Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum

Journal of Medicinal Chemistry

Volumn 51, Issue 5, 2008, Pages 1260-1277

  Friebolin, Wolfgang ^a   Jannack, Beate ^a   Wenzel, Nicole ^a   Furrer, Julien ^a   Oeser, Thomas ^a   Sanchez, Cecilia P ^b   Lanzer, Michael ^b   Yardley, Vanessa ^c   Becker, Katja ^d   Davioud Charvet, Elisabeth ^a,e  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Hygiene Institute   (Germany)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTESUNATE; CHLOROQUINE; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; GLUTATHIONE REDUCTASE INHIBITOR; MANNICH BASE; MEFLOQUINE; PARACETAMOL; PROTOPORPHYRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG UPTAKE; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CHLOROQUINE; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; GLUTATHIONE REDUCTASE; HUMANS; MALARIA; MICE; MICE, INBRED BALB C; NAPHTHALENES; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41649113120     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7009292     Document Type: Article

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