메뉴 건너뛰기




Volumn 6, Issue 12, 1999, Pages 1936-1951

Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat

Author keywords

Adenoviral vector; Aging; Gene therapy; Neurodegeneration; Parkinson's disease

Indexed keywords

6 HYDROXYDOPA; AMPHETAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; TYROSINE 3 MONOOXYGENASE; VIRUS VECTOR;

EID: 0033374356     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301033     Document Type: Article
Times cited : (129)

References (93)
  • 1
    • 0003026426 scopus 로고    scopus 로고
    • Neurotrophic factor gene therapy for neurodegenerative disease
    • Bohn MC, Choi-Lundberg DL. Neurotrophic factor gene therapy for neurodegenerative disease. Gene Ther Molec Biol 1998; 1: 265-277.
    • (1998) Gene Ther Molec Biol , vol.1 , pp. 265-277
    • Bohn, M.C.1    Choi-Lundberg, D.L.2
  • 2
    • 0012029453 scopus 로고    scopus 로고
    • Applications of gene therapy to neurological diseases and injuries
    • Quesenberry PJ, Stein GS, Forget B, Weissman S (eds). Wiley-Liss: New York
    • Choi-Lundberg DL, Bohn MC. Applications of gene therapy to neurological diseases and injuries. In: Quesenberry PJ, Stein GS, Forget B, Weissman S (eds). Stem Cell Biology find Gene Therapy. Wiley-Liss: New York, 1998, pp 503-553.
    • (1998) Stem Cell Biology Find Gene Therapy , pp. 503-553
    • Choi-Lundberg, D.L.1    Bohn, M.C.2
  • 3
    • 0032102110 scopus 로고    scopus 로고
    • The role of neuronal growth factors in neurodegenerative disorders of the human brain
    • Connor B, Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res 1998; 27: 1-39.
    • (1998) Brain Res , vol.27 , pp. 1-39
    • Connor, B.1    Dragunow, M.2
  • 4
    • 0028262267 scopus 로고
    • Neurotrophic growth factors and neurodegenerative diseases: Therapeutic potential of the neurotrophins and ciliary neurotrophic factor
    • Lindsay RM. Neurotrophic growth factors and neurodegenerative diseases: therapeutic potential of the neurotrophins and ciliary neurotrophic factor. Neurobiol Aging 1994; 15: 249-251.
    • (1994) Neurobiol Aging , vol.15 , pp. 249-251
    • Lindsay, R.M.1
  • 6
    • 0029804715 scopus 로고    scopus 로고
    • GDNF: A cytokine at the interface of TGF-betas and neurotrophins
    • Unsicker K. GDNF: a cytokine at the interface of TGF-betas and neurotrophins. Cell Tiss Res 1996; 286: 175-178.
    • (1996) Cell Tiss Res , vol.286 , pp. 175-178
    • Unsicker, K.1
  • 7
    • 0029414747 scopus 로고
    • Development of mesencephalic dopaminergic neurons and the transforming growth factor-beta superfamily
    • Krieglstein K, Suter-Crazzolara C, Unsicker K. Development of mesencephalic dopaminergic neurons and the transforming growth factor-beta superfamily. J Neural Transmis Suppl 1995; 46: 209-216.
    • (1995) J Neural Transmis Suppl , vol.46 , pp. 209-216
    • Krieglstein, K.1    Suter-Crazzolara, C.2    Unsicker, K.3
  • 8
    • 0027285510 scopus 로고
    • A glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin L-FH et al. A glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993; 260: 1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.-F.H.1
  • 9
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • Beck KD et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 1995; 373: 339-341.
    • (1995) Nature , vol.373 , pp. 339-341
    • Beck, K.D.1
  • 10
    • 0028109526 scopus 로고
    • Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo
    • Hoffer BJ et al. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 1994; 182: 107-111.
    • (1994) Neurosci Lett , vol.182 , pp. 107-111
    • Hoffer, B.J.1
  • 11
    • 0028874203 scopus 로고
    • GDNF protects nigral dopaminergic neurons against 6-hydroxydopamine in vivo
    • Kearns C, Gash D. GDNF protects nigral dopaminergic neurons against 6-hydroxydopamine in vivo. Brain Res 1995; 672: 104-111.
    • (1995) Brain Res , vol.672 , pp. 104-111
    • Kearns, C.1    Gash, D.2
  • 12
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 1995; 373: 335-339.
