Central cholinergic systems and cognition

Annual Review of Psychology

Volumn 48, Issue , 1997, Pages 649-684

  Everitt, Barry J ^a   Robbins, Trevor W ^a  

^a NONE

Author keywords

Acetylcholine; Attention; Basal forebrain; Learning; Memory

Indexed keywords

DOPAMINE;

ANIMAL; AROUSAL; BRAIN; BRAIN MAPPING; CHOLINERGIC NERVE; COGNITION; FOREBRAIN; HUMAN; LONG TERM MEMORY; PHYSIOLOGY; PONS; REVIEW; SHORT TERM MEMORY;

ANIMALS; AROUSAL; BRAIN; BRAIN MAPPING; CHOLINERGIC FIBERS; COGNITION; DOPAMINE; HUMANS; MEMORY, SHORT-TERM; PONS; PROSENCEPHALON; RETENTION (PSYCHOLOGY);

EID: 0030636350     PISSN: 00664308     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.psych.48.1.649     Document Type: Article

References (178)

1. Acquas E, Wilson C, Fibiger HC. 1996. Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release; effects of novelty, habituation and fear. J. Neurosci. 16:3089-96
2. Aggleton JP, Hunt PR, Rawlins JNP. 1986. The effects of hippocampal lesions upon spatial and nonspatial tests of working memory. Behav. Brain Res. 19:133-46
3. Aggleton JP, Keith AB, Rawlins JNP, Hunt PR, Saghal A. 1992. Removal of the hippocampus and transaction of the fornix produce comparable deficits on delayed non-matching to position in rats. Behav. Brain Res. 52:61-71
4. Aigner TG, Mitchell SJ, Aggleton JP, DeLong MR, Struble RG, et al. 1987. Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic acid lesions of the nucleus basalis of Meynert. Psychopharmacology 92:292-300
5. Aigner TG, Mitchell SJ, Aggleton JP, DeLong MR, Struble RG, et al. 1991. Transient impairment of recognition memory following ibotenic acid lesions of the basal forebrain in Macaques. Brain Res. 86: 18-26
6. Alheid GF, Heimer L. 1988. New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid and corticopetal components of the substantia innominata. Neuroscience 27:1-39
7. Ammassari-Teule M, Amoroso D, Forloni GL, Rossi-Arnaud C, Consolo S. 1993. Mechanical deafferentation of basal forebrain-cortical pathways and neurotoxic lesions of the nucleus basalis magnocellularis, comparative effect on spatial learning and cortical acetylcholine release in vivo. Behav. Brain Res. 54:145-52
8. Annett LE, McGregor A, Robbins TW. 1989. The effects of ibotenic acid lesions of the nucleus accumbens on spatial learning and extinction in the rat. Behav. Brain Res. 31: 231-42
9. Aspley S, Fone KCF. 1993. Galanin fails to alter both acquisition of a two trial per day water maze task and neurochemical markers of cholinergic or serotonergic neurones in adult rats. Brain Res. 622:330-36
10. Baratti CM, Opezzo JW, Kopf SR. 1993. Facilitation of memory storage by the acetylcholine M2 muscarinic receptor antagonist AF-DX 116. Behav. Neural Biol. 60:69-74
11. Barone S, Nanry KP, Mundy WR, McGinty JF, Tilson HA. 1991. Spatial learning deficits are not solely due to cholinergic deficits following medial septal lesions with cholchicine. Psychobiology 19:41-50
12. Bartus RT, Dean RLI, Beer B, Lippa AS. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-17
13. Baxter MG, Bucci DJ, Gorman LK, Wiley RG, Gallagher M. 1995. Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats. Behav. Neurosci. 109:714-22
14. Baxter MG, Bucci DJ, Sobel T, Williams MJ, Gorman LK, Gallagher M. 1996. Intact learning following lesions of basal forebrain cholinergic lesions. NeuroReport. In press
15. Baxter MG, Gallagher M. 1996. Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input. Behav. Neurosci. 110: 1-8
16. Berger-Sweeney J, Heckers S, Mesulam MM, Wiley RG, Lappi DA, Sharma M. 1994. Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. J. Neurosci. 14: 4507-19
17. Bouton ME. 1992. Context and retrieval in extinction and in other examples of interference in simple associative learning. In Current Topics in Animal Learning: Brain, Emotion and Cognition, ed. L Dachowski, CF Flaherty, pp. 25-53. Hillsdale, NJ: Erlbaum
