Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: Intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system

Journal of Neuroscience

Volumn 20, Issue 12, 2000, Pages 4686-4700

  Kirik, Deniz ^a   Rosenblad, Carl ^a   Björklund, Anders ^a   Mandel, Ronald J ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

6 hydroxydopamine; Cell death; Gene transfer; Glial cell line derived neurotrophic factor; Parkinson's disease; Paw use; Sensorimotor behavior; Stepping; Stereology; Tyrosine hydroxylase

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ADENO ASSOCIATED VIRUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; FEMALE; GENE TRANSFER; LONG TERM CARE; NERVE REGENERATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; TREATMENT OUTCOME;

EID: 0034659835     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-12-04686.2000     Document Type: Article

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