Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats

Neurobiology of Aging

Volumn 29, Issue 9, 2008, Pages 1366-1379

  Pertusa, M ^a   Garcia Matas S ^a   Mammeri, H ^b   Adell, A ^a   Rodrigo, T ^c   Mallet, J ^b   Cristofol R ^a   Sarkis, C ^b   Sanfeliu, C ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acetylcholine; Aging; Dopamine; Gene therapy; Glial cell line derived neurotrophic factor (GDNF); Learning and memory; Lentiviral vector; Rat; Serotonin

Indexed keywords

ACETYLCHOLINE; DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLYCOPROTEIN; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; SEROTONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL FUNCTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOMEGALOVIRUS; GENE EXPRESSION; GENETIC TRANSDUCTION; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; MEMORY; NERVE CELL; NEUROTRANSMITTER RELEASE; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

AGING; ANIMALS; ASTROCYTES; COGNITION; COGNITION DISORDERS; GENE THERAPY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MALE; RATS; RATS, INBRED F344; TRANSGENES;

EID: 47049096024     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.02.026     Document Type: Article

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