18. Bowen DM, Smith CB, White P, Davison AN. 1976. Neurotransmitter related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99:459-96
19. Buchanan SL, Powell DA. 1982. Cingulate cortex: its role in Pavlovian conditioning. J. Comp. Physiol. Psychol. 96:745-54
20. Bussey TJ, Muir JL, Everitt BJ, Robbins TW. 1996. Dissociable effects of anterior and posterior cingulate cortex lesions on the acquisition of a conditional visual discrimination: facilitation of early learning vs. impairment of late learning. Behav. Brain Res. In press
21. Buzsáki G. 1989. Two stage model of memory trace formation: a role for noisy brain states. Neuroscience 31:551-70
22. Buzsáki G, Bickford RG, Ponomareff G, Thal LJ, Mandel R, Gage FH. 1988. Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J. Neurosci. 8:4007-26
23. Buzsáki G, Ponomareff GL, Bayardo F, Ruiz R, Gage FH. 1989. Neuronal activity in the subcortically denervated hippocampus: a chronic model for epilepsy. Neuroscience 28:527-38
24. Bymaster FP, Heath I, Hendrix JC, Shannon HE. 1993. Comparative behavioral and neurochemical activities of cholinergic antagonists in rats. J. Pharmacol. Exp. Ther. 267:16-24
25. Carli M, Robbins TW, Evenden JL, Everitt BJ. 1983. Effects of lesions to ascending noradrenergic neurons on performance of a 5-choice serial reaction time task in rats: implications for theories of dorsal bundle noradrenergic function based on selective attention and arousal. Behav. Brain Res. 9: 361-80
26. Chiba AA, Ducci DJ, Holland PC, Gallagher M. 1995. Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing. J. Neurosci. 15:7315-22
27. Connor DJ, Langlais PJ, Thal LJ. 1991. Behavioral impairments after lesions of the nucleus basalis by ibotenic acid and quisqualic acid. Brain Res. 555:84-90
28. Connor DJ, Thal LJ. 1989. Effect of ibotenate and quisqualate lesions of the nbM on water maze performance. Soc. Neurosci. 15, (Part 1):37.1-0
29. Crawley JN. 1993. Functional interactions of galanin and acetylcholine: relevance to memory and Alzheimer's disease. Behav. Brain Res. 57:133-41
30. Decker MW, Radek RJ, Majchrzak MJ, Anderson JD. 1992. Differential effects of medial septal lesions on spatial memory tasks. Psychobiology 20:9-19
31. Dekker AJAM, Connor DJ, Gage FH, Thal LJ. 1990. Chronic treatment with NGF improves spatial learning after NBM lesions. Soc. Neurosci. 16:207-17
32. Dellu F, Mayo W, Cherkaoui J, Le Moal M, Simon H. 1991. Learning disturbances following excitotoxic lesions of cholinergic pedunculo=pontine nucleus in the rat. Brain Res. 544:126-32
33. Dokla CPJ, Thal LJ. 1988. Effect of cholin esterase inhibitors on Morris water-task behavior following lesions of the nucleus basalis magnocellularis. Behav. Neurosci. 102:861-71
34. Dornan WA, McCampbell ARV, Tinkler GP, Hickman LJ. 1995. Selective acetylcholine neurotoxins, in combination with glucocorticoids, as a potential model of Alzheimer's disease: the effects of AF64A and saporin on spatial learning in the male rat. Soc. Neurosci. 21:773.5
35. Drachman DR, Sahakian BJ. 1979. The effects of cholinergic agents on human learning and memory. In Nutrition in the Brain, ed. A Barbeau, JH Growden, RJ Wurtman, pp. 351-66. New York: Raven
36. Dudchenko P, Sarter M. 1991. GABAergic control of basal forebrain cholinergic neurons and memory. Behav. Brain Res. 42: 33-41
37. Dunnett SB. 1985. Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats. Psychopharmacology 87:357-63
38. Dunnett SB, Everitt BJ, Robbins TW. 1991. The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions. Trends Neurosci. 14(11):494-500
39. Dunnett SB, Toniolo G, Fine A, Ryan CN, Bjorklund A, Iversen SD. 1985. Transplantation of embryonic forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis. II. Sensorimotor and learning impairments. Neuroscience 16:787-97
40. Dunnett SB, Whishaw IQ, Jones GH, Bunch ST. 1987. Behavioral biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats. Neuroscience 20: 653-69
41. Eagger SA, Levy R, Sahakian BJ. 1991. Tacrine in Alzheimer's disease. Lancet 337: 989-92
