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Volumn 131, Issue 16, 2004, Pages 4059-4070

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

Author keywords

Differentiation; Neural progenitor; Neurogenesis; Telomerase knockout

Indexed keywords

PROTEIN P53; TELOMERASE;

EID: 4544256099     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01215     Document Type: Article
Times cited : (130)

References (76)
  • 1
    • 0036470478 scopus 로고    scopus 로고
    • Neurogenesis in adult subventricular zone
    • Alvarez-Buylla, A. and Garcia-Verdugo, J. M. (2002). Neurogenesis in adult subventricular zone. J. Neurosci. 22, 629-634.
    • (2002) J. Neurosci. , vol.22 , pp. 629-634
    • Alvarez-Buylla, A.1    Garcia-Verdugo, J.M.2
  • 3
    • 0035694469 scopus 로고    scopus 로고
    • Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
    • Barlev, N. A., Liu, L., Chehab, N. H., Mansfield, K., Harris, K. G., Halazonetis, T. D. and Berger, S. L. (2001). Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 8, 1243-1254.
    • (2001) Mol. Cell , vol.8 , pp. 1243-1254
    • Barlev, N.A.1    Liu, L.2    Chehab, N.H.3    Mansfield, K.4    Harris, K.G.5    Halazonetis, T.D.6    Berger, S.L.7
  • 4
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn, E. H. (2000). Telomere states and cell fates. Nature 408, 53-56.
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 6
    • 0036674425 scopus 로고    scopus 로고
    • Telomerase beyond telomeres
    • Blasco, M. A. (2002). Telomerase beyond telomeres. Nat. Rev. Cancer 2, 627-633.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 627-633
    • Blasco, M.A.1
  • 8
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • Brooks, C. L. and Gu, W. (2003). Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol. 15, 164-171.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 10
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S. L., Gottlieb, G. J., Greider, C. W. and DePinho, R. A. (1999). p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97, 527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 11
    • 0031047426 scopus 로고    scopus 로고
    • Replicative senescence and cell immortality: The role of telomeres and telomerase
    • Chiu, C. P. and Harley, C. B. (1997). Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc. Soc. Exp. Biol. Med. 214, 99-106.
    • (1997) Proc. Soc. Exp. Biol. Med. , vol.214 , pp. 99-106
    • Chiu, C.P.1    Harley, C.B.2
  • 13
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange, T. (2002). Protection of mammalian telomeres. Oncogene 21, 532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • de Lange, T.1
  • 14
    • 0030979469 scopus 로고    scopus 로고
    • Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain
    • Doetsch, F., Garcia-Verdugo, J. M. and Alvarez-Buylla, A. (1997). Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17, 5046-5061.
    • (1997) J. Neurosci. , vol.17 , pp. 5046-5061
    • Doetsch, F.1    Garcia-Verdugo, J.M.2    Alvarez-Buylla, A.3
  • 15
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M. and Alvarez-Buylla, A. (1999). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716.
    • (1999) Cell , vol.97 , pp. 703-716
    • Doetsch, F.1    Caille, I.2    Lim, D.A.3    Garcia-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 16
    • 0037112834 scopus 로고    scopus 로고
    • Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    • Espejel, S., Franco, S., Segura, A., Gae, D., Bailey, S. M., Taccioli, G. E. and Blasco, M. A. (2002b). Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J. 21, 6275-6287.
    • (2002) EMBO J. , vol.21 , pp. 6275-6287
    • Espejel, S.1    Franco, S.2    Segura, A.3    Gae, D.4    Bailey, S.M.5    Taccioli, G.E.6    Blasco, M.A.7
  • 17
    • 0030460869 scopus 로고    scopus 로고
    • Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors
    • Fariñas, I., Yoshida, C. K., Backus, C. and Reichardt, L. F. (1996). Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors. Neuron 17, 1065-1078.
    • (1996) Neuron , vol.17 , pp. 1065-1078
    • Fariñas, I.1    Yoshida, C.K.2    Backus, C.3    Reichardt, L.F.4
  • 18
    • 0034122088 scopus 로고    scopus 로고
    • The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function
    • Fu, W., Killen, M., Culmsee, C., Dhar, S., Pandita, T. K. and Mattson, M. P. (2000). The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J. Mol. Neurosci. 14, 3-15.
    • (2000) J. Mol. Neurosci. , vol.14 , pp. 3-15
    • Fu, W.1    Killen, M.2    Culmsee, C.3    Dhar, S.4    Pandita, T.K.5    Mattson, M.P.6
  • 19
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage, F. H. (2000). Mammalian neural stem cells. Science 287, 1433-1438.
