Recombination in telomere-length maintenance

Trends in Biochemical Sciences

Volumn 25, Issue 4, 2000, Pages 200-204

  Kass Eisler, Alyson ^a   Greider, Carol W ^b  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

CANCER; CELL SURVIVAL; GENE CONVERSION; GENETIC RECOMBINATION; HUMAN; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TELOMERE; YEAST CELL;

ANIMALS; HUMANS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; TELOMERASE; TELOMERE;

MAMMALIA;

EID: 0034176261     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01557-7     Document Type: Review

References (50)

1. Greider C.W. Telomere length regulation. Annu. Rev. Biochem. 65:1996;337-365.
2. Watson J.D. Origin of concatemeric T7 DNA. Nat. New Biol. 239:1972;197-201.
3. Olovnikov A.M. A theory of marginotomy. J. Theor. Biol. 41:1973;181-190.
4. Shampay J.et al. DNA sequences of telomeres maintained in yeast. Nature. 310:1984;154-157.
5. Szostak J.W., Blackburn E.H. Cloning yeast telomeres on linear plasmid vectors. Cell. 29:1982;245-255.
6. Walmsley R.W.et al. Unusual DNA sequences associated with the ends of yeast chromosomes. Nature. 310:1984;157-160.
7. Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 43:1985;405-413.
8. Harley C.B.et al. Telomeres shorten during aging of human fibroblasts. Nature. 345:1990;458-460.
9. Hastie N.D.et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:1990;866-868.
10. Kim N.W.et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:1994;2011-2015.
11. Bryan T.M., Cech T.R. Telomerase and the maintenance of chromosome ends. Curr. Opin. Cell Biol. 11:1999;318-324.
12. Biessmann H., Mason J.M. Telomere maintenance without telomerase. Chromosoma. 106:1997;63-69.
13. Lundblad V., Blackburn E.H. An alternative pathway for yeast telomere maintenance rescues est1 senescence. Cell. 73:1993;347-360.
14. McEachern M.J., Blackburn E.H. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature. 367:1996;403-409.
15. Singer M.S., Gottschling D.E. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science. 266:1994;404-409.
16. Lendvay T.S.et al. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics. 144:1996;1399-1412.
17. Lingner J.et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 276:1997;561-567.
18. Friedberg E.C. Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae. Microbiol. Rev. 52:1988;70-102.
19. McEachern M.J., Blackburn E.H. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1996;1822-1834.
20. Le S.et al. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics. 152:1999;143-152.
21. Kironmai K.M., Muniyappa K. Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells. 2:1997;443-455.
22. Nugent C.I.et al. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 8:1998;657-660.
23. Haber J.E. The many interfaces of Mre11. Cell. 25:1998;583-586.
24. Teng S-C., Zakian V.A. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol. Cell Biol. 19:1999;8083-8093.
25. Chan C.S.M., Tye B. Organization of DNA sequences and replication origins at yeast telomeres. Cell. 33:1983;563-573.
26. Gravel S.et al. Yeast Ku as a regulator of chromosomal DNA end structure. Science. 280:1998;741-744.
27. Hsu H.L.et al. Ku is associated with the telomere in mammals. Proc. Natl. Acad. Sci. U. S. A. 96:1999;12454-12458.
28. Boulton S.J., Jackson S.P. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric recombination. Nucleic Acids Res. 24:1996;4639-4648.
29. Porter S.E.et al. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res. 24:1996;582-585.
30. Laroche T.et al. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr. Biol. 8:1998;653-656.
31. Boulton S.J., Jackson S.P. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1998;1819-1828.
32. Polotnianka R.M.et al. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr. Biol. 8:1998;831-834.
33. Walmsley R.M., Petes T.D. Genetic control of chromosome length in yeast. Proc. Natl. Acad. Sci. U. S. A. 82:1985;506-510.
34. Shore D. Telomerase and telomere-binding proteins. controlling the endgame Trends Biochem. Sci. 22:1997;233-235.
35. Li B., Lustig A.J. A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev. 10:1996;1310-1326.
36. Murnane J.P.et al. Telomere dynamics in an immortal human cell line. EMBO J. 13:1994;4953-4962.
37. Bryan T.M.et al. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:1995;4240-4248.
38. Bryan T.M.et al. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 3:1997;1271-1274.
39. Wen J.et al. Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells. Hum. Mol. Genet. 7:1998;1137-1141.
40. Yeager T.R.et al. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res. 59:1999;4175-4179.
41. Mekeel K.L.et al. Inactivation of p53 results in high rates of homologous recombination. Oncogene. 14:1997;1847-1857.
42. Yin Y.et al. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 70:1992;937-948.
43. Blasco M.A.et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:1997;25-34.
44. Lee H.W.et al. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:1998;569-574.
45. Serrano M.et al. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 85:1996;27-37.
46. Greenberg R.A.et al. Short dysfunctional telomeres impair tumorigenesis in the INK4a (delta2/3) cancer-prone mouse. Cell. 97:1999;515-525.
47. Chin L.et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:1999;527-538.
48. Garvik B.et al. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell Biol. 15:1995;6128-6138.
49. Hahn W.C.et al. Inhibition of telomerase limits the growth of human cancer cells. Nat. Med. 5:1999;1164-1170.
50. Zhang X.et al. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13:1999;2388-2399.