42. Edeline J-M, Hars B, Maho C, Hennevin E. 1994. Transient and prolonged facilitation of tone-evoked responses induced by basal forebrain stimulations in the rat auditory cortex. Exp. Brain Res. 97:373-86
43. Etherington RE, Mittleman GM, Robbins TW. 1987. Comparative effects of nucleus basalis lesions and fimbria-fornix lesions on delayed matching and alternation in the rat. Neurosci. Res. Commun. 1:135-43
44. Everitt BJ, Robbins JL, Evenden IL, Marston HM, Jones GH, Sirkiä TE. 1987. The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional visual discriminations: implications for cholinergic hypothesis of learning and memory. Neuroscience 22:441-69
45. Fibiger HC. 1991 Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurosci. 14: 220-23
46. Fine A, Dunnett SB, Björklund A, Iversen SD. 1985. Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 82: 5227-30
47. Fisher LJ, Jinnah HA, Kale LC, Higgins GA, Gage FH. 1991. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron 6:371-80
48. Fisher LJ, Raymon HK, Gage FH. 1993. Cells engineered to produce acetylcholine: therapeutic potential for Alzheimer's disease. Ann. NY Acad. Sci. 695:278-84
49. Freed DM, Corkin S, Growdon JH, Nissen MJ. 1989. Selective attention in Alzheimer's disease: characterising cognitive subgroups of patients. Neuropsychologia 27:325-39
50. Gabriel M. 1990. Functions of anterior and posterior cingulate cortex during avoidance learning in rabbits. Prog. Brain Res. 85: 467-83
51. Gallagher M, Colombo PJ. 1995. Aging: the cholinergic hypothesis of cognitive decline. Curr. Opin. Neurobiol. 5:161-68
52. Good M, Honey RC. 1991. Conditioning and contextual retrieval in hippocampal rats. Behav. Neurosci. 4.499-509
53. Hagan JJ, Salamone JD, Simpson J, Iversen SD, Morris RGM. 1988. Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis. Behav. Brain Res. 27:9-20
54. Hars B, Maho C, Edeline J-M, Hennevin E. 1993. Basal forebrain stimulation facilitates tone-evoked responses in the auditory cortex of awake rat. Neuroscience 56:61-74
55. Heckers S, Ohtake T, Wiley RG, Lappi DA, Geula C, Mesulam M-M. 1994. Complete and selective denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the P75 NGF receptor. J. Neurosci. 14:1271-89
56. Heimer L, Zahm DS, Alheid GF. 1995. Basal ganglia. In The Rat Nervous System, ed. G Paxinos, pp. 579-628. Sydney: Academic. 2nd ed.
57. Himmelheber A-M, Moore H, McGaughy J, Givens B, Sarter M. 1995. Cortical acetylcholine efflux and single unit activity in rats performing operant procedures assessing behavioral vigilance or sensorimotor and motivational task components. Soc. Neurosci. Abstr. 21:763.6
58. Hiroi N, White NM. 1991. The lateral nucleus of the amygdala mediates the expression of the amphetamine-produced conditioned place preference. J. Neurosci. 11:2107-16
59. Hodges H, Allen Y, Sinden J, Lantos PL, Gray JA. 1991. Effects of cholinergic rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic system. II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplantation-induced functional recovery. Neuroscience 43:609-23
60. Hodges H, Trasher S, Gray JA. 1989. Improved radial maze performance induced by the benzodiazepine receptor antagonist ZK 93 426 in lesioned and alcohol-treated rats. Behav. Pharmacol. 1:45-55
61. Holley LA, Sarter M. 1995. Functions of cholinergic inputs to visual cortical areas: effects of visual cortical cholinergic deafferentation on visual attention in rats. Soc. Neurosci. Abstr. 21:763.4
62. Holley LA, Turchi J, Apple C, Sarter M. 1995. Dissociation between the attentional effects of infusions of a benzodiazepine receptor agonist and an inverse agonist into the basal forebrain. Psychopharmacology 120: 99-108
63. Inglis WL, Dunbar JS, Winn P. 1993. Barbiturate anesthesia reduces the neurotoxic effects of quinolinate but not ibotenate in the rat pedunculopontine nucleus. Neurosci. Lett. 156:78-82
