Albumin binding as a general strategy for improving the pharmacokinetics of proteins

Journal of Biological Chemistry

Volumn 277, Issue 38, 2002, Pages 35035-35043

  Dennis, Mark S ^a,b   Zhang, Min ^a,b   Gloria Meng, Y ^a,b   Kadkhodayan, Miryam ^a,b   Kirchhofer, Daniel ^a,b   Combs, Dan ^a,b   Damico, Lisa A ^a,b  

^a Department of Protein Engineering ^*  (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGES; PHARMACOKINETICS; PLASMAS; PROTEINS; STOICHIOMETRY; TISSUE;

ALBUMIN BINDING; PEPTIDE PHAGE DISPLAYS;

BIOCHEMISTRY;

IMMUNOGLOBULIN F(AB) FRAGMENT; MACROGOL; PROTEIN SA21; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; DISSOCIATION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PROTEIN BINDING; EQUILIBRIUM CONSTANT; GENETIC VARIABILITY; MALE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STOICHIOMETRY; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; ANIMALS; BACTERIOPHAGES; BINDING SITES; HALF-LIFE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEINS; RABBITS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SERUM ALBUMIN; SURFACE PLASMON RESONANCE;

ANIMALIA; ORYCTOLAGUS CUNICULUS; UNIDENTIFIED BACTERIOPHAGE;

EID: 0037144397     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205854200     Document Type: Article

References (33)