Role of MAP kinase in neurons

Molecular Neurobiology

Volumn 16, Issue 1, 1998, Pages 79-95

  Fukunaga, Kohji ^a   Miyamoto, Eishichi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; BDNF; Calmodulin dependent protein kinase; Central nervous system; Glutamate receptor; Hippocampus; MAP kinase; Stress activated protein kinase; Synaptic plasticity

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; BASIC FIBROBLAST GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CALPHOSTIN C; EPIDERMAL GROWTH FACTOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NEUROTRANSMITTER; NEUROTROPHIC FACTOR; NEUROTROPHIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HIPPOCAMPUS; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0031855511     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02740604     Document Type: Article

References (102)

1. Alderson R. F., Alterman A. L., Barde Y. A., and Lindsay R. M. (1990) Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 5, 297-306.
2. Anderson A. J., Cummings B. J., and Cotman C. W. (1994) Increased immunoreactivity for Jun-and Fos-related proteins in Alzheimer's disease: association with pathology. Exp. Neurology 125, 286-295.
3. Anderson A. J., Pike C. J., and Cotman C. W. (1995) Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis J. Neurochem. 65, 1487-1498.
4. Aoyagi A., Nishikawa K., Saito H., and Abe K. (1994) Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons. Brain Res. 661, 117-126.
5. Bading H. and Greenberg M. E. (1991) Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science 253, 912-914.
6. Bading H., Ginty D. D., and Greenberg M. E. (1993) Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260, 181-186.
7. Baraban J. M., Fiore R. S., Sanghera J. S., Paddon H. B., and Pelech S. L. (1993) Identification of p42 mitogen-activated protein kinase as a tyrosine kinase substrate activated by maximal electroconvulsive shock in hippocampus. J. Neurochem. 60, 330-336.
8. Barnier J. V., Papin C., Eychene A., Lecoq O., and Calothy G. (1995) The mouse B-Raf gene encodes multiple protein isoforms with tissue-specific expression. J. Biol. Chem. 270, 23,381-23,389.
9. Bazan N. G. and Allan G. (1996) Platelet-activating factor in the modulation of excitatory amino acid neurotransmitter release and of gene expression. J. Lipid Mediators Cell Signalling 14, 321-330.
10. Bazan N. G., Allan G., and Rodriguez de Turco E. B (1993) Role of phospholipase A2 and membrane-derived lipid second messengers in membrane function and transcriptional activation of genes: implications in cerebral ischemia and neuronal excitability. Prog. Brain Res. 247-257.
11. Blenis J. (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl Acad. Sci. USA 90, 5889-5892.
12. Blochl A. and Sirrenberg C. (1996) Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75Lntr receptors. J. Biol. Chem. 271, 21,100-21,107.
13. Boulton T. G., Nye S. H., Robbins D. J., Ip N. Y., Radziejewska E., Morgenbesser S. D., De Pinho R. A., Panayotatos N., Cobb M. H., and Yancopoulos G. D. (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65, 663-675.
14. Brondello J. M., Brunet A., Pouyssegur J., and McKenzie F R. (1997) The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade. J. Biol. Chem. 272, 1368-1376.
15. Brott B. K., Alessandrini A., Largaespada D. A., Copeland N. G., Jenkins N. A., Crews C. M., and Erikson R. L. (1993) MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth Differentiation 4, 921-929.
16. Burgering B. M., Pronk G. J., van W. P., Chardin P., and Bos J. L. (1993) cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12, 4211-4220.
17. Campos-González R. and Kindy M. S. (1992) Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain. J. Neurochem. 59, 1955-1958.
18. Carroll M. P. and May W. S. (1994) Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J. Biol. Chem. 269, 1249-1256.
19. Castren E., Pitkanen M., Sirvio J., Parsadanian A., Lindholm D., Thoenen H., and Riekkinen P. J. (1993) The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. NeuroReport 4, 895-898.
20. Catling A. D., Reuter C. W., Cox M. E., Parsons S. J., and Weber M. J. (1994) Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity. J. Biol. Chem. 269, 30,014-30,021.
21. Cook S. J. and McCormick F. (1993) Inhibition by cAMP of Ras-dependent activation of Raf [see comments]. Science 262, 1069-1072.
22. Cotman C. W. and Anderson A. J. (1995) A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10, 19-45.
23. Cowley S., Paterson H., Kemp P., and Marshall C. J. (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852.
24. Crews C. M. and Erikson R. L. (1993) Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell 74, 215-217.
25. Davis R. J. (1993) The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268, 14,553-14,556.
26. Drewes G., Lichtenberg K. B., Doring F., Mandelkow E. M., Biernat J., Goris J., Doree M., and Mandelkow E. (1992) Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state. EMBO J. 11, 2131-2138.
