Epidermal viral immunity induced by CD8α+ dendritic cells but not by langerhans cells

Science

Volumn 301, Issue 5641, 2003, Pages 1925-1928

  Allan, Rhys S ^a   Smith, Chris M ^b,c   Belz, Gabrielle T ^b,c   Van Lint, Allison L ^a   Wakim, Linda M ^a   Heath, William R ^b,c   Carbone, Francis R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c Tropical Savannas Cooperative Research Centre   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

SKIN; TOXICITY;

DENDRITIC CELLS;

CELLS;

CD8 ANTIGEN; CD8ALPHA ANTIGEN; UNCLASSIFIED DRUG;

BIOLOGY; IMMUNE RESPONSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EPIDERMIS; HERPES SIMPLEX VIRUS; LANGERHANS CELL; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS IMMUNITY;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD8; ANTIGENS, VIRAL; CELL SEPARATION; CHIMERA; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; EPIDERMIS; H-2 ANTIGENS; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS II; LANGERHANS CELLS; LECTINS, C-TYPE; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; RECEPTORS, CELL SURFACE; T-LYMPHOCYTES, CYTOTOXIC; VIRAL ENVELOPE PROTEINS;

ANIMALIA; MURINAE; SIMPLEXVIRUS;

EID: 0141654300     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087576     Document Type: Article

References (25)

1. D. Maurer, G. Stingl, in Dendritic Cells, A. Thomson, M. Lotze, Eds. (Academic Press, London, 2001), vol. 2, chap. 5.
2. N. Romani et al., J. Exp. Med. 169, 1169 (1989).
3. M. Cumberbatch, I. Kimber, Immunology 84, 31 (1995).
4. J. A. Roake et al., J. Exp. Med. 181, 2237 (1995).
5. I. Silberberg-Sinakin, G. J. Thorbecke, R. L. Baer, S. A. Rosenthal, V. Berezowsky, Cell Immunol. 25, 137 (1976).
6. J. M. Austyn, J. Exp. Med. 183, 1287 (1996).
7. J. Banchereau, R. M. Steinman, Nature 392, 245 (1998).
8. E. C. Hoefsmit, A. M. Duijvestijn, E. W. Kamperdijk, Immunobiology 161, 255 (1982).
9. R. M. Steinman, M. Pack, K. Inaba, Immunol. Rev. 156, 25 (1997).
10. S. E. Macatonia, S. C. Knight, A. J. Edwards, S. Griffiths, P. Fryer, J. Exp. Med. 166, 1654 (1987).
11. K. Shortman, Y. J. Liu, Nature Rev. Immunol. 2, 151 (2002).
12. S. Henri et al., J. Immunol. 167, 741 (2001).
13. R. S. Allan, C. M. Smith, G. T. Belz, W. R. Heath, F. R. Carbone, unpublished data.
14. S. N. Mueller, W. Heath, J. D. McLain, F. R. Carbone, C. M. Jones, Immunol. Cell Biol. 80, 156 (2002).
15. C. M. Smith et al., J. Immunol. 170, 4437 (2003).
16. D. Vremec et al., J. Exp. Med. 176, 47 (1992).
17. H. Nakano, M. Yanagita, M. D. Gunn, J. Exp. Med. 194, 1171 (2001).
18. M. O'Keeffe et al., J. Exp. Med. 196, 1307 (2002).
19. M. Merad et al., Nature Immunol. 3, 1135 (2002).
20. , R. M. Coles, S. N. Mueller, W. R. Heath, F. R. Carbone, A. G. Brooks, J. Immunol. 168, 834 (2002).
21. X. Zhao et al., J. Exp. Med. 197, 153 (2003).
22. G. J. Randolph, K. Inaba, D. F. Robbiani, R. M. Steinman, W. A. Muller, Immunity 11, 753 (1999).
23. H. Moll, H. Fuchs, C. Blank, M. Rollinghoff, Eur. J. Immunol. 23, 1595 (1993).
24. H. Hemmi et al., Int. Immunol. 13, 695 (2001).
25. We are grateful for the assistance and advice of K. Shortman and the technical help of L. Coverdale, S. Flynn, G. Behrens, and J.-L. Tan, Supported by grants from the National Health and Medical Research Council (Australia), Howard Hughes Medical Institute, and the Wellcome Trust (UK).