Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

Nature Immunology

Volumn 4, Issue 6, 2003, Pages 579-585

  Bousso, Philippe ^a   Robey, Ellen ^a  

^a University of California Berkeley   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; PEPTIDE;

ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL ADHESION; CELL FUNCTION; CELL INTERACTION; CELL SPECIFICITY; CONTROLLED STUDY; DENDRITIC CELL; FLUORESCENCE MICROSCOPY; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; DENDRITIC CELLS; FLOW CYTOMETRY; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL;

EID: 0037501371     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni928     Document Type: Article

References (27)

1. Ingulli, E., Mondino, A., Khoruts, A. & Jenkins, M.K. In vivo detection of dendritic cell antigen presentation to CD4± T cells. J. Exp. Med. 185, 2133-2141 (1997).
2. Schaefer, B.C., Schaefer, M.L., Kappler, J.W, Marrack, P. & Kedl, R.M. Observation of antigen-dependent CD8± T-cell/dendritic cell interactions in vivo. Cell Immunol. 214, 110-122 (2001).
3. + T cells by infected dendritic cells in vivo. Nat. Immunol. 3, 265-271 (2002).
4. + T cells after subcutaneous injection of antigen. J. Immunol. 169, 2247-2252 (2002).
5. Negulescu, P.A., Krasieva, T.B., Khan, A., Kerschbaum, H.H. & Cahalan, M.D. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4, 421-430 (1996).
6. Dustin, M.L., Bromley, S.K., Kan, Z., Peterson, D.A. & Unanue, E.R. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc. Natl. Acad. Sci. USA 94, 3909-3913 (1997).
7. Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
8. Wulfing, C. & Davis, M.M. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282, 2266-2269 (1998).
9. Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221-227 (1999).
10. Underhill, D.M., Bassetti, M., Rudensky, A. & Aderem, A. Dynamic interactions of macrophages with T cells during antigen presentation. J. Exp. Med. 190, 1909-1914 (1999).
11. Gunzer, M. et al. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13, 323-332 (2000).
12. Bousso, P., Bhakta, N.R., Lewis, R.B. & Robey, E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science 296, 1876-1880 (2002).
13. Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296, 1869-1873 (2002).
14. Stoll, S., Delon, J., Brotz, T.M. & Germain, R.N. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296, 1873-1876 (2002).
15. + T cells after gene gun immunization. J. Exp. Med. 188, 1075-1082 (1998).
16. Cumberbatch, M., Dearman, R.J. & Kimber, I. Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1β. Immunology 105, 466-477 (2002).
17. Pircher, H., Burki, K., Lang, R., Hengartner, H. & Zinkernagel, R.M. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559-561 (1989).
18. Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl. Acad. Sci. USA 100, 2506-2509 (2003).
19. Grufman, P., Wolpert, E.Z., Sandberg, J.K. & Karre, K. T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens. Eur. J. Immunol. 29, 2197-2204 (1999).
20. Kedl, R.M. et al. T cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med. 192, 1105-1113 (2000).
21. Savage, P.A., Boniface, J.J. & Davis, M, M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10, 485-492 (1999).
22. Busch, D.H. & Pamer, E.G. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189, 701-710 (1999).
23. + T cell responses in vivo and in vitro. Proc. Natl. Acad. Sci. USA 96, 9781-9786 (1999).
24. Kedl, R.M., Schaefer, B.C., Kappler, J.W. & Marrack, P. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat. Immunol. 3, 27-32 (2002).
25. Shortman, K. & Liu, Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 3, 151-161 (2002).
26. + T cells. J. Immunol. 166, 4278-4281 (2001).
27. + T cell engagement and synapse formation in vivo. Nat. Immunol. 3, 918-925 (2002).