-
1
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre V, Uchida T, Yenush L, Davis R, White MF 2000 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
2
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR et al 2005 IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
-
3
-
-
0035444539
-
Signal transduction by tumor necrosis factor and its relatives
-
Baud V, Karin M 2001 Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 11:372-377
-
(2001)
Trends Cell Biol
, vol.11
, pp. 372-377
-
-
Baud, V.1
Karin, M.2
-
4
-
-
29044447292
-
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver
-
Boden G, She P, Mozzoli M et al 2005 Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 54:3458-3465
-
(2005)
Diabetes
, vol.54
, pp. 3458-3465
-
-
Boden, G.1
She, P.2
Mozzoli, M.3
-
5
-
-
33747154772
-
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
-
Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2006 Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126:789-799
-
(2006)
Cell
, vol.126
, pp. 789-799
-
-
Bookout, A.L.1
Jeong, Y.2
Downes, M.3
Yu, R.T.4
Evans, R.M.5
Mangelsdorf, D.J.6
-
6
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF et al 2005 Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
-
7
-
-
33847385919
-
Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits
-
Chu WS, Das SK, Wang H 2007 Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 56:856-862
-
(2007)
Diabetes
, vol.56
, pp. 856-862
-
-
Chu, W.S.1
Das, S.K.2
Wang, H.3
-
8
-
-
29244462498
-
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
-
Cullinan SB, Diehl JA 2006 Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol 38:317-332
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 317-332
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
9
-
-
8644282751
-
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
-
Deng J, Lu PD, Zhang Y et al 2004 Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24:10161-10168
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10161-10168
-
-
Deng, J.1
Lu, P.D.2
Zhang, Y.3
-
10
-
-
0034717062
-
SOCS-3 is an insulin-induced negative regulator of insulin signaling
-
Emanuelli B, Peraldi P, Filloux C et al 2000 SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275:15985-15991
-
(2000)
J Biol Chem
, vol.275
, pp. 15985-15991
-
-
Emanuelli, B.1
Peraldi, P.2
Filloux, C.3
-
11
-
-
0035930605
-
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
-
Emanuelli B, Peraldi P, Filloux C et al 2001 SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 276:47944-47949
-
(2001)
J Biol Chem
, vol.276
, pp. 47944-47949
-
-
Emanuelli, B.1
Peraldi, P.2
Filloux, C.3
-
12
-
-
85030434746
-
Increased oxidative stress in obesity and its impact on metabolic syndrome
-
Furukawa S, Fujita T, Shimabukuro M et al 2004 Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752-1761
-
(2004)
J Clin Invest
, vol.114
, pp. 1752-1761
-
-
Furukawa, S.1
Fujita, T.2
Shimabukuro, M.3
-
13
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
-
Gao Z, Hwang D, Bataille F et al 2002 Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277:48115-48121
-
(2002)
J Biol Chem
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
-
14
-
-
0042591261
-
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
-
Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J 2003 Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem 278:24944-24950
-
(2003)
J Biol Chem
, vol.278
, pp. 24944-24950
-
-
Gao, Z.1
Zuberi, A.2
Quon, M.J.3
Dong, Z.4
Ye, J.5
-
15
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Cline GW et al 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48:1270-1274
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
-
16
-
-
33644750396
-
Role of endoplamic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
-
Hotamisligil GS 2005 Role of endoplamic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 (Suppl 2):S73-78
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Hotamisligil, G.S.1
-
17
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
18
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
19
-
-
0030061922
-
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
-
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271:665-668
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
20
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L et al 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
-
21
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N, Rosen ED, Lander ES 2006 Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944-948