64. Inglis WL, Winn P. 1995. The pedunculopontine tegmental nucleus: where the striatum meets the reticular formation. Prog. Neurobiol. 47:1-29
65. Jakala P, Sirvio J, Riekkinen PJ. 1993. The effects of lacrine and zacopride on the performance of adult rats in the working memory task. Gen. Pharmacol. 24:675-79
66. Jarrard LE. 1993. On the role of the hippocampus in learning and memory in the rat. Behav. Neur. Biol. 60:9-26
67. Jones DNC, Barnes JC, Kirkby DL, Higgins GA. 1995. Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems. J. Neurosci. 15:7282-92
68. Kelsey JE, Vargas H. 1993. Medial septal lesions disrupt spatial, but not nonspatial, working memory in rats. Behav. Neurosci. 107-565-74
69. Kim JJ, Fanselow MS. 1992. Modality specific retrograde amnesia of fear. Science 256: 675-76
70. Kolb B. 1984. Functions of the frontal cortex in the rat. Brain Res. Rev. 8:65-98
71. Krnjevic K. 1987. Role of acetlycholine in the cerebral cortex. In Neurobiology of Memory, ed. NJ Dun, RL Perlman, pp. 271-81. New York: Plenum
72. Krnjevic K, Ropert N, Casullo J. 1988. Septohippocampal disinhibition. Brain Res. 438: 182-92
73. Lawrence AD, Sahakian BJ. 1995. Alzheimer disease, attention and the cholinergic system. Alzheimer Dis. Assoc. Disord. 9:43-49
74. Lerer BE, Warner J. 1986. Radial maze performance deficits following lesions of rat basal forebrain. In Advances in Behavioral Biology, ed. A Fisher, I Hanin, C Lachman, 29:419-26. New York: Plenum
75. Levey AI, Armstrong DM, Atweh SF, Terry RD, Wainer BH. 1983. Monoclonal antibodies to choline acetyltransferase: specificity and immunohistochemistry. Brain Res. 218:313-87
76. Mandel RJ, Gage FH, Thal LJ. 1989a. Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen. Behav. Brain Res. 31:221-29
77. Mandel RJ, Gage FH, Thal LJ. 1989b. Spatial-learning in rats: correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage. Exp. Neurol. 104:208-17
78. Mandel RJ, Thal LJ. 1988. Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats. Psychopharmacology 96:421-25
79. Markowska AL, Olton DS, Murray EA, Gaffan D. 1989. A comparative analysis of the role of the fornix and cingulate cortex in rats. Exp. Brain Res. 74:187-201
80. Markowska AL, Wenk GL, Olton DS. 1990. Nucleus basalis magnocellularis and memory: differential effects of two neurotoxins. Behav. Neur. Biol. 54:13-26
81. Marlin NA. 1981. Contextual associations in trace conditioning. Anim. Learn. Behav. 9: 519-23
82. Marston HM, Everitt BJ, Robbins TW. 1993. Comparative effects of excitotoxic lesions of the hippocampus and septum/diagonal band on conditional visual discrimination and spatial learning. Neuropsychologia 31: 1099-118
83. Marston HM, West HL, Willdnson LS, Everitt BJ, Robbins TW. 1994. Effects of excitotoxic lesions of the septum and vertical limb nucleus of the diagonal band of Broca on conditional visual discrimination: relationship between performance and choline acetyltransferase activity in the cingulate cortex. J. Neurosci. 14:2009-19
84. McAlonan GM, Dawson GR, Wilkinson LO, Robbins TW, Everitt BJ. 1995a. The effects of AMPA-induced lesions of the medial septum and vertical limb nucleus of the diagonal band of Broca on spatial delayed non-matching to sample and spatial learning in the water maze. Eur. J. Neurosci. 7:1034-49
85. McAlonan GM, Wilkinson LS, Robbins TW, Everitt BJ. 1995b. The effects of AMPA-induced lesions of the septohippocampal cholinergic projection on aversive conditioning to explicit and contextual cues and spatial learning in the water maze. Eur. J. Neurosci. 7:281-92
86. McDonald RJ, White NM. 1993. A triple dissociation of memory systems: hippocampus, amygdala and dorsal striatum. Behav. Neurosci. 107:3-22
87. McGaughy J, Kaiser T, Sarter M. 1996. Behavioral vigilance following infusions of IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical ACHE-positive fiber density. Behav. Neurosci. 110:247-65
88. McNamara RK, Skelton RW. 1993. The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res. Rev. 18:33-49
