메뉴 건너뛰기




Volumn 6, Issue 6, 2007, Pages 758-766

Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis

Author keywords

Anthrax; Apoptosis; Caspase 1; Inflammasome; Interleukin 18; Lethal toxin; Macrophage; Necrosis

Indexed keywords

ANTHRAX TOXIN; BOC D FMK; CASPASE INHIBITOR; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG;

EID: 34047223819     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.6.3991     Document Type: Article
Times cited : (69)

References (51)
  • 3
    • 85047692288 scopus 로고    scopus 로고
    • Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice
    • Moayeri M, Haines D, Young HA, Leppla SH. Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice. J Clin Invest 2003; 112:670-82.
    • (2003) J Clin Invest , vol.112 , pp. 670-682
    • Moayeri, M.1    Haines, D.2    Young, H.A.3    Leppla, S.H.4
  • 4
    • 1242351553 scopus 로고    scopus 로고
    • The roles of anthrax toxin in pathogenesis
    • Moayeri M, Leppla SH. The roles of anthrax toxin in pathogenesis. Curr Opin Microbiol 2004; 7:19-24.
    • (2004) Curr Opin Microbiol , vol.7 , pp. 19-24
    • Moayeri, M.1    Leppla, S.H.2
  • 5
    • 0027097608 scopus 로고
    • Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells
    • Hanna PC, Kochi S, Collier RJ. Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells. Mol Biol Cell 1992; 3:1269-77.
    • (1992) Mol Biol Cell , vol.3 , pp. 1269-1277
    • Hanna, P.C.1    Kochi, S.2    Collier, R.J.3
  • 6
    • 0141994729 scopus 로고    scopus 로고
    • The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited
    • Tonello F, Ascenzi P, Montecucco C. The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited. J Biol Chem 2003; 278:40075-78.
    • (2003) J Biol Chem , vol.278 , pp. 40075-40078
    • Tonello, F.1    Ascenzi, P.2    Montecucco, C.3
  • 7
    • 0028088404 scopus 로고
    • Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
    • Klimpel KR, Arora N, Leppla SH. Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity. Mol Microbiol 1994; 13:1093-1100.
    • (1994) Mol Microbiol , vol.13 , pp. 1093-1100
    • Klimpel, K.R.1    Arora, N.2    Leppla, S.H.3
  • 8
    • 22744450986 scopus 로고    scopus 로고
    • Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge
    • Banks DJ, Barnajian M, Maldonado-Arocho FJ, Sanchez AM, Bradley KA. Anthrax toxin receptor 2 mediates Bacillus anthracis killing of macrophages following spore challenge. Cell Microbiol 2005; 7:1173-85.
    • (2005) Cell Microbiol , vol.7 , pp. 1173-1185
    • Banks, D.J.1    Barnajian, M.2    Maldonado-Arocho, F.J.3    Sanchez, A.M.4    Bradley, K.A.5
  • 9
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001; 410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 10
    • 0038322024 scopus 로고    scopus 로고
    • Anthrax lethal factor proteolysis and inactivation of MAPK kinase
    • Chopra AP, Boone SA, Liang X, Duesbery NS. Anthrax lethal factor proteolysis and inactivation of MAPK kinase. J Biol Chem 2003; 278:9402-6.
    • (2003) J Biol Chem , vol.278 , pp. 9402-9406
    • Chopra, A.P.1    Boone, S.A.2    Liang, X.3    Duesbery, N.S.4
  • 13
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
    • Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19:2435-44.
    • (1999) Mol Cell Biol , vol.19 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 16
    • 0037076364 scopus 로고    scopus 로고
    • The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen
    • Mogridge J, Cunningham K, Lacy DB, Mourez M, Collier RJ. The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci USA 2002; 99:7045-7048.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7045-7048
    • Mogridge, J.1    Cunningham, K.2    Lacy, D.B.3    Mourez, M.4    Collier, R.J.5
  • 17
  • 18
    • 36749009663 scopus 로고    scopus 로고
    • Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response
    • Alileche A, Serfass ER, Muehlbauer SM, Porcelli SA, Brojatsch J. Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response. PLoS Pathog 2005; 1:e19.
    • (2005) PLoS Pathog , vol.1
    • Alileche, A.1    Serfass, E.R.2    Muehlbauer, S.M.3    Porcelli, S.A.4    Brojatsch, J.5
  • 19
    • 0022891493 scopus 로고
    • Macrophages are sensitive to anthrax lethal toxin through an acid- dependent process
    • Friedlander AM. Macrophages are sensitive to anthrax lethal toxin through an acid- dependent process. J Biol Chem 1986; 261:7123-26.
    • (1986) J Biol Chem , vol.261 , pp. 7123-7126
