메뉴 건너뛰기




Volumn 286, Issue , 2007, Pages 86-94

Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE;

EID: 42449104952     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper
Times cited : (22)

References (58)
  • 1
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre V, Uchida T, Yenush L, Davis R, White MF 2000 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054
    • (2000) J Biol Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 2
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR et al 2005 IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11:191-198
    • (2005) Nat Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 3
    • 0035444539 scopus 로고    scopus 로고
    • Signal transduction by tumor necrosis factor and its relatives
    • Baud V, Karin M 2001 Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 11:372-377
    • (2001) Trends Cell Biol , vol.11 , pp. 372-377
    • Baud, V.1    Karin, M.2
  • 4
    • 29044447292 scopus 로고    scopus 로고
    • Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver
    • Boden G, She P, Mozzoli M et al 2005 Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 54:3458-3465
    • (2005) Diabetes , vol.54 , pp. 3458-3465
    • Boden, G.1    She, P.2    Mozzoli, M.3
  • 5
    • 33747154772 scopus 로고    scopus 로고
    • Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
    • Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ 2006 Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126:789-799
    • (2006) Cell , vol.126 , pp. 789-799
    • Bookout, A.L.1    Jeong, Y.2    Downes, M.3    Yu, R.T.4    Evans, R.M.5    Mangelsdorf, D.J.6
  • 6
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF et al 2005 Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 7
    • 33847385919 scopus 로고    scopus 로고
    • Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits
    • Chu WS, Das SK, Wang H 2007 Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 56:856-862
    • (2007) Diabetes , vol.56 , pp. 856-862
    • Chu, W.S.1    Das, S.K.2    Wang, H.3
  • 8
    • 29244462498 scopus 로고    scopus 로고
    • Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
    • Cullinan SB, Diehl JA 2006 Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol 38:317-332
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 317-332
    • Cullinan, S.B.1    Diehl, J.A.2
  • 9
    • 8644282751 scopus 로고    scopus 로고
    • Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
    • Deng J, Lu PD, Zhang Y et al 2004 Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24:10161-10168
    • (2004) Mol Cell Biol , vol.24 , pp. 10161-10168
    • Deng, J.1    Lu, P.D.2    Zhang, Y.3
  • 10
    • 0034717062 scopus 로고    scopus 로고
    • SOCS-3 is an insulin-induced negative regulator of insulin signaling
    • Emanuelli B, Peraldi P, Filloux C et al 2000 SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275:15985-15991
    • (2000) J Biol Chem , vol.275 , pp. 15985-15991
    • Emanuelli, B.1    Peraldi, P.2    Filloux, C.3
  • 11
    • 0035930605 scopus 로고    scopus 로고
    • SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
    • Emanuelli B, Peraldi P, Filloux C et al 2001 SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 276:47944-47949
    • (2001) J Biol Chem , vol.276 , pp. 47944-47949
    • Emanuelli, B.1    Peraldi, P.2    Filloux, C.3
  • 12
    • 85030434746 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity and its impact on metabolic syndrome
    • Furukawa S, Fujita T, Shimabukuro M et al 2004 Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752-1761
    • (2004) J Clin Invest , vol.114 , pp. 1752-1761
    • Furukawa, S.1    Fujita, T.2    Shimabukuro, M.3
  • 13
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
    • Gao Z, Hwang D, Bataille F et al 2002 Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277:48115-48121
    • (2002) J Biol Chem , vol.277 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3
  • 14
    • 0042591261 scopus 로고    scopus 로고
    • Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
    • Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J 2003 Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem 278:24944-24950
    • (2003) J Biol Chem , vol.278 , pp. 24944-24950
    • Gao, Z.1    Zuberi, A.2    Quon, M.J.3    Dong, Z.4    Ye, J.5
  • 15
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW et al 1999 Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48:1270-1274
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 16
    • 33644750396 scopus 로고    scopus 로고
    • Role of endoplamic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    • Hotamisligil GS 2005 Role of endoplamic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 (Suppl 2):S73-78
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Hotamisligil, G.S.1
  • 17
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 18
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 19