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 22
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A. J. and Kastanm M. B. (1998). The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12, 2973-2983.
    • (1998) Genes Dev. , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastanm, M.B.2
  • 23
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • González-Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martin-Caballero, J., Jorcano, J. L. and Blasco, M. A. (2001). Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 20, 619-630.
    • (2001) EMBO J. , vol.20 , pp. 619-630
    • González-Suárez, E.1    Samper, E.2    Ramírez, A.3    Flores, J.M.4    Martin-Caballero, J.5    Jorcano, J.L.6    Blasco, M.A.7
  • 24
    • 0036787840 scopus 로고    scopus 로고
    • Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
    • González-Suárez, E., Flores, J. M. and Blasco, M. A. (2002). Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol. Cell. Biol. 22, 7291-7301.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7291-7301
    • González-Suárez, E.1    Flores, J.M.2    Blasco, M.A.3
  • 25
    • 0037148330 scopus 로고    scopus 로고
    • Many ways to telomere dysfunction: In vivo studies using mouse models
    • Goytisolo, F. A. and Blasco, M. A. (2002), Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene 21, 584-591.
    • (2002) Oncogene , vol.21 , pp. 584-591
    • Goytisolo, F.A.1    Blasco, M.A.2
  • 26
    • 0032473931 scopus 로고    scopus 로고
    • Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
    • Greenberg, R. A., Allsopp, R. C., Chin, L., Morin, G. B. and DePinho, R. A. (1998). Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene 16, 1723-1730.
    • (1998) Oncogene , vol.16 , pp. 1723-1730
    • Greenberg, R.A.1    Allsopp, R.C.2    Chin, L.3    Morin, G.B.4    DePinho, R.A.5
  • 27
    • 0032567975 scopus 로고    scopus 로고
    • Telomeres and senescence: The history, the experiment, the future
    • Greider, C. W. (1998). Telomeres and senescence: the history, the experiment, the future. Curr. Biol. 8, 178-181.
    • (1998) Curr. Biol. , vol.8 , pp. 178-181
    • Greider, C.W.1
  • 29
    • 0344848564 scopus 로고    scopus 로고
    • Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain
    • Gritti, A., Frolichsthal-Schoeller, P., Galli, R., Parati, E. A., Cova, L., Pagano, S. F., Bjornson, C. R. and Vescovi, A. L. (1999). Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain. J. Neurosci. 19, 3287-3297.
    • (1999) J. Neurosci. , vol.19 , pp. 3287-3297
    • Gritti, A.1    Frolichsthal-Schoeller, P.2    Galli, R.3    Parati, E.A.4    Cova, L.5    Pagano, S.F.6    Bjornson, C.R.7    Vescovi, A.L.8
  • 31
    • 0034646304 scopus 로고    scopus 로고
    • Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
    • Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K., Ferguson, D., Hasty, P., Chun, J. and Alt, F. W. (2000). Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc. Natl. Acad. Sci. USA 97, 2668-2673.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2668-2673
    • Gu, Y.1    Sekiguchi, J.2    Gao, Y.3    Dikkes, P.4    Frank, K.5    Ferguson, D.6    Hasty, P.7    Chun, J.8    Alt, F.W.9
  • 32
  • 33
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande, M. P., Samper, E., Lansdorp, P. and Blasco, M. A. (1999). Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144, 589-601.
    • (1999) J. Cell Biol. , vol.144 , pp. 589-601
    • Hande, M.P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 34
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B. and Greider, C. W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 35
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann, M. T., Strong, M. A., Hao, L. Y. and Greider, C. W. (2001). The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 36
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated to telomerase deficiency appear earlier in mice with short telomeres
    • Herrera, E., Samper, E., Martin-Caballero, J., Flores, J. M., Lee, H. W. and Blasco M. A. (1999a). Disease states associated to telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960.
    • (1999) EMBO J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.W.5    Blasco, M.A.6
  • 37
    • 0033104511 scopus 로고    scopus 로고
    • -/- embryos is associated with failure to close the neural tube
    • -/- embryos is associated with failure to close the neural tube EMBO J. 18, 1172-1181.
    • (1999) EMBO J. , vol.18 , pp. 1172-1181
    • Herrera, E.1    Samper, E.2    Blasco, M.A.3
  • 38
    • 0343750697 scopus 로고    scopus 로고