    • Friedlander, A.M.1
  • 20
    • 0027470890 scopus 로고
    • Characterization of macrophage sensitivity and resistance to anthrax lethal toxin
    • Friedlander AM, Bhatnagar R, Leppla SH, Johnson L, Singh Y. Characterization of macrophage sensitivity and resistance to anthrax lethal toxin. Infect Immun 1993; 61:245-252.
    • (1993) Infect Immun , vol.61 , pp. 245-252
    • Friedlander, A.M.1    Bhatnagar, R.2    Leppla, S.H.3    Johnson, L.4    Singh, Y.5
  • 21
    • 0346251030 scopus 로고    scopus 로고
    • Anthrax lethal toxin induces human endothelial cell apoptosis
    • Kirby JE. Anthrax lethal toxin induces human endothelial cell apoptosis. Infect Immun 2004; 72:430-39.
    • (2004) Infect Immun , vol.72 , pp. 430-439
    • Kirby, J.E.1
  • 22
    • 0037022666 scopus 로고    scopus 로고
    • Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase
    • Koo HM, VanBrocklin M, McWilliams MJ, Leppla SH, Duesbery NS, Woude GF. Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase. Proc Natl Acad Sci USA 2002; 99:3052-57.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3052-3057
    • Koo, H.M.1    VanBrocklin, M.2    McWilliams, M.J.3    Leppla, S.H.4    Duesbery, N.S.5    Woude, G.F.6
  • 23
    • 0032510892 scopus 로고    scopus 로고
    • How anthrax kills
    • Hanna P. How anthrax kills. Science 1998; 280:1671,1673-74.
    • (1998) Science , vol.280 , Issue.1671 , pp. 1673-1674
    • Hanna, P.1
  • 24
    • 0037470038 scopus 로고    scopus 로고
    • Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha
    • Kim SO, Jing Q, Hoebe K, Beutler B, Duesbery NS, Han J. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha. J Biol Chem 2003; 278:7413-21.
    • (2003) J Biol Chem , vol.278 , pp. 7413-7421
    • Kim, S.O.1    Jing, Q.2    Hoebe, K.3    Beutler, B.4    Duesbery, N.S.5    Han, J.6
  • 27
    • 33644820576 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA
    • Batty S, Chow EM, Kassam A, Der SD, Mogridge J. Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA. Cell Microbiol 2006; 8:130-38.
    • (2006) Cell Microbiol , vol.8 , pp. 130-138
    • Batty, S.1    Chow, E.M.2    Kassam, A.3    Der, S.D.4    Mogridge, J.5
  • 32
    • 31744441475 scopus 로고    scopus 로고
    • Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    • Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 2006; 38:240-44.
    • (2006) Nat Genet , vol.38 , pp. 240-244
    • Boyden, E.D.1    Dietrich, W.F.2
  • 33
    • 3342965783 scopus 로고    scopus 로고
    • Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity
    • Moayeri M, Martinez NW, Wiggins J, Young HA, Leppla SH. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 2004; 72:4439-47.
    • (2004) Infect Immun , vol.72 , pp. 4439-4447
    • Moayeri, M.1    Martinez, N.W.2    Wiggins, J.3    Young, H.A.4    Leppla, S.H.5
  • 34
    • 0031875676 scopus 로고    scopus 로고
    • Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11
    • Roberts JE, Watters JW, Ballard JD, Dietrich WF. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol 1998; 29:581-91.
    • (1998) Mol Microbiol , vol.29 , pp. 581-591
    • Roberts, J.E.1    Watters, J.W.2    Ballard, J.D.3    Dietrich, W.F.4
  • 35
    • 31744439400 scopus 로고    scopus 로고
    • Anthrax target in macrophages unveiled
    • Bugge TH, Leppla SH. Anthrax target in macrophages unveiled. Nat Genet 2006; 38:137-38.
    • (2006) Nat Genet , vol.38 , pp. 137-138
    • Bugge, T.H.1    Leppla, S.H.2
  • 36
    • 2442701424 scopus 로고    scopus 로고
    • Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18
    • Cordoba-Rodriguez R, Fang H, Lankford CS, Frucht DM. Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18. J Biol Chem 2004; 279:20563-66.
    • (2004) J Biol Chem , vol.279 , pp. 20563-20566
    • Cordoba-Rodriguez, R.1    Fang, H.2    Lankford, C.S.3    Frucht, D.M.4
  • 37
    • 0033056295 scopus 로고    scopus 로고
    • Proteasome activity is required for anthrax lethal toxin to kill macrophages
    • Tang G, Leppla SH. Proteasome activity is required for anthrax lethal toxin to kill macrophages. Infect Immun 1999; 67:3055-60.
    • (1999) Infect Immun , vol.67 , pp. 3055-3060
    • Tang, G.1    Leppla, S.H.2
  • 39
    • 0242492811 scopus 로고    scopus 로고
    • Bystander killing during avian leukosis virus subgroup B infection requires TVB(S3) signaling
    • Diaz-Griffero F, Hoschander SA, Brojatsch J. Bystander killing during avian leukosis virus subgroup B infection requires TVB(S3) signaling. J Virol 2003; 77:12552-61.
