D4 dopamine receptor differentially regulates Akt/nuclear factor-κB and extracellular signal-regulated kinase pathways in D4MN9D cells

Molecular Pharmacology

Volumn 60, Issue 4, 2001, Pages 857-864

  Zhen, X ^a   Zhang, J ^a   Johnson, G P ^a   Friedman, E ^a  

^a CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PD 168077; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL PROLIFERATION; CLINICAL PATHWAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; GENES, SRC; HYBRID CELLS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RAS PROTEINS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SRC HOMOLOGY DOMAINS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0034807730     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. 2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats
2. 3 receptor mediates mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism
3. cAMP and βγ subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells
4. Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein βγ-subunit-initiated pathway
5. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
6. 4 sites in schizophrenic brains
7. Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients of Parkinson's disease
8. Making new connections: Role of ERK/MAP kinase signaling in neuronal plasticity
9. Induction of NF-κB by the Akt/PKB kinase
10. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI-3 kinase γ
11. 2L glioma cells
12. Role of c-Src tyrosine kinase in G protein-coupled receptor and Gβγ subunit-mediated activation of mitogen-activated protein kinases
13. Gβγ subunit mediate Src-dependent phosphorylation of the epidermal growth factor. A scaffold for G protein-coupled receptor-mediated Ras activation
14. PKB/Akt: Connecting phosphoinostide 3-kinase to cell survival and beyond
15. Roles of nuclear factor κB in neuronal survival and plasticity
16. Dopamine receptors: From structure to function
17. Activation of Akt/protein kinase B by G protein-coupled receptors
18. A novel role for phosphatidylinositol 3-kinase β in signaling from G protein-coupled receptors to Akt
19. NF-κB activation by tumor necrosis factor requires the Akt serine-threonine kinase
20. Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-κB activation in cultured human epithelial cells
21. Regulation of NF-κB activation by MAP kinase cascades
22. Lysophosphatidic acid activates NF-κB in fibroblasts. A requirement for multiple inputs
23. Molecular neurobiology of dopaminergic receptors
24. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors
25. 4 dopamine receptors in fibroblast and dopaminergic cell lines
26. Cloning of the gene for human dopamine D4 receptor with high affinity for the antipsychotic clozapine
27. Activation of microtubule-associated protein kinase (ERK) and p70 S6 kinase by D2 dopamine receptors
28. Activation of NF-κB by bradykinin through a Gαq-and Gβγ-dependent pathway that involves phosphoinositide 3-kinase and Akt
29. 4 dopamine receptor couples to cone transducin (Gαt2) to inhibit forskolin-stimulated cAMP accumulation
30. D2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
31. 1 dopamine receptor agonists mediate activation of p38 mitogen-activated protein kinase and c-Jun amino-terminal kinase by a protein kinase A-dependent mechanism in SK-N-MC human neuroblastoma cells