메뉴 건너뛰기




Volumn 44, Issue 7, 2008, Pages 921-927

Amplifying tumour-specific replication lesions by DNA repair inhibitors - A new era in targeted cancer therapy

Author keywords

Anti cancer treatments; DNA repair; Hypoxia; Oncogenes; Replication lesions

Indexed keywords

DNA;

EID: 42649123980     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.02.044     Document Type: Article
Times cited : (33)

References (62)
  • 1
    • 33751054292 scopus 로고    scopus 로고
    • Eukaryotic DNA replication in a chromatin context
    • Tabancay Jr. A.P., and Forsburg S.L. Eukaryotic DNA replication in a chromatin context. Curr Top Dev Biol 76 (2006) 129-184
    • (2006) Curr Top Dev Biol , vol.76 , pp. 129-184
    • Tabancay Jr., A.P.1    Forsburg, S.L.2
  • 2
    • 38049075810 scopus 로고    scopus 로고
    • The histone methyltransferase SET8 is required for S-phase progression
    • Jorgensen S., Elvers I., Trelle M.B., et al. The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol 179 7 (2007) 1337-1345
    • (2007) J Cell Biol , vol.179 , Issue.7 , pp. 1337-1345
    • Jorgensen, S.1    Elvers, I.2    Trelle, M.B.3
  • 3
    • 38049025837 scopus 로고    scopus 로고
    • PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase
    • Tardat M., Murr R., Herceg Z., Sardet C., and Julien E. PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol 179 7 (2007) 1413-1426
    • (2007) J Cell Biol , vol.179 , Issue.7 , pp. 1413-1426
    • Tardat, M.1    Murr, R.2    Herceg, Z.3    Sardet, C.4    Julien, E.5
  • 4
    • 37549026516 scopus 로고    scopus 로고
    • Transcription-associated recombination is dependent on replication in mammalian cells
    • Gottipati P., Cassel T.N., Savolainen L., and Helleday T. Transcription-associated recombination is dependent on replication in mammalian cells. Mol Cell Biol 28 1 (2008) 154-164
    • (2008) Mol Cell Biol , vol.28 , Issue.1 , pp. 154-164
    • Gottipati, P.1    Cassel, T.N.2    Savolainen, L.3    Helleday, T.4
  • 5
    • 0035853295 scopus 로고    scopus 로고
    • DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
    • Arnaudeau C., Lundin C., and Helleday T. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J Mol Biol 307 5 (2001) 1235-1245
    • (2001) J Mol Biol , vol.307 , Issue.5 , pp. 1235-1245
    • Arnaudeau, C.1    Lundin, C.2    Helleday, T.3
  • 6
    • 0036316015 scopus 로고    scopus 로고
    • Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
    • Lundin C., Erixon K., Arnaudeau C., et al. Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol 22 16 (2002) 5869-5878
    • (2002) Mol Cell Biol , vol.22 , Issue.16 , pp. 5869-5878
    • Lundin, C.1    Erixon, K.2    Arnaudeau, C.3
  • 7
    • 23344444636 scopus 로고    scopus 로고
    • Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
    • Saleh-Gohari N., Bryant H.E., Schultz N., Parker K.M., Cassel T.N., and Helleday T. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol 25 16 (2005) 7158-7169
    • (2005) Mol Cell Biol , vol.25 , Issue.16 , pp. 7158-7169
    • Saleh-Gohari, N.1    Bryant, H.E.2    Schultz, N.3    Parker, K.M.4    Cassel, T.N.5    Helleday, T.6
  • 8
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose)polymerase
    • Bryant H.E., Schultz N., Thomas H.D., et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose)polymerase. Nature 434 (2005) 913-917
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 9
    • 33644778778 scopus 로고    scopus 로고
    • A DNA integrity network in the yeast Saccharomyces cerevisiae
    • Pan X., Ye P., Yuan D.S., Wang X., Bader J.S., and Boeke J.D. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124 5 (2006) 1069-1081
    • (2006) Cell , vol.124 , Issue.5 , pp. 1069-1081
    • Pan, X.1    Ye, P.2    Yuan, D.S.3    Wang, X.4    Bader, J.S.5    Boeke, J.D.6
  • 10
    • 0037565292 scopus 로고    scopus 로고
    • Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines
    • Backus H.H., Wouters D., Ferreira C.G., et al. Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines. Eur J Cancer 39 9 (2003) 1310-1317