    • (2003) J Virol , vol.77 , pp. 12552-12561
    • Diaz-Griffero, F.1    Hoschander, S.A.2    Brojatsch, J.3
  • 41
    • 0027384648 scopus 로고
    • LPS-induced sTNF-receptor release in vivo in a murine model. Investigation of the role of tumor necrosis factor, IL-1, leukemia inhibiting factor, and IFN-gamma
    • Bemelmans MH, Gouma DJ, Buurman WA. LPS-induced sTNF-receptor release in vivo in a murine model. Investigation of the role of tumor necrosis factor, IL-1, leukemia inhibiting factor, and IFN-gamma. J Immunol 1993; 151:5554-62.
    • (1993) J Immunol , vol.151 , pp. 5554-5562
    • Bemelmans, M.H.1    Gouma, D.J.2    Buurman, W.A.3
  • 42
    • 13844318262 scopus 로고    scopus 로고
    • Differentiation of human monocytic cell lines confers susceptibility to Bacillus anthracis lethal toxin
    • Kassam A, Der SD, Mogridge J. Differentiation of human monocytic cell lines confers susceptibility to Bacillus anthracis lethal toxin. Cell Microbiol 2005; 7:281-92.
    • (2005) Cell Microbiol , vol.7 , pp. 281-292
    • Kassam, A.1    Der, S.D.2    Mogridge, J.3
  • 43
    • 0037144590 scopus 로고    scopus 로고
    • Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition
    • Park JM, Greten FR, Li ZW, Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 2002; 297:2048-51.
    • (2002) Science , vol.297 , pp. 2048-2051
    • Park, J.M.1    Greten, F.R.2    Li, Z.W.3    Karin, M.4
  • 44
    • 0034070797 scopus 로고    scopus 로고
    • The liver as a crucial organ in the first line of host defense: The roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses
    • Seki S, Habu Y, Kawamura T, Takeda K, Dobashi H, Ohkawa T, Hiraide H. The liver as a crucial organ in the first line of host defense: The roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev 2000; 174:35-46.
    • (2000) Immunol Rev , vol.174 , pp. 35-46
    • Seki, S.1    Habu, Y.2    Kawamura, T.3    Takeda, K.4    Dobashi, H.5    Ohkawa, T.6    Hiraide, H.7
  • 45
    • 33645318478 scopus 로고    scopus 로고
    • Mitochondrial impairment mediates cytolysis in anthrax lethal toxin-treated murine macrophages
    • Alileche A, Squires RC, Muehlbauer SM, Lisanti MP, Brojatsch J. Mitochondrial impairment mediates cytolysis in anthrax lethal toxin-treated murine macrophages. Cell Cycle 2006; 5:100-106.
    • (2006) Cell Cycle , vol.5 , pp. 100-106
    • Alileche, A.1    Squires, R.C.2    Muehlbauer, S.M.3    Lisanti, M.P.4    Brojatsch, J.5
  • 46
    • 0142091353 scopus 로고    scopus 로고
    • Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages
    • Salles II, Tucker AE, Voth DE, Ballard JD. Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages. Proc Natl Acad Sci USA 2003; 100:12426-31.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12426-12431
    • Salles, I.I.1    Tucker, A.E.2    Voth, D.E.3    Ballard, J.D.4
  • 47
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004; 20:319-25.
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 48
    • 0037312509 scopus 로고    scopus 로고
    • NALPs: A novel protein family involved in inflammation
    • Tschopp J, Martinon F, Burns K. NALPs: A novel protein family involved in inflammation. Nat Rev Mol Cell Biol 2003; 4:95-104.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 95-104
    • Tschopp, J.1    Martinon, F.2    Burns, K.3
  • 49
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon F, Tschopp J. Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
    • (2004) Cell , vol.117 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 50
    • 0036479134 scopus 로고    scopus 로고
    • Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production
    • Le Feuvre RA, Brough D, Iwakura Y, Takeda K, Rothwell NJ. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem 2002; 277:3210-18.
    • (2002) J Biol Chem , vol.277 , pp. 3210-3218
    • Le Feuvre, R.A.1    Brough, D.2    Iwakura, Y.3    Takeda, K.4    Rothwell, N.J.5
  • 51
    • 0032755353 scopus 로고    scopus 로고
    • Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha
    • Pellizzari R, Guidi-Rontani C, Vitale G, Mock M, Montecucco C. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha. FEBS Lett 1999; 462:199-204.
    • (1999) FEBS Lett , vol.462 , pp. 199-204
    • Pellizzari, R.1    Guidi-Rontani, C.2    Vitale, G.3    Mock, M.4    Montecucco, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.