Lysosomes and drug resistance in malaria

Lancet

Volumn 360, Issue 9345, 2002, Pages 1527-1529

  Warhurst, David C ^a   Craig, John C ^b   Adagu, Ipemida S ^b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE; AMINOALCOHOL; ARTEMISININ; CHLORIDE CHANNEL; CHLOROQUINE; DIHYDROARTEMISININ; HEMATIN; HEMOGLOBIN; MEFLOQUINE; MEPACRINE; MULTIDRUG RESISTANCE PROTEIN; QUININE; VERAPAMIL;

AFRICA; ALLELE; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ASIA; BACTERIAL STRAIN; CANCER CELL; CODON; CONTROLLED STUDY; CROSS RESISTANCE; DETOXIFICATION; DRUG EFFICACY; DRUG TARGETING; DRUG TRANSPORT; DRUG UPTAKE; ENZYME RELEASE; EPIDEMIC; HUMAN; HYDROPHOBICITY; LIPOPHILICITY; LYSOSOME; LYSOSOME MEMBRANE; MALARIA; MALARIA FALCIPARUM; MORBIDITY; MORTALITY; NOTE; PARASITE DEVELOPMENT; PH; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; SALMONELLA TYPHIMURIUM; SOUTH AMERICA;

EID: 0037121251     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)11577-7     Document Type: Note

References (18)

1. Trape J.F. The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg. 64:2001;12-17.
2. Chou A.C., Chevli R., Fitch C.D. Ferriprotoporphyrin IX fulfils the criteria for identification as the chloroquine receptor of malaria parasites. Biochemistry. 19:1980;1543-1549.
3. Pagola S., Stephens P.W., Bohle D.S., Kosar A.D., Madsen S.K. The structure of malaria pigment beta-haematin. Nature. 404:2000;307-310.
4. Homewood C.A., Warhurst D.C., Peters W., Baggaley V.C. Lysosomes, pH and the anti-malarial action of chloroquine. Nature. 235:1972;50-52.
5. Fitch C.D. Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity. Science. 169:1970;289-290.
6. Krogstad D.J., Gluzman I.Y., Kyle D.E., et al. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science. 238:1987;1283-1285.
7. Foote S.J., Kyle D.E., Martin R.K., et al. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature. 345:1990;255-258.
8. Wellems T.E., Panton L.J., Gluzman I.Y., et al. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Nature. 345:1990;253-255.
9. Fidock D.A., Nomura T., Talley A.K., et al. Mutations in the P falciparum digestive vacuole transmembrane protein PFCRT and evidence for their role in chloroquine resistance. Mol Cell. 6:2000;861-871.
10. Djimde A., Doumbo O.K., Cortese J.F., et al. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med. 344:2001;257-263.
11. Warhurst D.C. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med. 344:2001;299-302.
12. Sidhu A.B., Verdier-Pinard D., Fidock D.A. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science. 298:2002;210-213.
13. Bray P.G., Hawley S.R., Mungthin M., Ward S.A. Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum. Mol Pharmacol. 50:1996;1559-1566.
14. Warhurst, DC. Plasmodium falciparum chloroquine-resistance transporter: one of the usual channels? COST B9 Meeting on Antiprotozoal Chemotherapy, London, June 23, 2002: abstr 49.
15. Dutzler R., Campbell E.B., Cadene M., Chait B.T., MacKinnon R. Xray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 415:2002;287-294.
16. Martiney J.A., Cerami A., Slater A.F.G. Verapamil reversal of chloroquine-resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect. J Exp Med. 173:1991;961-969.
17. Kirsch G.E., Pascual J.M., Shieh C.C. Functional role of a conserved aspartate in the external mouth of voltage-gated potassium channels. Biophys J. 68:1995;1804-1813.
18. Zhang H, Howard EM, Roepe PD. Analysis of the antimalarial drug resistance protein Pfcrt in yeast. J Biol Chem Sep 25, 2002. http://www.jbc.org/cgi/reprint/M204005200v1 (accessed Nov 12, 2002).