NOD2 and Crohn's disease: Loss or gain of function?

Immunity

Volumn 22, Issue 6, 2005, Pages 661-667

  Eckmann, Lars ^a   Karin, Michael ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15;

APOPTOSIS; CROHN DISEASE; CYTOPLASM; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE FUNCTION; GENE MUTATION; GENETIC PROCEDURES; GENETIC VARIABILITY; HUMAN; INFLAMMATION; PATHOGENICITY; PLANT DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; REVIEW;

ANIMALS; CROHN DISEASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN;

EID: 20444459502     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2005.06.004     Document Type: Review

References (50)

1. D.W. Abbott, A. Wilkins, J.M. Asara, and L.C. Cantley The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO Curr. Biol. 14 2004 2217 2227
2. T. Ahmad, A. Armuzzi, M. Bunce, K. Mulcahy-Hawes, S.E. Marshall, T.R. Orchard, J. Crawshaw, O. Large, A. de Silva, and J.T. Cook The molecular classification of the clinical manifestations of Crohn's disease Gastroenterology 122 2002 854 866
3. P. Alhopuro, T. Ahvenainen, J.P. Mecklin, M. Juhola, H.J. Jarvinen, A. Karhu, and L.A. Aaltonen NOD2 3020insC alone is not sufficient for colorectal cancer predisposition Cancer Res. 64 2004 7245 7247
4. N. Barnich, T. Hisamatsu, J.E. Aguirre, R. Xavier, H.C. Reinecker, and D.K. Podolsky GRIM-19 interacts with NOD2 and serves as down-stream effector of anti-bacterial function in intestinal epithelial cells J. Biol. Chem. 280 2005 19021 19026
5. D.K. Bonen, Y. Ogura, D.L. Nicolae, N. Inohara, L. Saab, T. Tanabe, F.F. Chen, S.J. Foster, R.H. Duerr, and S.R. Brant Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan Gastroenterology 124 2003 140 146
6. G. Bouma, and W. Strober The immunological and genetic basis of inflammatory bowel disease Nat. Rev. Immunol. 3 2003 521 533
7. S.R. Brant, and Y.Y. Shugart Inflammatory bowel disease gene hunting by linkage analysis: rationale, methodology, and present status of the field Inflamm. Bowel Dis. 10 2004 300 311
8. L. Caradonna, L. Amati, P. Lella, E. Jirillo, and D. Caccavo Phagocytosis, killing, lymphocyte-mediated antibacterial activity, serum autoantibodies, and plasma endotoxins in inflammatory bowel disease Am. J. Gastroenterol. 95 2000 1495 1502
9. C.M. Chen, Y. Gong, M. Zhang, and J.J. Chen Reciprocal cross-talk between Nod2 and TAK1 signaling pathways J. Biol. Chem. 279 2004 25876 25882
10. M. Economou, T.A. Trikalinos, K.T. Loizou, E.V. Tsianos, and J.P. Ioannidis Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis Am. J. Gastroenterol. 99 2004 2393 2404
11. I.M. Fearnley, J. Carroll, R.J. Shannon, M.J. Runswick, J.E. Walker, and J. Hirst GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I) J. Biol. Chem. 276 2001 38345 38348
12. S.E. Girardin, I.G. Boneca, J. Viala, M. Chamaillard, A. Labigne, G. Thomas, D.J. Philpott, and P.J. Sansonetti Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J. Biol. Chem. 278 2003 8869 8872
13. T. Hisamatsu, M. Suzuki, H.C. Reinecker, W.J. Nadeau, B.A. McCormick, and D.K. Podolsky CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells Gastroenterology 124 2003 993 1000
14. K.A. Hogquist, M.A. Nett, E.R. Unanue, and D.D. Chaplin Interleukin 1 is processed and released during apoptosis Proc. Natl. Acad. Sci. USA 88 1991 8485 8489