89. Mesulam M-M, Mufson EJ, Wainer BH, Levey AI. 1983a. Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 10:1185-201
90. Mesulam M-M, Mufson EJ, Levey AI, Wainer BH. 1983b. Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the rhesus monkey. J. Comp. Neurol. 214: 170-97
91. Metherate R, Tremblay N, Dykes RW. 1988. Transient and prolonged effects of acetylcholine on responsiveness of cat somatosensory cortical neurons. J. Neurophysiol. 59:1253-75
92. Mohammed AH. 1993. Effects of cholinesterase inhibitors on learning and memory in rats: a brief review with special reference to THA. Acta Neurol. Scand. Suppl. 88:13-15
93. Morris RGM, Garrud P, Rawlins JNP, O'Keefe J. 1981. Place navigation impaired in rats with hippocampal lesions. Nature 297:681-83
94. Morris RGM, Schenk F, Tweedie F, Jarrard LE. 1990. Ibotenate lesions of the hippocampus and/or subiculum: Dissociating the components of allocentric spatial learning. Eur. J. Neurosci. 2:1016-28
95. Moyer JR, Deyo RA, Disterhoft JF. 1990. Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behav. Neurosci. 104:243-52
96. Muir JL, Bussey TJ, Everitt BJ, Robbins TW. 1996. Dissociable effects of AMPA-induced lesions of the vertical limb nucleus of the diagonal band of Broca on performance of the 5-choice serial reaction time task and on acquisition of a conditional visual discrimination. Behav. Brain Res. In press
97. Muir JL, Dunnett SB, Robbins TW, Everitt BJ. 1992a. Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Exp. Brain Res. 89.611-22
98. Muir JL, Everitt BJ, Robbins TW. 1994. AMPA-induced excitotoxic lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function J. Neurosci. 14:2313-26
99. Muir JL, Everitt BJ, Robbins TW. 1995. Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology 118: 82-92
100. Muir JL, Everitt BJ, Robbins TW. 1996. The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral and parietal cortex lesions on a 5-choice serial reaction time task. Cereb. Cortex. In press
101. Muir JL, Page KJ, Sirinathsinghji DJS, Robbins TW, Everitt BJ. 1993. Excitotoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and attention. Behav. Brain Res. 57:123-31
102. Muir JL, Robbins TW, Everitt BJ. 1992b. Disruptive effects of muscimol infused into the basal forebrain: differential interaction with cholinergic mechanisms. Psychopharmacology 107:541-50
103. Nadel C, Willner J 1980. Context and conditioning: a place for space. Physiol. Psychol. 8:218-28
104. Nilsson OG, Leanza G, Rosenblad C, Lappi DA, Wiley RG, Björklund A. 1992. Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system. NeuroReport 3:1005-8
105. Ogren SO, Andersson P, Pramanik A. 1993. Galanin: potential role in learning and memory. Eur. Neuropsychopharmacol. 3: 195-96
106. Ohno M, Yamamoto T, Watanabe S. 1994. Blockade of hippocampal M1 muscarinic receptors impairs working memory performance of rats. Brain Res. 650:260-66
107. Olton DS, Becker JT, Handelmann JE. 1979. Hippocampus, space and memory. Behav. Brain Sci. 2:313-65
108. Olton DS, Markowska AL, Pang K, Goiski S, Voytko ML, German LK. 1992. Comparative cognition and assessment of cognitive processes in animals. Behav. Pharmacol. 3:307-18
109. Olton DS, Wenk GL, Markowska AL. 1991. Basal forebrain, memory and attention. In Functional Aspects of the Basal Forebrain, ed. R Richardson, pp. 247-62. Boston: Birkhauser
110. Page KJ, Everitt BJ. 1993. Transsynaptic induction of c-fos in basal forebrain, diencephalic and midbrain neurons following AMPA-induced activation of the dorsal and ventral striatum. Exp. Brain Res. 93: 399-411
111. Page KJ, Everitt BJ. 1995. The distribution of neurons coexpressing immunoreactivity to AMPA-sensitive glutamate receptor subtypes (GluR1-4) and nerve growth factor receptor in the rat basal forebrain. Eur. J. Neurosci. 7:1022-33
112. Page KJ, Everitt BJ, Robbins TW, Marston HM, Wilkinson LS. 1991. Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA-and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: differential dependence on cholinergic neuronal loss. Neuroscience 43:457-72
