Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations

Journal of Neuroscience

Volumn 18, Issue 9, 1998, Pages 3470-3479

  Kelly, Michele A ^a,b   Rubinstein, Marcelo ^a   Phillips, Tamara J ^b,c   Lessov, Christina N ^b   Burkhart Kasch, Sue ^b   Zhang, Ge ^b   Bunzow, James R ^b   Fang, Yuan ^b   Gerhardt, Gregory A ^d   Grandy, David K ^b   Low, Malcolm J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Department of Cell Biology ^*  (United States)

^c PORTLAND VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

129 SvEv mice; C57BL 6 mice; D2 dopamine receptor; Dopamine; Gene knock out mice; Genetics; Locomotor activity; Rotarod

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; BRAIN MONOAMINE; DOPAMINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; QUINPIROLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DOSAGE; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL;

EID: 20244389989     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-09-03470.1998     Document Type: Article

References (50)

1. Accili D, Fishbourne CS, Drago J, Steiner H, Lachowicz JE, Park BH, Gauda EB, Lee EJ, Cool MH, Sibley DR, Gerfen CR, Westphal H, Fuchs S (1996) A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci USA 93:1945-1949.
2. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH (1995) Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 65:1157-1165.
3. Baik JH, Picetti R, Salardii A, Thirlet G, Dierich A, Depaulis A, Le Meur M, Borrelli E (1995) Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377:424-428.
4. Banbury conference on genetic background in mice (1997) Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 19:755-759.
5. Bunzow JR, Zhang G, Bouvier C, Saez C, Ronnekleiv OK, Kelly MJ, Grandy DK (1995) Characterization and distribution of a cloned rat μ,-opioid receptor. J Neurochem 64:14-24.
6. Cabib S, Castellano C, Cestari V, Filibeck U, Puglisi-Allegra S (1991) D1 and D2 receptor antagonists differently affect cocaine-induced locomotor hyperactivity in the mouse. Psychopharmacology 105:335-339.
7. Civelli O, Bunzow JR, Grandy DK (1993) Molecular diversity of the dopamine receptors. Annu Rev Pharmacol Toxicol 32:281-307.
8. Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R (1985) The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87:27-45.
9. Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Gringberg A, Lee EJ, Huang SP, Bartlett PF, Jose PA, Sibley DR, Westphal H (1994) Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA 91:12564-12568.
10. Ferré S, Herrera-Marschitz M, Grabowska-Andén M, Ungerstedt U, Casas M, Andén N-E (1991) Postsynaptic dopamine/adenosine interaction: I. adenosine analogues inhibit dopamine D2-mediated behaviour in short-term reserpinized mice. Eur J Pharmacol 192:25-30.
11. Ferré S, Giménez-Llort L, Artigas F, Martinez E (1994) Motor activation in short- and long-term reserpinized mice: role of N-methyl-D- aspartate, dopamine D1 and dopamine D2 receptors. Eur J Pharmacol 255:203-213.
12. Flint J, Corley R, DeFries JC, Fulker DW, Gray JA, Miller S, Collins AC (1995) A simple genetic basis for a complex psychological trait in laboratory mice. Science 269:1432-1435.
13. Freedman SB, Patel S, Marwood R, Emms F, Seabrook GR, Knowles MR, McAllister G (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J Pharmacol Exp Ther 268:417-426.
14. Fujimiya M, Okumiya K, Nakazawa M, Kitahama K, Kimura H, Maeda T (1994) Effect of reserpine on 5-hydroxytryptophan (5HTP)-immunoreactive neurons in the rat brain. Histochemistry 101:21-26.
15. Fujiwara H (1992) Comparative studies of sulpiride and classical neuroleptics of catalepsy, locomotor activity, and brain dopamine metabolism in mice. Pharmacol Biochem Behav 41:301-308.
16. Gerlai R (1996) Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181.
17. Gingrich JA, Caron MG (1993) Recent advances in the molecular biology of dopamine receptors. Annu Rev Neurosci 16:299-321.
18. Graybiel AM (1991) Basal ganglia-input, neural activity, and relation to the cortex. Curr Opin Neurobiol 1:644-651.
19. Hall ME, Hoffer BJ, Gerhardt GA (1989) Rapid and sensitive determination of catecholamines in small tissue samples by high performance chromatography coupled with dual-electrode coulometric electrochemical detection. Liq Chromatog Gas Chromatog 7:258-265.
20. Hikosaka O (1991) Basal ganglia-possible role in motor coordination and learning. Curr Opin Neurobiol 1:638-644.
21. Hornykiewicz O (1966) Dopamine (3-hydroxytyramine) and brain function. Pharmacol Rev 18:925-964.
