-
1
-
-
0032432550
-
The 1996 Bernard B. Brodie lecture: A journey in cytochrome P450 and drug metabolism research
-
Lu, A. Y. H. (1998) The 1996 Bernard B. Brodie lecture: A journey in cytochrome P450 and drug metabolism research. Drug Metab. Dispos. 26, 1168-1173.
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 1168-1173
-
-
Lu, A.Y.H.1
-
2
-
-
0026564816
-
Cytochrome P450: Progress and predictions
-
Coon, M. J., Ding, X. X., Pernecky, S. J., and Vaz, A. D. (1992) Cytochrome P450: progress and predictions. FASEB J. 6, 669-673.
-
(1992)
FASEB J.
, vol.6
, pp. 669-673
-
-
Coon, M.J.1
Ding, X.X.2
Pernecky, S.J.3
Vaz, A.D.4
-
3
-
-
0030077744
-
The remarkable P450s: A historical overview of these versatile hemoprotein catalysts
-
Estabrook, R. (1996) The remarkable P450s: a historical overview of these versatile hemoprotein catalysts. FASEB J. 10, 202-204.
-
(1996)
FASEB J.
, vol.10
, pp. 202-204
-
-
Estabrook, R.1
-
4
-
-
0032416603
-
Twenty years of biochemistry of human P450s. Purification, expression, mechanism, and relevance to drugs
-
Guengerich, F. P., Hosea, N. A., Parikh, A., Bell-Parikh, L. C., Johnson, W. W., Gillam, E. M. J., and Shimada, T. (1998) Twenty years of biochemistry of human P450s. Purification, expression, mechanism, and relevance to drugs. Drug Metab. Dispos. 26, 1175-1178.
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 1175-1178
-
-
Guengerich, F.P.1
Hosea, N.A.2
Parikh, A.3
Bell-Parikh, L.C.4
Johnson, W.W.5
Gillam, E.M.J.6
Shimada, T.7
-
6
-
-
0020431144
-
Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture
-
Conney, A. H. (1982) Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res. 42, 4875-4917.
-
(1982)
Cancer Res.
, vol.42
, pp. 4875-4917
-
-
Conney, A.H.1
-
7
-
-
0019829342
-
Mechanisms of chemical carcinogenesis
-
Miller, E. C., and Miller, J. A. (1981) Mechanisms of chemical carcinogenesis. Cancer 47, 1055-1064.
-
(1981)
Cancer
, vol.47
, pp. 1055-1064
-
-
Miller, E.C.1
Miller, J.A.2
-
8
-
-
0019074870
-
Benzo[α]pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes
-
Gelboin, H. (1980) Benzo[α]pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev. 60, 1107-1166.
-
(1980)
Physiol. Rev.
, vol.60
, pp. 1107-1166
-
-
Gelboin, H.1
-
9
-
-
0035496211
-
Tobacco and the global lung cancer epidemic
-
Proctor, R. N. (2001) Tobacco and the global lung cancer epidemic. Nat. Rev. Cancer 1, 82-86.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 82-86
-
-
Proctor, R.N.1
-
10
-
-
0030163010
-
Cytochromes P450 5: Induction of cytochrome P4501A1: A model for analyzing mammalian gene transcription
-
Whitlock, J. P., Jr., Okino, S. T., Dong, L., Ko, H. P., Clarke-Katzenberg, R., Ma, Q., and Li, H. (1996) Cytochromes P450 5: induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription. FASEB J. 10, 809-818.
-
(1996)
FASEB J.
, vol.10
, pp. 809-818
-
-
Whitlock J.P., Jr.1
Okino, S.T.2
Dong, L.3
Ko, H.P.4
Clarke-Katzenberg, R.5
Ma, Q.6
Li, H.7
-
11
-
-
0034969560
-
Induction of P4501A1. The AhR/DRE paradigm: Transcription, receptor regulation, and expanding biological roles
-
Ma, Q. (2001) Induction of P4501A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles. Curr. Drug Metab. 2, 149-164.
-
(2001)
Curr. Drug Metab.
, vol.2
, pp. 149-164
-
-
Ma, Q.1
-
12
-
-
0014439214
-
Stimulatory effect of cigarette smoking on the hydroxylation of 3,4-benzpyrene and the N-demethylation of 3-methyl-4-monomethylaminoazobenzene by enzymes in human placenta
-
Welch, R. M., Harrison, Y. E., Gommi, B. W., Poppers, P. J., Finster, M., and Conney, A. H. (1969) Stimulatory effect of cigarette smoking on the hydroxylation of 3,4-benzpyrene and the N-demethylation of 3-methyl-4-monomethylaminoazobenzene by enzymes in human placenta. Clin. Pharmacol. Ther. 10, 100-109.
-
(1969)
Clin. Pharmacol. Ther.
, vol.10
, pp. 100-109
-
-
Welch, R.M.1
Harrison, Y.E.2
Gommi, B.W.3
Poppers, P.J.4
Finster, M.5
Conney, A.H.6
-
13
-
-
0015543808
-
Inducibility of benzo[α]pyrene hydroxylase in human skin by polycylic hydrocarbons
-
Alvares, A. P., Kappas, A., Levin, W., and Conney, A. H. (1973) Inducibility of benzo[α]pyrene hydroxylase in human skin by polycylic hydrocarbons. Clin. Pharmacol. Ther. 14, 30-40.
-
(1973)
Clin. Pharmacol. Ther.
, vol.14
, pp. 30-40
-
-
Alvares, A.P.1
Kappas, A.2
Levin, W.3
Conney, A.H.4
-
14
-
-
0015682899
-
An aryl hydrocarbon hydroxylase inducibility and broncogenic carcinoma
-
Kellermann, G., Shaw, C., and Luyten-Kellermann, M. (1973) An aryl hydrocarbon hydroxylase inducibility and broncogenic carcinoma. N. Engl. J. Med. 289, 934-937.
-
(1973)
N. Engl. J. Med.
, vol.289
, pp. 934-937
-
-
Kellermann, G.1
Shaw, C.2
Luyten-Kellermann, M.3
-
15
-
-
0020385021
-
Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes
-
Kouri, R. E., McKinney, C. E., Slomiany, D. J., Snodgrass, D. R., Wray, N. P., and McLemore, T. L. (1982) Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. Cancer Res. 42, 5030-5037.
-
(1982)
Cancer Res.
, vol.42
, pp. 5030-5037
-
-
Kouri, R.E.1
McKinney, C.E.2
Slomiany, D.J.3
Snodgrass, D.R.4
Wray, N.P.5
McLemore, T.L.6
-
16
-
-
0031853744
-
The relationship between P4501A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population
-
Kiyohara, C., Nakanishi, Y., Inutsuka, S., Takayama, K., Hara, N., Motohiro, A., Tanaka, K., Kono, S., and Hirohata, T. (1998) The relationship between P4501A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population. Pharmacogenetics 8, 315-323.