113. Page KJ, Saha A, Everitt BJ. 1993. Differential activation and survival of basal forebrain neurons following infusions of excitatory amino acids: studies with the immediate early gene c-fos. Exp. Brain Res. 93: 412-22
114. Page KJ, Sirinathsinghji DJS, Everitt BJ. 1995. AMPA-induced lesions of the basal forebrain differentially affect cholinergic and noncholinergic neurons: Lesion assessment using quantitative in situ hybridization histochemistry. Eur. J. Neurosci. 7:1012-21
115. Pang K, Williams MJ, Egeth H, Olton DS. 1993. Nucleus basalis magnocellularis and attention: effects of muscimol infusions. Behav. Neurosci. 107:1031-38
116. Parasuraman R, Haxby JV. 1993. Attention and brain function in Alzheimer's disease: a review. Neuropsychology 7:242-72
117. Pasqualotto BA, Vincent SR. 1991. Galanin and NADPH-diaphorase coexistence in cholinergic neurons of the basal forebrain. Brain Res. 551:78-86
118. Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH. 1978. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J. 2:1457-59
119. Raffaele KC, Olton DS. 1988. Hipoocampal and amygdaloid involvement in working memory for nonspatial stimuli. Behav. Neurosci. 102(3)349-55
120. Rawlins JNP, Olton DS. 1982. The septohippocampal system and cognitive mapping. Behav. Brain Res. 5:331-58
121. Richardson RT, DeLong MR. 1988. A reappraisal of the functions of the nucleus basalis of Meynert. Trends Neurosci. 11: 264-67
122. Ridley RM, Aitken DM, Baker HF. 1989. Learning about rules but not about reward is impaired following lesions of the cholinergic projection to the hippocampus. Brain Res. 502:306-18
123. Ridley RM, Baker HF. 1993. Behavioral effects of cholinergic grafts. Ann. NY Acad. Sci. 695:274-77
124. Ridley RM, Baker HF, Drewett B, Johnson JA. 1985. Effects of ibotenic acid lesions of the basal forebrain on serial reversal-learning in the marmosets. Psychopharmacology 86:438-43
125. Ridley RM, Baker HF, Murray TK. 1988. Basal nucleus lesions in monkeys: recognition memory impairment or visual agnosia? Psychopharmacology 95:289-90
126. Ridley RM, Murray TK, Johnson JA, Baker HF. 1986. Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs. Brain Res. 376:108-16
127. Riekkinen P Jr, Sirvio J. 1990. Similar memory impairments found in medial septal-vertical diagonal band of Broca-and nucleus basalis lesioned rats: Are memory defects induced by nucleus basalis lesions related to the degree of nonspecific subcortical cell loss? Behav. Brain Res. 37:81-88
128. Riekkinen P Jr, Aaltonen M. 1991. Tetrahydro aminoacridine inhibits high-voltage spindle activity in aged rats after acute and chronic treatment. Psychopharmacology 103:265-67
129. Robbins TW, Everitt BJ. 1992. Functions of dopamine in the dorsal and ventral striatum. Sem. Neurosci. 4:119-28
130. Robbins TW, Everitt BJ. 1995. Arousal systems and attention. In The Cognitive Neurosciences, ed. MS Gazzaniga, pp. 703-20. Cambridge. MA: MIT Press
131. Robbins TW, Everitt BJ, Ryan CN, Marston HM, Jones GH, Page KJ. 1989a. Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination: differential effects on cholinergic mechanisms. Neuroscience 28:337-52
132. Robbins TW, Everitt BJ, Marston HM, Wilkinson J, Jones GH, Page KJ. 1989b. Comparative effects of ibotenic acid-and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes. Behav. Brain Res. 35:221-40
133. Roberts AC, De Salvia MA, Wilkinson LS, Collins P, Muir JL, et al. 1994. 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the Wisconsin card sort test: possible interactions with subcortical dopamine. J. Neurosci. 14:2531-44
134. Roberts AC, Robbins TW, Everitt BJ, Muir JL. 1992. A specific form of cognitive rigidity following excitotoxic lesions of the basal forebrain in marmosets. Neuroscience 47: 251-64
135. Rothblat LA, Kromer LF. 1991. Object recognition memory in the rat: the role of the hippocampus. Behav. Brain Res. 42:25-32