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1
  • 13
    • 0029047329 scopus 로고
    • Glial cell line-derived neurotrophic factor but not transforming growth factor beta-3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion
    • Sauer H, Rosenblad C, Bjorklund A. Glial cell line-derived neurotrophic factor but not transforming growth factor beta-3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc Nat Acad Sci USA 1995; 92: 8935-8939.
    • (1995) Proc Nat Acad Sci USA , vol.92 , pp. 8935-8939
    • Sauer, H.1    Rosenblad, C.2    Bjorklund, A.3
  • 14
    • 0029053195 scopus 로고
    • Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons
    • Bowenkamp KE et al. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp Neurol 1995; 355: 479-489.
    • (1995) J Comp Neurol , vol.355 , pp. 479-489
    • Bowenkamp, K.E.1
  • 15
    • 0030950227 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor attenuates behavioral deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopaminc-lesioned adult rats: Comparison of intraventricular and intranigral delivery
    • Lapchak PA, Miller PJ, Collins F, Jiao S. Glial cell line-derived neurotrophic factor attenuates behavioral deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopaminc-lesioned adult rats: comparison of intraventricular and intranigral delivery. Neuroscience 1997; 78: 61-72.
    • (1997) Neuroscience , vol.78 , pp. 61-72
    • Lapchak, P.A.1    Miller, P.J.2    Collins, F.3    Jiao, S.4
  • 16
    • 0030884756 scopus 로고    scopus 로고
    • Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease
    • Rosenblad C, Martinez-Serrano A, Bjorklund A. Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscice 1998; 82: 129-137.
    • (1998) Neuroscice , vol.82 , pp. 129-137
    • Rosenblad, C.1    Martinez-Serrano, A.2    Bjorklund, A.3
  • 17
    • 0028917168 scopus 로고
    • Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine deletions and Parkinsonian symptoms
    • Lindner MD et al. Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine deletions and Parkinsonian symptoms. Exp Neurol 1995; 132: 62-76.
    • (1995) Exp Neurol , vol.132 , pp. 62-76
    • Lindner, M.D.1
  • 18
    • 13344277993 scopus 로고    scopus 로고
    • Functional recovery in Parkinsonian monkeys treated with GDNF
    • Gash DM et al. Functional recovery in Parkinsonian monkeys treated with GDNF. Nature 1996; 380: 252-255.
    • (1996) Nature , vol.380 , pp. 252-255
    • Gash, D.M.1
  • 19
    • 0032213413 scopus 로고    scopus 로고
    • Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain
    • Ghodsi A et al. Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain. Hum Gene Ther 1998; 9: 2331-2340.
    • (1998) Hum Gene Ther , vol.9 , pp. 2331-2340
    • Ghodsi, A.1
  • 20
    • 0027408530 scopus 로고
    • Transfer of a foreign gene into the brain using adenovirus vectors
    • Akli S et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet 1993; 3: 224-228.
    • (1993) Nat Genet , vol.3 , pp. 224-228
    • Akli, S.1
  • 21
    • 0027477148 scopus 로고
    • Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
    • Bajocchi G, Feldman SH, Crystal RG, Mastrangeli A. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors Nat Genet 1993; 3: 229-234.
    • (1993) Nat Genet , vol.3 , pp. 229-234
    • Bajocchi, G.1    Feldman, S.H.2    Crystal, R.G.3    Mastrangeli, A.4
  • 22
    • 0027522920 scopus 로고
    • A model system for in vivo gene transfer into the central nervous system using an adenovirus vector
    • Davidson BL et al. A model system for in vivo gene transfer into the central nervous system using an adenovirus vector. Nat Genet 1993; 3: 219-223.
    • (1993) Nat Genet , vol.3 , pp. 219-223
    • Davidson, B.L.1
  • 23
    • 0027457561 scopus 로고
    • An adenovirus vector for gene transfer into neurons and glia in the brain
    • Le Gal La Salle G et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 1993; 259: 988-990.
    • (1993) Science , vol.259 , pp. 988-990
    • Le Gal La Salle, G.1
  • 24
    • 0031019795 scopus 로고    scopus 로고
    • Dopaminergic neurons protected from degeneration by GDNF gene therapy
    • Choi-Lundberg DL et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 1997; 275: 338-341.
