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Volumn 44, Issue 8, 2008, Pages 1506-1528

Sickle cell disease vasculopathy: A state of nitric oxide resistance

Author keywords

Endothelium; Hemolysis; NADPH oxidase; Nitric oxide; Nitric oxide resistance; Reactive oxygen species; Vasculopathy; Xanthine oxidase

Indexed keywords

APOCYNIN; APOLIPOPROTEIN A1; ARGININE; DIPHENYLIODONIUM SALT; ENDOTHELIN 1; HEME OXYGENASE 1; HEMOGLOBIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SALAZOSULFAPYRIDINE; VITAMIN; XANTHINE OXIDASE;

EID: 41549136868     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.01.008     Document Type: Review
Times cited : (185)

References (289)
  • 1
    • 34147141453 scopus 로고    scopus 로고
    • Sickle cell disease: old discoveries, new concepts, and future promise
    • Frenette P.S., and Atweh G.F. Sickle cell disease: old discoveries, new concepts, and future promise. J. Clin. Invest. 117 (2007) 850-858
    • (2007) J. Clin. Invest. , vol.117 , pp. 850-858
    • Frenette, P.S.1    Atweh, G.F.2
  • 2
    • 33845254119 scopus 로고    scopus 로고
    • Hospitalization rates and costs of care of patients with sickle-cell anemia in the state of Maryland in the era of hydroxyurea
    • Lanzkron S., Haywood Jr. C., Segal J.B., and Dover G.J. Hospitalization rates and costs of care of patients with sickle-cell anemia in the state of Maryland in the era of hydroxyurea. Am. J. Hematol. 81 (2006) 927-932
    • (2006) Am. J. Hematol. , vol.81 , pp. 927-932
    • Lanzkron, S.1    Haywood Jr., C.2    Segal, J.B.3    Dover, G.J.4
  • 4
    • 0038540202 scopus 로고    scopus 로고
    • Hospital resource utilization among patients with sickle cell disease
    • Mayer M.L., Konrad T.R., and Dvorak C.C. Hospital resource utilization among patients with sickle cell disease. J. Health Care Poor Underserved 14 (2003) 122-135
    • (2003) J. Health Care Poor Underserved , vol.14 , pp. 122-135
    • Mayer, M.L.1    Konrad, T.R.2    Dvorak, C.C.3
  • 6
    • 0031030086 scopus 로고    scopus 로고
    • Cost of hospitalizations associated with sickle cell disease in the United States
    • Davis H., Moore Jr. R.M., and Gergen P.J. Cost of hospitalizations associated with sickle cell disease in the United States. Public Health Rep. 112 (1997) 40-43
    • (1997) Public Health Rep. , vol.112 , pp. 40-43
    • Davis, H.1    Moore Jr., R.M.2    Gergen, P.J.3
  • 8
    • 0033624253 scopus 로고    scopus 로고
    • Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    • Kaul D.K., and Hebbel R.P. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. J. Clin. Invest. 106 (2000) 411-420
    • (2000) J. Clin. Invest. , vol.106 , pp. 411-420
    • Kaul, D.K.1    Hebbel, R.P.2
  • 9
    • 0023857266 scopus 로고
    • Sickle cell chronic lung disease: prior morbidity and the risk of pulmonary failure
    • Powars D., Weidman J.A., Odom-Maryon T., Niland J.C., and Johnson C. Sickle cell chronic lung disease: prior morbidity and the risk of pulmonary failure. Medicine 67 (1988) 66-76
    • (1988) Medicine , vol.67 , pp. 66-76
    • Powars, D.1    Weidman, J.A.2    Odom-Maryon, T.3    Niland, J.C.4    Johnson, C.5
  • 11
    • 0030745431 scopus 로고    scopus 로고
    • Irreversibly sickled cell beta-actin: defective filament formation
    • Shartava A., Korn W., Shah A.K., and Goodman S.R. Irreversibly sickled cell beta-actin: defective filament formation. Am. J. Hematol. 55 (1997) 97-103
    • (1997) Am. J. Hematol. , vol.55 , pp. 97-103
    • Shartava, A.1    Korn, W.2    Shah, A.K.3    Goodman, S.R.4
  • 12
    • 0037423394 scopus 로고    scopus 로고
    • Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization
    • Aslan M., Ryan T.M., Townes T.M., Coward L., Kirk M.C., Barnes S., Alexander C.B., Rosenfeld S.S., and Freeman B.A. Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization. J. Biol. Chem. 278 (2003) 4194-4204
    • (2003) J. Biol. Chem. , vol.278 , pp. 4194-4204
    • Aslan, M.1    Ryan, T.M.2    Townes, T.M.3    Coward, L.4    Kirk, M.C.5    Barnes, S.6    Alexander, C.B.7    Rosenfeld, S.S.8    Freeman, B.A.9
  • 14
    • 0023518452 scopus 로고
    • Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical
    • Ignarro L.J., Byrns R.E., Buga G.M., and Wood K.S. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ. Res. 61 (1987) 866-879
    • (1987) Circ. Res. , vol.61 , pp. 866-879
    • Ignarro, L.J.1    Byrns, R.E.2    Buga, G.M.3    Wood, K.S.4
  • 15
    • 0025812495 scopus 로고
    • Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro-and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release
    • Vargas H.M., Cuevas J.M., Ignarro L.J., and Chaudhuri G. Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro-and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. J. Pharmacol. Exp. Ther. 257 (1991) 1208-1215
    • (1991) J. Pharmacol. Exp. Ther. , vol.257 , pp. 1208-1215
    • Vargas, H.M.1    Cuevas, J.M.2    Ignarro, L.J.3    Chaudhuri, G.4
  • 16
    • 0001599370 scopus 로고
    • Role of endothelium-derived nitric oxide in the regulation of blood pressure
    • Rees D.D., Palmer R.M., and Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 3375-3378
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 3375-3378
    • Rees, D.D.1    Palmer, R.M.2    Moncada, S.3
  • 17
    • 0024475102 scopus 로고
    • NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?
