Antibody production by a hybridoma cell line at high cell density is limited by two independent mechanisms

Biotechnology and Bioengineering

Volumn 79, Issue 3, 2002, Pages 277-283

  Gramer, Michael J ^a   Britton, Tracey L ^a  

^a Biovest International Inc   (United States)

Author keywords

Hollow fiber bioreactor; Medium limitation; Model system; Optimization; Oxygen limitation; Scale up

Indexed keywords

ANTIBODIES; BIOREACTORS; FIBERS; GROWTH KINETICS; OXIDATION; SILICONES; VOLUMETRIC ANALYSIS;

HOLLOW-FIBER SYSTEMS; VIABLE CELL DENSITY;

BIOTECHNOLOGY;

ANTIBODY; OXYGEN; SILICONE;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; BIOREACTOR; CELL DENSITY; CELL GROWTH; CELL SECRETION; CELL SPECIFICITY; CELL VIABILITY; CONTROLLED STUDY; HOLLOW FIBER; HYBRIDOMA CELL CULTURE; NONHUMAN; OXYGENATION; THEORETICAL MODEL; TUBE; VOLUMETRY;

ANIMALS; BIOREACTORS; CELL COUNT; CELL LINE; CELL SURVIVAL; GLUCOSE; HYBRIDOMAS; IMMUNOGLOBULIN G; LACTIC ACID; MICE; OXYGEN; PILOT PROJECTS; PROTONS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0037026238     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10282     Document Type: Article

References (9)

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