    • (2003) Eur J Cancer , vol.39 , Issue.9 , pp. 1310-1317
    • Backus, H.H.1    Wouters, D.2    Ferreira, C.G.3
  • 11
    • 0038277105 scopus 로고    scopus 로고
    • Tumour cell senescence in cancer treatment
    • Roninson I.B. Tumour cell senescence in cancer treatment. Cancer Res 63 11 (2003) 2705-2715
    • (2003) Cancer Res , vol.63 , Issue.11 , pp. 2705-2715
    • Roninson, I.B.1
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 1 (2000) 57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes. Gatekeepers and caretakers
    • Kinzler K.W., and Vogelstein B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386 6627 (1997) 761-763
    • (1997) Nature , vol.386 , Issue.6627 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 14
    • 0038013875 scopus 로고    scopus 로고
    • Senescence, apoptosis and therapy - cutting the lifelines of cancer
    • Schmitt C.A. Senescence, apoptosis and therapy - cutting the lifelines of cancer. Nat Rev Cancer 3 4 (2003) 286-295
    • (2003) Nat Rev Cancer , vol.3 , Issue.4 , pp. 286-295
    • Schmitt, C.A.1
  • 15
    • 23244461708 scopus 로고    scopus 로고
    • Oncogene-induced senescence as an initial barrier in lymphoma development
    • Braig M., Lee S., Loddenkemper C., et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436 7051 (2005) 660-665
    • (2005) Nature , vol.436 , Issue.7051 , pp. 660-665
    • Braig, M.1    Lee, S.2    Loddenkemper, C.3
  • 16
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan M.B., and Bartek J. Cell-cycle checkpoints and cancer. Nature 432 7015 (2004) 316-323
    • (2004) Nature , vol.432 , Issue.7015 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 17
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis V.G., Vassiliou L.V., Karakaidos P., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434 7035 (2005) 907-913
    • (2005) Nature , vol.434 , Issue.7035 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3
  • 18
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumourigenesis
    • Bartkova J., Horejsi Z., Koed K., et al. DNA damage response as a candidate anti-cancer barrier in early human tumourigenesis. Nature 434 7035 (2005) 864-870
    • (2005) Nature , vol.434 , Issue.7035 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3
  • 19
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumourigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J., Rezaei N., Liontos M., et al. Oncogene-induced senescence is part of the tumourigenesis barrier imposed by DNA damage checkpoints. Nature 444 7119 (2006) 633-637
    • (2006) Nature , vol.444 , Issue.7119 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3
  • 20
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco R., Fumagalli M., Cicalese A., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444 7119 (2006) 638-642
    • (2006) Nature , vol.444 , Issue.7119 , pp. 638-642
    • Di Micco, R.1    Fumagalli, M.2    Cicalese, A.3
  • 21
    • 33847013757 scopus 로고    scopus 로고
    • c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability
    • Menssen A., Epanchintsev A., Lodygin D., et al. c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability. Cell Cycle 6 3 (2007) 339-352
    • (2007) Cell Cycle , vol.6 , Issue.3 , pp. 339-352
    • Menssen, A.1    Epanchintsev, A.2    Lodygin, D.3
  • 22
    • 35848935069 scopus 로고    scopus 로고
    • DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
    • Bartkova J., Horejsi Z., Sehested M., et al. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 26 53 (2007) 7414-7422
    • (2007) Oncogene , vol.26 , Issue.53 , pp. 7414-7422
    • Bartkova, J.1    Horejsi, Z.2    Sehested, M.3
  • 23
    • 34247187543 scopus 로고    scopus 로고
    • Myc deletion rescues Apc deficiency in the small intestine
    • Sansom O.J., Meniel V.S., Muncan V., et al. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 7136 (2007) 676-679
    • (2007) Nature , vol.446 , Issue.7136 , pp. 676-679