136. Rugg EL, Dunbar JS, Latimer M, Winn P. 1992. Excitotoxic lesions of the pedunculopontine tegmental nucleus of the rat 1. Comparison of the effects of various excitotoxins, with particular reference to the loss of immunohistochemically identified cholinergic neurons. Brain Res. 589: 181-93
137. Rye DB, Saper CB, Lee HJ, Wainer BH. 1987. Pedunculopontine tegmental nucleus in the rat: cytoarchilecture, cytochemistry and some extrapyramidal connections of the mesopontine tegmentum. J. Comp. Neurol. 259:483-528
138. Sahakian BJ, Coull JT. 1994. Nicotine and tetrahydroaminoacridine: evidence for improved attention in patients with dementia of the Alzheimer type. Drug Dev. Res. 31: 80-88
139. Sahakian BJ, Downes JJ, Eagger S, Evenden JL, Levy R, et al. 1990. Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type. Neuropsychologia 28: 1197-213
140. Sahakian BJ, Jones GMM, Levy R, Gray JA, Warburton DM. 1989. The effects of nicotine on attention, information processing and short-term memory in patients with dementia of the Alzheimer type. Br. J. Psychiatry 154:797-800
141. Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, et al. 1993. Further analysis of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology 110:395-401
142. Salamone JD, Channell SL, Welner SA, Gill R, Robbins TW, Iversen SD 1987. Nucleus basalis lesions and anticholinergic drugs impair spatial memory and visual discrimination performance in the rat. In Cellular and Molecular Basis of Cholinergic Function, ed. MJ Dowdall, JN Hawthorn, pp. 835-40. Chichester: Ellis Horwood
143. Santucci AC, Haroutinian V. 1989. Nucleus basalis lesions impair memory in rats trained on nonspatial and spatial discrimination tasks. Physiol. Behav. 45:1025-31
144. Sarter M. 1994. Neuronal mechanisms of the attentional dysfunctions in senile dementia and schizophrenia. Psychopharmacology 114:539-50
145. Sarter M, Bruno JP. 1997. Trans-synaptic stimulation of cortical acetylcholine and enhancement of attentional functions: a rational approach for the development of cognitive enhancers. Behav. Brain Res. In press
146. Sarter M, Bruno JP, Dudchenko P. 1990. Activating the damaged basal forebrain system: tonic stimulation versus signal amplification. Psychopharmacology 101:1-17
147. Sarter M, Schneider HH, Stephens DN. 1988. Treatment strategies for senile dementia: antagonist beta-carbolines. Trends Neurosci. 11:13-17
148. Sato H, Hata Y, Masui H, Tsumoto T. 1987. A functional role of cholinergic innervation to neurons in cat visual cortex. J. Neurophysiol. 58:765-80
149. Schultz W. 1992. Activity of dopamine neurons in the behaving primate. Semin. Neurosci. 4:129-38
150. Segal M, Bloom FE. 1976. The action of norepinephrine in the rat hippocampus. IV. The effects of locus coeruleus stimulation on evoked hippocampal activity. Brain Res. 107:513-25
151. Selden NRW, Everitt BJ, Jarrard LE, Robbins TW. 1991. Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience 42:335-50
152. Selden NRW, Robbins TW, Everitt BJ. 1990. Enhanced behavioral conditioning to context and impaired behavioral and neuroendocrine responses to conditioned-stimuli following ceruleocortical noradrenergic lesions: support for an attentional theory of central noradrenergic function. J. Neurosci. 10:531-39
153. Semba K. 1993. Aminergic and cholinergic afferents to REM sleep induction regions of the pontine reticular formation in the rat. J. Comp. Neurol. 330.543-56
154. Sillito AM, Kemp JA. 1983. Cholinergic modulation of the functional organization of the cat visual cortex Brain Res. 289: 143-55
155. Singer W. 1979. Central-core control of visual cortex function. In The Neurosciences, Fourth Study Program, ed. FO Schmitt, FG Worden, pp. 1093-109. Cambridge, MA: MIT Press
156. Solomon PR, Vander Schaaf ER, Thompson RF, Weisz DJ. 1986. Hippocampus and trace conditioning of the rabbits classically conditioned nictitating membrane response. Behav. Neurosci. 100:729-44