-
(1998)
Pharmacogenetics
, vol.8
, pp. 315-323
-
-
Kiyohara, C.1
Nakanishi, Y.2
Inutsuka, S.3
Takayama, K.4
Hara, N.5
Motohiro, A.6
Tanaka, K.7
Kono, S.8
Hirohata, T.9
-
17
-
-
0035173344
-
Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: Relationship with P4501A1 inducibility and lung cancer
-
Cauchi, S., Stucker, I., Solas, C., Laurent-Puig, P., Cenee, S., Hemon, D., Jacquet, M., Kremers, P., Beaune, P., and Massaad-Massade, L. (2001) Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with P4501A1 inducibility and lung cancer. Carcinogenesis 22, 1819- 1824.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1819-1824
-
-
Cauchi, S.1
Stucker, I.2
Solas, C.3
Laurent-Puig, P.4
Cenee, S.5
Hemon, D.6
Jacquet, M.7
Kremers, P.8
Beaune, P.9
Massaad-Massade, L.10
-
18
-
-
0017659351
-
Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk
-
Paigen, B., Gurtoo, H. L., Minowada, J., Houten, L., Vincent, R., Paigen, K., Parker, N. B., Ward, E., and Hayner, N. T. (1977) Questionable relation of aryl hydrocarbon hydroxylase to lung- cancer risk. N. Engl. J. Med. 297, 346-350.
-
(1977)
N. Engl. J. Med.
, vol.297
, pp. 346-350
-
-
Paigen, B.1
Gurtoo, H.L.2
Minowada, J.3
Houten, L.4
Vincent, R.5
Paigen, K.6
Parker, N.B.7
Ward, E.8
Hayner, N.T.9
-
19
-
-
0033514998
-
Cytochrome P450 P4501B1 determines susceptibility to 7, 12-dimethylbenz[α]anthracene-induced lymphomas
-
Buters, J. T., Sakai, S., Richter, T., Pineau, T., Alexander, D. L., Savas, U., Doehmer, J., Ward, J. M., Jefcoate, C. R., and Gonzalez, F. J. (1999) Cytochrome P450 P4501B1 determines susceptibility to 7, 12-dimethylbenz[α]anthracene-induced lymphomas. Proc. Natl. Acad. Sci. U.S.A. 96, 1977-1982.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 1977-1982
-
-
Buters, J.T.1
Sakai, S.2
Richter, T.3
Pineau, T.4
Alexander, D.L.5
Savas, U.6
Doehmer, J.7
Ward, J.M.8
Jefcoate, C.R.9
Gonzalez, F.J.10
-
20
-
-
0034234231
-
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[α]anthracene
-
Heidel, S. M., MacWilliams, P. S., Baird, W. M., Dashwood, W. M., Buters, J. T., Gonzalez, F. J., Larsen, M. C., Czuprynski, C. J., and Jefcoate, C. R. (2000) Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[α]anthracene. Cancer Res. 60, 3454-3460.
-
(2000)
Cancer Res.
, vol.60
, pp. 3454-3460
-
-
Heidel, S.M.1
MacWilliams, P.S.2
Baird, W.M.3
Dashwood, W.M.4
Buters, J.T.5
Gonzalez, F.J.6
Larsen, M.C.7
Czuprynski, C.J.8
Jefcoate, C.R.9
-
21
-
-
0000289267
-
Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver
-
Conney, A. H., Miller, E. C., and Miller, J. A. (1957) Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. J. Biol. Chem. 228, 753-766.
-
(1957)
J. Biol. Chem.
, vol.228
, pp. 753-766
-
-
Conney, A.H.1
Miller, E.C.2
Miller, J.A.3
-
22
-
-
0035032568
-
Interindividual variability in inhibition and induction of cytochrome P450 enzymes
-
Lin, J. H., and Lu, A. Y. H. (2001) Interindividual variability in inhibition and induction of cytochrome P450 enzymes. Annu. Rev. Pharmacol. Toxicol. 41, 535-567.
-
(2001)
Annu. Rev. Pharmacol. Toxicol.
, vol.41
, pp. 535-567
-
-
Lin, J.H.1
Lu, A.Y.H.2
-
24
-
-
0023742858
-
Association of the Ah receptor with the hsp90-kDa heat shock protein
-
Perdew, G. H. (1988) Association of the Ah receptor with the hsp90-kDa heat shock protein. J. Biol. Chem. 263, 13802-13805.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 13802-13805
-
-
Perdew, G.H.1
-
25
-
-
0031002895
-
A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
-
Ma, Q., and Whitlock, J. P., Jr. (1997) A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Biol. Chem. 272, 8878-8884.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 8878-8884
-
-
Ma, Q.1
Whitlock J.P., Jr.2
-
26
-
-
0030897705
-
Ligand-dependent interaction of the Aryl hydrocarbon receptor with a novel immunophilin homologue in vivio
-
Carver, L. A., and Bradfield, C. A. (1997) Ligand-dependent interaction of the Aryl hydrocarbon receptor with a novel immunophilin homologue in vivio. J. Biol. Chem. 272, 11452-11456.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11452-11456
-
-
Carver, L.A.1
Bradfield, C.A.2
-
27
-
-
0031882767
-
Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
-
Meyer, B. K., Pray-Grant, M. G., Vanden Heuvel, J. P., and Perdew, G. H. (1998) Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol. Cell. Biol. 18, 978-988.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 978-988
-
-
Meyer, B.K.1
Pray-Grant, M.G.2
Vanden Heuvel, J.P.3
Perdew, G.H.4
-
28
-
-
0035104164
-
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor
-
Kazlauskas, A., Sundstrom, S., Poellinger, L., and Pongratz, I. (2001) The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol. Cell. Biol. 21, 2594-2607.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2594-2607
-
-
Kazlauskas, A.1
Sundstrom, S.2
Poellinger, L.3
Pongratz, I.4
-
29
-
-
0032899367
-
Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
-
Mimura, J., Ema, M., Sogawa, K., and Fujii-Kuriyama, Y. (1999) Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev. 13, 20-25.
-
(1999)
Genes Dev.
, vol.13
, pp. 20-25
-
-
Mimura, J.1
Ema, M.2
Sogawa, K.3
Fujii-Kuriyama, Y.4
-
30
-
-
0034725042
-
Superinduction of P4501A1 gene expression. Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide
-
Ma, Q., Renzelli, A. J., Baldwin, K. T., and Antonini, J. M. (2000) Superinduction of P4501A1 gene expression. Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide. J. Biol. Chem. 275, 12676-12683.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12676-12683
-
-
Ma, Q.1
Renzelli, A.J.2
Baldwin, K.T.3
Antonini, J.M.4
-
31
-
-
0037151121
-
Myb-binding protein la augments AhR-dependent gene expression
-
Jones, L. C., Okino, S. T., Gonda, T. J., and Whitlock, J. P., Jr. (2002) Myb-binding protein la augments AhR-dependent gene expression. J. Biol. Chem. 277, 22515-22519.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22515-22519
-
-
Jones, L.C.1
Okino, S.T.2
Gonda, T.J.3
Whitlock J.P., Jr.4
-
32
-
-
0030667728
-
CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt)
-
Tokyo
-
Kobayashi, A., Numayama-Tsuruta, K., Sogawa, K., and Fujii-Kuriyama, Y. (1997) CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J. Biochem. (Tokyo) 122, 703-710.
