D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLCβ1-IP3-Calcineurin-signaling cascade

Journal of Neuroscience

Volumn 20, Issue 24, 2000, Pages 8987-8995

  Hernádez López, Salvador ^a   Tkatch, Tatiana ^a   Perez Garci, Enrique ^b   Galarraga, Elvira ^b   Bargas, José ^b   Hamm, Heidi ^a   Surmeier, D James ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

Author keywords

Basal ganglia; Calcium; Dopamine; Electrophysiology; Ion channel; Medium spiny neuron; Neostriatum; Neuromodulation; Patch clamp; Single cell RT PCR

Indexed keywords

CALCINEURIN; CALCIUM CHANNEL L TYPE; DOPAMINE 2 RECEPTOR; ENKEPHALIN; PHOSPHOLIPASE C; ADENYLATE CYCLASE; BARIUM; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; INOSITOL 1,4,5 TRISPHOSPHATE; ISOENZYME; PHOSPHOLIPASE C BETA; SULPIRIDE;

ANIMAL CELL; ARTICLE; BASAL GANGLION; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM MOBILIZATION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; MEMBRANE POTENTIAL; NEOSTRIATUM; NERVE CELL; NERVE CELL STIMULATION; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ACTION POTENTIAL; ANIMAL; CORPUS STRIATUM; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; IN VITRO STUDY; ION TRANSPORT; METABOLISM; PATCH CLAMP; PHYSIOLOGY;

ACTION POTENTIALS; ADENYLATE CYCLASE; ANIMALS; BARIUM; CALCINEURIN; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CORPUS STRIATUM; DOPAMINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; INOSITOL 1,4,5-TRISPHOSPHATE; ION TRANSPORT; ISOENZYMES; NEURONS; PATCH-CLAMP TECHNIQUES; PHOSPHOLIPASE C; RATS; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION; SULPIRIDE;

EID: 0034670368     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-24-08987.2000     Document Type: Article

References (62)

1. The M1 muscarinic acetylcholine receptor in cultured rat neostriatum regulates phosphoinositide hydrolysis
2. The functional anatomy of basal ganglia disorders
3. Enzymatic gating of voltage-activated calcium channels
4. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways
5. Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels
6. An early outward conductance modulates the firing latency and frequency of neostriatal neurons of the rat brain
7. 2+ currents in acutely isolated, adult rat neostriatal neurons
8. D2 dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat striatum
9. Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes
10. A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons
11. Cortically driven Fos induction in the striatum is amplified by local dopamine D2-class receptor blockade
12. Long-term synaptic depression in the striatum: Physiological and pharmacological characterization
13. An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones
14. Dopamine control of gene expression in basal ganglia nuclei: Striatal and nonstriatal mechanisms
15. Novel form of crosstalk between G protein and tyrosine kinase pathways
16. Muscarinic receptor activation attenuates D2 dopamine receptor mediated inhibition of acetylcholine release in rat striatum: Indications for a common signal transduction pathway
17. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases
18. Xestospongins: Potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor
19. The neostriatal mosaic: Multiple levels of compartmental organization in the basal ganglia
20. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
21. The effect of dopamine D1 and D2 receptor agonists on inositol phosphate turnover in rat striatal slices
22. Identification of an autoinhibitory domain in calcineurin
23. 2+ conductance
24. Dopamine in the basal ganglia. Its role and therapeutic implications
25. 2+ currents in rat striatal neurons through parallel pathways
26. 2+ channels
27. Regenerative potentials in rat neostriatal neurons in an in vitro slice preparation
28. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling
29. D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: Relationship to dopamine stimulation of tyrosine phosphorylations
30. 2+ channels in NG108-G115 (rodent neuroblastoma x glioma hybrid) cells
31. Characterization of the human dopamine D3 receptor expressed in transfected cell lines
32. The dopamine hypothesis of schizophrenia: A review
33. Properties of Q-type calcium channels in neostriatal and cortical neurons are correlated with beta subunit expression
34. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials
35. Regulation of effectors by G-protein alpha- and beta gamma-subunits. Recent insights from studies of the phospholipase C-beta isoenzymes
36. Molecular and cellular basis of addiction
37. Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
38. Bidirectional regulation of DARPP-32 phosphorylation by dopamine
39. 2+-dependent inactivation of L-type calcium channels
40. 2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons
41. Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176
42. Regulation of phosphoinositide-specific phospholipase C isozymes
43. Further evidence against the coupling of dopamine receptors to phosphoinositide hydrolysis in rat striatum
44. Gilles de la Tourette syndrome: A neuropsychiatric disorder
45. Molecular biology of dopamine receptors
46. 2+ stores: Activation and function
47. Voltage-dependent facilitation of calcium currents in rat neostriatal neurons
48. Regulation of phospholipase C by G proteins
49. D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons
50. Dopamine receptor subtypes colocalize in rat striatonigral neurons
51. Modulation of calcium currents by a D1 dopaminergic protein kinase/ phosphatase cascade in rat neostriatal neurons
52. Coordinated expression of dopamine receptors in neostriatal medium spiny neurons
53. 2+ concentration decrease in GH4C1 cells
54. 2+ channels via phosphoinositide 3-kinase
55. Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotcnin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration
56. Expression of a dopamine D2 receptor-activated K+ channel on identified striatopallidal and striatonigral neurons
57. D2-dopamine receptor-mediated inhibition of cyclic AMP formation in striatal neurons in primary culture
58. The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons
59. 2+ currents in rat neostriatal cholinergic interneurons through a membrane-delimited, protein-kinase-C-insensitive pathway
60. D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
61. Reduction of dopamine D2 receptor transduction by activation of adenosine A2a receptors in stably A2a/D2 (long-form) receptor co-transfected mouse fibroblast cell lines: Studies on intracellular calcium levels