Telomere maintenance in telomerase-deficient mouse embryonic stem cells: Characterization of an amplified telomeric DNA

Molecular and Cellular Biology

Volumn 20, Issue 11, 2000, Pages 4115-4127

  Niida, Hiroyuki ^a,f   Shinkai, Yoichi ^b   Hande, M Prakash ^c,g   Matsumoto, Takehisa ^a   Takehara, Shoko ^d   Tachibana, Makoto ^b   Oshimura, Mitsuo ^d   Lansdorp, Peter M ^c,e   Furuichi, Yasuhiro ^a  

^a AGENE Research Institute   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d TOTTORI UNIVERSITY   (Japan)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL VIABILITY; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE DELETION; GROWTH RATE; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; STEM CELL; TELOMERE;

ANIMALS; BASE SEQUENCE; CELL SURVIVAL; CLONING, MOLECULAR; DNA; DNA, COMPLEMENTARY; MICE; MOLECULAR SEQUENCE DATA; STEM CELLS; TELOMERASE; TELOMERE;

ANIMALIA; MAMMALIA;

EID: 0034077143     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.11.4115-4127.2000     Document Type: Article

References (59)

1. Bilaud, T., C. Brun, K. Ancelin, C. E. Koering, T. Laroche, and E. Gilson. 1997. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 17:236-239.
2. Blackburn, E. H. 1991. Structure and function of telomeres. Nature 350: 569-573.
3. Blasco, M. A., W. D. Funk, B. Villeponteau, and C. W. Greider. 1995. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269:1267-1270.
4. Blasco, M. A., H. W. Lee, M. P. Hande, E. Samper, P. M. Lansdorp, R. A. DePinho, and C. W. Greider. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34.
5. Bodnar, A. G., M. Ouellette, M. Frolkis, S. E. Holt, C. P. Chiu, G. B. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner, and W. E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352.
6. Broccoli, D., A. Smogorzewska, L. Chong, and T. de Lange. 1997. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 17:231-235.
7. Bryan, T. M., A. Englezou, J. Gupta, S. Bacchetti, and K. R. Reddel. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:4240-4248.
8. Bryan, T. M., L. Marusic, S. Bacchetti, M. Namba, and R. R. Reddel. 1997. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum. Mol. Genet. 6:921-926.
9. Chin, L., S. E. Artandi, Q. Shen, A. Tam, S. L. Lee, G. J. Gottlieb, C. W. Greider, and R. A. DePinho. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97:527-538.
10. Chong, L., B. van Steensel, D. Broccoli, H. Erdjument-Bromage, J. Hanish, P. Tempst, and T. de Lange. 1995. A human telomeric protein. Science 270:1663-1667.
11. de Lange, T. 1995. Telomere dynamics and genomic instability, p. 69-106. In E. H. Blackburn and C. W. Greider (ed.), Telomeres. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
12. Dunn, B., P. Szauter, M. L. Pardue, and J. W. Szostak. 1984. Transfer of yeast telomeres to linear plasmids by recombination. Cell 39:191-201.
13. Feng, J., W. D. Funk, S. Wang, S. L. Weinrich, A. A. Avilion, C. P. Chiu, R. R. Adams, E. Chang, R. C. Allsopp, J. Yu, S. Le, M. D. West, C. B. Harley, W. H. Andrews, C. W. Greider, and B. Villeponteau. 1995. The RNA component of human telomerase. Science 269:1236-1241.
14. Δ2/3 cancer-prone mouse. Cell 97:515-525.
15. Greider, C. W. 1996. Telomere length regulation. Annu. Rev. Biochem. 65:337-365.
16. Griffith, J. D., L. Comeau, S. Rosenfield, R. M. Stansel, A. Bianchi, H. Moss, and T. de Lange. 1999. Mammalian telomeres end in a large duplex loop. Cell 97:503-514.
17. Hande, M. P., J. J. Boei, F. Granath, and A. T. Natarajan. 1996. Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridisation. II. Micronuclei. Int. J. Radiat. Biol. 69:437-446.
18. Hande, M. P., E. Samper, P. Lansdorp, and M. A. Blasco. 1999 Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:589-601.
19. Harley, C. B., A. B. Gutcher, and C. W. Greider. 1990 Telomeres shorten during aging of human fibroblasts. Nature 345:458-460.
20. Harley, C. B. 1995. Telomeres and aging, p. 247-262. In E. H. Blackburn and C. W. Greider (ed.), Telomeres. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
21. Harrington, L., W. Zhou, T. McPhail, R. Oulton, D. S. Yeung, V. Mar, M. B. Bass, and M. O. Robinson. 1997. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 11:3109-3115.
22. Hastie, N. D., M. Dempster, M. G. Dunlop, A. M. Thompson, D. K. Green, and R. C. Allshire. 1990. Telomere reduction in human colorectal carcinoma and with aging. Nature 346:866-868.
23. Herrera, E., E. Samper, J. Martin-Caballero, J. M. Flores, H. W. Lee, and M. A. Blasco. 1999. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18:2950-2960.
24. Horowitz, H., P. Thorburn, and J. E. Haber. 1984. Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae. Mol. Cell. Biol. 4:2509-2517.
25. n generated by PCR. Nucleic Acids Res. 19:4780.
26. Ikeno, M., H. Masumoto, and T. Okazaki. 1994. Distribution of CENP-B boxes reflected in CREST centromere antigenic sites on long-range alpha-satellite DNA arrays of human chromosome 21. Hum. Mol. Genet. 3:1245-1254.
27. Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. P53- and ATM-dependent apoptosis induced by telomere lacking TRF2. Science 283: 1321-1325.
28. Kilian, A., D. D. Bowtell, H. E. Abud, G. R. Hime, D. J. Venter, P. K. Keese, E. L. Duncan, R. R. Reddel, and R. A. Jefferson. 1997 Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet. 6:2011-2019.
29. Kipling, D., and H. J. Cooke. 1990. Hypervariable ultra-long telomeres in mice. Nature 347:400-402.
30. Kiyono, T., S. A. Foster, J. I. Koop, J. K. McDougall, D. A. Galloway, and A. J. Klingelhutz. 1998. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88.
31. Lansdorp, P. M., N. P. Verwoerd, F. M. van de Rijke, V. Dragowska, M. T. Little, R. W. Dirks, A. K. Raap, and H. J. Tanke. 1996. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5:685-691.
32. Le, S., J. K. Moore, J. E. Haber, and C. W. Greider. 1999. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152:143-152.
33. Lee, H. W., M. A. Blasco, G. J. Gottlieb, J. W. Horner, C. W. Greider, and R. A. DePinho. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392:569-574.
34. Lundblad, V., and J. W. Szostak. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-643.
35. Lundblad, V., and E. H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues estl-senescence. Cell 73:347-360.
36. Martens, U. M., J. M. Zjjlmans, S. S. Poon, W. Dragowska, J. Yui, E. A. Chavez, R. K. Ward, and P. M. Lansdorp. 1998. Short telomeres on human chromosome 17p. Nat. Genet. 18:76-80.
37. Mason, J. M., and H. Biessmann. 1995. The unusual telomeres of Drosophila. Trends Genet. 11:58-62.
38. McClintock, B. 1939. The behavior in successive nuclear divisions of a chromosome broken at meiosis. Proc. Natl. Acad. Sci. USA 25:405-416.
39. McClintock, B. 1941. The stability of broken ends of chromosomes in Zea mays. Genetics 26:234-282.
40. McEachern, M. J., and E. H. Blackburn. 1996. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyccs lactis lacking telomerase. Genes Dev. 10:1822-1834.
41. Meyerson, M., C. M. Counter, E. N. Eaton, L. W. Ellisen, P. Steiner, S. D. Caddie, L. Ziaugra, R. L. Beijersbergen, M. J. Davidoff, Q. Liu, S. Bacchetti, D. A. Haber, and R. A. Weinberg. 1997. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785-795.
42. Miller, S. A., D. D. Dykes, and H. F. Polesky. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:1215.
43. Muller, H. J. 1938. The remaking of chromosomes. Collecting Net. 13:183-195.
44. Nakamura, T. M., G. B. Morin, K. B. Chapman, S. A. L. Weirich, W. H. Andrews, J. Lingner, C. B. Barley, and T. Cech. 1997. Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959.
45. Nakamura, T. M., J. P. Cooper, and T. R. Cech. 1998. Two modes of survival of fission yeast without telomerase. Science 282:493-496.
46. Niida, H., T. Matsumoto, H. Satoh, M. Shiwa, Y. Tokutake, Y. Furuichi, and Y. Shinkai. 1998. Severe growth defect in mouse cells lacking the telomerase RNA component. Nat. Genet. 19:203-206.
47. Pluta, A. F., and A. Zakian. 1989. Recombination occurs during telomere formation in yeast. Nature 337:429-433.
48. Rudolph, K. L., S. Chang, H. W. Lee, M. Blasco, G. J. Gottlieb, C. Greider, and R. A. DePinho. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96:701-712.
49. Shay, J. W., and S. Bacchetti. 1997. A survey of telomerase activity in human cancer. Eur. J. Cancer 33:787-791.
50. Singer, M. S., and D. E. Gottschling. 1994. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266:404-409.
51. Sullivan, B. A., and S. Schwartz. 1995. Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres. Hum. Mol. Genet. 4:2189-2197.
52. Tatematsu, K., J. Nakayama, M. Danbara, S. Shionoya, H. Sato, M. Omine, and F. Ishikawa. 1996. A novel quantitative "stretch PCR assay," that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias. Oncogene 13:2265-2274.
53. Uejima, H., T. Shinohara, Y. Nakayama, H. Kugoh, and M. Oshimura. 1998. Mapping a novel cellular senescence gene to human chromosome 2q37 via irradiation microcell-mediated chromosome transfer. Mol. Carcinog. 22:34-45.
54. van Steensel, B., A. Smogoraewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
55. Vaziri, H., and S. Benchimol. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:279-282.
56. Wang, J., L. Y. Xie, S. Allan, D. Beach, and G. J. Hannon. 1998. Myc activates telomerase. Genes Dev. 12:1769-1774.
57. Weinrich, S. L., R. Pruzan, L. Ma, M. Ouellette, V. M. Tesmer, S. E. Holt, A. G. Bodnar, S. Lichtsteiner, N. W. Kim, J. B. Trager, R. D. Taylor, R. Carlos, W. H. Andrews, W. E. Wright, J. W. Shay, C. B. Harley, and G. B. Morin. 1997. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17: 498-502.
58. Zhu, J., H. Wang, J. M. Bishop, and E. H. Blackburn. 1999. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96:3723-3728.
59. 3 repeats. Proc. Natl. Acad. Sci. USA 94:7423-7428.