    • (1997) Science , vol.275 , pp. 338-341
    • Choi-Lundberg, D.L.1
  • 25
    • 0031105816 scopus 로고    scopus 로고
    • Recombinant adenovirus: A gene transfer vector for study and treatment of CNS disease
    • Davidson BL, Bohn MC. Recombinant adenovirus: a gene transfer vector for study and treatment of CNS disease. Exp Neurol 1997; 144: 125-130.
    • (1997) Exp Neurol , vol.144 , pp. 125-130
    • Davidson, B.L.1    Bohn, M.C.2
  • 26
    • 0031106006 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer to the central nervous system for Parkinson's disease
    • Horellou P, Sabate O, Buc-Caron M-H, Mallet J. Adenovirus-mediated gene transfer to the central nervous system for Parkinson's disease. Exp Neurol 1997; 144: 131-138.
    • (1997) Exp Neurol , vol.144 , pp. 131-138
    • Horellou, P.1    Sabate, O.2    Buc-Caron, M.-H.3    Mallet, J.4
  • 27
    • 0032423612 scopus 로고    scopus 로고
    • Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor
    • Choi-Lundberg DL et al. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Exp Neurol 1998; 154: 261-275.
    • (1998) Exp Neurol , vol.154 , pp. 261-275
    • Choi-Lundberg, D.L.1
  • 28
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial cell-line derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease
    • Bilang-Bleuel A et al. Intrastriatal injection of an adenoviral vector expressing glial cell-line derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease. Proc Natl Acad Sci USA 1997; 94: 8818-8823.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1
  • 29
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    • Mandel R, Spratt S, Snyder R, Leff S. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci 1997; 94: 14083-14088.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 14083-14088
    • Mandel, R.1    Spratt, S.2    Snyder, R.3    Leff, S.4
  • 30
    • 0030596531 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor reverses motor impairment in 16-17 month old rats
    • Bowenkamp K, Lapchak P, Hoffer B, Bickford P. Glial cell line-derived neurotrophic factor reverses motor impairment in 16-17 month old rats. Neurosci Lett 1996; 211: 81-84.
    • (1996) Neurosci Lett , vol.211 , pp. 81-84
    • Bowenkamp, K.1    Lapchak, P.2    Hoffer, B.3    Bickford, P.4
  • 31
    • 0030854870 scopus 로고    scopus 로고
    • Behavioural and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats
    • Hebert MA, Gerhardt GA. Behavioural and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats. J Pharmacol Exp Ther 1997; 282: 760-768.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 760-768
    • Hebert, M.A.1    Gerhardt, G.A.2
  • 32
    • 0031550611 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer-344 rats
    • Lapchak P, Miller P, Jiao S. Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer-344 rats. Neuroscience 1997; 77: 745-752.
    • (1997) Neuroscience , vol.77 , pp. 745-752
    • Lapchak, P.1    Miller, P.2    Jiao, S.3
  • 33
    • 0030583639 scopus 로고    scopus 로고
    • Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts
    • Emerich DF et al. Alleviation of behavioral deficits in aged rodents following implantation of encapsulated GDNF-producing fibroblasts. Brain Res 1996; 736: 99-110.
    • (1996) Brain Res , vol.736 , pp. 99-110
    • Emerich, D.F.1
  • 34
    • 0032514206 scopus 로고    scopus 로고
    • GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice
    • Date I et al. GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice. NeuroReport 1998; 9: 2365-2369.
    • (1998) Neuroreport , vol.9 , pp. 2365-2369
    • Date, I.1
  • 35
    • 0002625939 scopus 로고
    • Compensatory responses to partial loss of dopaminergic neurons: Studies with 6-hydroxydopamine
    • Schneider J, Gupta M (eds). Hogrefe and Huber: Göttingen
    • Zigmond M et al. Compensatory responses to partial loss of dopaminergic neurons: studies with 6-hydroxydopamine. In: Schneider J, Gupta M (eds). Current Concepts in Parkinson's Disease Research. Hogrefe and Huber: Göttingen, 1993, pp 99-140.
    • (1993) Current Concepts in Parkinson's Disease Research , pp. 99-140
    • Zigmond, M.1
  • 36
    • 0018851790 scopus 로고
    • Characteristics of dopaminergic neurons in the aged male rat
    • Demarest KT, Riegle GD, Moore KE. Characteristics of dopaminergic neurons in the aged male rat. Neuroendocrinology 1980; 31: 222-227.