27. Durstin M., Durstin S., Molski T. F., Becker E. L., and Sha'afi R. I. (1994) Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase. Proc. Natl. Acad Sci. USA 91, 3142-3146.
28. Enslen H., Tokumitsu H., Stork P. J., Davis R. J., and Soderling T. R. (1996) Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc. Natl. Acad. Sci. USA 93, 10,803-10,808.
29. Fahrig T. and Sommermeyer H. (1993) Dibutyryl cyclic AMP-induced morphological differentiation of rat brain astrocytes increases alpha 1-adrenoceptor induced phosphoinositide breakdown by a mechanism involving protein synthesis. Brain Res. 602, 318-324.
30. Farnsworth C. L., Freshney N. W., Rosen L. B., Chosh A., Greenberg M. E., and Feig L. A. (1995) Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 376, 524-527.
31. 2+ dependent in primary cultures of hippocampal neurons. J. Neurochem. 61, 1105-1112.
32. 2+-dependent routes to Ras, mechanisms for neuronal survival, differentiation, and plasticity? Neuron 16, 233-236.
33. Fiore R. S., Murphy T. H., Sanghera J. S., Pelech S. L., and Baraban J. M. (1993) Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. J. Neurochem. 61, 1626-1633.
34. Frodin M., Peraldi P., and Obberghen E. V. (1994) Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. J. Biol. Chem. 269, 6207-6214.
35. Fukunaga K., Ohmitsu M., and Miyamoto E. (1995) PAF-induced activation of CaM kinase II and MAP kinase in cultured rat hippocampal neurons. Abs. Soc. Neurosc.. 21, 598.
36. Gass P., Kiessling M., and Bading H. (1993) Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain. Neurosci. Lett. 162, 39-42.
37. Häfner S., Adler H. S., Mischak H., Janosch P., Heidecker G., Wolfman A., Pippig S., Lohse M., Ueffing M., and Kolch W. (1994) Mechanism of inhibition of Raf-1 by protein kinase A. Mol. Cell. Biol. 14, 6696-6703.
38. Hawes B. E., van B. T., Koch W. J., Luttrell L. M., and Lefkovvitz R. J. (1995) Distinct pathways of Gi-and Gq-mediated mitogen-activated protein kinase activation. J. Biol. Chem. 270, 17,148-17,153.
39. Hazzalin C. A., Cano E., Cuenda A., Barratt M. J., Cohen P., and Mahadevan L. C. (1996) p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient. Current Biol. 6, 1028-1031.
40. Heidenreich K. A. and Kummer J. L. (1996) Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons J. Biol. Chem 271, 9891-9894.
41. Hirsch D. D. and Stork P. J. (1997) Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo. J. Biol. Chem. 272, 4568-4575.
42. Honda Z., Takano T., Gotoh Y., Nishida E., Ito K., and Shimizu T. (1994) Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J. Biol. Chem. 269, 2307-2315.
43. Hu B. R. and Wieloch T. (1994) Tyrosine phosphorylation and activation of mitogen-activated protein kinase in the rat brain following transient cerebral ischemia J. Neurochem. 62, 1357-1367.
44. Hyman C., Hofer M., Barde Y. A., Juhasz M., Yancopoulos G. D., Squinto S. P., and Lindsay R. M. (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230-232.
45. Janknecht R. and Nordheim A. (1996) Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene 12, 1961-1969.
46. Johnson J. E., Barde Y. A., Schwab M., and Thoenen H. (1986) Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells. J. Neurosci. 6, 3031-3038.
47. Jovanovic J. N., Benfenati F., Siow Y. L., Sihra T. S., Sanghera J. S., Pelech S. L., Greengard P., and Czernik A. J. (1996) Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc. Natl. Acad. Sci. USA 93, 3679-3683.
48. Kan H., Ruan Y., and Malik K. U. (1996) Involvement of mitogen-activated protein kinase and translocation of cytosolic phospholipase A2 to the nuclear envelope in acetylcholine-induced prostacyclin synthesis in rabbit coronary endothelial cells. Mol. Pharmacol. 50, 1139-1147.
49. Kang H. and Schuman E. M. (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267, 1658-1662.
50. Klein R., Parada L. F., Coulier F., and Barbacid M. (1989) trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 8, 3701-3709.
