Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

EMBO Journal

Volumn 22, Issue 1, 2003, Pages 131-139

  Leri, Annarosa ^a   Franco, Sonia ^a   Zacheo, Antonella ^a   Barlucchi, Laura ^a   Chimenti, Stefano ^a   Limana, Federica ^a   Nadal Ginard, Bernardo ^a   Kajstura, Jan ^a   Anversa, Piero ^b   Blasco, María A ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Aging; Heart failure; P53; Telomerase; Telomeres

Indexed keywords

PROTEIN P53; TELOMERASE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CAUSE OF DEATH; CELL DEATH; CELL DIVISION; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; HEART DILATATION; HEART DISEASE; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HYPERTROPHY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TELOMERE;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENES, P53; HEART; HEART FAILURE, CONGESTIVE; HUMANS; MICE; MICE, KNOCKOUT; MUSCLE CELLS; TELOMERASE; TELOMERE; TUMOR SUPPRESSOR PROTEIN P53; VASODILATION;

ANIMALIA;

EID: 0037413726     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg013     Document Type: Article

References (32)

1. Anversa, A. and Nadal-Ginard, B. (2002) Myocyte renewal and ventricular remodelling. Nature, 415, 240-243.
2. Anversa, P. and Olivetti, G. (2001) Cellular basis of physiologic myocardial growth. In Page, E., Fozzard, H. and Solaro, J. (eds), Handbook of Physiology, Section 2: The Cardiovascular System, Volume I: The Heart. Oxford University Press, New York, NY, 75-144.
3. Beltrami, A.P. et al. (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med., 344, 1750-1757.
4. Blasco, M.A. (2002) Telomerase beyond telomeres. Nat. Rev. Cancer, 2, 627-632.
5. Blasco, M.A., Lee, H.W., Hande, M., Samper, E., Lansdorp, P.M., DePinho, R.A. and Greider, C.W. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell, 91, 25-34.
6. Bodnar, A.G. et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science, 279, 349-352.
7. Chan, S.W.-L. and Blackbum, E.H. (2002) New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene, 21, 553-563.
8. Chin, L., Artandi, S.E., Shen, Q., Tam, A., Lee, S.L., Gottlieb, G.J., Greider, C.W. and DePinho, R.A. (1999) p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell, 97, 527-538.
9. Collins, K. and Mitchell, J.R. (2002) Telomerase in the human organism. Oncogene, 21, 564-579.
10. De Lange, T. (2002) Protection of mammalian telomeres. Oncogene, 21, 532-540.
11. Espejel, S., Franco, S., Rodriguez-Perales, S., Bouffle, S.D., Cigudosa, J.C. and Blasco, M.A. (2002) Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J., 21, 2207-2219.
12. Franco, S., Segura, I., Riese, H. and Blasco, M.A. (2002) Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res., 62, 552-559.
13. González-Suárez, E., Samper, E., Flores, J.M. and Blasco, M.A. (2000) Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet., 26, 114-117.
14. Goytisolo, F.A. and Blasco, M.A. (2002) Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene, 21, 584-591.
15. Guerra, S., Leri, A., Wang, X., Finato, N., Di Loreto, C., Beltrami, C.A., Kajstura, J. and Anversa, P. (1999) Myocyte death in the failing human heart is gender dependent. Circ. Res., 85, 856-866.
16. Harley, C.B., Futcher, A.B. and Greider, C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
17. Hemann, M.T., Strong, M.A., Hao, L.Y. and Greider, C.W. (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell, 107, 67-77.
18. Herrera, E., Samper, E., Martin-Caballero, J., Flores, J.M., Lee,H.W. and Blasco, M.A. (1999) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J., 18, 2950-2960.
19. Herrera, E., Martinez, A.C. and Blasco, M.A. (2000) Impaired germinal center reaction in mice with short telomeres. EMBO J., 19, 472-481.
20. Kajstura, J. et al. (1996) Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am. J. Physiol., 271, H1215-H1228.
21. Kajstura, J., Leri, A., Finato, N., Di Loreto, C., Beltrami, C.A. and Anversa, P. (1998) Myocyte proliferation in end-stage cardiac failure in humans. Proc. Natl Acad. Sci. USA, 95, 8801-8805.
22. Lee, H.W., Blasco, M.A., Gottlieb, G.J., Horner, J.W., Greider, C.W. and DePinho, R.A. (1998) Essential role of mouse telomerase in highly proliferative organs. Nature, 392, 569-574.
23. Leri, A., Liu, Y., Wang, X., Kajstura, J., Malhotra, A., Meggs, L.G. and Anversa, P. (1999) Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice. Circ. Res. 84, 752-762.
24. Leri, A., Barlucchi, L., Limana, F., Deptala, A., Darzynkiewicz, Z., Hintze, T.H., Kajstura, J., Nadal-Ginard, B. and Anversa, P. (2001) Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart. Proc. Natl Acad. Sci. USA, 98, 8626-8631.
25. McIlrath, J. et al. (2001) Telomere length anormalities in mammalian radiosensitive cells. Cancer Res., 61, 612-915.
26. Orlic, D. et al. (2001a) Bone marrow cells regenerate infarcted myocardium. Nature, 410, 701-705.
27. Orlic, D. et al. (2001b) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl Acad. Sci. USA, 98, 10344-10349.
28. Quaini, F., Urbanek, K., Beltrami, A.P., Finato, N., Beltrami, C.A., Nadal-Ginard, B., Kajstura, J., Leri, A. and Anversa, P. (2002) Chimerism of the transplanted heart. N. Engl. J. Med., 346, 5-15.
29. Rudolph, K.L., Chang, S., Lee, H.W., Blasco, M., Gottlieb, G.J., Greider, C. and DePinho, R.A. (1999) Longevity, stress response and cancer in aging telomerase-deficient mice. Cell, 96, 701-712.
30. -/- mice with short telomeres. EMBO Rep., 2, 1-8.
31. Samper, E., Fernández, P., Martín-Rivera, L., Bernad, A., Blasco, M.A. and Aracil, M. (2002) Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood, 99, 2767-2775.
32. Smogorzewska, A. and De Lange, T. (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J., 21, 4338-4348.