    • Sansom, O.J.1    Meniel, V.S.2    Muncan, V.3
  • 25
    • 0021318794 scopus 로고
    • Gene amplification in a single cell cycle in Chinese hamster ovary cells
    • Mariani B.D., and Schimke R.T. Gene amplification in a single cell cycle in Chinese hamster ovary cells. J Biol Chem 259 3 (1984) 1901-1910
    • (1984) J Biol Chem , vol.259 , Issue.3 , pp. 1901-1910
    • Mariani, B.D.1    Schimke, R.T.2
  • 26
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C., Kinzler K.W., and Vogelstein B. Genetic instabilities in human cancers. Nature 396 6712 (1998) 643-649
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 27
    • 37049240892 scopus 로고
    • Effect of hypoxia on DNA synthesis in the bone marrow and spleen of the rat
    • Rambach W.A., Cooper J.A., and Alt H.L. Effect of hypoxia on DNA synthesis in the bone marrow and spleen of the rat. Science 119 3090 (1954) 380-381
    • (1954) Science , vol.119 , Issue.3090 , pp. 380-381
    • Rambach, W.A.1    Cooper, J.A.2    Alt, H.L.3
  • 29
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • Hammond E.M., Dorie M.J., and Giaccia A.J. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 278 14 (2003) 12207-12213
    • (2003) J Biol Chem , vol.278 , Issue.14 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 30
    • 28244496609 scopus 로고    scopus 로고
    • Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner
    • Gibson S.L., Bindra R.S., and Glazer P.M. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res 65 23 (2005) 10734-10741
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 10734-10741
    • Gibson, S.L.1    Bindra, R.S.2    Glazer, P.M.3
  • 31
    • 34547114718 scopus 로고    scopus 로고
    • Regulation of DNA repair in hypoxic cancer cells
    • Bindra R.S., Crosby M.E., and Glazer P.M. Regulation of DNA repair in hypoxic cancer cells. Cancer Metastasis Rev 26 2 (2007) 249-260
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.2 , pp. 249-260
    • Bindra, R.S.1    Crosby, M.E.2    Glazer, P.M.3
  • 33
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumour microenvironment
    • Reynolds T.Y., Rockwell S., and Glazer P.M. Genetic instability induced by the tumour microenvironment. Cancer Res 56 24 (1996) 5754-5757
    • (1996) Cancer Res , vol.56 , Issue.24 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 34
    • 4644318239 scopus 로고    scopus 로고
    • Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
    • Hammond E.M., Dorie M.J., and Giaccia A.J. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res 64 18 (2004) 6556-6562
    • (2004) Cancer Res , vol.64 , Issue.18 , pp. 6556-6562
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 35
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
    • Bronner C.E., Baker S.M., Morrison P.T., et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368 6468 (1994) 258-261
    • (1994) Nature , vol.368 , Issue.6468 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3
  • 36
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108 2 (2002) 171-182
    • (2002) Cell , vol.108 , Issue.2 , pp. 171-182
    • Venkitaraman, A.R.1
  • 38
    • 0035796023 scopus 로고    scopus 로고
    • The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
    • Jackson A.L., and Loeb L.A. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res 477 1-2 (2001) 7-21
    • (2001) Mutat Res , vol.477 , Issue.1-2 , pp. 7-21
    • Jackson, A.L.1    Loeb, L.A.2
  • 39
    • 33746775293 scopus 로고    scopus 로고
    • Translesion synthesis in mammalian cells
    • Lehmann A.R. Translesion synthesis in mammalian cells. Exp Cell Res 312 14 (2006) 2673-2676
    • (2006) Exp Cell Res , vol.312 , Issue.14 , pp. 2673-2676
    • Lehmann, A.R.1
  • 40
    • 31844456472 scopus 로고    scopus 로고
    • Replication fork reactivation downstream of a blocked nascent leading strand
    • Heller R.C., and Marians K.J. Replication fork reactivation downstream of a blocked nascent leading strand. Nature 439 7076 (2006) 557-562