51. Klein R., Martin Z. D., Barbacid M., and Parada L. F. (1990a) Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development 109, 845-850.
52. Klein R., Conway D., Parada L. F., and Barbacid M. (1990b) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61, 647-656.
53. Knipper M, da, Penha, Berzaghi, M., Blochl A., Breer H., Thoenen H., and Lindholm D. (1994a) Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus. Eur. J. Neurosci. 6, 668-671.
54. Knipper M., Leung L. S., Zhao D., and Rylett R. J. (1994b) Short-term modulation of glutamatergic synapses in adult rathippo campus by NGF. NeuroReport 5, 2433-2436.
55. Knusel B., Winslow J. W., Rosenthal A., Burton L. E., Seid D. P., Nikolics K., and Hefti F. (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proc. Natl. Acad. Sci. USA 88, 961-965.
56. Kolch W., Heidecher G., Kochs G., Hummel R., Vahidi H., Mischak H., Finkenzeller G., Marmé D., and Rapp U. R. (1993) Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature 364, 249-252.
57. Korte M., Carroll P., Wolf E., Brem G., Thoenen H., and Bonhoeffer T. (1995) Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc. Natl. Acad Sci. USA 92, 8856-8860.
58. Kramer R M., Roberts E. F., Um S. L., Borsch H. A., Watson S. P., Fisher M. J., and Jakubowski J. A. (1996) p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. J. Biol. Chem. 271, 27,723-27, 729.
59. Kurino M., Fukunaga K., Ushio Y., and Miyamoto E. (1995) Activation of mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors. J. Neurochem. 65, 1282-1289.
60. Kurino M., Fukunaga K., Ushio Y., and Miyamoto E. (1996) Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes. J. Neurochem. 67, 2246-2255.
61. Lamballe F., Smeyne R. J., and Barbacid M. (1994) Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. J. Neurosci. 14, 14-28.
62. Lazarewicz J. W., Salinska E., and Wroblewski J. T. (1992) NMDA receptor-mediated arachidonic acid release in neurons: role in signal transduction and pathological aspects. Adv. Exp. Med. Biol. 73-89.
63. Lessmann V., Gottmann K., and Heumann R. (1994) BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. NeuroReport 6, 21-25.
64. Levine E. S., Dreyfus C. F., Black I. B., and Plummer M. R. (1995) Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc. Natl. Acad. Sci. USA 92, 8074-8077.
65. Lin L. L., Wartmann M., Lin A. Y., Knopf J. L., Seth A., and Davis R. J. (1993) cPLA2 is phosphorylated and activated by MAP kinase. Cell 72, 269-278.
66. Lopez I. M., Crespo P., Pellici P. G., Gutkind J. S., and Wetzker R. (1997) Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science 275, 394-397.
67. Lu Q., Soria J. P., and Wood J. G. (1993) p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons. J. Neurosci. Res. 35, 439-444.
68. Maisonpierre P. C., Belluscio L., Squinto S., Ip N. Y., Furth M. E., Lindsay R. M., and Yancopoulos G. D. (1990) Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247, 1446-1451.
69. Mandelkow E. M., Drewes G., Biernat J., Gustke N., Van L. J., Vandenheede J. R., and Mandelkow E. (1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett. 314, 315-321.
70. Marsh H. N. and Palfrey H. C. (1996) Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons. J. Neurochem. 67, 952-963.
71. Marsh H. N., Scholz W. K., Lamballe F., Klein R., Nanduri V., Barbacid M.; and Palfrey H. C. (1993) Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture. J. Neurosci. 13, 4281-4292
72. Marshall C. J. (1995) Specificity of receptor tyrosine kinase signaling transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
73. 2+/calmodulin-dependent kinase. Mol. Cell Biol. 15, 3672-3684.
74. Muthalif M. M., Benter I. F., Uddin M. R., and Malik K. U. (1996) Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells. J. Biol. Chem. 271, 30,149-30,157.
75. Nishida E. and Gotoh Y. (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18, 128-131.
76. Norris J. G., Tang L. P., Sparacio S. M., and Benveniste E. N. (1994) Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha. J. Immunol. 152, 841-50.
77. Ohtsuka T., Shimizu K., Yamamori B., Kuroda S., and Takai Y. (1996) Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein. J. Biol. Chem. 271, 1258-1261.
78. Ortiz J., Harris H. W., Guitart X., Terwilliger R. Z., Haycock J. W., and Nestler E. J. (1995) Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine. J. Neurosci. 15, 1285-1297.
79. Owada Y., Tominaga T., Yoshimoto T., and Kondo H. (1994) Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia. Brain Res. Mol. Brain Res. 25, 364-368.