-
(1997)
J. Biochem.
, vol.122
, pp. 703-710
-
-
Kobayashi, A.1
Numayama-Tsuruta, K.2
Sogawa, K.3
Fujii-Kuriyama, Y.4
-
33
-
-
0029789568
-
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
-
Gradin, K., McGuire, J., Wenger, R. H., Kvietikova, I., Fhitelaw, M. L., Toftgard, R., Tora, L., Gassmann, M., and Poellinger, L. (1996) Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol. Cell. Biol. 16, 5221-5231.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5221-5231
-
-
Gradin, K.1
McGuire, J.2
Wenger, R.H.3
Kvietikova, I.4
Fhitelaw, M.L.5
Toftgard, R.6
Tora, L.7
Gassmann, M.8
Poellinger, L.9
-
34
-
-
0035065262
-
Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein
-
Elferink, C. J., Ge, N. L., and Levine, A. (2001) Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein. Mol. Pharmacol. 59, 664-673.
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 664-673
-
-
Elferink, C.J.1
Ge, N.L.2
Levine, A.3
-
35
-
-
0035955649
-
Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide
-
Ke, S., Rabson, A. B., Germino, J. F., Gallo, M. A., and Tian, Y. (2001) Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-alpha and lipopolysaccharide. J. Biol. Chem. 276, 39638-39644.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39638-39644
-
-
Ke, S.1
Rabson, A.B.2
Germino, J.F.3
Gallo, M.A.4
Tian, Y.5
-
36
-
-
0029616617
-
Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms
-
Schuetz, E. G., Furuya, K. N., and Schuetz, J. D. (1995) Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J. Pharmacol. Exp. Ther. 275, 1011-1018.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 1011-1018
-
-
Schuetz, E.G.1
Furuya, K.N.2
Schuetz, J.D.3
-
37
-
-
0031794361
-
Inhibition and induction of cytochrome P450 and the clinical implications
-
Lin, J. H., and Lu, A. Y. H. (1998) Inhibition and induction of cytochrome P450 and the clinical implications. Clin. Pharmacokinet. 35, 361-390.
-
(1998)
Clin. Pharmacokinet.
, vol.35
, pp. 361-390
-
-
Lin, J.H.1
Lu, A.Y.H.2
-
38
-
-
0027345632
-
Function and regulation of the human multidrug resistance gene
-
Chin, K. V., Pastan, I., and Gottesman, M. M. (1993) Function and regulation of the human multidrug resistance gene. Adv. Cancer Res. 60, 157-180.
-
(1993)
Adv. Cancer Res.
, vol.60
, pp. 157-180
-
-
Chin, K.V.1
Pastan, I.2
Gottesman, M.M.3
-
39
-
-
0026490937
-
A new functional role for P-glycoprotein: Efflux pump for benzo-(alpha)pyrene in human breast cancer MCF-7 cells
-
Yeh, G. C., Lopaczynska, J., Poore, C. M., and Phang, J. M. (1992) A new functional role for P-glycoprotein: efflux pump for benzo-(alpha)pyrene in human breast cancer MCF-7 cells. Cancer Res. 52, 6692-6695.
-
(1992)
Cancer Res.
, vol.52
, pp. 6692-6695
-
-
Yeh, G.C.1
Lopaczynska, J.2
Poore, C.M.3
Phang, J.M.4
-
40
-
-
0027132062
-
Flavonol-stimulated efflux of 7,12-dimethylbenz[α]anthracene in multidrug-resistant breast cancer cells
-
Phang, J. M., Poore, C. M., Lopaczynska, J., and Yeh, G. C. (1993) Flavonol-stimulated efflux of 7,12-dimethylbenz[α]anthracene in multidrug-resistant breast cancer cells. Cancer Res. 53, 5977-5981.
-
(1993)
Cancer Res.
, vol.53
, pp. 5977-5981
-
-
Phang, J.M.1
Poore, C.M.2
Lopaczynska, J.3
Yeh, G.C.4
-
41
-
-
0028958395
-
Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes
-
Schuetz, E. G., Schuetz, J. D., Thompson, M. T., Fisher, R. A., Madariage, J. R., and Strom, S. C. (1995) Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes. Mol. Carcinog. 12, 61-65.
-
(1995)
Mol. Carcinog.
, vol.12
, pp. 61-65
-
-
Schuetz, E.G.1
Schuetz, J.D.2
Thompson, M.T.3
Fisher, R.A.4
Madariage, J.R.5
Strom, S.C.6
-
42
-
-
0035895894
-
Aromatic hydrocarbon receptor (AhR). AhR nuclear translocator-and p53-mediated induction of the murine multidrug resistance mdrl gene by 3-methylcholanthrene and benzo[α]pyrene in hepatoma cells
-
Mathieu, M. C., Lapierre, I., Brault, K., and Raymond, M. (2001) Aromatic hydrocarbon receptor (AhR). AhR nuclear translocator-and p53-mediated induction of the murine multidrug resistance mdrl gene by 3-methylcholanthrene and benzo[α]pyrene in hepatoma cells. J. Biol. Chem. 276, 4819-4827.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4819-4827
-
-
Mathieu, M.C.1
Lapierre, I.2
Brault, K.3
Raymond, M.4
-
43
-
-
0029977698
-
Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole
-
Andersson, T. (1996) Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole. Clin. Pharmacokinet. 31, 9-28.
-
(1996)
Clin. Pharmacokinet.
, vol.31
, pp. 9-28
-
-
Andersson, T.1
-
44
-
-
0027366623
-
Oxidative metabolism of omeprazole in human liver microsomes: Cosegregation with S-mephenytoin 4′-hydroxylation
-
Chiba, K., Kobayashi, K., Manabe, K., Tani, M., Kamataki, T., and Ishizaki, T. (1993) Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4′- hydroxylation. J. Pharmacol. Exp. Ther. 266, 52-59.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.266
, pp. 52-59
-
-
Chiba, K.1
Kobayashi, K.2
Manabe, K.3
Tani, M.4
Kamataki, T.5
Ishizaki, T.6
-
45
-
-
0026806412
-
Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylation recruited from an Oriental population
-
Sohn, D. R., Kobayashi, K., Chiba, K., Lee, K. H., Shin, S. G., and Ishizaki, T. (1992) Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylation recruited from an Oriental population. J. Pharmacol. Exp. Ther. 262, 1195-1202.
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.262
, pp. 1195-1202
-
-
Sohn, D.R.1
Kobayashi, K.2
Chiba, K.3
Lee, K.H.4
Shin, S.G.5
Ishizaki, T.6
-
46
-
-
0026699994
-
Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-[N-3-methyl] caffeine breath test in poor and extensive metabolizers of S-mephenytoin
-
Rost, K. L., Brosicke, H., Brockmoller, J., Scheffler, M., Helge, H., and Roots, I. (1992) Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl] caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin. Pharmacol. Ther. 52, 170-180.
-
(1992)
Clin. Pharmacol. Ther.
, vol.52
, pp. 170-180
-
-
Rost, K.L.1
Brosicke, H.2
Brockmoller, J.3
Scheffler, M.4
Helge, H.5
Roots, I.6
-
47
-
-
0028051743
-
Specific and dose-dependent enzyme induction by omeprazole in human beings
-
Rost, K. L., Brosicke, H., Heinemeyer, G., and Roots, I. (1994) Specific and dose-dependent enzyme induction by omeprazole in human beings. Hepatology 20, 1204-1212.