    • (2006) Nature , vol.439 , Issue.7076 , pp. 557-562
    • Heller, R.C.1    Marians, K.J.2
  • 41
    • 0032518657 scopus 로고    scopus 로고
    • Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
    • Sonoda E., Sasaki M.S., Buerstedde J.M., et al. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J 17 2 (1998) 598-608
    • (1998) EMBO J , vol.17 , Issue.2 , pp. 598-608
    • Sonoda, E.1    Sasaki, M.S.2    Buerstedde, J.M.3
  • 42
    • 0023025598 scopus 로고
    • Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis
    • Bianchi V., Pontis E., and Reichard P. Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J Biol Chem 261 34 (1986) 16037-16042
    • (1986) J Biol Chem , vol.261 , Issue.34 , pp. 16037-16042
    • Bianchi, V.1    Pontis, E.2    Reichard, P.3
  • 43
    • 0042466524 scopus 로고    scopus 로고
    • DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1
    • Cobb J.A., Bjergbaek L., Shimada K., Frei C., and Gasser S.M. DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J 22 16 (2003) 4325-4336
    • (2003) EMBO J , vol.22 , Issue.16 , pp. 4325-4336
    • Cobb, J.A.1    Bjergbaek, L.2    Shimada, K.3    Frei, C.4    Gasser, S.M.5
  • 44
    • 1442351990 scopus 로고    scopus 로고
    • Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing
    • Lucca C., Vanoli F., Cotta-Ramusino C., et al. Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing. Oncogene 23 6 (2004) 1206-1213
    • (2004) Oncogene , vol.23 , Issue.6 , pp. 1206-1213
    • Lucca, C.1    Vanoli, F.2    Cotta-Ramusino, C.3
  • 45
    • 0035797383 scopus 로고    scopus 로고
    • The DNA replication checkpoint response stabilizes stalled replication forks
    • Lopes M., Cotta-Ramusino C., Pellicioli A., et al. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 412 6846 (2001) 557-561
    • (2001) Nature , vol.412 , Issue.6846 , pp. 557-561
    • Lopes, M.1    Cotta-Ramusino, C.2    Pellicioli, A.3
  • 46
    • 0037178740 scopus 로고    scopus 로고
    • Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects
    • Sogo J.M., Lopes M., and Foiani M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297 5581 (2002) 599-602
    • (2002) Science , vol.297 , Issue.5581 , pp. 599-602
    • Sogo, J.M.1    Lopes, M.2    Foiani, M.3
  • 47
    • 13944261496 scopus 로고    scopus 로고
    • Temporal separation of replication and recombination requires the intra-S checkpoint
    • Meister P., Taddei A., Vernis L., Poidevin M., Gasser S.M., and Baldacci G. Temporal separation of replication and recombination requires the intra-S checkpoint. J Cell Biol 168 4 (2005) 537-544
    • (2005) J Cell Biol , vol.168 , Issue.4 , pp. 537-544
    • Meister, P.1    Taddei, A.2    Vernis, L.3    Poidevin, M.4    Gasser, S.M.5    Baldacci, G.6
  • 48
    • 35848930133 scopus 로고    scopus 로고
    • The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
    • Hanada K., Budzowska M., Davies S.L., et al. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007)
    • (2007) Nat Struct Mol Biol
    • Hanada, K.1    Budzowska, M.2    Davies, S.L.3
  • 49
    • 13944266820 scopus 로고    scopus 로고
    • The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    • Sorensen C.S., Hansen L.T., Dziegielewski J., et al. The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 7 2 (2005) 195-201
    • (2005) Nat Cell Biol , vol.7 , Issue.2 , pp. 195-201
    • Sorensen, C.S.1    Hansen, L.T.2    Dziegielewski, J.3
  • 50
    • 1842432466 scopus 로고    scopus 로고
    • p53 protects from replication-associated DNA double-strand breaks in mammalian cells
    • Kumari A., Schultz N., and Helleday T. p53 protects from replication-associated DNA double-strand breaks in mammalian cells. Oncogene 23 13 (2004) 2324-2329
    • (2004) Oncogene , vol.23 , Issue.13 , pp. 2324-2329
    • Kumari, A.1    Schultz, N.2    Helleday, T.3
  • 51
    • 0037415735 scopus 로고    scopus 로고
    • Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
