Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys

Journal of Neuroscience

Volumn 23, Issue 5, 2003, Pages 1974-1980

  Grondin, Richard ^a   Cass, Wayne A ^a   Zhang, Zhiming ^a   Stanford, John A ^a   Gash, Don M ^a   Gerhardt, Greg A ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Aging; Basal ganglia; Chronic GDNF; In vivo microdialysis; Motor speed; Rhesus monkeys

Indexed keywords

DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

AGING; ANIMAL EXPERIMENT; ARM; ARTICLE; BASAL GANGLION; CAUDATE NUCLEUS; CONTROLLED STUDY; DOPAMINE RELEASE; EVOKED RESPONSE; FEMALE; LATERAL BRAIN VENTRICLE; MOTOR ACTIVITY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; RHESUS MONKEY; SENESCENCE; SUBSTANTIA NIGRA; TASK PERFORMANCE;

EID: 0037336930     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-05-01974.2003     Document Type: Article

References (38)

1. Ai Y, Zhang Z, Grondin R, Gerhardt GA, Gash DM (2002) Effects of chronic intraputamenal delivery of GDNF on the nigrostriatal dopamine system in aging rhesus monkeys. Soc Neurosci Abstr 28:691.4.
2. Andersen AH, Zhang Z, Zhang M, Gash DM, Avison MJ (1999) Age-associated changes in rhesus CNS composition identified by MRI. Brain Res 829:90-98.
3. Bachevalier J, Landis LS, Walker WC, Brickson M, Mishkin M, Price DL, Cork LC (1991) Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiol Aging 12:99-111.
4. Bannon MJ, Poosch MS, Xia Y, Goebel DJ, Cassin B, Kapatos G (1992) Dopamine transporter mRNA content in the human substantia nigra decreases precipitously with age. Proc Natl Acad Sci USA 89:7095-7099.
5. Bennett DA, Beckett LA, Murray AM, Shannon KM, Goetz CG, Pilgrim DM, Evans DA (1996) Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med 334:71-76.
6. Bowenkamp KE, Lapchak PA, Hoffer BJ, Bickford PC (1996) Glial cell line-derived neurotrophic factor reverses motor impairment in 16-17 month old rats. Neurosci Lett 211:81-84.
7. Brundin P (2002) GDNF treatment in Parkinson's disease: time for controlled clinical trials? Brain 125:1449-1451.
8. Cass WA (1996) GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine. J Neurosci 16:8132-8139.
9. Cass WA, Manning MW (1999) Recovery of presynaptic dopaminergic functions in rats treated with neurotoxic doses of methamphetamine. J Neurosci 19:7653-7660.
10. Emborg ME, Ma SY, Mufson EJ, Levey AI, Taylor MD, Brown WD, Holden JE, Kordower JH (1998) Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys. J Comp Neurol 401:253-265.
11. Fearnley JM, Lees AJ (1991) Aging and Parkinson's disease: substantia nigra regional selectivity. Brain 114:2283-2301.
12. Gash DM, Zhang Z, Ovadia A, Cass WA, Yi A, Simmerman L, Russell D, Martin D, Lapchak PA, Collins F, Hoffer BJ, Gerhardt GA (1996) Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380:252-255.
13. Gash DM, Zhang Z, Gerhardt GA (1998) Neuroprotective and neurorestorative properties of GDNF. Ann Neurol 44:S121-S125.
14. Gash DM, Zhang Z, Umberger G, Mahood K, Smith M, Smith C, Gerhardt GA (1999) An automated movement assessment panel for upper limb motor functions in rhesus monkeys and humans. J Neurosci Methods 89:111-117.
15. Gerhardt GA, Cass WA, Henson M, Zhang Z, Ovadia A, Hoffer BJ, Gash DM (1995) Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkeys. Neurobiol Aging 16:939-946.
16. Gerhardt GA, Cass WA, Yi A, Zhang Z, Gash DM (2002) Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys. J Neurochem 80:168-177.
17. Glick SD, Dong N, Keller Jr RW, Carlson JN (1994) Estimating extracellular concentrations of dopamine and 3,4-dihydroxyphenylacetic acid in nucleus accumbens and striatum using microdialysis: relationships between in vitro and in vivo recoveries. J Neurochem 62:2017-2021.