    • Aisaka K., Gross S.S., Griffith O.W., and Levi R. NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?. Biochem. Biophys. Res. Commun. 160 (1989) 881-886
    • (1989) Biochem. Biophys. Res. Commun. , vol.160 , pp. 881-886
    • Aisaka, K.1    Gross, S.S.2    Griffith, O.W.3    Levi, R.4
  • 18
    • 0028127737 scopus 로고
    • Endothelium and the regulation of vascular tone with emphasis on the role of nitric oxide. Physiology, pathophysiology and clinical implications
    • Rongen G.A., Smits P., and Thien T. Endothelium and the regulation of vascular tone with emphasis on the role of nitric oxide. Physiology, pathophysiology and clinical implications. Neth. J. Med. 44 (1994) 26-35
    • (1994) Neth. J. Med. , vol.44 , pp. 26-35
    • Rongen, G.A.1    Smits, P.2    Thien, T.3
  • 19
    • 0032410741 scopus 로고    scopus 로고
    • Role of nitric oxide in the control of renin secretion
    • Kurtz A., and Wagner C. Role of nitric oxide in the control of renin secretion. Am. J. Physiol. 275 (1998) F849-F862
    • (1998) Am. J. Physiol. , vol.275
    • Kurtz, A.1    Wagner, C.2
  • 20
    • 0025100874 scopus 로고
    • Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide
    • Boulanger C., and Luscher T.F. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J. Clin. Invest. 85 (1990) 587-590
    • (1990) J. Clin. Invest. , vol.85 , pp. 587-590
    • Boulanger, C.1    Luscher, T.F.2
  • 21
    • 10844265344 scopus 로고    scopus 로고
    • Nitric oxide-cyclic GMP pathway with some emphasis on cavernosal contractility
    • Ghalayini I.F. Nitric oxide-cyclic GMP pathway with some emphasis on cavernosal contractility. Int. J. Impot. Res. 16 (2004) 459-469
    • (2004) Int. J. Impot. Res. , vol.16 , pp. 459-469
    • Ghalayini, I.F.1
  • 23
    • 33750730317 scopus 로고    scopus 로고
    • ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms
    • Meng W., Ma J., Ayata C., Hara H., Huang P.L., Fishman M.C., and Moskowitz M.A. ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. Am. J. Physiol. 271 (1996) H1145-H1150
    • (1996) Am. J. Physiol. , vol.271
    • Meng, W.1    Ma, J.2    Ayata, C.3    Hara, H.4    Huang, P.L.5    Fishman, M.C.6    Moskowitz, M.A.7
  • 24
    • 0022559195 scopus 로고
    • Functions of the endothelial cell surface
    • Simionescu M., and Simionescu N. Functions of the endothelial cell surface. Annu. Rev. Physiol. 48 (1986) 279-293
    • (1986) Annu. Rev. Physiol. , vol.48 , pp. 279-293
    • Simionescu, M.1    Simionescu, N.2
  • 26
    • 0027280338 scopus 로고
    • Pathological implications of nitric oxide, superoxide and peroxynitrite formation
    • Beckman J.S., and Crow J.P. Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem. Soc. Trans. 21 (1993) 330-334
    • (1993) Biochem. Soc. Trans. , vol.21 , pp. 330-334
    • Beckman, J.S.1    Crow, J.P.2
  • 27
    • 0031740360 scopus 로고    scopus 로고
    • Peroxynitrite reactions with carbon dioxide-bicarbonate
    • Radi R., Denicola A., and Freeman B.A. Peroxynitrite reactions with carbon dioxide-bicarbonate. Methods Enzymol. 301 (1999) 353-367
    • (1999) Methods Enzymol. , vol.301 , pp. 353-367
    • Radi, R.1    Denicola, A.2    Freeman, B.A.3
  • 28
    • 0020427486 scopus 로고
    • Biology of disease: free radicals and tissue injury
    • Freeman B.A., and Crapo J.D. Biology of disease: free radicals and tissue injury. Lab. Invest. 47 (1982) 412-426
    • (1982) Lab. Invest. , vol.47 , pp. 412-426
    • Freeman, B.A.1    Crapo, J.D.2
  • 29
    • 0030961521 scopus 로고    scopus 로고
    • Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells
    • Durante W., Kroll M.H., Christodoulides N., Peyton K.J., and Schafer A.I. Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ. Res. 80 (1997) 557-564
    • (1997) Circ. Res. , vol.80 , pp. 557-564
    • Durante, W.1    Kroll, M.H.2    Christodoulides, N.3    Peyton, K.J.4    Schafer, A.I.5
  • 30
    • 34249857235 scopus 로고    scopus 로고
    • Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism
    • Sheftel A.D., Kim S.F., and Ponka P. Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism. J. Biol. Chem. 282 (2007) 10480-10486
    • (2007) J. Biol. Chem. , vol.282 , pp. 10480-10486
    • Sheftel, A.D.1    Kim, S.F.2    Ponka, P.3
  • 31
    • 33750260791 scopus 로고    scopus 로고
    • NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells
    • Jiang F., Roberts S.J., Datla S., and Dusting G.J. NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells. Hypertension 48 (2006) 950-957
    • (2006) Hypertension , vol.48 , pp. 950-957
    • Jiang, F.1    Roberts, S.J.2    Datla, S.3    Dusting, G.J.4
  • 34
    • 18844446494 scopus 로고    scopus 로고
    • Platelet-vessel wall interactions in the microcirculation
    • Tailor A., Cooper D., and Granger D.N. Platelet-vessel wall interactions in the microcirculation. Microcirculation 12 (2005) 275-285
    • (2005) Microcirculation , vol.12 , pp. 275-285
    • Tailor, A.1    Cooper, D.2    Granger, D.N.3
  • 35
    • 0031748618 scopus 로고    scopus 로고
    • Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants
    • Spiecker M., Darius H., Kaboth K., Hubner F., and Liao J.K. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J. Leukoc. Biol. 63 (1998) 732-739
    • (1998) J. Leukoc. Biol. , vol.63 , pp. 732-739
    • Spiecker, M.1    Darius, H.2    Kaboth, K.3    Hubner, F.4    Liao, J.K.5
  • 37
    • 2442583364 scopus 로고    scopus 로고
    • Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats
    • Schafer A., Widder J., Eigenthaler M., Ertl G., and Bauersachs J. Reduced basal nitric oxide bioavailability and platelet activation in young spontaneously hypertensive rats. Biochem. Pharmacol. 67 (2004) 2273-2279
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 2273-2279
    • Schafer, A.1    Widder, J.2    Eigenthaler, M.3    Ertl, G.4    Bauersachs, J.5
  • 38
    • 0029804897 scopus 로고    scopus 로고
    • A thromboelastography study on the in vitro effects of L-arginine and L-NG-nitro arginine methyl ester on human whole blood coagulation and fibrinolysis
    • Dambisya Y.M., and Lee T.L. A thromboelastography study on the in vitro effects of L-arginine and L-NG-nitro arginine methyl ester on human whole blood coagulation and fibrinolysis. Blood Coagul. Fibrinolysis 7 (1996) 678-683
    • (1996) Blood Coagul. Fibrinolysis , vol.7 , pp. 678-683
    • Dambisya, Y.M.1    Lee, T.L.2
  • 39
    • 33947207946 scopus 로고    scopus 로고
    • Tissue factor and nitric oxide: a controversial relationship!