    • Zachos G., Rainey M.D., and Gillespie D.A. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J 22 3 (2003) 713-723
    • (2003) EMBO J , vol.22 , Issue.3 , pp. 713-723
    • Zachos, G.1    Rainey, M.D.2    Gillespie, D.A.3
  • 52
    • 14844315930 scopus 로고    scopus 로고
    • A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation
    • Xiao Z., Xue J., Sowin T.J., Rosenberg S.H., and Zhang H. A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene 24 8 (2005) 1403-1411
    • (2005) Oncogene , vol.24 , Issue.8 , pp. 1403-1411
    • Xiao, Z.1    Xue, J.2    Sowin, T.J.3    Rosenberg, S.H.4    Zhang, H.5
  • 53
    • 30044440857 scopus 로고    scopus 로고
    • Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress
    • Rodriguez R., and Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 17 1 (2006) 402-412
    • (2006) Mol Biol Cell , vol.17 , Issue.1 , pp. 402-412
    • Rodriguez, R.1    Meuth, M.2
  • 54
    • 0035802112 scopus 로고    scopus 로고
    • Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
    • Feijoo C., Hall-Jackson C., Wu R., et al. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol 154 5 (2001) 913-923
    • (2001) J Cell Biol , vol.154 , Issue.5 , pp. 913-923
    • Feijoo, C.1    Hall-Jackson, C.2    Wu, R.3
  • 55
    • 0347991859 scopus 로고    scopus 로고
    • Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
    • Lomonosov M., Anand S., Sangrithi M., Davies R., and Venkitaraman A.R. Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev 17 24 (2003) 3017-3022
    • (2003) Genes Dev , vol.17 , Issue.24 , pp. 3017-3022
    • Lomonosov, M.1    Anand, S.2    Sangrithi, M.3    Davies, R.4    Venkitaraman, A.R.5
  • 56
    • 0033213392 scopus 로고    scopus 로고
    • Brca1 controls homology-directed DNA repair
    • Moynahan M.E., Chiu J.W., Koller B.H., and Jasin M. Brca1 controls homology-directed DNA repair. Mol Cell 4 4 (1999) 511-518
    • (1999) Mol Cell , vol.4 , Issue.4 , pp. 511-518
    • Moynahan, M.E.1    Chiu, J.W.2    Koller, B.H.3    Jasin, M.4
  • 57
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan M.E., Pierce A.J., and Jasin M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 7 2 (2001) 263-272
    • (2001) Mol Cell , vol.7 , Issue.2 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 58
    • 0031990269 scopus 로고    scopus 로고
    • Involvement of Brca2 in DNA repair
    • Patel K.J., Yu V.P., Lee H., et al. Involvement of Brca2 in DNA repair. Mol Cell 1 3 (1998) 347-357
    • (1998) Mol Cell , vol.1 , Issue.3 , pp. 347-357
    • Patel, K.J.1    Yu, V.P.2    Lee, H.3
  • 59
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H., McCabe N., Lord C.J., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434 7035 (2005) 917-921
    • (2005) Nature , vol.434 , Issue.7035 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 60
    • 25444471892 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
    • Helleday T., Bryant H.E., and Schultz N. Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 4 9 (2005) 1176-1178
    • (2005) Cell Cycle , vol.4 , Issue.9 , pp. 1176-1178
    • Helleday, T.1    Bryant, H.E.2    Schultz, N.3
  • 61
    • 0344875495 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
    • Schultz N., Lopez E., Saleh-Gohari N., and Helleday T. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res 31 17 (2003) 4959-4964
    • (2003) Nucleic Acids Res , vol.31 , Issue.17 , pp. 4959-4964
    • Schultz, N.1    Lopez, E.2    Saleh-Gohari, N.3    Helleday, T.4
  • 62
    • 34547225606 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 accelerates single-strand break repair in concert with poly (ADP-ribose) glycohydrolase
    • Fisher A., Hochegger H., Takeda S., and Caldecott K.W. Poly (ADP-ribose) polymerase-1 accelerates single-strand break repair in concert with poly (ADP-ribose) glycohydrolase. Mol Cell Biol (2007)
    • (2007) Mol Cell Biol
    • Fisher, A.1    Hochegger, H.2    Takeda, S.3    Caldecott, K.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.