Carbon isosteres of the 4-aminopyridine substructure of chloroquine: Effects on pKa, hematin binding, inhibition of hemozoin formation, and parasite growth

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 3166-3169

  Cheruku, Srinivasa R ^a   Maiti, Souvik ^a   Dorn, Arnulf ^b   Scorneaux, Bernard ^c   Bhattacharjee, Apurba K ^d   Ellis, William Y ^d   Vennerstrom, Jonathan L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE DERIVATIVE; [5 (7 CHLOROQUINOLIN 4 YL) 4 METHYLPENTYL]DIETHYLAMINE; CARBON; CHLOROQUINE; HEMATIN; HEMOZOIN; N4 (6 CHLORONAPHTHALEN 1 YL) N1,N1 DIETHYLPENTANE 1,4 DIAMINE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG STRUCTURE; MOLECULAR MODEL; NONHUMAN; PKA; PLASMODIUM FALCIPARUM; STRUCTURE ANALYSIS; THERMODYNAMICS;

4-AMINOPYRIDINE; ANIMALS; ANTIMALARIALS; CHLOROQUINE; HEMIN; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0038143278     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030038x     Document Type: Article

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