    • Dusse L.M., Cooper A.J., and Lwaleed B.A. Tissue factor and nitric oxide: a controversial relationship!. J. Thromb. Thrombolysis 23 (2007) 129-133
    • (2007) J. Thromb. Thrombolysis , vol.23 , pp. 129-133
    • Dusse, L.M.1    Cooper, A.J.2    Lwaleed, B.A.3
  • 40
    • 0033380349 scopus 로고    scopus 로고
    • Vascular biosynthesis of nitric oxide: effect on hemostasis and fibrinolysis
    • Schini-Kerth V.B. Vascular biosynthesis of nitric oxide: effect on hemostasis and fibrinolysis. Transfus. Clin. Biol. 6 (1999) 355-363
    • (1999) Transfus. Clin. Biol. , vol.6 , pp. 355-363
    • Schini-Kerth, V.B.1
  • 48
    • 9644260566 scopus 로고    scopus 로고
    • Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice
    • Kaul D.K., Liu X.D., Chang H.Y., Nagel R.L., and Fabry M.E. Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. J. Clin. Invest. 114 (2004) 1136-1145
    • (2004) J. Clin. Invest. , vol.114 , pp. 1136-1145
    • Kaul, D.K.1    Liu, X.D.2    Chang, H.Y.3    Nagel, R.L.4    Fabry, M.E.5
  • 50
    • 20444468127 scopus 로고    scopus 로고
    • Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice
    • Wood K.C., Hebbel R.P., and Granger D.N. Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice. FASEB J. 19 (2005) 989-991
    • (2005) FASEB J. , vol.19 , pp. 989-991
    • Wood, K.C.1    Hebbel, R.P.2    Granger, D.N.3
  • 52
    • 33749677309 scopus 로고    scopus 로고
    • Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias
    • Jeffers A., Gladwin M.T., and Kim-Shapiro D.B. Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias. Free Radic. Biol. Med. 41 (2006) 1557-1565
    • (2006) Free Radic. Biol. Med. , vol.41 , pp. 1557-1565
    • Jeffers, A.1    Gladwin, M.T.2    Kim-Shapiro, D.B.3
  • 53
    • 4544363652 scopus 로고    scopus 로고
    • Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay
    • Fink B., Laude K., McCann L., Doughan A., Harrison D.G., and Dikalov S. Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay. Am. J. Physiol., Cell Physiol. 287 (2004) C895-C902
    • (2004) Am. J. Physiol., Cell Physiol. , vol.287
    • Fink, B.1    Laude, K.2    McCann, L.3    Doughan, A.4    Harrison, D.G.5    Dikalov, S.6
  • 54
    • 0038368985 scopus 로고    scopus 로고
    • Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide
    • Zhao H., Kalivendi S., Zhang H., Joseph J., Nithipatikom K., Vasquez-Vivar J., and Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 34 (2003) 1359-1368
    • (2003) Free Radic. Biol. Med. , vol.34 , pp. 1359-1368
    • Zhao, H.1    Kalivendi, S.2    Zhang, H.3    Joseph, J.4    Nithipatikom, K.5    Vasquez-Vivar, J.6    Kalyanaraman, B.7
  • 55
    • 84918833988 scopus 로고
    • Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (.OH/.O-) in aqueous solution
    • Buxton G.V., Greenstock C.L., Helman W.P., and Ross A.B. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (.OH/.O-) in aqueous solution. J. Phys. Chem. Ref. Data 17 (1988) 513-886
    • (1988) J. Phys. Chem. Ref. Data , vol.17 , pp. 513-886
    • Buxton, G.V.1    Greenstock, C.L.2    Helman, W.P.3    Ross, A.B.4
  • 56
    • 0028090219 scopus 로고
    • Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide
    • Castro L., Rodriguez M., and Radi R. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J. Biol. Chem. 269 (1994) 29409-29415
    • (1994) J. Biol. Chem. , vol.269 , pp. 29409-29415
    • Castro, L.1    Rodriguez, M.2    Radi, R.3
  • 59
    • 1242315424 scopus 로고    scopus 로고
    • Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients
    • Conran N., Oresco-Santos C., Acosta H.C., Fattori A., Saad S.T., and Costa F.F. Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients. Br. J. Haematol. 124 (2004) 547-554
    • (2004) Br. J. Haematol. , vol.124 , pp. 547-554
    • Conran, N.1    Oresco-Santos, C.2    Acosta, H.C.3    Fattori, A.4    Saad, S.T.5    Costa, F.F.6
  • 60
    • 0031001007 scopus 로고    scopus 로고
    • Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia
    • Pegelow C.H., Colangelo L., Steinberg M., Wright E.C., Smith J., Phillips G., and Vichinsky E. Natural history of blood pressure in sickle cell disease: risks for stroke and death associated with relative hypertension in sickle cell anemia. Am. J. Med. 102 (1997) 171-177
    • (1997) Am. J. Med. , vol.102 , pp. 171-177
    • Pegelow, C.H.1    Colangelo, L.2    Steinberg, M.3    Wright, E.C.4    Smith, J.5    Phillips, G.6    Vichinsky, E.7
  • 62
    • 26244465889 scopus 로고    scopus 로고
    • Explaining the phenomenon of nitrate tolerance
    • Munzel T., Daiber A., and Mulsch A. Explaining the phenomenon of nitrate tolerance. Circ. Res. 97 (2005) 618-628
    • (2005) Circ. Res. , vol.97 , pp. 618-628
    • Munzel, T.1    Daiber, A.2    Mulsch, A.3
  • 64
    • 0017855570 scopus 로고
    • Irreversibly sickled cells and red cell survival in sickle cell anemia. A study wtih both DF32P and 51Cr
    • McCurdy P.R., and Sherman A.S. Irreversibly sickled cells and red cell survival in sickle cell anemia. A study wtih both DF32P and 51Cr. Am. J. Med. 64 (1978) 253
    • (1978) Am. J. Med. , vol.64 , pp. 253
    • McCurdy, P.R.1    Sherman, A.S.2
  • 65
    • 0014645884 scopus 로고
    • The irreversibly sickled cell: A determinant of hemolysis in sickle cell anemia
    • Serjeant G.R., Serjeant B.E., and Milner P.F. The irreversibly sickled cell: A determinant of hemolysis in sickle cell anemia. Br. J. Haematol. 17 (1969) 527
    • (1969) Br. J. Haematol. , vol.17 , pp. 527
    • Serjeant, G.R.1    Serjeant, B.E.2    Milner, P.F.3
  • 67
    • 0021809585 scopus 로고
    • A simple model for estimating the hemolytic rate in patients with sickle cell anemia
    • Chen Y.H., and Wang S.C. A simple model for estimating the hemolytic rate in patients with sickle cell anemia. J. Lab. Clin. Med. 105 (1985) 201-208
    • (1985) J. Lab. Clin. Med. , vol.105 , pp. 201-208
    • Chen, Y.H.1    Wang, S.C.2
  • 68
    • 0030853520 scopus 로고    scopus 로고
    • Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity
    • Brugnara C., Zelmanovic D., Sorette M., Ballas S.K., and Platt O. Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity. Am. J. Clin. Pathol. 108 (1997) 133-142
    • (1997) Am. J. Clin. Pathol. , vol.108 , pp. 133-142
    • Brugnara, C.1    Zelmanovic, D.2    Sorette, M.3    Ballas, S.K.4    Platt, O.5
  • 69
    • 33644775612 scopus 로고    scopus 로고
    • Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    • Kato G.J., McGowan V., Machado R.F., Little J.A., Taylor J.t., Morris C.R., Nichols J.S., Wang X., Poljakovic M., Morris Jr. S.M., and Gladwin M.T. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 107 (2006) 2279-2285
    • (2006) Blood , vol.107 , pp. 2279-2285
    • Kato, G.J.1    McGowan, V.2    Machado, R.F.3    Little, J.A.4    Taylor, J.t.5    Morris, C.R.6    Nichols, J.S.7    Wang, X.8    Poljakovic, M.9    Morris Jr., S.M.10    Gladwin, M.T.11
  • 70
    • 0019798651 scopus 로고
    • Serum alpha-hydroxybutyrate dehydrogenase levels in children with sickle cell disease
    • Karayalcin G., Lanzkowsky P., and Kari A.B. Serum alpha-hydroxybutyrate dehydrogenase levels in children with sickle cell disease. Am. J. Pediatr. Hematol. Oncol. 3 (1981) 169-171
    • (1981) Am. J. Pediatr. Hematol. Oncol. , vol.3 , pp. 169-171
    • Karayalcin, G.1    Lanzkowsky, P.2    Kari, A.B.3
  • 72
    • 0034760144 scopus 로고    scopus 로고
    • Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia
    • Passon R.G., Howard T.A., Zimmerman S.A., Schultz W.H., and Ware R.E. Influence of bilirubin uridine diphosphate-glucuronosyltransferase 1A promoter polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia. J. Pediatr. Hematol. Oncol. 23 (2001) 448-451
    • (2001) J. Pediatr. Hematol. Oncol. , vol.23 , pp. 448-451
    • Passon, R.G.1    Howard, T.A.2    Zimmerman, S.A.3    Schultz, W.H.4    Ware, R.E.5
  • 74
    • 0027981469 scopus 로고
    • Reference values and hematologic changes from birth to 5 years in patients with sickle cell disease. Cooperative Study of Sickle Cell Disease
    • Brown A.K., Sleeper L.A., Miller S.T., Pegelow C.H., Gill F.M., and Waclawiw M.A. Reference values and hematologic changes from birth to 5 years in patients with sickle cell disease. Cooperative Study of Sickle Cell Disease. Arch. Pediatr. Adolesc. Med. 148 (1994) 796-804
    • (1994) Arch. Pediatr. Adolesc. Med. , vol.148 , pp. 796-804
    • Brown, A.K.1    Sleeper, L.A.2    Miller, S.T.3    Pegelow, C.H.4    Gill, F.M.5    Waclawiw, M.A.6
  • 75
    • 0023837736 scopus 로고
    • Hemolysis in sickle cell disease as measured by endogenous carbon monoxide production. A preliminary report
    • Solanki D.L., McCurdy P.R., Cuttitta F.F., and Schechter G.P. Hemolysis in sickle cell disease as measured by endogenous carbon monoxide production. A preliminary report. Am. J. Clin. Pathol. 89 (1988) 221-225
    • (1988) Am. J. Clin. Pathol. , vol.89 , pp. 221-225
    • Solanki, D.L.1    McCurdy, P.R.2    Cuttitta, F.F.3    Schechter, G.P.4
  • 76
    • 0017851209 scopus 로고
    • Serum-alpha-hydroxybutyrate dehydrogenase levels in sickle-cell disease and sickle-cell crisis
    • White J.M., Billimoria F., Muller M.A., Davis L.R., and Stroud C.E. Serum-alpha-hydroxybutyrate dehydrogenase levels in sickle-cell disease and sickle-cell crisis. Lancet 1 (1978) 532-533
    • (1978) Lancet , vol.1 , pp. 532-533
    • White, J.M.1    Billimoria, F.2    Muller, M.A.3    Davis, L.R.4    Stroud, C.E.5
  • 77
    • 33644764856 scopus 로고    scopus 로고
    • Hyperhemolysis during the evolution of uncomplicated acute painful episodes in patients with sickle cell anemia
    • Ballas S.K., and Marcolina M.J. Hyperhemolysis during the evolution of uncomplicated acute painful episodes in patients with sickle cell anemia. Transfusion 46 (2006) 105-110
    • (2006) Transfusion , vol.46 , pp. 105-110
    • Ballas, S.K.1    Marcolina, M.J.2
  • 78
    • 5044239523 scopus 로고    scopus 로고
    • Sickle-cell disease
    • Stuart M.J., and Nagel R.L. Sickle-cell disease. Lancet 364 (2004) 1343-1360
    • (2004) Lancet , vol.364 , pp. 1343-1360
    • Stuart, M.J.1    Nagel, R.L.2
  • 79
    • 0032946891 scopus 로고    scopus 로고
    • Erythropoietic activity in patients with sickle cell anaemia before and after treatment with hydroxyurea
    • Ballas S.K., Marcolina M.J., Dover G.J., and Barton F.B. Erythropoietic activity in patients with sickle cell anaemia before and after treatment with hydroxyurea. Br. J. Haematol. 105 (1999) 491-496
    • (1999) Br. J. Haematol. , vol.105 , pp. 491-496
    • Ballas, S.K.1    Marcolina, M.J.2    Dover, G.J.3    Barton, F.B.4
  • 80
    • 33746592856 scopus 로고    scopus 로고
    • The effect of fetal hemoglobin on the survival characteristics of sickle cells
    • Franco R.S., Yasin Z., Palascak M.B., Ciraolo P., Joiner C.H., and Rucknagel D.L. The effect of fetal hemoglobin on the survival characteristics of sickle cells. Blood 108 (2006) 1073-1076
    • (2006) Blood , vol.108 , pp. 1073-1076
    • Franco, R.S.1    Yasin, Z.2    Palascak, M.B.3    Ciraolo, P.4    Joiner, C.H.5    Rucknagel, D.L.6
  • 82
    • 0022406911 scopus 로고
    • Erythrophagocytosis in vivo in sickle cell anemia
    • Solanki D. Erythrophagocytosis in vivo in sickle cell anemia. Am. J. Hematol. 20 (1985) 353-357
    • (1985) Am. J. Hematol. , vol.20 , pp. 353-357
    • Solanki, D.1
  • 83
    • 0021280297 scopus 로고
    • Phagocytosis of sickle erythrocytes: immunologic and oxidative determinants of hemolytic anemia
    • Hebbel R.P., and Miller W.J. Phagocytosis of sickle erythrocytes: immunologic and oxidative determinants of hemolytic anemia. Blood 64 (1984) 733-741
    • (1984) Blood , vol.64 , pp. 733-741
    • Hebbel, R.P.1    Miller, W.J.2
  • 84
    • 0035045670 scopus 로고    scopus 로고
    • Therapeutic strategies for prevention of sickle cell dehydration
    • Brugnara C. Therapeutic strategies for prevention of sickle cell dehydration. Blood Cells Mol. Dis. 27 (2001) 71-80
    • (2001) Blood Cells Mol. Dis. , vol.27 , pp. 71-80
    • Brugnara, C.1
  • 87
    • 0029740898 scopus 로고    scopus 로고
    • Reverse sequestration in a case of sickle crisis
    • Lee E.S., and Chu P.C. Reverse sequestration in a case of sickle crisis. Postgrad. Med. J. 72 (1996) 487-488
    • (1996) Postgrad. Med. J. , vol.72 , pp. 487-488
    • Lee, E.S.1    Chu, P.C.2
  • 90
    • 0028040030 scopus 로고
    • Defective regulation of complement by the sickle erythrocyte: evidence for a defect in control of membrane attack complex formation
    • Test S.T., and Woolworth V.S. Defective regulation of complement by the sickle erythrocyte: evidence for a defect in control of membrane attack complex formation. Blood 83 (1994) 842-852
    • (1994) Blood , vol.83 , pp. 842-852
    • Test, S.T.1    Woolworth, V.S.2
  • 93
    • 0021799078 scopus 로고
    • Abnormal redox status of membrane-protein thiols in sickle erythrocytes