    • (1980) Neuroendocrinology , vol.31 , pp. 222-227
    • Demarest, K.T.1    Riegle, G.D.2    Moore, K.E.3
  • 37
    • 0030065914 scopus 로고    scopus 로고
    • Differential effects of the intraventricular administration of 6-hydroxydoparnine on the induction of type II beta-tubulin and tyrosine hydroxylase mRNA in the locus coeruleus of the aging Fischer 344 rat
    • Unnerstall JR, Long MM. Differential effects of the intraventricular administration of 6-hydroxydoparnine on the induction of type II beta-tubulin and tyrosine hydroxylase mRNA in the locus coeruleus of the aging Fischer 344 rat. J Comp Neurol 1996; 364: 363-381.
    • (1996) J Comp Neurol , vol.364 , pp. 363-381
    • Unnerstall, J.R.1    Long, M.M.2
  • 38
    • 0041287160 scopus 로고
    • Aging-dependent emergence of sensorimotor dysfunction in rats recovered from dopamine sustained early in life
    • Joseph JA (ed). Annals of New York Academy of Science: New York
    • Schallert T. Aging-dependent emergence of sensorimotor dysfunction in rats recovered from dopamine sustained early in life. In: Joseph JA (ed). Central Determinants of Age-Related Decline in Motor Function. Annals of New York Academy of Science: New York, 1988, pp 108-119.
    • (1988) Central Determinants of Age-related Decline in Motor Function , pp. 108-119
    • Schallert, T.1
  • 39
    • 0030725572 scopus 로고    scopus 로고
    • Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • Bjorklund A, Rosenblad C, Winkler C, Kirik D. Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol Dis 1997; 4: 186-200.
    • (1997) Neurobiol Dis , vol.4 , pp. 186-200
    • Bjorklund, A.1    Rosenblad, C.2    Winkler, C.3    Kirik, D.4
  • 40
    • 0015176277 scopus 로고
    • Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior
    • Ungerstedt U. Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior. Acta Physiol Scand 1971; 82: 49-68.
    • (1971) Acta Physiol Scand , vol.82 , pp. 49-68
    • Ungerstedt, U.1
  • 41
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine a combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H, Oertel WH. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 1994; 59; 401-415.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 42
    • 0025264678 scopus 로고
    • Intrastriatal grafts derived from fetal striatal primordia. II. Reconstitution of cholinergic and dopaminergic systems
    • Liu FC, Graybiel AM, Dunnett SB, Braughman RW. Intrastriatal grafts derived from fetal striatal primordia. II. Reconstitution of cholinergic and dopaminergic systems. J Comp Neurol 1990; 295: 1-14.
    • (1990) J Comp Neurol , vol.295 , pp. 1-14
    • Liu, F.C.1    Graybiel, A.M.2    Dunnett, S.B.3    Braughman, R.W.4
  • 43
    • 0025959674 scopus 로고
    • Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun
    • Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Ann Rev Neurosci 1991; 14: 421-451.
    • (1991) Ann Rev Neurosci , vol.14 , pp. 421-451
    • Morgan, J.I.1    Curran, T.2
  • 44
    • 0026536649 scopus 로고
    • Dopaminergic transplants normalize amphetamine and apomorphine-induced Fos expression in the 6-hydroxy-dopamine lesioned striatum
    • Cenci M et al. Dopaminergic transplants normalize amphetamine and apomorphine-induced Fos expression in the 6-hydroxy-dopamine lesioned striatum. Neuroscience 1992; 46: 943-957.
    • (1992) Neuroscience , vol.46 , pp. 943-957
    • Cenci, M.1
  • 45
    • 0030003742 scopus 로고    scopus 로고
    • Time course of striatal changes induced by 6-hydroxydopamine lesion of the nigrostriatal pathway, as studied by combined evaluation of rotational behavior and striatal Fos expression
    • Labandeira-Garcia J et al. Time course of striatal changes induced by 6-hydroxydopamine lesion of the nigrostriatal pathway, as studied by combined evaluation of rotational behavior and striatal Fos expression. Exp Brain Res 1996; 108: 69-84.
    • (1996) Exp Brain Res , vol.108 , pp. 69-84
    • Labandeira-Garcia, J.1
  • 46
    • 0024471981 scopus 로고
    • D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behavior
    • Robertson HA, Peterson MR, Murphy K, Robertson GS. D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behavior. Brain Res 1989; 503: 346-349.