-
(1994)
Hepatology
, vol.20
, pp. 1204-1212
-
-
Rost, K.L.1
Brosicke, H.2
Heinemeyer, G.3
Roots, I.4
-
48
-
-
0035214120
-
Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein
-
Pauli-Magnus, C., Rekersbrink, S., Klotz, U., and Fromm, M. F. (2001) Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. Naunyn-Schmiedebergs Arch. Pharmacol. 364, 551-557.
-
(2001)
Naunyn-Schmiedebergs Arch. Pharmacol.
, vol.364
, pp. 551-557
-
-
Pauli-Magnus, C.1
Rekersbrink, S.2
Klotz, U.3
Fromm, M.F.4
-
49
-
-
0027171481
-
Specific nuclear protein binding to a negative regulatory element on the human P4501A1 gene
-
Boucher, P. D., Ruch, R. J., and Hines, R. N. (1993) Specific nuclear protein binding to a negative regulatory element on the human P4501A1 gene. J. Biol. Chem. 268, 17384-17391.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 17384-17391
-
-
Boucher, P.D.1
Ruch, R.J.2
Hines, R.N.3
-
50
-
-
0031819422
-
Functional characterization of the human P4501A1 negative regulatory element: Modulation of Ah receptor mediated transcriptional activity
-
Piechocki, M. P., and Hines, R. N. (1998) Functional characterization of the human P4501A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity. Carcinogenesis 19, 771-780.
-
(1998)
Carcinogenesis
, vol.19
, pp. 771-780
-
-
Piechocki, M.P.1
Hines, R.N.2
-
51
-
-
0024362285
-
The human cytochrome P4501A2 gene contains regulatory elements responsive to 3-methylcholanthrene
-
Quattrochi, L. C., and Tukey, R. H. (1989) The human cytochrome P4501A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol. Pharmacol. 36, 66-71.
-
(1989)
Mol. Pharmacol.
, vol.36
, pp. 66-71
-
-
Quattrochi, L.C.1
Tukey, R.H.2
-
52
-
-
0031568830
-
Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (P4501A2) gene
-
Chung, I., and Bresnick, E. (1997) Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (P4501A2) gene. Arch. Biochem. Biophys. 338, 220-226.
-
(1997)
Arch. Biochem. Biophys.
, vol.338
, pp. 220-226
-
-
Chung, I.1
Bresnick, E.2
-
53
-
-
0032929010
-
Genetic polymorphism in the 5′-flanking region of human P4501A2 gene: Effect on the P4501A2 inducibility in humans
-
Tokyo
-
Nakajima, M., Yokoi, T., Mizutani, M., Kinoshita, M., Funayama, M., and Kamataki, T. (1999) Genetic polymorphism in the 5′-flanking region of human P4501A2 gene: effect on the P4501A2 inducibility in humans. J. Biochem. (Tokyo) 125, 803-808.
-
(1999)
J. Biochem
, vol.125
, pp. 803-808
-
-
Nakajima, M.1
Yokoi, T.2
Mizutani, M.3
Kinoshita, M.4
Funayama, M.5
Kamataki, T.6
-
54
-
-
0028987872
-
The aryl hydrocarbon receptor complex
-
Hankinson, O. (1995) The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35, 307-340.
-
(1995)
Annu. Rev. Pharmacol. Toxicol.
, vol.35
, pp. 307-340
-
-
Hankinson, O.1
-
55
-
-
0032908778
-
Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 P4501A2 gene tested with caffeine
-
Sachse, C., Brockmoller, J., Bauer, S., and Roots, I. (1999) Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 P4501A2 gene tested with caffeine. Br. J. Clin. Pharmacol. 47, 445-449.
-
(1999)
Br. J. Clin. Pharmacol.
, vol.47
, pp. 445-449
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
56
-
-
0015323626
-
The genetics of aryl hydrocarbon hydroxylase induction in mice: A single gene difference between C57BL-6J and DBA-2J
-
Thomas, P. E., Kouri, R. E., and Hutton, J. J. (1972) The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem. Genet. 6, 157-168.
-
(1972)
Biochem. Genet.
, vol.6
, pp. 157-168
-
-
Thomas, P.E.1
Kouri, R.E.2
Hutton, J.J.3
-
57
-
-
0015522481
-
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo
-
Gielen, J. E., Goujon, F. M., and Nebert, D. W. (1972) Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J. Biol. Chem. 247, 1125-1137.
-
(1972)
J. Biol. Chem.
, vol.247
, pp. 1125-1137
-
-
Gielen, J.E.1
Goujon, F.M.2
Nebert, D.W.3
-
58
-
-
0016663590
-
Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the "responsive" homozygote and heterozygote at the Ah locus
-
Niwa, A., Kumaki, K., Nebert, D. W., and Poland, A. P. (1975) Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the "responsive" homozygote and heterozygote at the Ah locus. Arch. Biochem. Biophys. 166, 559-564.
-
(1975)
Arch. Biochem. Biophys.
, vol.166
, pp. 559-564
-
-
Niwa, A.1
Kumaki, K.2
Nebert, D.W.3
Poland, A.P.4
-
59
-
-
0016706001
-
Genetic expression of aryl hydrocarbon hydroxylase by TCDD: Evidence for a receptor mutation in genetically nonresponsible mice
-
Poland, A., and Glover, E. (1975) Genetic expression of aryl hydrocarbon hydroxylase by TCDD: evidence for a receptor mutation in genetically nonresponsible mice. Mol. Pharmacol. 11, 389-398.
-
(1975)
Mol. Pharmacol.
, vol.11
, pp. 389-398
-
-
Poland, A.1
Glover, E.2
-
60
-
-
0016739812
-
Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse
-
Nebert, D. W., Robinson, J. R., Niwa, A., Kumaki, K., and Poland, A. P. (1975) Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J. Cell. Physiol. 85, 393-414.
-
(1975)
J. Cell. Physiol.
, vol.85
, pp. 393-414
-
-
Nebert, D.W.1
Robinson, J.R.2
Niwa, A.3
Kumaki, K.4
Poland, A.P.5
-
61
-
-
0017145975
-
Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
-
Poland, A., Glover, E., and Kende, A. S. (1976) Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J. Biol. Chem. 251, 4936-4946.
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 4936-4946
-
-
Poland, A.1
Glover, E.2
Kende, A.S.3
-
62
-
-
0020788230
-
Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line. Hepa-1, and assignment of recessive mutants to three complementation groups
-
Hankinson, O. (1983) Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups. Somatic Cell Genet. 9, 497-514.
-
(1983)
Somatic Cell Genet.
, vol.9
, pp. 497-514
-
-
Hankinson, O.1
-
63
-
-
0020579467
-
Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo[α]pyrene-metabolizing enzyme activity
-
Miller, A. G., Israel, D., and Whitlock, J. P., Jr. (1983) Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo[α]pyrene-metabolizing enzyme activity. J. Biol. Chem. 258, 3523-3527.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 3523-3527
-
-
Miller, A.G.1
Israel, D.2
Whitlock J.P., Jr.3
-
64
-
-
0026071422
-
Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse
-
Bradfield, C. A., Glover, E., and Poland, A. (1991) Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. Mol. Pharmacol. 39, 13-19.
-
(1991)
Mol. Pharmacol.