157. Steckler T, Inglis W, Winn P, Sahgal A. 1994. The pedunculopontine tegmental nucleus: a role in cognitive processes? Brain Res. Rev. 19:298-318
158. Steriade M. 1991. Alertness, quiet sleep, dreaming. In Cerebral Cortex, ed. A Peters, 9:279-357. New York: Plenum
159. Steriade M. 1993. Central core modulation of spontaneous oscillations and sensory transmission in thalamocortical systems. Curr. Opin. Neurobiol. 3:619-25
160. Sutherland RJ, Rodriguez AJ. 1989. Role of the fornix/fimbria and some related subcortical structures in place learning and memory. Behav. Brain Res 32:265-77
161. Sutherland RJ, Whishaw IQ, Kolb B. 1983. Abehavioural analysis of spatial localization following electrolytic, kainate-or colchicine-induced damage to the hippocampal formation in the rat. Behav. Brain Res. 7:133-53
162. Terry AV Jr, Buccafusco JJ, Jackson WJ. 1993. Scopolamine reversal of nicotine enhanced delayed matching-to-sample performance in monkeys. Pharmacol. Biochem. Behav. 45:925-29
163. Torres EM, Perry TA, Blokland A, Wilkinson LS, Wiley RG, et al. 1994. Behavioral, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 63:95-122
164. Tremblay N, Warren RA, Dykes RW. 1990. Electrophysiological studies of acetylcholine and the role of the basal forebrain in somatosensory cortex of the cat, I. Cortical neurons excited by somatic stimuli. J. Neurophysiol. 64:1199-211
165. Turner JJ, Hodges H, Sinden JD, Gray JA. 1992 Comparison of radial maze performance of rats after ibotenate and quisqualate lesions of the forebrain cholinergic projection system: effects of pharmacological challenge and changes in training regime. Behav. Pharmacol. 3:359-74
166. Vogt BA. 1985. Cingulate cortex. In Cerebral Cortex, ed. EG Jones, A Peters, pp. 89-149. New York: Plenum
167. Vogt BA, Gabriel M, Vogt LJ, Poremba A, Jensen EL, et al. 1991. Muscarinic receptor binding increases in anterior thalamus and cingulate cortex during discriminative avoidance learning. J. Neurosci. 11: 1508-14
168. Voytko ML. 1996. Cognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention. Behav. Brain Res. 75:13-25
169. Voytko ML, Olton DS, Richardson RT, Gorman LK, Tobin JR, Price DL. 1994. Basal forebrain lesions in monkeys disrupt attention but not learning and memory. J. Neurosci. 14:167-86
170. Warburton DM. 1977. Stimulus selection and behavioural inhibition. In Handbook of Psychopharmacology, ed. LL Iversen, SD Iversen, SH Snyder, 8:385-431. New York: Plenum
171. Wendelin D, McGaughy J, Smith BH, Sarter M. 1995. Comparison between the effects of infusions of 192 IgG-saporin into the basal forebrain or the cortex on behavioral vigilance. Soc. Neurosci. Abstr. 21:763.8
172. Wenk GL, Harrington CA, Tucker DA, Rance NE. 1992. Basal forebrain neurons and memory: a biochemical, histological and behavioral study of differential vulnerability to ibotenate and quisqualate. Behav. Neurosci. 106:909-23
173. Wenk GL, Stoehr JD, Quintana G, Mobley S, Wiley RG. 1994. Behavioral, biochemical, histological and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats. J. Neurosci. 14: 5896-995
174. Wiley RG, Oeltmann TN, Lappi DA. 1991. Immunolesioning: selective destruction of neurons using imrnunotoxin to rat NGF receptor. Brain Res. 562:149-53
175. Wilson FAW, Rolls ET. 1990. Learning and memory is reflected in the responses of reinforcement-related neurons in the primate basal forebrain. J. Neurosci. 10:1254-67
176. Winkler J, Suhr ST, Gage FH, Thal LJ, Fisher LJ. 1995. Essential role of neocortical acetylcholine in spatial memory. Nature 375: 484-87
177. Winn P. 1990. Cholinergic stimulation of substantia nigra: effects on feeding, drinking and sexual behavior in the male rat. Psychopharmacology 104:208-14
178. Winn P, Farrell A, Maconick A, Robbins TW. 1983. Behavioral and pharmacological specificity of the feeding elicited by cholinergic stimulation of the substantia nigra in the rat. Behav. Neurosci. 97:794-809