    • (1989) Brain Res , vol.503 , pp. 346-349
    • Robertson, H.A.1    Peterson, M.R.2    Murphy, K.3    Robertson, G.S.4
  • 47
    • 0025155482 scopus 로고
    • Amphetamine and cocaine induces drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum
    • Graybiel AM, Moratalla R, Robertson HA. Amphetamine and cocaine induces drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc Natl Acad Sci USA 1990; 87: 6912-6916.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6912-6916
    • Graybiel, A.M.1    Moratalla, R.2    Robertson, H.A.3
  • 48
    • 0026616998 scopus 로고
    • D1 and D2 dopamine receptors differentially regulate c-fos exprssion in striatonigral and striatopallidal neurons
    • Robertson GS, Vincenty SR, Fibiger HC. D1 and D2 dopamine receptors differentially regulate c-fos exprssion in striatonigral and striatopallidal neurons. Neuroscience 1992; 49: 285-296.
    • (1992) Neuroscience , vol.49 , pp. 285-296
    • Robertson, G.S.1    Vincenty, S.R.2    Fibiger, H.C.3
  • 49
    • 0026670276 scopus 로고
    • D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease
    • Paul ML, Graybiel AM, David JC, Robertson HA. D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease. J Neurosci 1992; 12: 3729-3742.
    • (1992) J Neurosci , vol.12 , pp. 3729-3742
    • Paul, M.L.1    Graybiel, A.M.2    David, J.C.3    Robertson, H.A.4
  • 50
    • 0028018276 scopus 로고
    • Amphetamine regulates gene expression in rat striatum via transcription factor CREB
    • Konradi C, Cole RL, Heckers S, Hyman SE. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 1994; 14: 5623-5634.
    • (1994) J Neurosci , vol.14 , pp. 5623-5634
    • Konradi, C.1    Cole, R.L.2    Heckers, S.3    Hyman, S.E.4
  • 51
    • 0026702547 scopus 로고
    • Dopamine and glutamine agonists stimulate neuron-specific expression of Fos-like protein in the striatum
    • Berretta S, Robertson HA, Graybiel AM. Dopamine and glutamine agonists stimulate neuron-specific expression of Fos-like protein in the striatum. J Neurophysiol 1992; 68: 767-777.
    • (1992) J Neurophysiol , vol.68 , pp. 767-777
    • Berretta, S.1    Robertson, H.A.2    Graybiel, A.M.3
  • 52
    • 0031031298 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: Comparison with the effects of the neurotrophins
    • Matheson CR et al. Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins. J Neurobiol 1997; 32: 22-32.
    • (1997) J Neurobiol , vol.32 , pp. 22-32
    • Matheson, C.R.1
  • 54
    • 0033135782 scopus 로고    scopus 로고
    • Adenoviral-mediated transgene expression in non-human primate brain
    • Bohn MC et al. Adenoviral-mediated transgene expression in non-human primate brain. Hum Gene Ther 1999; 10: 1175-1184.
    • (1999) Hum Gene Ther , vol.10 , pp. 1175-1184
    • Bohn, M.C.1
  • 55
    • 0032819559 scopus 로고    scopus 로고
    • Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus
    • Lawrence MS et al. Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus. Gene Therapy 1999; 6: 1368-1379.
    • (1999) Gene Therapy , vol.6 , pp. 1368-1379
    • Lawrence, M.S.1
  • 56
    • 0030593912 scopus 로고    scopus 로고
    • Intranigral or intrastriatal injections of GDNF - effects on monoamine levels and behavior in rats
    • Martin D et al. Intranigral or intrastriatal injections of GDNF - effects on monoamine levels and behavior in rats. Euro J Pharmacol 1996; 317: 247-256.
    • (1996) Euro J Pharmacol , vol.317 , pp. 247-256
    • Martin, D.1
  • 57
    • 0030837593 scopus 로고    scopus 로고
    • Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): Preclinical development and application to the treatment of Parkinson's disease
    • Lapchak P et al. Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to the treatment of Parkinson's disease. Exp Neurol 1997; 145: 309-321.
    • (1997) Exp Neurol , vol.145 , pp. 309-321
    • Lapchak, P.1
  • 58
    • 0023614993 scopus 로고    scopus 로고
    • Dopaminergic changes in the basal ganglia: A generalized phenomenon of aging in mammals
    • Morgan D, Finch C. Dopaminergic changes in the basal ganglia: a generalized phenomenon of aging in mammals. Ann NY Acad Sci 1998; 515: 145-160.