, vol.39
, pp. 13-19
-
-
Bradfield, C.A.1
Glover, E.2
Poland, A.3
-
65
-
-
0026725943
-
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
-
Burbach, K. M., Poland, A., and Bradfield, C. A. (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc. Natl. Acad. Sci. U.S.A. 89, 8185-8189.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 8185-8189
-
-
Burbach, K.M.1
Poland, A.2
Bradfield, C.A.3
-
66
-
-
0026749010
-
cDNA cloning and structure of mouse putative Ah receptor
-
Ema, M., Sogawa, K., Watanabe, N., Chujoh, Y., Matsushita, N., Gotoh, O., Funae, Y., and Fujii-Kuriyama, Y. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem. Biophys. Res. Commun. 184, 246-253.
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.184
, pp. 246-253
-
-
Ema, M.1
Sogawa, K.2
Watanabe, N.3
Chujoh, Y.4
Matsushita, N.5
Gotoh, O.6
Funae, Y.7
Fujii-Kuriyama, Y.8
-
67
-
-
0025906014
-
Cloning of a factor required for activity of the Ah (dioxin) receptor
-
Hoffman, E. C., Reyes, H., Chu, F. F., Sander, F., Conley, L. H., Brooks, B. A., and Hankinson, O. (1991) Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252, 954-958.
-
(1991)
Science
, vol.252
, pp. 954-958
-
-
Hoffman, E.C.1
Reyes, H.2
Chu, F.F.3
Sander, F.4
Conley, L.H.5
Brooks, B.A.6
Hankinson, O.7
-
68
-
-
0028034621
-
Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors
-
Ema, M., Ohe, N., Suzuki, M., Mimura, J., Sogawa, K., Ikawa, S., and Fujii-Kuriyama, Y. (1994) Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J. Biol. Chem. 269, 27337-27343.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27337-27343
-
-
Ema, M.1
Ohe, N.2
Suzuki, M.3
Mimura, J.4
Sogawa, K.5
Ikawa, S.6
Fujii-Kuriyama, Y.7
-
69
-
-
0029020636
-
Polymorphic forms of the Ah receptor and induction of the P4501A1 gene
-
Fujii-Kuriyama, Y., Ema, M., Mimura, J., Matsushita, N., and Sogawa, K. (1995) Polymorphic forms of the Ah receptor and induction of the P4501A1 gene. Pharmacogenetics 5, S149-S153.
-
(1995)
Pharmacogenetics
, vol.5
-
-
Fujii-Kuriyama, Y.1
Ema, M.2
Mimura, J.3
Matsushita, N.4
Sogawa, K.5
-
70
-
-
0028239139
-
Interindividual difference in expression of human Ah receptor and related P450 genes
-
Hayashi, S., Watanabe, J., Nakachi, K., Eguchi, H., Gotoh, O., and Kawajiri, K. (1994) Interindividual difference in expression of human Ah receptor and related P450 genes. Carcinogenesis 15, 801-806.
-
(1994)
Carcinogenesis
, vol.15
, pp. 801-806
-
-
Hayashi, S.1
Watanabe, J.2
Nakachi, K.3
Eguchi, H.4
Gotoh, O.5
Kawajiri, K.6
-
71
-
-
0030448768
-
Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line
-
Zhang, J., Watson, A. J., Probst, M. R., Minehart, E., and Hankinson, O. (1996) Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line. Mol. Pharmacol. 50, 1454-1462.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 1454-1462
-
-
Zhang, J.1
Watson, A.J.2
Probst, M.R.3
Minehart, E.4
Hankinson, O.5
-
72
-
-
0001283939
-
Ah receptor characterization in human placenta samples
-
Okey, A. B., Manchester, D. K., Feeley, M. M., Grant, D. L., and Gilman, A. (1995) Ah receptor characterization in human placenta samples. Organohalogen Compd. 25, 177-184.
-
(1995)
Organohalogen Compd.
, vol.25
, pp. 177-184
-
-
Okey, A.B.1
Manchester, D.K.2
Feeley, M.M.3
Grant, D.L.4
Gilman, A.5
-
73
-
-
0030977819
-
Human Ah receptor (AHR) gene: Localization to 7p15 and suggestive correlation of polymorphism with P4501A1 inducibility
-
Micka, J., Milatovich, A., Menon, A., Grabowski, G. A., Puga, A., and Nebert, D. W. (1997) Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with P4501A1 inducibility. Pharmacogenetics 7, 95-101.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 95-101
-
-
Micka, J.1
Milatovich, A.2
Menon, A.3
Grabowski, G.A.4
Puga, A.5
Nebert, D.W.6
-
74
-
-
0029078019
-
Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility
-
Kawajiri, K., Watanabe, J., Eguchi, H., and Hayashi, S. (1995) Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility. Pharmacogenetics 5, S70-S73.
-
(1995)
Pharmacogenetics
, vol.5
-
-
Kawajiri, K.1
Watanabe, J.2
Eguchi, H.3
Hayashi, S.4
-
75
-
-
0034054613
-
Variation in induced P4501A1 levels: Relationship to P4501A1. Ah receptor and GSTM1 polymorphisms
-
Smart, J., and Daly, A. K. (2000) Variation in induced P4501A1 levels: relationship to P4501A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics 10, 11-24.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 11-24
-
-
Smart, J.1
Daly, A.K.2
-
76
-
-
0035834558
-
Human aryl hydrocarbon receptor polymorphisms that result in loss of P4501A1 induction
-
Wong, J. M., Okey, A. B., and Harper, P. A. (2001) Human aryl hydrocarbon receptor polymorphisms that result in loss of P4501A1 induction. Biochem. Biophys. Res. Commun. 288, 990-996.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.288
, pp. 990-996
-
-
Wong, J.M.1
Okey, A.B.2
Harper, P.A.3
-
77
-
-
0037145057
-
Polymorphisms in the human AH receptor
-
Harper, P., Wong, J., Lam, M., and Okey, A. (2002) Polymorphisms in the human AH receptor. Chem. Biol. Interact. 141, 161.
-
(2002)
Chem. Biol. Interact.
, vol.141
, pp. 161
-
-
Harper, P.1
Wong, J.2
Lam, M.3
Okey, A.4
-
78
-
-
0029019489
-
Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions
-
Ma, Q., Dong, L., and Whitlock, J. P., Jr. (1995) Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions. J. Biol. Chem. 270, 12697-12703.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12697-12703
-
-
Ma, Q.1
Dong, L.2
Whitlock J.P., Jr.3
-
79
-
-
0029000839
-
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
-
Fernandez-Salguero, P. M., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., and Gonzalez, F. J. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268, 722-726.
-
(1995)
Science
, vol.268
, pp. 722-726
-
-
Fernandez-Salguero, P.M.1
Pineau, T.2
Hilbert, D.M.3
McPhail, T.4
Lee, S.S.T.5
Kimura, S.6
Nebert, D.W.7
Rudikoff, S.8
Ward, J.M.9
Gonzalez, F.J.10
-
80
-
-
0030015421
-
Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
-
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., and Bradfield, C. A. (1996) Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. U.S.A. 93, 6731-6736.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6731-6736
-
-
Schmidt, J.V.1
Su, G.H.2
Reddy, J.K.3
Simon, M.C.4
Bradfield, C.A.5
-
81
-
-
0034681182
-
Benzo[α]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
-
Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii-Kuriyama, Y., and Ishikawa, T. (2000) Benzo[α]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. U.S.A. 97, 779-782.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 779-782
-
-
Shimizu, Y.1
Nakatsuru, Y.2
Ichinose, M.3
Takahashi, Y.4
Kume, H.5
Mimura, J.6
Fujii-Kuriyama, Y.7
Ishikawa, T.8
-
82
-
-
0031241140
-
Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor
-
Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T. N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., Katsuki, M., and Fujii-Kuriyama, Y. (1997) Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2, 645-654.