    • Rank B.H., Carlsson J., and Hebbel R.P. Abnormal redox status of membrane-protein thiols in sickle erythrocytes. J. Clin. Invest. 75 (1985) 1531-1537
    • (1985) J. Clin. Invest. , vol.75 , pp. 1531-1537
    • Rank, B.H.1    Carlsson, J.2    Hebbel, R.P.3
  • 94
    • 0018854950 scopus 로고
    • Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation of normal and sickled erythrocytes
    • Das S.K., and Nair R.C. Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation of normal and sickled erythrocytes. Br. J. Haematol. 44 (1980) 87-92
    • (1980) Br. J. Haematol. , vol.44 , pp. 87-92
    • Das, S.K.1    Nair, R.C.2
  • 95
    • 33644810234 scopus 로고    scopus 로고
    • Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy
    • Iyamu E.W., Cecil R., Parkin L., Woods G., Ohene-Frempong K., and Asakura T. Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy. Br. J. Haematol. 131 (2005) 389-394
    • (2005) Br. J. Haematol. , vol.131 , pp. 389-394
    • Iyamu, E.W.1    Cecil, R.2    Parkin, L.3    Woods, G.4    Ohene-Frempong, K.5    Asakura, T.6
  • 97
    • 44949287472 scopus 로고
    • Use of ektacytometry to determine red cell susceptibility to oxidative stress
    • Kuypers F.A., Scott M.D., Schott M.A., Lubin B., and Chiu D.T. Use of ektacytometry to determine red cell susceptibility to oxidative stress. J. Lab. Clin. Med. 116 (1990) 535-545
    • (1990) J. Lab. Clin. Med. , vol.116 , pp. 535-545
    • Kuypers, F.A.1    Scott, M.D.2    Schott, M.A.3    Lubin, B.4    Chiu, D.T.5
  • 98
    • 0021719627 scopus 로고
    • Neutrophils mediate lipid peroxidation in human red cells
    • Claster S., Chiu D.T., Quintanilha A., and Lubin B. Neutrophils mediate lipid peroxidation in human red cells. Blood 64 (1984) 1079-1084
    • (1984) Blood , vol.64 , pp. 1079-1084
    • Claster, S.1    Chiu, D.T.2    Quintanilha, A.3    Lubin, B.4
  • 99
    • 0023123126 scopus 로고
    • Neutrophil-induced K + leak in human red cells: a potential mechanism for infection-mediated hemolysis
    • Claster S., Quintanilha A., Schott M.A., Chiu D., and Lubin B. Neutrophil-induced K + leak in human red cells: a potential mechanism for infection-mediated hemolysis. J. Lab. Clin. Med. 109 (1987) 201-210
    • (1987) J. Lab. Clin. Med. , vol.109 , pp. 201-210
    • Claster, S.1    Quintanilha, A.2    Schott, M.A.3    Chiu, D.4    Lubin, B.5
  • 100
    • 0024989557 scopus 로고
    • Oxidation-induced changes in microrheologic properties of the red blood cell membrane
    • Hebbel R.P., Leung A., and Mohandas N. Oxidation-induced changes in microrheologic properties of the red blood cell membrane. Blood 76 (1990) 1015-1020
    • (1990) Blood , vol.76 , pp. 1015-1020
    • Hebbel, R.P.1    Leung, A.2    Mohandas, N.3
  • 101
    • 0028108649 scopus 로고
    • In vivo polymerization of sickle-cell hemoglobin: a theoretical study
    • Makhijani V.B., and Cokelet G.R. In vivo polymerization of sickle-cell hemoglobin: a theoretical study. Blood Cells 20 (1994) 169-183
    • (1994) Blood Cells , vol.20 , pp. 169-183
    • Makhijani, V.B.1    Cokelet, G.R.2
  • 102
    • 0025078255 scopus 로고
    • Dynamics of oxygen unloading from sickle erythrocytes
    • Makhijani V.B., Cokelet G.R., and Clark Jr. A. Dynamics of oxygen unloading from sickle erythrocytes. Biophys. J. 58 (1990) 1025-1052
    • (1990) Biophys. J. , vol.58 , pp. 1025-1052
    • Makhijani, V.B.1    Cokelet, G.R.2    Clark Jr., A.3
  • 103
    • 0027398484 scopus 로고
    • The polymerization of sickle hemoglobin in solutions and cells
    • Ferrone F.A. The polymerization of sickle hemoglobin in solutions and cells. Experientia 49 (1993) 110-117
    • (1993) Experientia , vol.49 , pp. 110-117
    • Ferrone, F.A.1
  • 104
    • 4544329005 scopus 로고    scopus 로고
    • Crowding and the polymerization of sickle hemoglobin
    • Ferrone F.A., and Rotter M.A. Crowding and the polymerization of sickle hemoglobin. J. Mol. Recognit. 17 (2004) 497-504
    • (2004) J. Mol. Recognit. , vol.17 , pp. 497-504
    • Ferrone, F.A.1    Rotter, M.A.2
  • 105
    • 0022624817 scopus 로고
    • Influence of oxygen tension on the viscoelastic behavior of red blood cells in sickle cell disease
    • Nash G.B., Johnson C.S., and Meiselman H.J. Influence of oxygen tension on the viscoelastic behavior of red blood cells in sickle cell disease. Blood 67 (1986) 110-118
    • (1986) Blood , vol.67 , pp. 110-118
    • Nash, G.B.1    Johnson, C.S.2    Meiselman, H.J.3
  • 106
    • 0035117938 scopus 로고    scopus 로고
    • Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells
    • Brown M.D., Wick T.M., and Eckman J.R. Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells. Pediatr. Pathol. Mol. Med. 20 (2001) 47-72
    • (2001) Pediatr. Pathol. Mol. Med. , vol.20 , pp. 47-72
    • Brown, M.D.1    Wick, T.M.2    Eckman, J.R.3
  • 107
    • 0036083026 scopus 로고    scopus 로고
    • Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso-occlusion
    • Montes R.A., Eckman J.R., Hsu L.L., and Wick T.M. Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vaso-occlusion. Am. J. Hematol. 70 (2002) 216-227
    • (2002) Am. J. Hematol. , vol.70 , pp. 216-227
    • Montes, R.A.1    Eckman, J.R.2    Hsu, L.L.3    Wick, T.M.4
  • 108
    • 9644295644 scopus 로고    scopus 로고
    • Sickle cell adhesion depends on hemodynamics and endothelial activation
    • discussion: 227-268
    • Wagner M.C., Eckman J.R., and Wick T.M. Sickle cell adhesion depends on hemodynamics and endothelial activation. J. Lab. Clin. Med. 144 (2004) 260-267 discussion: 227-268
    • (2004) J. Lab. Clin. Med. , vol.144 , pp. 260-267
    • Wagner, M.C.1    Eckman, J.R.2    Wick, T.M.3
  • 111
    • 0018742687 scopus 로고
    • The rate of oxygen uptake by human red blood cells
    • Coin J.T., and Olson J.S. The rate of oxygen uptake by human red blood cells. J. Biol. Chem. 254 (1979) 1178-1190
    • (1979) J. Biol. Chem. , vol.254 , pp. 1178-1190
    • Coin, J.T.1    Olson, J.S.2
  • 112
    • 0034102968 scopus 로고    scopus 로고
    • Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium
    • Space S.L., Lane P.A., Pickett C.K., and Weil J.V. Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium. Am. J. Hematol. 63 (2000) 200-204
    • (2000) Am. J. Hematol. , vol.63 , pp. 200-204
    • Space, S.L.1    Lane, P.A.2    Pickett, C.K.3    Weil, J.V.4
  • 113
    • 0027427981 scopus 로고
    • Mechanism of oxyhemoglobin-induced release of endothelin-1 from cultured vascular endothelial cells and smooth-muscle cells