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
22
-
-
33645815074
-
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
-
Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH 2006 Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol 26:3071-3084
-
(2006)
Mol Cell Biol
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
23
-
-
0036099857
-
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
-
Hundal RS, Petersen KF, Mayerson AB et al 2002 Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109:1321-1326
-
(2002)
J Clin Invest
, vol.109
, pp. 1321-1326
-
-
Hundal, R.S.1
Petersen, K.F.2
Mayerson, A.B.3
-
24
-
-
21044453408
-
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
-
Jaeschke A, Rincon M, Doran B et al 2005 Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci USA 102:6931-6935
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 6931-6935
-
-
Jaeschke, A.1
Rincon, M.2
Doran, B.3
-
25
-
-
7044230885
-
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
-
Kaneto HNY, Miyatsuka T, Kawamori D et al 2004 Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med 10:1128-1132
-
(2004)
Nat Med
, vol.10
, pp. 1128-1132
-
-
Kaneto, H.N.Y.1
Miyatsuka, T.2
Kawamori, D.3
-
26
-
-
8544244084
-
PKC-theta knockout mice are protected from fat-induced insulin resistance
-
Kim JK, Fillmore JJ, Sunshine MJ et al 2004 PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114:823-827
-
(2004)
J Clin Invest
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
Fillmore, J.J.2
Sunshine, M.J.3
-
27
-
-
0038165514
-
Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids
-
Koshkin V, Wang X, Scherer PE, Chan CB, Wheeler MB 2003 Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. J Biol Chem 278:19709-19715
-
(2003)
J Biol Chem
, vol.278
, pp. 19709-19715
-
-
Koshkin, V.1
Wang, X.2
Scherer, P.E.3
Chan, C.B.4
Wheeler, M.B.5
-
28
-
-
0036319579
-
Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians
-
Kovacs P, Yang X, Permana PA, Bogardus C, Baier LJ 2002 Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. Diabetes 51:1618-1621
-
(2002)
Diabetes
, vol.51
, pp. 1618-1621
-
-
Kovacs, P.1
Yang, X.2
Permana, P.A.3
Bogardus, C.4
Baier, L.J.5
-
29
-
-
0034637439
-
The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
-
Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro LS, Scherer PE 2000 The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 275:24255-24263
-
(2000)
J Biol Chem
, vol.275
, pp. 24255-24263
-
-
Lin, Y.1
Lee, H.2
Berg, A.H.3
Lisanti, M.P.4
Shapiro, L.S.5
Scherer, P.E.6
-
30
-
-
27544487938
-
JNK: Bridging the insulin signaling and inflammatory pathway
-
Liu G, Rondinone CM 2005 JNK: bridging the insulin signaling and inflammatory pathway. Curr Opin Investig Drugs 6:979-987
-
(2005)
Curr Opin Investig Drugs
, vol.6
, pp. 979-987
-
-
Liu, G.1
Rondinone, C.M.2
-
31
-
-
33749492425
-
Endoplasmic reticulum stress signaling in disease
-
Marciniak SJ, Ron D 2006 Endoplasmic reticulum stress signaling in disease. Physiol Rev 86:1133-1149
-
(2006)
Physiol Rev
, vol.86
, pp. 1133-1149
-
-
Marciniak, S.J.1
Ron, D.2
-
32
-
-
0035854723
-
Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance
-
Mooney RA, Senn J, Cameron S et al 2001 Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. J Biol Chem 276:25889-25893
-
(2001)
J Biol Chem
, vol.276
, pp. 25889-25893
-
-
Mooney, R.A.1
Senn, J.2
Cameron, S.3
-
33
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
-
Ogawa S, Lozach J, Benner C et al 2005 Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122:707-721
-
(2005)
Cell
, vol.122
, pp. 707-721
-
-
Ogawa, S.1
Lozach, J.2
Benner, C.3
-
34
-
-
14644397903
-
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
-
Ozawa K, Miyazaki M, Matsuhisa M 2005 The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 54:657-663
-
(2005)
Diabetes
, vol.54
, pp. 657-663
-
-
Ozawa, K.1
Miyazaki, M.2
Matsuhisa, M.3
-
35
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E et al 2004 Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
-
36
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L et al 2006 Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
-
37
-
-
19944430402
-
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
-
Nakatani Y, Kaneto H, Kawamori D et al 2005 Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 280:847-851
-
(2005)
J Biol Chem
, vol.280
, pp. 847-851
-
-
Nakatani, Y.1
Kaneto, H.2
Kawamori, D.3
-
38
-
-
0030669392