-
(1997)
Genes Cells
, vol.2
, pp. 645-654
-
-
Mimura, J.1
Yamashita, K.2
Nakamura, K.3
Morita, M.4
Takagi, T.N.5
Nakao, K.6
Ema, M.7
Sogawa, K.8
Yasuda, M.9
Katsuki, M.10
Fujii-Kuriyama, Y.11
-
83
-
-
0030245635
-
Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity
-
Fernandez-Salguero, P. M., Hilbert, D. M., Rudikoff, S., Ward, J. M., and Gonzalez, F. (1996) Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol. Appl. Pharmacol. 140, 173-179.
-
(1996)
Toxicol. Appl. Pharmacol.
, vol.140
, pp. 173-179
-
-
Fernandez-Salguero, P.M.1
Hilbert, D.M.2
Rudikoff, S.3
Ward, J.M.4
Gonzalez, F.5
-
84
-
-
0030968826
-
A point mutation responsible for defective function of the aryl-hydrocarbon-receptor nuclear translocator in mutant Hepa-1c1c7 cells
-
Numayama-Tsuruta, K., Kobayashi, A., Sogawa, K., and Fujii-Kuriyama, Y. (1997) A point mutation responsible for defective function of the aryl-hydrocarbon-receptor nuclear translocator in mutant Hepa-1c1c7 cells. Eur. J. Biochem. 246, 486-495.
-
(1997)
Eur. J. Biochem.
, vol.246
, pp. 486-495
-
-
Numayama-Tsuruta, K.1
Kobayashi, A.2
Sogawa, K.3
Fujii-Kuriyama, Y.4
-
85
-
-
0033658607
-
An uncommon phenotype of poor inducibility of P4501A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or P4501A1 genes
-
Anttila, S., Lei, X. D., Elovaara, E., Karjalainen, A., Sun, W., Vainio, H., and Hankinson, O. (2000) An uncommon phenotype of poor inducibility of P4501A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or P4501A1 genes. Pharmacogenetics 10, 741-751.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 741-751
-
-
Anttila, S.1
Lei, X.D.2
Elovaara, E.3
Karjalainen, A.4
Sun, W.5
Vainio, H.6
Hankinson, O.7
-
86
-
-
0034103544
-
Human aryl hydrocarbon receptor nuclear translocator gene (ARNT) D/N511 polymorphism
-
Cao, H., and Hegele, R. A. (2000) Human aryl hydrocarbon receptor nuclear translocator gene (ARNT) D/N511 polymorphism. J. Hum. Genet. 45, 92-93.
-
(2000)
J. Hum. Genet.
, vol.45
, pp. 92-93
-
-
Cao, H.1
Hegele, R.A.2
-
87
-
-
0034987564
-
Human arylhydrocarbon receptor repressor (AHRR) gene: Genomic structure and analysis of polymorphism in endometriosis
-
Watanabe, T., Imoto, I., Kosugi, Y., Fukuda, Y., Mimura, J., Fujii, Y., Isaka, K., Takayama, M., Sato, A., and Inazawa, J. (2001) Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. J. Hum. Genet. 46, 342-346.
-
(2001)
J. Hum. Genet.
, vol.46
, pp. 342-346
-
-
Watanabe, T.1
Imoto, I.2
Kosugi, Y.3
Fukuda, Y.4
Mimura, J.5
Fujii, Y.6
Isaka, K.7
Takayama, M.8
Sato, A.9
Inazawa, J.10
-
88
-
-
17544384815
-
ARNT-deficient mice and placental differentiation
-
Kozak, K. R., Abbott, B., and Hankinson, O. (1997) ARNT- deficient mice and placental differentiation. Dev. Biol. 191, 297-305.
-
(1997)
Dev. Biol.
, vol.191
, pp. 297-305
-
-
Kozak, K.R.1
Abbott, B.2
Hankinson, O.3
-
89
-
-
0033777202
-
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
-
Tomita, S., Sinal, C. J., Yim, S. H., and Gonzalez, F. J. (2000) Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol. Endocrinol. 14, 1674-1681.
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1674-1681
-
-
Tomita, S.1
Sinal, C.J.2
Yim, S.H.3
Gonzalez, F.J.4
-
90
-
-
0029928689
-
cDNA cloning and tissue-specific expression of a noval basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to teh aryl hydrocarbon receptor nuclear translocator (Arnt)
-
Hirose, K., Morita, M., Ema, M., Mimura, J., Hamada, H., Fujii, H., Saijo, Y., Gotoh, O., Sogawa, K., and Fujii-Kuriyama, Y. (1996) cDNA cloning and tissue-specific expression of a noval basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to teh aryl hydrocarbon receptor nuclear translocator (Arnt). Mol. Cell. Biol. 16, 1706-1713.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1706-1713
-
-
Hirose, K.1
Morita, M.2
Ema, M.3
Mimura, J.4
Hamada, H.5
Fujii, H.6
Saijo, Y.7
Gotoh, O.8
Sogawa, K.9
Fujii-Kuriyama, Y.10
-
91
-
-
0028116593
-
Suspension-mediated induction of Hepa 1c1c7 P4501a-1 expression is dedendent on the Ah receptor signal transduction pathway
-
Sadek, C. M., and Allen-Hoffmann, B. L. (1994) Suspension- mediated induction of Hepa 1c1c7 P4501a-1 expression is dedendent on the Ah receptor signal transduction pathway. J. Biol. Chem. 269, 31505-31509.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 31505-31509
-
-
Sadek, C.M.1
Allen-Hoffmann, B.L.2
-
92
-
-
0034641727
-
Portosystemic shunting and persistent fetal vascular structure in aryl hydrocarbon receptor-defient mice
-
Lahvis, G. P., Lindell, S. L., Thomas, R. S., McCuskey, R. S., Murphy, C., Glover, E., Bentz, M., Southard, J., and Bradfield, C. A. (2000) Portosystemic shunting and persistent fetal vascular structure in aryl hydrocarbon receptor-defient mice. Proc. Natl. Acad. Sci. U.S.A. 2000, 10442-10447.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.2000
, pp. 10442-10447
-
-
Lahvis, G.P.1
Lindell, S.L.2
Thomas, R.S.3
McCuskey, R.S.4
Murphy, C.5
Glover, E.6
Bentz, M.7
Southard, J.8
Bradfield, C.A.9
-
93
-
-
0033166447
-
p27-(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells
-
Kolluri, S., Weiss, C., Koff, A., and Gottlicher, M. (1999) p27-(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13, 1742-1753.
-
(1999)
Genes Dev.