    • Kasuya H., Weir B.K., White D.M., and Stefansson K. Mechanism of oxyhemoglobin-induced release of endothelin-1 from cultured vascular endothelial cells and smooth-muscle cells. J. Neurosurg. 79 (1993) 892-898
    • (1993) J. Neurosurg. , vol.79 , pp. 892-898
    • Kasuya, H.1    Weir, B.K.2    White, D.M.3    Stefansson, K.4
  • 114
    • 34548821573 scopus 로고    scopus 로고
    • Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension and nitric oxide scavenging by cell-free hemoglobin
    • Villagra J., Shiva S., Hunter L.A., Machado R.F., Gladwin M.T., and Kato G.J. Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension and nitric oxide scavenging by cell-free hemoglobin. Blood 110 (2007) 2166-2172
    • (2007) Blood , vol.110 , pp. 2166-2172
    • Villagra, J.1    Shiva, S.2    Hunter, L.A.3    Machado, R.F.4    Gladwin, M.T.5    Kato, G.J.6
  • 115
    • 0035048143 scopus 로고    scopus 로고
    • Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease
    • Mondoro T.H., Ryan B.B., Hrinczenko B.W., Schechter A.N., Vostal J.G., and Alayash A.I. Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease. Br. J. Haematol. 112 (2001) 1048-1054
    • (2001) Br. J. Haematol. , vol.112 , pp. 1048-1054
    • Mondoro, T.H.1    Ryan, B.B.2    Hrinczenko, B.W.3    Schechter, A.N.4    Vostal, J.G.5    Alayash, A.I.6
  • 116
    • 0036843943 scopus 로고    scopus 로고
    • Ability of sickle cells to scavenge endothelium-derived nitric oxide is reduced
    • Olmos L., Mombouli J.V., Wasserstrum N., and Vanhoutte P.M. Ability of sickle cells to scavenge endothelium-derived nitric oxide is reduced. Acta Pharmacol. Sin. 23 (2002) 967-973
    • (2002) Acta Pharmacol. Sin. , vol.23 , pp. 967-973
    • Olmos, L.1    Mombouli, J.V.2    Wasserstrum, N.3    Vanhoutte, P.M.4
  • 117
    • 15944398355 scopus 로고    scopus 로고
    • The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease
    • Rother R.P., Bell L., Hillmen P., and Gladwin M.T. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA 293 (2005) 1653-1662
    • (2005) JAMA , vol.293 , pp. 1653-1662
    • Rother, R.P.1    Bell, L.2    Hillmen, P.3    Gladwin, M.T.4
  • 122
    • 2942542718 scopus 로고    scopus 로고
    • Haptoglobin polymorphisms and iron homeostasis in health and in disease
    • Van Vlierberghe H., Langlois M., and Delanghe J. Haptoglobin polymorphisms and iron homeostasis in health and in disease. Clin. Chim. Acta 345 (2004) 35-42
    • (2004) Clin. Chim. Acta , vol.345 , pp. 35-42
    • Van Vlierberghe, H.1    Langlois, M.2    Delanghe, J.3
  • 123
    • 0014167324 scopus 로고
    • Rate of haptoglobin in synthesis in normal man. Determinations by the return to normal levels following hemoglobin infusion
    • Noyes W.D., and Garby L. Rate of haptoglobin in synthesis in normal man. Determinations by the return to normal levels following hemoglobin infusion. Scand. J. Clin. Lab. Invest. 20 (1967) 33-38
    • (1967) Scand. J. Clin. Lab. Invest. , vol.20 , pp. 33-38
    • Noyes, W.D.1    Garby, L.2
  • 124
    • 0014360531 scopus 로고
    • Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases
    • Muller-Eberhard U., Javid J., Liem H.H., Hanstein A., and Hanna M. Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood 32 (1968) 811-815
    • (1968) Blood , vol.32 , pp. 811-815
    • Muller-Eberhard, U.1    Javid, J.2    Liem, H.H.3    Hanstein, A.4    Hanna, M.5
  • 128
    • 33644867595 scopus 로고    scopus 로고
    • Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis
    • Liu Y., Liu J., Tetzlaff W., Paty D.W., and Cynader M.S. Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis. Free Radic. Biol. Med. 40 (2006) 960-967
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 960-967
    • Liu, Y.1    Liu, J.2    Tetzlaff, W.3    Paty, D.W.4    Cynader, M.S.5
  • 129
    • 2542577882 scopus 로고    scopus 로고
    • Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle
    • Sedlak T.W., and Snyder S.H. Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113 (2004) 1776-1782
    • (2004) Pediatrics , vol.113 , pp. 1776-1782
    • Sedlak, T.W.1    Snyder, S.H.2
  • 130
    • 34248561968 scopus 로고    scopus 로고
    • Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin-haptoglobin complex
    • Yamazaki H., Ohta K., Tsukiji H., Toma T., Hashida Y., Ishizaki A., Saito T., Arai S., Koizumi S., and Yachie A. Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin-haptoglobin complex. Biochem. Biophys. Res. Commun. 358 (2007) 506-512
    • (2007) Biochem. Biophys. Res. Commun. , vol.358 , pp. 506-512
    • Yamazaki, H.1    Ohta, K.2    Tsukiji, H.3    Toma, T.4    Hashida, Y.5    Ishizaki, A.6    Saito, T.7    Arai, S.8    Koizumi, S.9    Yachie, A.10
  • 134
    • 17344391561 scopus 로고    scopus 로고
    • Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease
    • Talano J.A., Hillery C.A., Gottschall J.L., Baylerian D.M., and Scott J.P. Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease. Pediatrics 111 (2003) e661-e665
    • (2003) Pediatrics , vol.111
    • Talano, J.A.1    Hillery, C.A.2    Gottschall, J.L.3    Baylerian, D.M.4    Scott, J.P.5
  • 135
    • 0029034749 scopus 로고
    • Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia
    • Bernini J.C., Mustafa M.M., Sutor L.J., and Buchanan G.R. Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia. J. Pediatr. 126 (1995) 813-815
    • (1995) J. Pediatr. , vol.126 , pp. 813-815
    • Bernini, J.C.1    Mustafa, M.M.2    Sutor, L.J.3    Buchanan, G.R.4
  • 136
    • 33947497535 scopus 로고    scopus 로고
    • In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease
    • Asleh R., and Levy A.P. In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease. Vasc. Health Risk Manag. 1 (2005) 19-28
    • (2005) Vasc. Health Risk Manag. , vol.1 , pp. 19-28
    • Asleh, R.1    Levy, A.P.2
  • 138
    • 3242720605 scopus 로고    scopus 로고
    • Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake
    • Afolabi P.R., Jahoor F., Gibson N.R., and Jackson A.A. Response of hepatic proteins to the lowering of habitual dietary protein to the recommended safe level of intake. Am. J. Physiol. Endocrinol. Metab. 287 (2004) E327-E330
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287
    • Afolabi, P.R.1    Jahoor, F.2    Gibson, N.R.3    Jackson, A.A.4
  • 139
    • 0035206279 scopus 로고    scopus 로고
    • Does age affect liver function and the hepatic acute phase response after major abdominal surgery?
