Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 16, 1997, Pages 8818-8823

  Bilang Bleuel, Alicia ^a,c   Revah, Frédéric ^b   Colin, Phillippe ^a   Locquet, Isabelle ^b   Robert, Jean Jacques ^b   Mallet, Jacques ^a   Horellou, Philippe ^a  

^a CNRS   (France)

^b SANOFI   (France)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Recombinant adenovirus

Indexed keywords

AMPHETAMINE; BETA GALACTOSIDASE; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; OXIDOPAMINE;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; EXPRESSION VECTOR; FEMALE; GENE THERAPY; GENE TRANSFER; GLIA CELL; MOTOR PERFORMANCE; NERVE CELL DEGENERATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY;

ADENOVIRIDAE; ANIMALIA;

EID: 0030795798     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.16.8818     Document Type: Article

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