Changes in Spinal GDNF, BDNF, and NT-3 Expression After Transient Spinal Cord Ischemia in the Rat

Journal of Neuroscience Research

Volumn 74, Issue 4, 2003, Pages 552-561

  Tokumine, Joho ^c   Kakinohana, Osamu ^a   Cizkova, Dasa ^a   Smith, Doug W ^b   Marsala, Martin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c NONE

Author keywords

BDNF; ELISA; Expression; GDNF; NT 3; Spinal ischemia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR; NEUROTROPHIN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY; NERVE CELL PLASTICITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; SPINAL CORD ISCHEMIA; SPINAL CORD NERVE CELL; TISSUE LEVEL; TRANSIENT ISCHEMIC ATTACK; UPREGULATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MALE; MICROSCOPY, FLUORESCENCE; NERVE GROWTH FACTORS; NEUROGLIA; NEURONAL PLASTICITY; NEURONS; NEUROTROPHIN 3; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD ISCHEMIA; UP-REGULATION;

EID: 0242267622     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10760     Document Type: Article

References (25)

1. Bates B, Hirt L, Thomas SS, Akbarian S, Le D, Amin-Hanjani S, Whalen M, Jaenisch R, Moskowitz MA. 2002. Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiol Dis 9:24-37.
2. Boris-Moller F, Kamme F, Wieloch T. 1998. The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. Brain Res Mol Brain Res 63:163-173.
3. Bowes M, Tuszynski MH, Conner J, Zivin JA. 2000. Continuous intrathecal fluid infusions elevate nerve growth factor levels and prevent functional deficits after spinal cord ischemia. Brain Res 883:178-183.
4. Bradbury EJ, Khemani S, Von R, King, Priestley JV, McMahon SB. 1999. NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord. Eur J Neurosci 11:3873-3883.
5. Cheng B, Mattson MP. 1991. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis. Neuron 7:1031-1041.
6. Dinda M, Galik J, Marsala J, Vanicky i, Marsala M. 1995. Sciatic nerve stimulation increases the degree of histopathological damage in lumbosacral segments after short lasting spinal cord ischemia in rabbit. Rest Neurol Neurosci 7:145-150.
7. Hashino E, Dolnick RY, Cohan CS. 1999. Developing vestibular ganglion neurons switch trophic sensitivity from BDNF to GDNF after target innervation. J Neurobiol 38:414-427.
8. Henrich-Noack P, Prehn JH, Krieglstein J. 1996. TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose-response relationship and potential neuroprotective mechanisms. Stroke 27:1609-1614; discussion 1615.
9. Kiprianova I, Freiman TM, Desiderato S, Schwab S, Galmbacher R, Gillardon F, Spranger M. 1999. Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat. J Neurosci Res 56:21-27.
10. Kokaia Z, Zhao Q, Kokaia M, Elmér E, Metsis M, Smith ML, Siesjö BK, Lindvall O. 1995. Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage. Exp Neurol 136:73-88.
11. Li Q, Stephenson D. 2002. Postischemic administration of basic fibroblast growth factor improves sensorimotor function and reduces infarct size following permanent focal cerebral ischemia in the rat. Exp Neurol 177:531-537.
12. Marsala J, Sulla I, Santa M, Marsala M, Mechírová E, Jalc P. 1989. Early neurohistopathological changes of canine lumbosacral spinal cord segments in ischemia-reperfusion-induced paraplegia. Neurosci Lett 106:83-88.
13. Menei P, Montero-Menei C, Whittemore SR, Bunge RP, Bunge MB. 1998. Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci 10:607-621.
14. Miyazaki H, Nagashima K, Okuma Y, Nomura Y. 2001. Expression of glial cell line-derived neurotrophic factor induced by transient forebrain ischemia in rats. Brain Res 922:165-172.
15. Ogata N, Ogata K, Imhof HG, Yonekawa Y. 1996. Effect of CNTF on ischaemic cell damage in rat hippocampus. Acta Neurochir (Wien) 138:580-583.
16. Rosenblad C, Kirik D, Bjorklund A. 2000. Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Exp Neurol 161:503-516.
17. Sakurai M, Abe K, Hayashi T, Setoguchi Y, Yaginuma G, Meguro T, Tabayashi K. 2000. Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 120:1148-1157.
18. Sakurai M, Hayashi T, Abe K, Yaginuma G, Meguro T, Itoyama Y, Tabayashi K. 1999. Induction of glial cell line-derived neurotrophic factor and c-ret porto-oncogene-like immunoreactivity in rabbit spinal cord after transient ischemia. Neurosci Lett 276:123-126.
19. Shigeno T, Mima T, Takakura K, Graham DI, Kato G, Hashimoto Y, Furukawa S. 1991. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. J Neurosci 11:2914-2919.
20. Taira Y, Marsala M. 1996. Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat [see comments]. Stroke 27:1850-1858.
21. von Meyenburg J, Brösamle C, Metz GA, Schwab ME. 1998. Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAb IN-1, which neutralizes myelin-associated neurite growth inhibitors. Exp Neurol 154:583-594.
22. Wang Y, Chang CF, Morales M, Chiang YH, Hoffer J. 2002. Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury. Ann N Y Acad Sci 962:423-437.
23. Wang Y, Lin SZ, Chiou AL, Williams LR, Hoffer BJ. 1997. Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. J Neurosci 17:4341-4348.
24. Yanamoto H, Mizuta I, Nagata I, Xue J, Zhang Z, Kikuchi H. 2000. Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei. Brain Res 877:331-344.
25. Zhou XF, Rush PA. 1996. Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons. Neuroscience 74:945-953.