    • Suttner S.W., Surder C., Lang K., Piper S.N., Kumle B., and Boldt J. Does age affect liver function and the hepatic acute phase response after major abdominal surgery?. Intensive Care Med. 27 (2001) 1762-1769
    • (2001) Intensive Care Med. , vol.27 , pp. 1762-1769
    • Suttner, S.W.1    Surder, C.2    Lang, K.3    Piper, S.N.4    Kumle, B.5    Boldt, J.6
  • 140
    • 14844345323 scopus 로고    scopus 로고
    • Haptoglobin genotype-and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo
    • Asleh R., Guetta J., Kalet-Litman S., Miller-Lotan R., and Levy A.P. Haptoglobin genotype-and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo. Circ. Res. 96 (2005) 435-441
    • (2005) Circ. Res. , vol.96 , pp. 435-441
    • Asleh, R.1    Guetta, J.2    Kalet-Litman, S.3    Miller-Lotan, R.4    Levy, A.P.5
  • 142
    • 33745141905 scopus 로고    scopus 로고
    • Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke
    • Lezcano N.E., Odo N., Kutlar A., Brambilla D., and Adams R.J. Regular transfusion lowers plasma free hemoglobin in children with sickle-cell disease at risk for stroke. Stroke 37 (2006) 1424-1426
    • (2006) Stroke , vol.37 , pp. 1424-1426
    • Lezcano, N.E.1    Odo, N.2    Kutlar, A.3    Brambilla, D.4    Adams, R.J.5
  • 144
    • 27644535417 scopus 로고    scopus 로고
    • Hemolysis-associated priapism in sickle cell disease
    • Nolan V.G., Wyszynski D.F., Farrer L.A., and Steinberg M.H. Hemolysis-associated priapism in sickle cell disease. Blood 106 (2005) 3264-3267
    • (2005) Blood , vol.106 , pp. 3264-3267
    • Nolan, V.G.1    Wyszynski, D.F.2    Farrer, L.A.3    Steinberg, M.H.4
  • 149
    • 26444579276 scopus 로고    scopus 로고
    • Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management
    • vii
    • Castro O., and Gladwin M.T. Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management. Hematol. Oncol. Clin. North Am. 19 (2005) 881-896 vii
    • (2005) Hematol. Oncol. Clin. North Am. , vol.19 , pp. 881-896
    • Castro, O.1    Gladwin, M.T.2
  • 150
    • 34347269612 scopus 로고    scopus 로고
    • Pulmonary hypertension in patients with sickle cell/beta thalassemia: incidence and correlation with serum N-terminal pro-brain natriuretic peptide concentrations
    • Voskaridou E., Tsetsos G., Tsoutsias A., Spyropoulou E., Christoulas D., and Terpos E. Pulmonary hypertension in patients with sickle cell/beta thalassemia: incidence and correlation with serum N-terminal pro-brain natriuretic peptide concentrations. Haematologica 92 (2007) 738-743
    • (2007) Haematologica , vol.92 , pp. 738-743
    • Voskaridou, E.1    Tsetsos, G.2    Tsoutsias, A.3    Spyropoulou, E.4    Christoulas, D.5    Terpos, E.6
  • 151
    • 34347327183 scopus 로고    scopus 로고
    • Pulmonary hypertension in sickle-cell disease: comorbidities and echocardiographic findings
    • Akgul F., Yalcin F., Seyfeli E., Ucar E., Karazincir S., Balci A., and Gali E. Pulmonary hypertension in sickle-cell disease: comorbidities and echocardiographic findings. Acta Haematol. 118 (2007) 53-60
    • (2007) Acta Haematol. , vol.118 , pp. 53-60
    • Akgul, F.1    Yalcin, F.2    Seyfeli, E.3    Ucar, E.4    Karazincir, S.5    Balci, A.6    Gali, E.7
  • 153
    • 33646231295 scopus 로고    scopus 로고
    • Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia
    • Gladwin M.T., and Kato G.J. Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia. Hematol. Am. Soc. Hematol. Educ. Program 51-57 (2005)
    • (2005) Hematol. Am. Soc. Hematol. Educ. Program , vol.51-57
    • Gladwin, M.T.1    Kato, G.J.2
  • 155
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312 (1985) 159-163
    • (1985) N. Engl. J. Med. , vol.312 , pp. 159-163
    • McCord, J.M.1
  • 156
    • 0023934253 scopus 로고
    • Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation
    • Parks D.A., Williams T.K., and Beckman J.S. Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation. Am. J. Physiol. 254 (1988) G768-G774
    • (1988) Am. J. Physiol. , vol.254
    • Parks, D.A.1    Williams, T.K.2    Beckman, J.S.3
  • 157
    • 0033582522 scopus 로고    scopus 로고
    • Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling
    • Houston M., Estevez A., Chumley P., Aslan M., Marklund S., Parks D.A., and Freeman B.A. Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. J. Biol. Chem. 274 (1999) 4985-4994
    • (1999) J. Biol. Chem. , vol.274 , pp. 4985-4994
    • Houston, M.1    Estevez, A.2    Chumley, P.3    Aslan, M.4    Marklund, S.5    Parks, D.A.6    Freeman, B.A.7
  • 158
    • 0022527932 scopus 로고
    • Significance of xanthine oxidase in capillary endothelial cells
    • Jarasch E.D., Bruder G., and Heid H.W. Significance of xanthine oxidase in capillary endothelial cells. Acta Physiol. Scand., Suppl. 548 (1986) 39-46
    • (1986) Acta Physiol. Scand., Suppl. , vol.548 , pp. 39-46
    • Jarasch, E.D.1    Bruder, G.2    Heid, H.W.3
  • 159
    • 0036530221 scopus 로고    scopus 로고
    • Hydroxyurea corrects the dysregulated L-selectin expression and increased H(2)O(2) production of polymorphonuclear neutrophils from patients with sickle cell anemia
    • Benkerrou M., Delarche C., Brahimi L., Fay M., Vilmer E., Elion J., Gougerot-Pocidalo M.A., and Elbim C. Hydroxyurea corrects the dysregulated L-selectin expression and increased H(2)O(2) production of polymorphonuclear neutrophils from patients with sickle cell anemia. Blood 99 (2002) 2297-2303
    • (2002) Blood , vol.99 , pp. 2297-2303
    • Benkerrou, M.1    Delarche, C.2    Brahimi, L.3    Fay, M.4    Vilmer, E.5    Elion, J.6    Gougerot-Pocidalo, M.A.7    Elbim, C.8
  • 160
    • 0342313670 scopus 로고    scopus 로고
    • Hydroxy-urea protects erythrocytes against oxidative damage
    • Agil A., and Sadrzadeh S.M. Hydroxy-urea protects erythrocytes against oxidative damage. Redox Rep. 5 (2000) 29-34
    • (2000) Redox Rep. , vol.5 , pp. 29-34
    • Agil, A.1    Sadrzadeh, S.M.2
  • 161
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: role in cardiovascular biology and disease
    • Griendling K.K., Sorescu D., and Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ. Res. 86 (2000) 494-501
    • (2000) Circ. Res. , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 162
    • 0036086266 scopus 로고    scopus 로고
    • Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids
    • Haynes Jr. J., and Obiako B. Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. Am. J. Physiol., Heart Circ. Physiol. 282 (2002) H122-H130
    • (2002) Am. J. Physiol., Heart Circ. Physiol. , vol.282
    • Haynes Jr., J.1    Obiako, B.2
  • 163
    • 33646060766 scopus 로고    scopus 로고
    • Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction
    • Wood K.C., Hebbel R.P., Lefer D.J., and Granger D.N. Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. Free Radic. Biol. Med. 40 (2006) 1443-1453
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 1443-1453
    • Wood, K.C.1    Hebbel, R.P.2    Lefer, D.J.3    Granger, D.N.4
  • 164
    • 0028863627 scopus 로고
    • Molecular mechanisms and therapeutic strategies related to nitric oxide
    • Moncada S., and Higgs E.A. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J. 9 (1995) 1319-1330
    • (1995) FASEB J. , vol.9 , pp. 1319-1330
    • Moncada, S.1    Higgs, E.A.2
  • 165
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: structure, function and inhibition
    • Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357 (2001) 593-615
    • (2001) Biochem. J. , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 166
    • 5444229764 scopus 로고    scopus 로고
    • Arginine supplementation improves rotorod performance in sickle transgenic mice
    • Fasipe F.R., Ubawike A.E., Eva R., and Fabry M.E. Arginine supplementation improves rotorod performance in sickle transgenic mice. Hematology 9 (2004) 301-305
    • (2004) Hematology , vol.9 , pp. 301-305
    • Fasipe, F.R.1    Ubawike, A.E.2    Eva, R.3    Fabry, M.E.4
  • 167
    • 0037082452 scopus 로고    scopus 로고
    • Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity
    • Romero J.R., Suzuka S.M., Nagel R.L., and Fabry M.E. Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity. Blood 99 (2002) 1103-1108
    • (2002) Blood , vol.99 , pp. 1103-1108
    • Romero, J.R.1    Suzuka, S.M.2    Nagel, R.L.3    Fabry, M.E.4
  • 169
    • 34247203723 scopus 로고    scopus 로고
    • [Asymmetric dimethyl arginine (ADMA): a novel cardiovascular risk factor?]