22. Jackson DM, Hashizume M (1986) Bromocriptine induces marked lo- comotor stimulation in dopamine-depleted mice when D-l dopamine receptors are stimulated with SKF38393. Psychopharmacology 90:147-154.
23. Janowsky A, Neve KA, Kinzie M, Taylor B, de Paulis T, Belknap JK (1992) Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine. J Pharmacol Exp Ther 26:1282-1290.
24. Kelly MA, Rubinstein M, Asa S, Zhang G, Saez C, Bunzow JR, Allen R, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ (1997) Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 19:103-113.
25. Koller W, Herbster G, Andersen D, Wack R, Gordon J (1987) Quinpirole hydrochloride, a potential anti-parkinsonism drug. Neuropharmacology 26:1031-1036.
26. LaHoste GJ, Marshall JF (1992) Dopamine supersensitivity and D1/D2 synergism are unrelated to changes in striatal receptor density. Synapse 12:14-26.
27. Lathe R (1996) Mice, gene targeting and behaviour: more than just genetic background. Trends Neurosci 19:183-185.
28. Le Moine C, Bloch B (1995) D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of Dl and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. J Comp Neurol 355:418-426.
29. Lidow MS, Elsworth JD, Goldman-Rakic PS (1997) Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. J Pharmacol Exp Ther 281:597-603.
30. Mansour A, Meador-Woodruff JH, Bunzow JR, Civelli O, Akil H, Watson SJ (1990) Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J Neurosci 10:2587-2600.
31. Meller E, Puza T, Miller JC, Friedhoff AJ, Schweitzer JW (1991) Receptor reserve for D2 dopaminergic inhibition of prolactin release in vivo and invitro. J Pharmacol Exp Ther 257:668-674.
32. Mink JW, Thach WT (1993) Basal ganglia intrinsic circuits and their role in behavior. Curr Opin Neurobiol 3:950-957.
33. Rubinstein M, Gershanik O, Stefano FJE (1988) Different roles of D1 and D2 dopamine receptors involved in locomotor activity of supersensitive mice. Eur J Pharmacol 148:419-426.
34. Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougal JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, and Grandy DK (1997) Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90:991-1001.
35. Setler PE, Sarau HM, Zirkle CL, Saunders HL (1978) The central effects of a novel dopamine agonist. Eur J Pharmacol 50:419-430.
36. Sibley DR, Monsma FJ, Shen Y (1993) Molecular neurobiology of dopaminergic receptors, Int Rev Neurobiol 35:391-415.
37. Silvia CP, King GR, Lee TH, Xue ZY, Caron MG, Ellinwood EH (1994) Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine. Mol Pharmacol 46:51-57.
38. Simpson EM, Linder CC, Sargent EE, Davisson MT, Mobraaten LE, Sharp JJ (1997) Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet 16:19-27.
39. Starr BS, Starr MS, Kilpatrick IC (1987) Behavioural role of dopamine D1 receptors in the reserpine-treated mouse. Neuroscience 22:179-188.
40. Surmeier DJ, Song WJ, Yan Z (1996) Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci 16:6579-6591.
41. Svenningsson P, LeMoine C, Kull B, Sunahara R, Bloch B, Fredholm BB (1997) Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience 80:1171-1185.
42. Svensson J, Carlsson A, Huff RM, Kling-Petersen T, Waters N (1994) Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors. Eur J Pharmacol 263:235-243.
43. Threadgill DW, Yee D, Matin A, Nadeau JH, Magnuson T (1997) Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome 8:390-393.
44. Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79:729-742.
45. Xu M, Koeltzow TE, Santiago GT, Moratalla R, Cooper DC, Hu X-T, White NM, Graybiel AM, White FJ, Tonegawa S (1997) Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron 19:837-848.
46. Zarrindast MR, Eliassi A (1991) Differential effects of dopamine agonists on locomotion in intact and reserpine-treated mice. Gen Pharmacol 22:1027-1031.
47. Zhang G, Lagrange AH, Ronnekleiv OK, Kelly MJ (1996) Tolerance of hypothalamic β-endorphin neurons to μ-opioid receptor activation following chronic morphine treatment. J Pharmacol Exp Ther 277:551-558.
48. Zhang M, Creese I (1993) Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: behavioral correlates. Neurosci Lett 161:223-226.
49. Zhou LW, Zhang SP, Qin ZH, Weiss B (1994) In vivo administration of an oligodeoxynucleotide antisense to the D2 dopamine receptor messenger RNA inhibits D2 dopamine receptor-mediated behavior and the expression of D2 dopamine receptors in mouse striatum. J Pharmacol Exp Ther 268:1015-1023.
50. Zhou Q-Y, Grandy DK, Thambi L, Kushner JA, Van Tol HHM, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O (1990) Cloning and expression of human and rat D1 dopamine receptors. Nature 347:76-70.