15. E. Hollenbach, M. Vieth, A. Roessner, M. Neumann, P. Malfertheiner, and M. Naumann Inhibition of RICK/nuclear factor-κB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease J. Biol. Chem. 280 2005 14981 14988
16. J.P. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J.P. Cezard, J. Belaiche, S. Almer, C. Tysk, C.A. O'Morain, and M. Gassull Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 2001 599 603
17. T. Huzarski, M. Lener, W. Domagala, J. Gronwald, T. Byrski, G. Kurzawski, J. Suchy, M. Chosia, J. Woyton, and M. Ucinski The 3020insC allele of NOD2 predisposes to early-onset breast cancer Breast Cancer Res. Treat. 89 2005 91 93
18. N. Inohara, Y. Ogura, A. Fontalba, O. Gutierrez, F. Pons, J. Crespo, K. Fukase, S. Inamura, S. Kusumoto, and M. Hashimoto Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease J. Biol. Chem. 278 2003 5509 5512
19. N. Inohara, M. Chamaillard, C. McDonald, and G. Nunez NOD-LRR Proteins: Role in Host-Microbial Interactions and Inflammatory Disease Annu. Rev. Biochem. 74 2004 355 383
20. K.L. Isaacs, and R.B. Sartor Treatment of inflammatory bowel disease with antibiotics Gastroenterol. Clin. North Am. 33 2004 335 345
21. M. Karin, and A. Lin NF-κB at the crossroads of life and death Nat. Immunol. 3 2002 221 227
22. K.S. Kobayashi, M. Chamaillard, Y. Ogura, O. Henegariu, N. Inohara, G. Nunez, and R.A. Flavell Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract Science 307 2005 731 734
23. G. Kurzawski, J. Suchy, J. Kladny, E. Grabowska, M. Mierzejewski, A. Jakubowska, T. Debniak, C. Cybulski, E. Kowalska, and Z. Szych The NOD2 3020insC mutation and the risk of colorectal cancer Cancer Res. 64 2004 1604 1606
24. S. Lala, Y. Ogura, C. Osborne, S.Y. Hor, A. Bromfield, S. Davies, O. Ogunbiyi, G. Nunez, and S. Keshav Crohn's disease and the NOD2 gene: a role for paneth cells Gastroenterology 125 2003 47 57
25. M. Lecuit, S. Vandormael-Pournin, J. Lefort, M. Huerre, P. Gounon, C. Dupuy, C. Babinet, and P. Cossart A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier Science 292 2001 1722 1725
26. J. Li, T. Moran, E. Swanson, C. Julian, J. Harris, D.K. Bonen, M. Hedl, D.L. Nicolae, C. Abraham, and J.H. Cho Regulation of IL-8 and IL-1β expression in Crohn's disease associated NOD2/CARD15 mutations Hum. Mol. Genet. 13 2004 1715 1725
27. S. Maeda, L.C. Hsu, H. Liu, L.A. Bankston, M. Iimura, M.F. Kagnoff, L. Eckmann, and M. Karin Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing Science 307 2005 734 738
28. P. Mamula, J.E. Markowitz, and R.N. Baldassano Inflammatory bowel disease in early childhood and adolescence: special considerations Gastroenterol. Clin. North Am. 32 2003 967 995
29. P.J. Mannon, I.J. Fuss, L. Mayer, C.O. Elson, W.J. Sandborn, D. Present, B. Dolin, N. Goodman, C. Groden, and R.L. Hornung Anti-interleukin-12 antibody for active Crohn's disease N. Engl. J. Med. 351 2004 2069 2079
30. M.E. McAlindon, C.J. Hawkey, and Y.R. Mahida Expression of interleukin 1β and interleukin 1β converting enzyme by intestinal macrophages in health and inflammatory bowel disease Gut 42 1998 214 219
31. C. Miceli-Richard, S. Lesage, M. Rybojad, A.M. Prieur, S. Manouvrier-Hanu, R. Hafner, M. Chamaillard, H. Zouali, G. Thomas, and J.P. Hugot CARD15 mutations in Blau syndrome Nat. Genet. 29 2001 19 20
32. M.G. Netea, B.J. Kullberg, D.J. de Jong, B. Franke, T. Sprong, T.H. Naber, J.P. Drenth, and J.W. Van der Meer NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease Eur. J. Immunol. 34 2004 2052 2059
