Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

Nature

Volumn 402, Issue 6762, 1999, Pages 669-671

  Bibb, James A ^a   Snyder, Gretchen L ^a   Nishi, Akinori ^b   Yan, Zhen ^a   Meijer, Laurent ^c   Flenberg, Allen A ^a   Tsai, Li Huel ^d   Kwon, Young T ^d   Girault, Jean Antoine ^e   Czernik, Andrew J ^a   Huganir, Richard L ^f   Hemmings Jr , Hugh C ^g   Nairn, Angus C ^a   Greengard, Paul ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c STATION BIOLOGIQUE   (France)

^d HARVARD MEDICAL SCHOOL   (United States)

^e INSERM   (France)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PHOSPHOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; IN VITRO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CDC2 PROTEIN KINASE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; ENZYME INHIBITORS; MICE; NERVE TISSUE PROTEINS; NEURONS; PHOSPHOPROTEINS; PHOSPHORYLATION; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THREONINE;

EID: 0033540078     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/45251     Document Type: Article

References (23)

1. Hunter, T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225-236 (1995).
2. Hemmings, H. C. Jr, Greengard, P., Tung, H. Y. L. & Cohen, P. DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature 310, 503-505 (1984).
3. Greengard, P., Allen, P. B. & Nairn, A. C. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23, 435-447 (1999).
4. Fienberg, A. A. et al. DARPP-32: Regulator of the efficacy of dopaminergic neurotransmission. Science 281, 838-842 (1998).
5. Lew, J. et al. A brain-specific activator of cyclin-dependent kinase 5. Nature 371, 423-426 (1994).
6. Tsai, L.-H., Delalle, I., Caviness, V. S. Jr, Chae, T. & Harlow, E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371, 419-423 (1994).
7. Meijer, L. et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243, 527-536 (1997).
8. Ouimet, C. C., Langley-Gullion, K. C. & Greengard, P. Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen. Brain Res. 808, 8-12 (1998).
9. r = 21,000) enriched in dopamine-innervated brain regions: Amino-acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. J. Biol. Chem. 264, 7726-7733 (1989).
10. Roche, K. W., O'Brien, R. J., Mammen, A. L., Bernhardt, J. & Huganir, R. L. Characterization of multiple phosphorylation sites on the AMPA receptor GluRI subunit. Neuron 16, 1179-1188 (1996).
11. Horiuchi, A., Williams, K. R., Kurihara, T., Nairn, A. C. & Greengard, P. Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. J. Biol. Chem. 265, 9476-9484 (1990).
12. Surmeier, D. J., Bargas, J. Hemmings, H. C. Jr, Nairn, A. C. & Greengard, P. Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron 14, 385-397 (1995).
13. Gray, P. C., Scott, J. D. & Caterall, W. A. Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins. Curr. Opin. Neurobiol. 8, 330-334 (1998).
14. Nicola, S. M., Surmeier, J. D. & Malenka, R. C. Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens. Annu. Rev. Neurosci. (in the press).
15. Pawson, T. & Scott, J. D. Signaling through scaffold, anchoring, and adaptor proteins. Science 278, 2075-2080 (1997).
16. Klauck, T. M. et al. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271, 1589-1592 (1996).
17. 2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A. Science 280, 1258-1261 (1998).
18. Tsai, L.-H., Takahashi, T., Caviness, V. S. Jr & Harlow, E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119, 1029-1040 (1993).
19. Czernik, A. J., Mathers, J., Tsou, K., Greengard, P. & Mische, S. M. in Regulatory Protein Modification, Neuromethods vol. 30 (ed. Hemmings, H. C. Jr) 219-246 (Humana, Totowa, New Jersey, 1997).
20. Girault, J.-A., Hemmings, H. C. Jr, Williams, K. R., Nairn, A. C. & Greengard, P. Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. J. Biol. Chem. 264, 21748-21759 (1989).
21. Nishi, A., Snyder, G. L. & Greengard, P. Bidirectional regulation of DARPP-32 phosphorylation by dopamine. J. Neurosci. 17, 8147-8155 (1997).
22. Snyder, G. L. et al. Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: Regulation by factors other than dopamine. J. Neurosci. 12, 3071-3083 (1992).
23. Caporaso, G. et al. Dopamine and drugs of abuse modulate phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the neostriatum. Neuropharmacology (in press).