    • Impaired germinal center reaction in mice with short telomeres
    • Herrera, E., Martinez-A, C. and Blasco, M. A. (2000). Impaired germinal center reaction in mice with short telomeres. EMBO J. 19, 472-481.
    • (2000) EMBO J. , vol.19 , pp. 472-481
    • Herrera, E.1    Martinez-A, C.2    Blasco, M.A.3
  • 39
    • 0030448423 scopus 로고    scopus 로고
    • Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
    • Johe, K. K., Hazel, T. G., Muller, T., Dugich-Dlorjevic, M. M. and McKay, R. D. G. (1996). Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10, 3129-3140.
    • (1996) Genes Dev. , vol.10 , pp. 3129-3140
    • Johe, K.K.1    Hazel, T.G.2    Muller, T.3    Dugich-Dlorjevic, M.M.4    McKay, R.D.G.5
  • 40
    • 0034176261 scopus 로고    scopus 로고
    • Recombination in telomere-length maintenance
    • Kass-Eisler, A. and Greider, C. W. (2000). Recombination in telomere-length maintenance. Trends Biochem. Sci. 25, 200-204.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 200-204
    • Kass-Eisler, A.1    Greider, C.W.2
  • 42
    • 0035339824 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and TERT expression during brain development in mice
    • Klapper, W., Shin, T. and Mattson, M. P. (2001). Differential regulation of telomerase activity and TERT expression during brain development in mice. J. Neurosci. Res. 64, 252-260.
    • (2001) J. Neurosci. Res. , vol.64 , pp. 252-260
    • Klapper, W.1    Shin, T.2    Mattson, M.P.3
  • 43
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • Lai, K., Kaspar, B. K., Gage, F. H. and Schaffer, D. V. (2003). Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat. Neurosci. 6, 21-27.
    • (2003) Nat. Neurosci. , vol.6 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 47
    • 0028361594 scopus 로고
    • Long-distance neuronal migration in the adult mammalian brain
    • Lois, C. and Alvarez-Buylla, A. (1994). Long-distance neuronal migration in the adult mammalian brain. Science 264, 1145-1148.
    • (1994) Science , vol.264 , pp. 1145-1148
    • Lois, C.1    Alvarez-Buylla, A.2
  • 48
    • 0035913911 scopus 로고    scopus 로고
    • Negative control of p53 by Sir2alpha promotes cell survival under stress
    • Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L. and Gu, W. (2001). Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107, 137-148.
    • (2001) Cell , vol.107 , pp. 137-148
    • Luo, J.1    Nikolaev, A.Y.2    Imai, S.3    Chen, D.4    Su, F.5    Shiloh, A.6    Guarente, L.7    Gu, W.8
  • 49
    • 0027291286 scopus 로고
    • Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
    • Luskin, M. B. (1993). Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11, 173-189.
    • (1993) Neuron , vol.11 , pp. 173-189
    • Luskin, M.B.1
  • 50
    • 0032168370 scopus 로고    scopus 로고
    • Expression of mouse telomerase catalytic subunit in embryos and adult tissues
    • Martín-Rivera, L., Herrera, E., Albar, J. P. and Blasco, M. A. (1998). Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc. Natl. Acad. Sci. USA 95, 10471-10476.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10471-10476
    • Martín-Rivera, L.1    Herrera, E.2    Albar, J.P.3    Blasco, M.A.4
  • 52
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison, S. J., Prowse, K. R., Ho, P. and Weissman, I. L. (1996). Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5, 201-216.
    • (1996) Immunity , vol.5 , pp. 201-216
    • Morrison, S.J.1    Prowse, K.R.2    Ho, P.3    Weissman, I.L.4
  • 55
    • 0035839458 scopus 로고    scopus 로고
    • Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain
    • Ohtsuka, T., Sakamoto, M., Guillemot, F. and Kageyama, R. (2001). Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J. Biol. Chem. 276, 30467-30474.
    • (2001) J. Biol. Chem. , vol.276 , pp. 30467-30474
    • Ohtsuka, T.1    Sakamoto, M.2    Guillemot, F.3    Kageyama, R.4
  • 56
    • 0033929434 scopus 로고    scopus 로고
    • Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
    • Ostenfeld, T., Cladwell, M. A., Prowse, K. R., Linskens, M. H., Jauniaux, E. and Svendsen, C. N. (2000). Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation. Exp. Neurol. 164, 215-226.
    • (2000) Exp. Neurol. , vol.164 , pp. 215-226
    • Ostenfeld, T.1    Cladwell, M.A.2    Prowse, K.R.3    Linskens, M.H.4    Jauniaux, E.5    Svendsen, C.N.6
  • 57
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse, K. R. and Greider, C. W. (1995). Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA 92, 4818-4822.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 58