18. Grondin R, Zhang Z, Beck K, Hilt D, Elsberry D, Gash DM (1998) Chronic intracerebral infusion of glial cell line-derived neurotrophic factor (GDNF) in parkinsonian rhesus monkeys. Soc Neurosci Abstr 24:42.
19. Grondin R, Zhang Z, Gerhardt GA, Gash DM (2000) Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys. Ann Neurol 48:250-253.
20. Grondin R, Zhang Z, Elsberry D, Gerhardt GA, Gash DM (2001) Chronic intracerebral delivery of trophic factors via a programmable pump as a treatment for parkinsonism. In: Parkinson's disease: methods and protocols, Vol 62 (Mouradian MM, ed), pp 257-267. Totowa, NJ: Humana.
21. Grondin R, Zhang Z, Cass WA, Ai Y, Maswood N, Andersen AH, Elsberry DD, Klein MC, Gerhardt GA, Gash DM (2002a) Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain 125:2191-2201.
22. Grondin R, Zhang Z, Ai Y, Surgener SP, Loveland AD, Gerhardt GA, Gash DM (2002b) Chronic, pulsatile delivery of GDNF into the substantia nigra increases motor speed and dopamine levels in the basal ganglia of MPTP-treated parkinsonian monkeys. Soc Neurosci Abstr 28:691.3.
23. Hebert MA, Gerhardt GA (1997) Behavioral and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats. J Pharmacol Exp Ther 282:760-768.
24. Irwin I, DeLanney LE, McNeil T, Chan P, Forno LS, Murphy Jr GM, Di Monte DA, Sandy MS, Langston JW (1994) Aging and the nigrostriatal dopamine system: a non-human primate study. Neurodegeneration 3:251-265.
25. Kish SJ, Shannak K, Rajput A, Deck JHM, Hornykiewicz O (1992) Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of Parkinson's disease. J Neurol Sci 53:347-357.
26. Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen E-Y, Palfi S, Zion Roitberg B, Brown WD, Holden JE, Pyzalski R, Taylor MD, Carvey P, Ling Z, Trono D, Hantraye P, Deglon N, Aebischer P (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290:767-773.
27. Kubis N, Faucheux MA, Ransmayr G, Damier P, Duyckaerts C, Henin D, Forette B, Le Charpentier Y, Hauw J-J, Agid Y, Hirsh EC (2000) Preservation of midbrain catecholaminergic neurons in very old human subjects. Brain 123:366-373.
28. Lapchak PA, Jiao S, Collins F, Miller PJ (1997a) Glial cell line-derived neurotrophic factor: distribution and pharmacology in the rat following a bolus intraventricular injection. Brain Res 747:92-102.
29. Lapchak PA, Miller PJ, Jiao S (1997b) Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats. Neuroscience 77:745-752.
30. 125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection. Brain Res 789:9-22.
31. Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Lanciego JL, Artieda J, Gonzalo N, Olanow CW (2000) Pathophysiology of the basal ganglia in Parkinson's disease. Trends Neurosci [Suppl] 23:S8-S9.
32. Ovadia A, Zhang Z, Gash DM (1995) Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys. Neurobiol Aging 16:931-937.
33. Parent A, Hazrati LN (1995) Functional anatomy ofthe basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res Brain Res Rev 20:91-127.
34. Smith C, Umberger G, Manning EL, Slevin JT, Wekstein DR, Markesbery WR, Zhang Z, Gerhardt GA, Gash DM (1999) A critical decline in fine motor hand movements in human aging. Neurology 53:1458-1461.
35. Smith Y, Kieval JZ (2000) Anatomy of the dopamine system in the basal ganglia. Trends Neurosci [Suppl] 23:S28-S33.
36. Tomac A, Widenfalk, Lin LF, Kohno T, Ebendal T, Hoffer BJ, Olson L (1995) Retrograde axonal transport of GDNF in the adult nigrostriatal system suggests a trophic role in the adult. Proc Natl Acad Sci USA 92:8274-8278.
37. + channels in midbrain dopaminergic neurons. Nat Neurosci 4:1071-1078.
38. Zhang Z, Andersen A, Smith C, Grondin R, Gerhardt GA, Gash DM (2000) Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging. J Gerontol Biol Sci Med Sci 55A:473-480.