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation. Proc. Natl. Acad. Sci. USA. 93:1996;15429-15434.
30. ++. J. Gen. Physiol. 108:1996;381-391.
31. +. J. Physiol. 502.3:1997;559-567.
32. Tang L., Todd R. D., Heller A., O'Malley K. L. Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines. J. Pharmacol. Exp. Ther. 268:1994a;495-502.
33. Tang L., Todd R. D., O'Malley K. L. Dopamine D2 and D3 receptors inhibit dopamine release. J. Pharmacol. Exp. Ther. 270:1994b;475-479.
34. Vorobiov D., Levin G., Lotan I., Dascal N. Agonist-independent inactivation and agonist-induced desensitization of the G protein-activated K+ channel (GIRK) inXenopus. Pfluger Archiv- Eur. J. Physiol. 436:1998;56-68.
35. Werner P., Hussy N., Buell G., Jones K. A., North R. A. D2, D3, and D4 dopamine receptors couple to G protein-regulated potassium channels inXenopus. Mol. Pharmacol. 49:1996;656-661.
36. Wickman K. D., Clapham D. E. G-protein regulation of ion channels. Curr. Opin. Neurobio. 5:1995;278-285.