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271:665-668
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 20
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L et al 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 21
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES 2006 Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944-948
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 22
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
    • Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH 2006 Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol 26:3071-3084
    • (2006) Mol Cell Biol , vol.26 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 23
    • 0036099857 scopus 로고    scopus 로고
    • Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
    • Hundal RS, Petersen KF, Mayerson AB et al 2002 Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109:1321-1326
    • (2002) J Clin Invest , vol.109 , pp. 1321-1326
    • Hundal, R.S.1    Petersen, K.F.2    Mayerson, A.B.3
  • 24
    • 21044453408 scopus 로고    scopus 로고
    • Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
    • Jaeschke A, Rincon M, Doran B et al 2005 Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci USA 102:6931-6935
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6931-6935
    • Jaeschke, A.1    Rincon, M.2    Doran, B.3
  • 25
    • 7044230885 scopus 로고    scopus 로고
    • Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
    • Kaneto HNY, Miyatsuka T, Kawamori D et al 2004 Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat Med 10:1128-1132
    • (2004) Nat Med , vol.10 , pp. 1128-1132
    • Kaneto, H.N.Y.1    Miyatsuka, T.2    Kawamori, D.3
  • 26
    • 8544244084 scopus 로고    scopus 로고
    • PKC-theta knockout mice are protected from fat-induced insulin resistance
    • Kim JK, Fillmore JJ, Sunshine MJ et al 2004 PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114:823-827
    • (2004) J Clin Invest , vol.114 , pp. 823-827
    • Kim, J.K.1    Fillmore, J.J.2    Sunshine, M.J.3
  • 27
    • 0038165514 scopus 로고    scopus 로고
    • Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids
    • Koshkin V, Wang X, Scherer PE, Chan CB, Wheeler MB 2003 Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. J Biol Chem 278:19709-19715
    • (2003) J Biol Chem , vol.278 , pp. 19709-19715
    • Koshkin, V.1    Wang, X.2    Scherer, P.E.3    Chan, C.B.4    Wheeler, M.B.5
  • 28
    • 0036319579 scopus 로고    scopus 로고
    • Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians
    • Kovacs P, Yang X, Permana PA, Bogardus C, Baier LJ 2002 Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. Diabetes 51:1618-1621
    • (2002) Diabetes , vol.51 , pp. 1618-1621
    • Kovacs, P.1    Yang, X.2    Permana, P.A.3    Bogardus, C.4    Baier, L.J.5
  • 29
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro LS, Scherer PE 2000 The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 275:24255-24263
    • (2000) J Biol Chem , vol.275 , pp. 24255-24263
    • Lin, Y.1    Lee, H.2    Berg, A.H.3    Lisanti, M.P.4    Shapiro, L.S.5    Scherer, P.E.6
  • 30
    • 27544487938 scopus 로고    scopus 로고
    • JNK: Bridging the insulin signaling and inflammatory pathway
    • Liu G, Rondinone CM 2005 JNK: bridging the insulin signaling and inflammatory pathway. Curr Opin Investig Drugs 6:979-987
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 979-987
    • Liu, G.1    Rondinone, C.M.2
  • 31
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak SJ, Ron D 2006 Endoplasmic reticulum stress signaling in disease. Physiol Rev 86:1133-1149
    • (2006) Physiol Rev , vol.86 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 32
    • 0035854723 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance
    • Mooney RA, Senn J, Cameron S et al 2001 Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. J Biol Chem 276:25889-25893
    • (2001) J Biol Chem , vol.276 , pp. 25889-25893
    • Mooney, R.A.1    Senn, J.2    Cameron, S.3
  • 33
    • 24144465889 scopus 로고    scopus 로고
    • Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    • Ogawa S, Lozach J, Benner C et al 2005 Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 122:707-721
    • (2005) Cell , vol.122 , pp. 707-721
    • Ogawa, S.1    Lozach, J.2    Benner, C.3
  • 34
    • 14644397903 scopus 로고    scopus 로고
    • The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
    • Ozawa K, Miyazaki M, Matsuhisa M 2005 The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 54:657-663
    • (2005) Diabetes , vol.54 , pp. 657-663
    • Ozawa, K.1    Miyazaki, M.2    Matsuhisa, M.3
  • 35
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E et al 2004 Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 36
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan U, Yilmaz E, Ozcan L et al 2006 Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3
  • 37