, vol.13
, pp. 1742-1753
-
-
Kolluri, S.1
Weiss, C.2
Koff, A.3
Gottlicher, M.4
-
94
-
-
0029963257
-
The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
-
Ma, Q., and Whitlock, J. P., Jr. (1996) The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell. Biol. 16, 2144-2150.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2144-2150
-
-
Ma, Q.1
Whitlock J.P., Jr.2
-
95
-
-
0037069401
-
A ligand for the aryl hydrocarbon receptor isolated from lung
-
Song, J., Clagett-Dame, M., Peterson, R. E., Hahn, M. E., Westler, W. M., Sicinski, R. R., and DeLuca, H. F. (2002) A ligand for the aryl hydrocarbon receptor isolated from lung. Proc. Natl. Acad. Sci. U.S.A. 99, 14694-14699.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 14694-14699
-
-
Song, J.1
Clagett-Dame, M.2
Peterson, R.E.3
Hahn, M.E.4
Westler, W.M.5
Sicinski, R.R.6
DeLuca, H.F.7
-
96
-
-
0035943634
-
Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine
-
Adachi, J., Mori, Y., Matsui, S., Takigami, H., Fujino, J., Kitagawa, H., Miller, C. A., III, Kato, T., Saeki, K., and Matsuda, T. (2001) Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J. Biol. Chem. 276, 31475- 31478.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 31475-31478
-
-
Adachi, J.1
Mori, Y.2
Matsui, S.3
Takigami, H.4
Fujino, J.5
Kitagawa, H.6
Miller C.A. III7
Kato, T.8
Saeki, K.9
Matsuda, T.10
-
97
-
-
0035793598
-
7-Ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor
-
Savouret, J. F., Antenos, M., Quesne, M., Xu, J., Milgrom, E., and Casper, R. F. (2001) 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. J. Biol. Chem. 276, 3054-3059.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3054-3059
-
-
Savouret, J.F.1
Antenos, M.2
Quesne, M.3
Xu, J.4
Milgrom, E.5
Casper, R.F.6
-
98
-
-
0034975420
-
Hepatic cytochrome P450 regulation in disease states
-
Cheng, P. Y., and Morgan, E. T. (2001) Hepatic cytochrome P450 regulation in disease states. Curr. Drug Metab. 2, 165-183.
-
(2001)
Curr. Drug Metab.
, vol.2
, pp. 165-183
-
-
Cheng, P.Y.1
Morgan, E.T.2
-
99
-
-
0020056612
-
Altered theophylline clearance during an influenza B outbreak
-
Kraemer, M. J., Furukawa, C. T., Koup, J. R., Shapiro, G. G., Pierson, W. E., and Bierman, C. W. (1982) Altered theophylline clearance during an influenza B outbreak. Pediatrics 69, 476- 480.
-
(1982)
Pediatrics
, vol.69
, pp. 476-480
-
-
Kraemer, M.J.1
Furukawa, C.T.2
Koup, J.R.3
Shapiro, G.G.4
Pierson, W.E.5
Bierman, C.W.6
-
100
-
-
0018190964
-
Altered theophylline pharmacokinetics during acute respiratory viral illness
-
Chang, K. C., Bell, T. D., Lauer, B. A., and Chai, H. (1978) Altered theophylline pharmacokinetics during acute respiratory viral illness. Lancet 1, 1132-1133.
-
(1978)
Lancet
, vol.1
, pp. 1132-1133
-
-
Chang, K.C.1
Bell, T.D.2
Lauer, B.A.3
Chai, H.4
-
101
-
-
0021087234
-
Depression of theophylline elimination following BCG vaccination
-
Gray, J. D., Renton, K. W., and Hung, O. R. (1983) Depression of theophylline elimination following BCG vaccination. Br. J. Clin. Pharmacol. 16, 735-737.
-
(1983)
Br. J. Clin. Pharmacol.
, vol.16
, pp. 735-737
-
-
Gray, J.D.1
Renton, K.W.2
Hung, O.R.3
-
102
-
-
0018821573
-
Decreased elimination of theophylline after influenza vaccination
-
Renton, K. W., Gray, J. D., and Hall, R. I. (1980) Decreased elimination of theophylline after influenza vaccination. Can. Med. Assoc. J. 123, 288-290.
-
(1980)
Can. Med. Assoc. J.
, vol.123
, pp. 288-290
-
-
Renton, K.W.1
Gray, J.D.2
Hall, R.I.3
-
103
-
-
0027179010
-
Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients
-
Israel, B. C., Blouin, R. A., McIntyre, W., and Shedlofsky, S. I. (1993) Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients. Br. J. Clin. Pharmacol. 36, 229-235.
-
(1993)
Br. J. Clin. Pharmacol.
, vol.36
, pp. 229-235
-
-
Israel, B.C.1
Blouin, R.A.2
McIntyre, W.3
Shedlofsky, S.I.4
-
104
-
-
0027390659
-
Depression of drug-metabolizing activity in the human liver by interferon-beta
-
Okuno, H., Takasu, M., Kano, H., Seki, T., Shiozaki, Y., and Inoue, K. (1993) Depression of drug-metabolizing activity in the human liver by interferon-beta. Hepatology 17, 65-69.
-
(1993)
Hepatology
, vol.17
, pp. 65-69
-
-
Okuno, H.1
Takasu, M.2
Kano, H.3
Seki, T.4
Shiozaki, Y.5
Inoue, K.6
-
105
-
-
0030834106
-
Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women
-
Shedlofsky, S. I., Israel, B. C., Tosheva, R., and Blouin, R. A. (1997) Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women. Br. J. Clin. Pharmacol. 43, 627-632.
-
(1997)
Br. J. Clin. Pharmacol.
, vol.43
, pp. 627-632
-
-
Shedlofsky, S.I.1
Israel, B.C.2
Tosheva, R.3
Blouin, R.A.4
-
106
-
-
0025015369
-
Depression of drug metabolizing activity in the human liver by interferon-alpha
-
Okuno, H., Kitao, Y., Takasu, M., Kano, H., Kunieda, K., Seki, T., Shiozaki, Y., and Sameshima, Y. (1990) Depression of drug metabolizing activity in the human liver by interferon-alpha. Eur. J. Clin. Pharmacol. 39, 365-367.
-
(1990)
Eur. J. Clin. Pharmacol.
, vol.39
, pp. 365-367
-
-
Okuno, H.1
Kitao, Y.2
Takasu, M.3
Kano, H.4
Kunieda, K.5
Seki, T.6
Shiozaki, Y.7
Sameshima, Y.8
-
107
-
-
0029126915
-
Differential effects of cytokines on the inducible expression of P4501A1, P4501A2, and P4503A4 in human hepatocytes in primary culture
-
Muntane-Relat, J., Ourlin, J. C., Domergue, J., and Maurel, P. (1995) Differential effects of cytokines on the inducible expression of P4501A1, P4501A2, and P4503A4 in human hepatocytes in primary culture. Hepatology 22, 1143-1153.
-
(1995)
Hepatology
, vol.22
, pp. 1143-1153
-
-
Muntane-Relat, J.1
Ourlin, J.C.2
Domergue, J.3
Maurel, P.4
-
108
-
-
0028670237
-
Transforming growth factor-beta 1 down- regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture
-
Abdel-Razzak, Z., Corcos, L., Fautrel, A., Campion, J. P., and Guillouzo, A. (1994) Transforming growth factor-beta 1 down- regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture. Mol. Pharmacol. 46, 1100-1110.
-
(1994)
Mol. Pharmacol.
