The 1996 Bernard B. Brodie lecture. A journey in cytochrome p450 and drug metabolism research

Drug Metabolism and Disposition

Volumn 26, Issue 12, 1998, Pages 1168-1173

  Lu, Anthony Y H ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; OXYGENASE;

DRUG HYDROXYLATION; DRUG METABOLISM; DRUG RESEARCH; ENZYME INDUCTION; LIVER MICROSOME; PRIORITY JOURNAL; REVIEW;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; PHARMACEUTICAL PREPARATIONS;

EID: 0032432550     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (14)

1. Alvaro RF, Wislocki PG, Miwa GT and Lu AYH (1992) Drug residue formation from ronidazole, a 5-nitroimidazole: VIII. Identification of the 2-methylene position as a site of protein alkylation. Chem Biol Interact 82:21-30.
2. Atkins WM, Wang RW, Bird AW, Newton DJ and Lu AYH (1993) The catalytic mechanism of gluthathione S-transferase: Spectroscopic determination of the pKa of Tyr-9 in rat α1-1 GST. J Biol Chem 268:19188-19191.
3. Chiu SHL, Taub R, Sestokas E. Lu AYH and Jacob TA (1987) Comparative in vivo and in vitro metabolism of ivermectin in steers, sheep, swine, and rat. Drug Metab Rev 18:289-302.
4. Coon MJ (1981) The 1980 Bernard B. Brodie Award Lecture - Drug metabolism by cytochrome P450: Progress and perspectives. Drug Metab Dispos 9:1-4.
5. Gillette JR (1979) The 1978 Bernard B. Brodie Award Lecture: Extrapolations from microsomes to mice and man. Drug Metab Dispos 7:121-123.
6. Gillette JR, Conney AH, Cosmides GJ, Estabrook RW, Fouls JR and Mannering GJ (1969) Microsomes and Drug Oxidations. Academic Press, New York.
7. Guengerich FP (1993) The 1992 Bernard B. Brodie Award Lecture: Bioactivation and detoxication of toxic and carcinogenic chemicals. Drug Metab Dispos 21:1-6.
8. Harada N, Miwa GT, Walsh JS and Lu AYH (1984) Kinetic isotope effects on cytochrome P450-catalyzed oxidation reactions: Evidence for the irreversible formation of an activated oxygen intermediate of cytochrome P448. J Biol Chem 259:3005-3010.
9. Huang MT, West SB and Lu AYH (1976) Separation, purification, and properties of multiple forms of cytochrome P450 from the liver microsomes of phenobarbital-treated mice. J Biol Chem 251:4659-4665.
10. Huskey SEW, Huskey WP and Lu AYH (1991) Contributions of thiolate desolvation to catalysis by glutathione S-transferase isozymes 1-1 and 2-2: Evidence from kinetic solvent isotope effects. J Am Chem Soc 113:2283-2290.
11. Jerina DM (1983) The 1982 Bernard B. Brodie Award Lecture: Metabolism of aromatic hydrocarbons by the cytochrome P450 system and epoxide hydrolase. Drug Metab Dispos 11:1-4.
12. Kawalek JC, Levin W, Ryan D, Thomas PE and Lu AYH (1975) Purification of liver microsomal cytochrome P448 from 3-methylcholanthrene-treated rabbits. Mol Pharmacol 11:874-878.
13. Levin W (1990) The 1988 Bernard B. Brodie Award Lecture: Functional diversity of hepatic cytochromes P450. Drug Metab Dispos 18:824-830.
14. Lin JH and Lu AYH (1997a) Inhibition of cytochrome P450 and implications in drug metabolism. Ann Report Med Chem 32:295-304.