    • 19944430402 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in insulin resistance and diabetes
    • Nakatani Y, Kaneto H, Kawamori D et al 2005 Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. J Biol Chem 280:847-851
    • (2005) J Biol Chem , vol.280 , pp. 847-851
    • Nakatani, Y.1    Kaneto, H.2    Kawamori, D.3
  • 38
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • Paz K, Hemi R, LeRoith D et al 1997 A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272:29911-29918
    • (1997) J Biol Chem , vol.272 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    LeRoith, D.3
  • 39
    • 9444277846 scopus 로고    scopus 로고
    • Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
    • Ricci R, Sumara G, Sumara I et al 2004 Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306:1558-1561
    • (2004) Science , vol.306 , pp. 1558-1561
    • Ricci, R.1    Sumara, G.2    Sumara, I.3
  • 40
    • 11144356766 scopus 로고    scopus 로고
    • Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance
    • Rohl M, Pasparakis M, Baudler S et al 2004 Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest 113:474-481
    • (2004) J Clin Invest , vol.113 , pp. 474-481
    • Rohl, M.1    Pasparakis, M.2    Baudler, S.3
  • 41
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR 2001 Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414:799-806
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 44
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB 2006 Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346:739-745
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 45
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR 2006 Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 47
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A et al 2000 Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-666
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3
  • 48
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS 1997 Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610-614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 49
    • 0030864185 scopus 로고    scopus 로고
    • Targeted disruption of the tumor necrosis factor-alpha gene - metabolic consequences in obese and nonobese mice
    • Ventre J, Doebber T, Wu M et al 1997 Targeted disruption of the tumor necrosis factor-alpha gene - metabolic consequences in obese and nonobese mice. Diabetes 46:1526-1531
    • (1997) Diabetes , vol.46 , pp. 1526-1531
    • Ventre, J.1    Doebber, T.2    Wu, M.3
  • 50
    • 0034104298 scopus 로고    scopus 로고
    • The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
    • Waeber G, Delplanque J, Bonny C et al 2000 The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet 24:291-295
    • (2000) Nat Genet , vol.24 , pp. 291-295
    • Waeber, G.1    Delplanque, J.2    Bonny, C.3
  • 51
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen KE, Hotamisligil GS 2005 Inflammation, stress, and diabetes. J Clin Invest 115:1111-1119
    • (2005) J Clin Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 52
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW et al 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3
  • 53
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted distruption of Ikkbeta
    • Yuan M, Konstantopoulos N, Lee J et al 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted distruption of Ikkbeta. Science 293:1673-1677
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 54
    • 33244481462 scopus 로고    scopus 로고
    • Zick Y 2005 Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005(268):pe4
    • Zick Y 2005 Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005(268):pe4
  • 55
    • 33644858343 scopus 로고    scopus 로고
    • The unfolded protein response: A stress signaling pathway critical for health and disease
    • Zhang K, Kaufman RJ 2006 The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66(2 Suppl 1):S102-109
    • (2006) Neurology , vol.66 , Issue.2 SUPPL. 1
    • Zhang, K.1    Kaufman, R.J.2
  • 56
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • Zhang K, Shen X, Wu J et al 2006 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124:587-599
    • (2006) Cell , vol.124 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3
  • 57
    • 33745844503 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in health and disease
    • Zhao L, Ackerman SL 2006 Endoplasmic reticulum stress in health and disease. Curr Opin Cell Biol 18:444-452
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 444-452
    • Zhao, L.1    Ackerman, S.L.2
  • 58
    • 26644450729 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha
    • Xue X, Piao J, Nakajima A et al 2005 Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha. J Biol Chem 280:33917-33925
    • (2005) J Biol Chem , vol.280 , pp. 33917-33925
    • Xue, X.1    Piao, J.2    Nakajima, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.