-
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
-
Paz K, Hemi R, LeRoith D et al 1997 A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272:29911-29918
-
(1997)
J Biol Chem
, vol.272
, pp. 29911-29918
-
-
Paz, K.1
Hemi, R.2
LeRoith, D.3
-
39
-
-
9444277846
-
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
-
Ricci R, Sumara G, Sumara I et al 2004 Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306:1558-1561
-
(2004)
Science
, vol.306
, pp. 1558-1561
-
-
Ricci, R.1
Sumara, G.2
Sumara, I.3
-
40
-
-
11144356766
-
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance
-
Rohl M, Pasparakis M, Baudler S et al 2004 Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest 113:474-481
-
(2004)
J Clin Invest
, vol.113
, pp. 474-481
-
-
Rohl, M.1
Pasparakis, M.2
Baudler, S.3
-
41
-
-
0035856949
-
Insulin signaling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR 2001 Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414:799-806
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
42
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS 2006 TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116:3015-3025
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
44
-
-
33745187112
-
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
-
Song MJ, Kim KH, Yoon JM, Kim JB 2006 Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346:739-745
-
(2006)
Biochem Biophys Res Commun
, vol.346
, pp. 739-745
-
-
Song, M.J.1
Kim, K.H.2
Yoon, J.M.3
Kim, J.B.4
-
45
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
Taniguchi CM, Emanuelli B, Kahn CR 2006 Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
46
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS 2006 Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA 103:10741-10746
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
47
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F, Wang X, Bertolotti A et al 2000 Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-666
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
-
48
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS 1997 Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610-614
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
49
-
-
0030864185
-
Targeted disruption of the tumor necrosis factor-alpha gene - metabolic consequences in obese and nonobese mice
-
Ventre J, Doebber T, Wu M et al 1997 Targeted disruption of the tumor necrosis factor-alpha gene - metabolic consequences in obese and nonobese mice. Diabetes 46:1526-1531
-
(1997)
Diabetes
, vol.46
, pp. 1526-1531
-
-
Ventre, J.1
Doebber, T.2
Wu, M.3
-
50
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
Waeber G, Delplanque J, Bonny C et al 2000 The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet 24:291-295
-
(2000)
Nat Genet
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
-
52
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, Chen Y, Cline GW et al 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
-
53
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted distruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J et al 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted distruption of Ikkbeta. Science 293:1673-1677
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
-
54
-
-
33244481462
-
-
Zick Y 2005 Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005(268):pe4
-
Zick Y 2005 Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005(268):pe4
-
-
-
-
55
-
-
33644858343
-
The unfolded protein response: A stress signaling pathway critical for health and disease
-
Zhang K, Kaufman RJ 2006 The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66(2 Suppl 1):S102-109
-
(2006)
Neurology
, vol.66
, Issue.2 SUPPL. 1
-
-
Zhang, K.1
Kaufman, R.J.2
-
56
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
Zhang K, Shen X, Wu J et al 2006 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124:587-599
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
-
57
-
-
33745844503
-
Endoplasmic reticulum stress in health and disease
-
Zhao L, Ackerman SL 2006 Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol 18:444-452
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 444-452
-
-
Zhao, L.1
Ackerman, S.L.2
-
58
-
-
26644450729
-
Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha
-
Xue X, Piao J, Nakajima A et al 2005 Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem 280:33917-33925
-
(2005)
J Biol Chem
, vol.280
, pp. 33917-33925
-
-
Xue, X.1
Piao, J.2
Nakajima, A.3
|