33. Y. Ogura, D.K. Bonen, N. Inohara, D.L. Nicolae, F.F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, and R.H. Duerr A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 2001 603 606
34. Y. Ogura, N. Inohara, A. Benito, F.F. Chen, S. Yamaoka, and G. Nunez Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB J. Biol. Chem. 276 2001 4812 4818
35. Y. Ogura, S. Lala, W. Xin, E. Smith, T.A. Dowds, F.F. Chen, E. Zimmermann, M. Tretiakova, J.H. Cho, and J. Hart Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis Gut 52 2003 1591 1597
36. A.L. Pauleau, and P.J. Murray Role of nod2 in the response of macrophages to toll-like receptor agonists Mol. Cell. Biol. 23 2003 7531 7539
37. D. Rachmilewitz, K. Katakura, F. Karmeli, T. Hayashi, C. Reinus, B. Rudensky, S. Akira, K. Takeda, J. Lee, K. Takabayashi, and E. Raz Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis Gastroenterology 126 2004 520 528
38. P. Rahman, S. Bartlett, F. Siannis, F.J. Pellett, V.T. Farewell, L. Peddle, C.T. Schentag, C.A. Alderdice, S. Hamilton, and M. Khraishi CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis Am. J. Hum. Genet. 73 2003 677 681
39. S. Rakoff-Nahoum, J. Paglino, F. Eslami-Varzaneh, S. Edberg, and R. Medzhitov Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis Cell 118 2004 229 241
40. G. Rogler, K. Brand, D. Vogl, S. Page, R. Hofmeister, T. Andus, R. Knuechel, P.A. Baeuerle, J. Scholmerich, and V. Gross Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa Gastroenterology 115 1998 357 369
41. P. Rosenstiel, M. Fantini, K. Brautigam, T. Kuhbacher, G.H. Waetzig, D. Seegert, and S. Schreiber TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells Gastroenterology 124 2003 1001 1009
42. S. Schreiber, S. Nikolaus, and J. Hampe Activation of nuclear factor κB inflammatory bowel disease Gut 42 1998 477 484
43. B. Siegmund, H.A. Lehr, G. Fantuzzi, and C.A. Dinarello IL-1 beta-converting enzyme (caspase-1) in intestinal inflammation Proc. Natl. Acad. Sci. USA 98 2001 13249 13254
44. G. Takaesu, R.M. Surabhi, K.J. Park, J. Ninomiya-Tsuji, K. Matsumoto, and R.B. Gaynor TAK1 is critical for IκB kinase-mediated activation of the NF-κB pathway J. Mol. Biol. 326 2003 105 115
45. D.A. van Heel, S. Ghosh, M. Butler, K.A. Hunt, A.M. Lundberg, T. Ahmad, D.P. McGovern, C. Onnie, K. Negoro, and S. Goldthorpe Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease Lancet 365 2005 1794 1796
46. T. Watanabe, A. Kitani, P.J. Murray, and W. Strober NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses Nat. Immunol. 5 2004 800 808
47. J. Wehkamp, J. Harder, M. Weichenthal, M. Schwab, E. Schaffeler, M. Schlee, K.R. Herrlinger, A. Stallmach, F. Noack, and P. Fritz NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression Gut 53 2004 1658 1664
48. C.L. Wilson, A.J. Ouellette, D.P. Satchell, T. Ayabe, Y.S. Lopez-Boado, J.L. Stratman, S.J. Hultgren, L.M. Matrisian, and W.C. Parks Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense Science 286 1999 113 117
49. N.J. Yoo, W.S. Park, S.Y. Kim, J.C. Reed, S.G. Son, J.Y. Lee, and S.H. Lee Nod1, a CARD protein, enhances pro-interleukin-1β processing through the interaction with pro-caspase-1 Biochem. Biophys. Res. Commun. 299 2002 652 658
50. J. Zhang, J. Yang, S.K. Roy, S. Tininini, J. Hu, J.F. Bromberg, V. Poli, G.R. Stark, and D.V. Kalvakolanu The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3 Proc. Natl. Acad. Sci. USA 100 2003 9342 9347