, vol.46
, pp. 1100-1110
-
-
Abdel-Razzak, Z.1
Corcos, L.2
Fautrel, A.3
Campion, J.P.4
Guillouzo, A.5
-
109
-
-
0033074472
-
Effects of disease on expression and regulation of P450s
-
Farrell, G. (1999) Effects of disease on expression and regulation of P450s. Mol. Aspects Med. 20, 55-70, 137.
-
(1999)
Mol. Aspects Med.
, vol.20
, pp. 55-70
-
-
Farrell, G.1
-
110
-
-
0026756018
-
Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine
-
Vistisen, K., Poulsen, H. E., and Loft, S. (1992) Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis 13, 1561-1568.
-
(1992)
Carcinogenesis
, vol.13
, pp. 1561-1568
-
-
Vistisen, K.1
Poulsen, H.E.2
Loft, S.3
-
111
-
-
0028336794
-
Phenotyping of P4501A2 in Japaneses population by analysis of caffeine urinary metabolites: Absence of mutation prescribing the phenotype in the P4501A2 gene
-
Nakajima, M., Yokoi, T., Mizutani, M., Shin, S., Kadlubar, F. F., and Kamataki, T. (1994) Phenotyping of P4501A2 in Japaneses population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the P4501A2 gene. Cancer Epidemiol., Biomarkers Prev. 3, 413-421.
-
(1994)
Cancer Epidemiol., Biomarkers Prev.
, vol.3
, pp. 413-421
-
-
Nakajima, M.1
Yokoi, T.2
Mizutani, M.3
Shin, S.4
Kadlubar, F.F.5
Kamataki, T.6
-
112
-
-
0029859993
-
Hormonal regulation of hepatic enzymes involved in foreign compound metabolism
-
Prough, R. A., Linder, M. W., Pinaire, J. A., Xiao, G. H., and Falkner, K. C. (1996) Hormonal regulation of hepatic enzymes involved in foreign compound metabolism. FASEB J. 10, 1369- 1377.
-
(1996)
FASEB J.
, vol.10
, pp. 1369-1377
-
-
Prough, R.A.1
Linder, M.W.2
Pinaire, J.A.3
Xiao, G.H.4
Falkner, K.C.5
-
113
-
-
0017603250
-
Regulation of drug metabolism in man by environmental chemicals and diet
-
Conney, A. H., Pantuck, E. J., Hsiao, K. C., Kuntzman, R., Alvares, A. P., and Kappas, A. (1977) Regulation of drug metabolism in man by environmental chemicals and diet. Fed. Proc. 36, 1647-1652.
-
(1977)
Fed. Proc.
, vol.36
, pp. 1647-1652
-
-
Conney, A.H.1
Pantuck, E.J.2
Hsiao, K.C.3
Kuntzman, R.4
Alvares, A.P.5
Kappas, A.6
-
114
-
-
0017057209
-
Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef
-
Conney, A. H., Pantuck, E. J., Hsiao, K. C., Garland, W. A., Anderson, K. E., Alvares, A. P., and Kappas, A. (1976) Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin. Pharmacol. Ther. 20, 633-642.
-
(1976)
Clin. Pharmacol. Ther.
, vol.20
, pp. 633-642
-
-
Conney, A.H.1
Pantuck, E.J.2
Hsiao, K.C.3
Garland, W.A.4
Anderson, K.E.5
Alvares, A.P.6
Kappas, A.7
-
115
-
-
0017655196
-
Phenacetin metabolism: Effect of hydrocarbons and cigarette smoking
-
Kuntzman, R., Pantuck, E. J., Kaplan, S. A., and Conney, A. H. (1977) Phenacetin metabolism: effect of hydrocarbons and cigarette smoking. Clin. Pharmacol. Ther. 22, 757-764.
-
(1977)
Clin. Pharmacol. Ther.
, vol.22
, pp. 757-764
-
-
Kuntzman, R.1
Pantuck, E.J.2
Kaplan, S.A.3
Conney, A.H.4
-
116
-
-
0032535055
-
Resveratrol inhibits transcription of P4501A1 in vitro by preventing activation of the aryl hydrocarbon receptor
-
Ciolino, H. P., Daschner, P. J., and Yeh, G. C. (1998) Resveratrol inhibits transcription of P4501A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res. 58, 5707-5712.
-
(1998)
Cancer Res.
, vol.58
, pp. 5707-5712
-
-
Ciolino, H.P.1
Daschner, P.J.2
Yeh, G.C.3
-
117
-
-
0032861582
-
Resveratrol has antagonist activity on the aryl hydrocarbon receptor: Implications for prevention of dioxin toxicity
-
Casper, R. F., Quesne, M., Rogers, I. M., Shirota, T., Jolivet, A., Milgrom, E., and Savouret, J. F. (1999) Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity. Mol. Pharmacol. 56, 784-790.
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 784-790
-
-
Casper, R.F.1
Quesne, M.2
Rogers, I.M.3
Shirota, T.4
Jolivet, A.5
Milgrom, E.6
Savouret, J.F.7
-
118
-
-
0034617461
-
Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin
-
Ashida, H., Fukuda, I., Yamashita, T., and Kanazawa, K. (2000) Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin. FEBS Lett. 476, 213-217.
-
(2000)
FEBS Lett.
, vol.476
, pp. 213-217
-
-
Ashida, H.1
Fukuda, I.2
Yamashita, T.3
Kanazawa, K.4
-
119
-
-
0023637761
-
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity
-
Bannister, R., Davis, D., Zacharewski, T., Tizard, I., and Safe, S. (1987) Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effects on enzyme induction and immunotoxicity. Toxicology 46, 29-42.
-
(1987)
Toxicology
, vol.46
, pp. 29-42
-
-
Bannister, R.1
Davis, D.2
Zacharewski, T.3
Tizard, I.4
Safe, S.5
-
120
-
-
0024516732
-
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice
-
Bannister, R., Biegel, L., Davis, D., Astroff, B., and Safe, S. (1989) 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology 54, 139-150.
-
(1989)
Toxicology
, vol.54
, pp. 139-150
-
-
Bannister, R.1
Biegel, L.2
Davis, D.3
Astroff, B.4
Safe, S.5
-
121
-
-
0032833399
-
Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-Up of the Taiwan Yucheng cohort
-
Guo, Y. L., Yu, M. L., Hsu, C. C., and Rogan, W. J. (1999) Chloracne, goiter, arthritis, and anemia after polychlorinated biphenyl poisoning: 14-year follow-Up of the Taiwan Yucheng cohort. Environ. Health Perspect. 107, 715-719.
-
(1999)
Environ. Health Perspect.
, vol.107
, pp. 715-719
-
-
Guo, Y.L.1
Yu, M.L.2
Hsu, C.C.3
Rogan, W.J.4
-
122
-
-
0034802482
-
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: Clinical and laboratory effects
-
Geusau, A., Abraham, K., Geissler, K., Sator, M. O., Stingl, G., and Tschachler, E. (2001) Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects. Environ. Health Perspect. 109, 865-869.
-
(2001)
Environ. Health Perspect.
, vol.109
, pp. 865-869
-
-
Geusau, A.1
Abraham, K.2
Geissler, K.3
Sator, M.O.4
Stingl, G.5
Tschachler, E.6
|