Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: A within-subject, within-task comparison of reference and working spatial memory

European Journal of Neuroscience

Volumn 19, Issue 3, 2004, Pages 705-712

  Pothuizen, Helen H J ^a   Zhang, Wei Ning ^a   Jongen Rêlo, Ana L ^a,b   Feldon, Joram ^a   Yee, Benjamin K ^a  

^a ETH ZURICH   (Switzerland)

^b ABBOTT GMBH AND CO KG   (Germany)

Author keywords

Four baited four unbaited; Hippocampal formation; Place task; Radial maze; Spatial memory

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN INJURY; CONTROLLED STUDY; EVALUATION; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY; TASK PERFORMANCE; WORKING MEMORY;

ANIMALS; BEHAVIOR, ANIMAL; DISSOCIATIVE DISORDERS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; N-METHYLASPARTATE; RATS; RATS, WISTAR; REACTION TIME; SPACE PERCEPTION; SPATIAL BEHAVIOR;

EID: 1242340464     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-816X.2004.03170.x     Document Type: Article

References (31)

1. Amaral, D.G. & Witter, M.P. (1995) The hippocampal formation. In Paxinos. P.E. (Ed.), The Rat Nervous System. Academic Press, New York, pp. 443-494.
2. Bannerman, D.M., Deacon, R., Offen, S., Friswell, J., Grubb, M. & Rawlins, J. (2002) Double dissociation of function within the hippocampus: spatial memory and hyponeophagia. Behav. Neurosci., 116, 884-901.
3. Bannerman, D.M., Grubb, M., Deacon, R.M., Yee, B.K., Feldon, J. & Rawlins, J.N. (2003) Ventral hippocampal lesions affect anxiety but not spatial learning. Behav. Brain Res., 139, 197-213.
4. Bannerman, D.M., Yee, B.K., Good, M.A., Heupel, M.J., Iversen, S.D. & Rawlins, J.N. (1999) Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions. Behav. Neurosci., 113, 1170-1188.
5. Burwell, R.D. (2000) The parahippocampal region: corticocortical connectivity. Ann. N Y Acad. Sci., 911, 25-42.
6. Burwell, R.D., Witter, M.P. & Amaral, D.G. (1995) Perirhinal and postrhinal cortices of the rat: a review of the neuroanatomical literature and comparison with findings from the monkey brain. Hippocampus, 5, 390-408.
7. Dolorfo, C.L. & Amaral, D.G. (1998) Entorhinal cortex of the rat topographic organization of the cells of origin of the perforant path projection to the dentate gyrus. J. Comp. Neurol., 398, 25-48.
8. Gundersen, H.J., Bendtsen, T.F., Korbo, L., Marcussen, N., Moller, A., Nielsen, K., Nyengaard, J.R., Pakkenberg, B., Sorensen, F.B., Vesterby, A. & West, M.J. (1988) Some new, simple, and efficient stereological methods and their use in pathological research and diagnosis. APMIS, 69, 379-394.
9. Gundersen, H.J. & Jensen, E.B. (1987) The efficiency of systematic sampling in stereology and its prediction. J. Microsc., 147, 229-263.
10. Hodges, H. (1996) Maze procedures: the radial-arm and water maze compared. Cogn. Brain Res., 3, 167-181.
11. de Hoz, L., Knox, J. & Morris, R.G. (2003) Longitudinal axis of the hippocampus: both septal and temporal poles of the hippocampus support water maze spatial learning depending on the training protocol. Hippocampus, 13, 587-603.
12. Hudon, C., Doré, F.Y. & Goulet, S. (2002) Spatial memory and choice behavior in the radial arm maze after fornix transaction. Progr. Neuro-Psychopharmacol. Biol. Psychiatry, 26, 1113-1123.
13. Jarrard, L.E. (1983) Selective hippocampal lesions and behavior: effects of kainic acid lesions on performance of place and cue tasks. Behav. Neurosci., 97, 873-889.
14. Jarrard, L.E. (1993) On the role of the hippocampus in learning and memory in the rat. Behav. Neural. Biol., 60, 9-26.
15. Jongen-Rêlo, A.L., Kaufman, S. & Feldon, J. (2003) A differential involvement of the shell and core subterritories of the nucleus accumbens of rats in memory processes. Behav. Neurosci., 117, 150-168.
16. Jung, M.W., Wiener, S.I. & McNaughton, B.L. (1994) Comparison of spatial firing characteristics of units in dorsal and ventral hippocampus of the rat. J. Neurosci., 14, 7347-7356.
17. Kjelstrup, K.G., Tuvnes, F.A., Steffenach, H.A., Murison, R., Moser, E.I. & Moser, M.B. (2002) Reduced fear expression after lesions of the ventral hippocampus. Proc. Natl Acad. Sci. USA, 99, 10825-10830.
18. Krettik, J.E. & Price, J.L. (1977) Projections from the amygdaloid complex and adjacent olfactory structures to the entorhinal cortex and to the subiculum in the rat and cat. J. Comp. Neurol., 172, 723-752.
19. Lomber, S.G. (1999) The advantages and limitations of permanent or reversible deactivation techniques in the assessment of neural function. J. Neurosci. Methods, 86, 109-117.
20. Malpeli, J.G. (1999) Revesible inactivation of subcortical sites by drug injection. J. Neurosci. Methods, 86, 119-128.
21. Malpeli, J.G. & Schiller, P.H. (1979) A method of revesible inactivation of small regions of brain tissue. J. Neurosci. Methods, 1, 143-151.
22. Moser, M.B. & Moser, E.I. (1998) Functional differentiation in the hippocampus. Hippocampus, 8, 608-619.
23. Moser, E., Moser, M.B. & Andersen, P. (1993) Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci., 13, 3916-3925.
24. Moser, M.B., Moser, E.I., Forrest, E., Andersen, P. & Morris, R.G. (1995) Spatial learning with a minislab in the dorsal hippocampus. Proc. Natl Acad. Sci. USA, 92, 9697-9701.
25. Okaichi, H. & Oshima, Y. (1990) Choice behavior of hippocampectomized rats in the radial arm maze. Psychobiology, 18, 416-421.
26. Paxinos, G. & Watson, C. (1997) The Rat Brain in Stereotaxic Coordinates, 3rd edition. Academic Press, San Diego.
27. Poucet, B. & Buhot, M.-C. (1994) Effects of medial septal or unilateral hippocampal inactivations on reference and working spatial memory in rats. Hippocampus, 4, 315-321.
28. Pouzet, B., Welzl, H., Gubler, M.K., Broersen, L., Veenman, C.L., Feldon, J., Rawlins, J.N.P. & Yee, B.K. (1999) The effects of NMDA-induced retrohippocampal lesions on performance of four spatial memory tasks known to be sensitive to hippocampal damage in the rat. Eur. J. Neurosci., 11, 123-140.
29. Richmond, M.A., Yee, B.K., Pouzet, B., Veenman, L., Rawlins, J.N., Feldon, J. & Bannerman, D.M. (1999) Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning. Behav. Neurosci., 113, 1189-1203.
30. Schmitt, W.B., Deacon, R.M., Seeburg, P.H., Rawlins, J.N. & Bannerman, D.M. (2003) A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice. J. Neurosci., 23, 3953-3959.
31. Witter, M.P., Wouterlood, F.G., Naber, P.A. & Van Haeften, T. (2000) Anatomical organization of the parahippocampal-hippocampal network. Ann. N Y Acad. Sci., 911, 1-24.