    • (1998) Ann NY Acad Sci , vol.515 , pp. 145-160
    • Morgan, D.1    Finch, C.2
  • 59
    • 0026718688 scopus 로고
    • Age-related decline in the dopaminergic nigrostriatal system: The oxidative hypothesis and protective strategies
    • Felter D et al. Age-related decline in the dopaminergic nigrostriatal system: the oxidative hypothesis and protective strategies. Ann Neurol 1992; 32: S133-S136.
    • (1992) Ann Neurol , vol.32
    • Felter, D.1
  • 60
    • 0028239717 scopus 로고
    • Cellular and molecular mechanisms of impaired dopaminergic function during aging
    • Roth GS, Joseph JA. Cellular and molecular mechanisms of impaired dopaminergic function during aging. Ann NY Acad Sci 1994; 719: 129-135.
    • (1994) Ann NY Acad Sci , vol.719 , pp. 129-135
    • Roth, G.S.1    Joseph, J.A.2
  • 61
    • 0031689761 scopus 로고    scopus 로고
    • Aging and the basal ganglia
    • Hubble JP. Aging and the basal ganglia. Neurol Clin 1998; 16: 649-657.
    • (1998) Neurol Clin , vol.16 , pp. 649-657
    • Hubble, J.P.1
  • 62
    • 0032526954 scopus 로고    scopus 로고
    • Expression of GDNF family receptor components during development: Implications in the mechanisms of interaction
    • Yu T et al. Expression of GDNF family receptor components during development: implications in the mechanisms of interaction. J Neurosci 1998; 18: 4684-4696.
    • (1998) J Neurosci , vol.18 , pp. 4684-4696
    • Yu, T.1
  • 63
    • 0030915959 scopus 로고    scopus 로고
    • Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
    • Trupp M, Belluardo N, Funakoshi H, Ibanez CF. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J Neurosci 1997; 17: 3554-3567.
    • (1997) J Neurosci , vol.17 , pp. 3554-3567
    • Trupp, M.1    Belluardo, N.2    Funakoshi, H.3    Ibanez, C.F.4
  • 64
    • 0032472794 scopus 로고    scopus 로고
    • Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system
    • Glazner GW, Mu X, Springer JE. Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system. J Comp Neurol 1998; 391: 42-49.
    • (1998) J Comp Neurol , vol.391 , pp. 42-49
    • Glazner, G.W.1    Mu, X.2    Springer, J.E.3
  • 65
    • 0032143368 scopus 로고    scopus 로고
    • Characterization of behavioral and neurodegeneration changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    • Kirik D, Rosenblad C, Bjorklund A. Characterization of behavioral and neurodegeneration changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp Neurol 1998; 153: 259-277.
    • (1998) Exp Neurol , vol.153 , pp. 259-277
    • Kirik, D.1    Rosenblad, C.2    Bjorklund, A.3
  • 66
    • 0029963121 scopus 로고    scopus 로고
    • Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine
    • Shults CW, Kimber T, Martin D. Intrastriatal injection of GDNF attenuates the effects of 6-hydroxydopamine. NeuroReport 1996; 7: 627-631.
    • (1996) NeuroReport , vol.7 , pp. 627-631
    • Shults, C.W.1    Kimber, T.2    Martin, D.3
  • 67
    • 0030272769 scopus 로고    scopus 로고
    • The unilateral 6-hydroxydopamine lesion model in behavioral brain research analysis of functional deficits, recovery and treatments
    • Schwarting R, Huston J. The unilateral 6-hydroxydopamine lesion model in behavioral brain research analysis of functional deficits, recovery and treatments. Prog Neurobiol 1996; 50: 275-331.
    • (1996) Prog Neurobiol , vol.50 , pp. 275-331
    • Schwarting, R.1    Huston, J.2
  • 68
    • 0019401962 scopus 로고
    • Sex difference in drug-induced rotation in two strains of rats
    • Brass CA, Glick SD. Sex difference in drug-induced rotation in two strains of rats. Brain Res 1981; 223: 229-234.
    • (1981) Brain Res , vol.223 , pp. 229-234
    • Brass, C.A.1    Glick, S.D.2
  • 69
    • 0003060653 scopus 로고    scopus 로고
    • Motor rehabilitation of forelimb use in unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease
    • Tillerson JL, Castro SL, Zigmond MJ, Schallert T. Motor rehabilitation of forelimb use in unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease. Soc Neurosci Abstr 1998; 24: 1720.
