Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2931-2934

  Romeo, Sergio ^a   Dell'Agli, Mario ^a   Parapini, Silvia ^a   Rizzi, Luca ^a   Galli, Germana ^a   Mondani, Monica ^a   Sparatore, Anna ^a   Taramelli, Donatella ^a   Bosisio, Enrica ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Chimera drug; Double drug; In vitro inhibition; P. falciparum; Plasmepsin II; Primaquine; Statine

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLASMEPSIN II; PRIMAQUINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; ENZYME INHIBITION; GROWTH INHIBITION; IC 50; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PLASMODIUM FALCIPARUM;

AMINO ACIDS; ANIMALS; ANTIMALARIALS; ASPARTIC ENDOPEPTIDASES; CHLOROQUINE; CROSS-LINKING REAGENTS; DRUG DESIGN; DRUG RESISTANCE; ERYTHROCYTES; HUMANS; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; PRIMAQUINE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 2342463719     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.030     Document Type: Article

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