80. Patterson S. L., Grover L. M., Schwartzkroin P. A., and Bothwell M. (1992) Neurotropin expression in rat hippocampal slices, a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9, 1081-1088.
81. Pelech S. L. (1995) Networking with proline-directed protein kinases implicated in tau phosphorylation. Neurobiol. Aging 16, 247-256.
82. Quinlan E. M. and Halpain S. (1996) Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development. J. Neurosci. 16, 7629-7637.
83. Riva M. A., Molteni R., Lovati E., Fumagalli F., Rusnati M., and Racagni G. (1996) Cyclic AMP-dependent regulation of fibroblast growth factor-2 messenger RNA levels in rat cortical astrocytes.: comparison with fibroblast growth factor-1 and ciliary neurotrophic factor. Mol. Pharmacol. 49, 699-706.
84. Roback J. D., Marsh H. N., Downen M., Palfrey H. C., and Wainer B. H. (1995) BDNF-activated signal transduction in rat cortical glial cells. Eur. J. Neurosci. 7, 849-862.
85. Robbins D. J., Cheng M., Zhen E., Vanderbilt C. A., Feig L. A., and Cobb M. H. (1992) Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc. Natl. Acad. Sci. USA 89, 6924-6928.
86. Sa G., Murugesan G., Jaye M., Ivashchenko Y., and Fox P. L. (1995) Activation of cytosolic phospholipase A2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J. Biol. Chem. 270, 2360-2366.
87. Storm S. M., Cleveland J. L., and Rapp U. R. (1990) Expression of raf family protooncogenes in normal mouse tissues. Oncogene 5, 345-351.
88. Stratton K. R., Worley P. F., Litz J. S., Parsons S. J., Huganir R. L., and Baraban J. M. (1991) Electroconvulsive treatment induces a rapid and transient increase in tyrosine phosphorylation of a 40-kilodalton protein associated with microtubule-associated protein 2 kinase activity. J. Neurochem. 56, 147-152.
89. Tan Y., Rouse J., Zhang A., Cariati S., Cohen P., and Comb M. J. (1996) FGF and stress regulate CREB and ATF-1 via pathway involving p38 MAP kinase and MAPKAP kinase-2 EMBO J. 15, 462-4642.
90. Tanaka T., Saito H. and Matsuki N. (1996) Basic fibroblast growth factor modulates synaptic transmission in cultured rat hippocampal neurons. Brain Res. 723, 190-195.
91. Thomas K. L. and Hunt S. P. (1993) The regional distribution of extracellularly regulated kinase-1 and -2 messenger RNA in the adult rat central nervous system. Neuroscience 56, 741-757.
92. Tokutomi N., Fukunaga K., Tokutomi Y., Miyamoto E., and Nishi K. (1997) Platelet-activating factor, a dual modulation of excitatory synaptic transmission in the rat hippocampus. Japan J. Pharmacol. 73, 176P.
93. Tournier C., Pomerance M., Gavaret J. M., and Pierre M. (1994) MAP kinase cascade in astrocytes. Glia 10, 81-88.
94. Traverse S., Gomez N., Paterson H., Marshall C., and Cohen P. (1992) Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288, 351-355.
95. van B. T., Hawes B. E., Luttrell D. K., Krueger K. M., Touhara K., Porfiri E., Sakaue M., Luttrell L. M., and Lefkowitz R. J. (1995) Receptor-tyrosine-kinase-and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature 376, 781-784.
96. Vossler M. R., Yao H., York R. D., Pan M.-G., Rim C. S., and Stork P. J. S. (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf-and Rap1-dependent pathway. Cell 89, 73-82.
97. Wiessner C. (1995) The dual specificity phosphatase PAC-1 is transcriptionally induced in the rat brain following transient forebrain ischemia. Brain Res. Mol. Brain Res. 28, 353-356.
98. Winitz S., Russell M., Qian N. X., Gardner A., Dwyer L., and Johnson G. L. (1993) Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. J. Biol. Chem. 268, 19,196-19,199.
99. Wood K. W., Sarnecki C., Roberts T. M., and Blenis J. (1992) ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68, 1041-1050.
100. Xia Z., Dickens M., Raingeaud J., Davis R. J., and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
101. Xia Z., Dudek H., Miranti C. K., and Greenberg M. E. (1996) Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J. Neurosci. 16, 5425-5436.
102. Young S. W., Dickens, M., and Tavaré J. M. (1994) Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters. FEBS Lett. 338, 212-216.