    • (1998) Soc Neurosci Abstr , vol.24 , pp. 1720
    • Tillerson, J.L.1    Castro, S.L.2    Zigmond, M.J.3    Schallert, T.4
  • 70
    • 0029993858 scopus 로고    scopus 로고
    • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini L et al. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 1996; 93: 11382-11388.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11382-11388
    • Naldini, L.1
  • 71
    • 0030716959 scopus 로고    scopus 로고
    • Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
    • Kafri T et al. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 1997; 17: 314-317.
    • (1997) Nat Genet , vol.17 , pp. 314-317
    • Kafri, T.1
  • 72
    • 0028169741 scopus 로고
    • Long-term expression and phenotypic correction using adeno-associafed virus vectors in the mammalian brain
    • Kaplitt MG et al. Long-term expression and phenotypic correction using adeno-associafed virus vectors in the mammalian brain. Nat Genet 1994; 8: 148-154.
    • (1994) Nat Genet , vol.8 , pp. 148-154
    • Kaplitt, M.G.1
  • 73
    • 0030003480 scopus 로고    scopus 로고
    • Differential and persistent expression pattern of CNS gene transfer by an adeno-associated virus (AAV) vector
    • McCown TJ et al. Differential and persistent expression pattern of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res 1996; 713: 99-107.
    • (1996) Brain Res , vol.713 , pp. 99-107
    • McCown, T.J.1
  • 74
    • 0033585514 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated gene transfer to the brain: Duration and modulation of expression
    • Lo WD et al. Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression. Hum Gene Ther 1999; 10: 201-213.
    • (1999) Hum Gene Ther , vol.10 , pp. 201-213
    • Lo, W.D.1
  • 75
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
    • Yang Y et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994; 7: 362-369.
    • (1994) Nat Genet , vol.7 , pp. 362-369
    • Yang, Y.1
  • 76
    • 0029670374 scopus 로고    scopus 로고
    • Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2a mutation in immunocompetent mice and hemophilia B dogs
    • Fang B et al. Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2a mutation in immunocompetent mice and hemophilia B dogs. Gene Therapy 1996; 3: 217-222.
    • (1996) Gene Therapy , vol.3 , pp. 217-222
    • Fang, B.1
  • 77
    • 0030892490 scopus 로고    scopus 로고
    • Isolation and characterization of packaging cell lines that coexpress the adenovirus E1, DNA polymerase, and preterminal proteins: Implications for gene therapy
    • Amalfitano A, Chamberlain JS. Isolation and characterization of packaging cell lines that coexpress the adenovirus E1, DNA polymerase, and preterminal proteins: implications for gene therapy. Gene Therapy 1997; 4: 258-263.
    • (1997) Gene Therapy , vol.4 , pp. 258-263
    • Amalfitano, A.1    Chamberlain, J.S.2
  • 78
    • 0029918572 scopus 로고    scopus 로고
    • Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors
    • Amalfitano A, Begy CR, Chamberlain JS. Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors. Proc Natl Acad Sci USA 1996; 93: 3352-3356.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3352-3356
    • Amalfitano, A.1    Begy, C.R.2    Chamberlain, J.S.3
  • 79
    • 0031883829 scopus 로고    scopus 로고
    • Production and characterization of improved adenovirus vectors with E1, E2b and E3 genes deleted
    • Amalfitano A et al. Production and characterization of improved adenovirus vectors with E1, E2b and E3 genes deleted. J Virol 1998; 72: 926-933.
    • (1998) J Virol , vol.72 , pp. 926-933
    • Amalfitano, A.1
  • 80
    • 12644295024 scopus 로고    scopus 로고
    • Recombinational construction in Escherichia coli of infectious adenoviral genomes
    • Crouzet J et al. Recombinational construction in Escherichia coli of infectious adenoviral genomes. Proc Natl Acad Sci USA 1997; 94: 1414-1419.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1414-1419
    • Crouzet, J.1
  • 81
    • 0028863880 scopus 로고
    • Characterization of an adenovirus gene transfer vector containing an E4 deletion
    • Armentano D et al. Characterization of an adenovirus gene transfer vector containing an E4 deletion. Hum Gene Ther 1995; 6: 1343-1353.