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds, B. A. and Weiss, S. (1992). Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707-1710.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 60
    • 0034769105 scopus 로고    scopus 로고
    • Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres
    • Samper, E., Flores, J. M. and Blasco, M. A. (2001). Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres. EMBO Reports 2, 800-807.
    • (2001) EMBO Reports , vol.2 , pp. 800-807
    • Samper, E.1    Flores, J.M.2    Blasco, M.A.3
  • 61
    • 0037089438 scopus 로고    scopus 로고
    • Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
    • Samper, E., Fernández, P., Martín-Rivera, L., Bernad, A., Blasco, M. A. and Aracil, M. (2002). Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood 99, 2767-2775.
    • (2002) Blood , vol.99 , pp. 2767-2775
    • Samper, E.1    Fernández, P.2    Martín-Rivera, L.3    Bernad, A.4    Blasco, M.A.5    Aracil, M.6
  • 62
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • Sherr, C. J. and DePinho, R. A. (2000). Cellular senescence: mitotic clock or culture shock? Cell 102, 407-410.
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 63
    • 0035478280 scopus 로고    scopus 로고
    • The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells
    • Shimazaki, T., Shingo, T. and Weiss, S. (2001). The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J. Neurosci. 21, 7642-7653.
    • (2001) J. Neurosci. , vol.21 , pp. 7642-7653
    • Shimazaki, T.1    Shingo, T.2    Weiss, S.3
  • 64
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • Smith, L. L., Coller, H. A. and Roberts, J. M. (2003).Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat. Cell Biol. 5, 474-479.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 65
    • 0036792871 scopus 로고    scopus 로고
    • DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2
    • Smogorzewska, A., Karlseder, J., Holtgreve-Grez, H., Jauch, A. and de Lange, T. (2002). DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr. Biol. 12, 1635-1644.
    • (2002) Curr. Biol. , vol.12 , pp. 1635-1644
    • Smogorzewska, A.1    Karlseder, J.2    Holtgreve-Grez, H.3    Jauch, A.4    de Lange, T.5
  • 66
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska, A. and de Lange, T. (2002). Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348.
    • (2002) EMBO J. , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    de Lange, T.2
  • 67
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. and de Lange, T. (2003). DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556.
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 68
    • 0033635021 scopus 로고    scopus 로고
    • FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor
    • Taupin, P., Ray, J., Fischer, W. H., Suhr, S. T., Hakansson, K., Grubb, A. and Gage, F. H. (2000). FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron 28, 385-397.
    • (2000) Neuron , vol.28 , pp. 385-397
    • Taupin, P.1    Ray, J.2    Fischer, W.H.3    Suhr, S.T.4    Hakansson, K.5    Grubb, A.6    Gage, F.H.7
  • 69
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple, S. (2001). The development of neural stem cells. Nature 414, 112-127.
    • (2001) Nature , vol.414 , pp. 112-127
    • Temple, S.1
  • 71
    • 0030826603 scopus 로고    scopus 로고
    • Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    • Tropepe, V., Craig, C. G., Morshead, C. M. and van der Kooy, D. (1997).Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J. Neurosci. 17, 7850-7859.
    • (1997) J. Neurosci. , vol.17 , pp. 7850-7859
    • Tropepe, V.1    Craig, C.G.2    Morshead, C.M.3    van der Kooy, D.4
  • 74
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B., Lane, D. and Levine, A. J. (2000). Surfing the p53 network. Nature 408, 307-310.
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 75
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong, K. K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W. and DePinho, R. A. (2003). Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421, 643-648.
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1    Maser, R.S.2    Bachoo, R.M.3    Menon, J.4    Carrasco, D.R.5    Gu, Y.6    Alt, F.W.7    DePinho, R.A.8
  • 76
    • 0036683054 scopus 로고    scopus 로고
    • Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells
    • Xu, D., Wilson, T. J., Chan, D., De Luca, E., Zhou, J., Hertzog, P. J. and Kola, I. (2002). Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells. EMBO J. 21, 4081-4093.
    • (2002) EMBO J. , vol.21 , pp. 4081-4093
    • Xu, D.1    Wilson, T.J.2    Chan, D.3    De Luca, E.4    Zhou, J.5    Hertzog, P.J.6    Kola, I.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.