    • (1995) Hum Gene Ther , vol.6 , pp. 1343-1353
    • Armentano, D.1
  • 82
    • 0031041586 scopus 로고    scopus 로고
    • Effect of the E4 region on the persistence of transgene expression from adenovirus vectors
    • Armentano D et al. Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. J Virol 1997; 71: 2408-2416.
    • (1997) J Virol , vol.71 , pp. 2408-2416
    • Armentano, D.1
  • 83
    • 0030462599 scopus 로고    scopus 로고
    • A helper-dependent adenovirus vector system: Removal of helper virus by cre-mediated excision of the viral packaging signal
    • Parks RJ et al. A helper-dependent adenovirus vector system: removal of helper virus by cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA 1996; 93: 13565-13570.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13565-13570
    • Parks, R.J.1
  • 84
    • 0029943155 scopus 로고    scopus 로고
    • A new adenoviral vector: Replacement of all viral coding sequences with a 26 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase
    • Kochanek S et al. A new adenoviral vector: replacement of all viral coding sequences with a 26 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA 1996; 93: 5731-5736.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5731-5736
    • Kochanek, S.1
  • 85
    • 0029966514 scopus 로고    scopus 로고
    • Recombinant adenovirus deleted of all viral genes for gene therapy therapy of cystic fibrosis
    • Fisher KJ et al. Recombinant adenovirus deleted of all viral genes for gene therapy therapy of cystic fibrosis. Virology 1996; 217: 11-22.
    • (1996) Virology , vol.217 , pp. 11-22
    • Fisher, K.J.1
  • 86
    • 13144283616 scopus 로고    scopus 로고
    • An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
    • Morsy MA et al. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc Natl Acad Sci USA 1998; 95: 7866-7871.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7866-7871
    • Morsy, Ma.1
  • 87
    • 0026969268 scopus 로고
    • A clinically relevant unilateral rat model of Parkinsonian akinesia
    • Schallert T, Jones TA, Norton DA. A clinically relevant unilateral rat model of Parkinsonian akinesia. J Neural Transplant Plast 1992; 3: 332-333.
    • (1992) J Neural Transplant Plast , vol.3 , pp. 332-333
    • Schallert, T.1    Jones, T.A.2    Norton, D.A.3
  • 88
    • 0025440376 scopus 로고
    • Rescuing neurons from trans-synaptic degeneration after brain damage: Helpful, harmful, or neutral in recovery of function?
    • Schallert T, Lindner MD. Rescuing neurons from trans-synaptic degeneration after brain damage: helpful, harmful, or neutral in recovery of function? Can J Psychol 1990; 44: 276-292.
    • (1990) Can J Psychol , vol.44 , pp. 276-292
    • Schallert, T.1    Lindner, M.D.2
  • 89
    • 0026642175 scopus 로고
    • Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage
    • Jones TA, Schallert T. Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage. Brain Res 1992; 581: 156-160.
    • (1992) Brain Res , vol.581 , pp. 156-160
    • Jones, T.A.1    Schallert, T.2
  • 90
    • 0028296570 scopus 로고
    • Use-dependent growth of pyramidal neurons after neocortical damage
    • Jones TA, Schallert T. Use-dependent growth of pyramidal neurons after neocortical damage. J Neurosci 1994; 14: 2140-2152.
    • (1994) J Neurosci , vol.14 , pp. 2140-2152
    • Jones, T.A.1    Schallert, T.2
  • 91
    • 0029941372 scopus 로고    scopus 로고
    • Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions
    • Kozlowski DA, James DC, Schallert T. Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci 1996; 16: 4776-4786.
    • (1996) J Neurosci , vol.16 , pp. 4776-4786
    • Kozlowski, D.A.1    James, D.C.2    Schallert, T.3
  • 92
    • 0030027461 scopus 로고    scopus 로고
    • Methods for determining numbers of cells and synapses: A case for more uniform standards of review
    • Coggeshall RE, Lekan HA. Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J Comp Neurol 1996; 364: 6-15.
    • (1996) J Comp Neurol , vol.364 , pp. 6-15
    • Coggeshall, R.E.1    Lekan, H.A.2
  • 93
    • 84914639435 scopus 로고
    • Estimation of nuclear population from microtome sections
    • Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946; 94: 239-247.
    • (1946) Anat Rec , vol.94 , pp. 239-247
    • Abercrombie, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.