    • Stuhlinger M. [Asymmetric dimethyl arginine (ADMA): a novel cardiovascular risk factor?]. Wien Med. Wochenschr. 157 (2007) 57-60
    • (2007) Wien Med. Wochenschr. , vol.157 , pp. 57-60
    • Stuhlinger, M.1
  • 170
    • 10044245949 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats
    • Meininger C.J., Cai S., Parker J.L., Channon K.M., Kelly K.A., Becker E.J., Wood M.K., Wade L.A., and Wu G. GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats. FASEB J. 18 (2004) 1900-1902
    • (2004) FASEB J. , vol.18 , pp. 1900-1902
    • Meininger, C.J.1    Cai, S.2    Parker, J.L.3    Channon, K.M.4    Kelly, K.A.5    Becker, E.J.6    Wood, M.K.7    Wade, L.A.8    Wu, G.9
  • 171
    • 85047690420 scopus 로고    scopus 로고
    • Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression
    • Alp N.J., Mussa S., Khoo J., Cai S., Guzik T., Jefferson A., Goh N., Rockett K.A., and Channon K.M. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J. Clin. Invest. 112 (2003) 725-735
    • (2003) J. Clin. Invest. , vol.112 , pp. 725-735
    • Alp, N.J.1    Mussa, S.2    Khoo, J.3    Cai, S.4    Guzik, T.5    Jefferson, A.6    Goh, N.7    Rockett, K.A.8    Channon, K.M.9
  • 172
    • 0041915626 scopus 로고    scopus 로고
    • Gene transfer of human guanosine 5′-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension
    • Zheng J.S., Yang X.Q., Lookingland K.J., Fink G.D., Hesslinger C., Kapatos G., Kovesdi I., and Chen A.F. Gene transfer of human guanosine 5′-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation 108 (2003) 1238-1245
    • (2003) Circulation , vol.108 , pp. 1238-1245
    • Zheng, J.S.1    Yang, X.Q.2    Lookingland, K.J.3    Fink, G.D.4    Hesslinger, C.5    Kapatos, G.6    Kovesdi, I.7    Chen, A.F.8
  • 173
    • 0035726142 scopus 로고    scopus 로고
    • Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats
    • Hong H.J., Hsiao G., Cheng T.H., and Yen M.H. Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 38 (2001) 1044-1048
    • (2001) Hypertension , vol.38 , pp. 1044-1048
    • Hong, H.J.1    Hsiao, G.2    Cheng, T.H.3    Yen, M.H.4
  • 174
    • 0034739459 scopus 로고    scopus 로고
    • Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis
    • Tiefenbacher C.P., Bleeke T., Vahl C., Amann K., Vogt A., and Kubler W. Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis. Circulation 102 (2000) 2172-2179
    • (2000) Circulation , vol.102 , pp. 2172-2179
    • Tiefenbacher, C.P.1    Bleeke, T.2    Vahl, C.3    Amann, K.4    Vogt, A.5    Kubler, W.6
  • 175
    • 1542344000 scopus 로고    scopus 로고
    • Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
    • Alp N.J., McAteer M.A., Khoo J., Choudhury R.P., and Channon K.M. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 445-450
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 445-450
    • Alp, N.J.1    McAteer, M.A.2    Khoo, J.3    Choudhury, R.P.4    Channon, K.M.5
  • 176
    • 33644524711 scopus 로고    scopus 로고
    • Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia
    • Hasanato R.M. Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia. Ann. Saudi Med. 26 (2006) 17-21
    • (2006) Ann. Saudi Med. , vol.26 , pp. 17-21
    • Hasanato, R.M.1
  • 177
    • 0036157124 scopus 로고    scopus 로고
    • Zinc deficiency in patients with sickle cell disease
    • Prasad A.S. Zinc deficiency in patients with sickle cell disease. Am. J. Clin. Nutr. 75 (2002) 181-182
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 181-182
    • Prasad, A.S.1
  • 178
    • 41549150923 scopus 로고    scopus 로고
    • Compromised antioxidants status may partly explain the low levels of eicosapentaenoic and docosahexaaenoic acids in patients with sickle cell disease [abstract]
    • St Louis, MO
    • Ren H., Ghebremeskel K., Lee A., Okpala I., Ibegulam O., Ugochukwu C., and Crawford M. Compromised antioxidants status may partly explain the low levels of eicosapentaenoic and docosahexaaenoic acids in patients with sickle cell disease [abstract]. 97th AOCS Annual Meeting and Expo (2006) St Louis, MO
    • (2006) 97th AOCS Annual Meeting and Expo
    • Ren, H.1    Ghebremeskel, K.2    Lee, A.3    Okpala, I.4    Ibegulam, O.5    Ugochukwu, C.6    Crawford, M.7
  • 179
    • 0023833103 scopus 로고
    • Altered amount and activity of superoxide dismutase in sickle cell anemia
    • Schacter L., Warth J.A., Gordon E.M., Prasad A., and Klein B.L. Altered amount and activity of superoxide dismutase in sickle cell anemia. FASEB J. 2 (1988) 237-243
    • (1988) FASEB J. , vol.2 , pp. 237-243
    • Schacter, L.1    Warth, J.A.2    Gordon, E.M.3    Prasad, A.4    Klein, B.L.5
  • 180
    • 3943095410 scopus 로고    scopus 로고
    • Pro-oxidant and anti-oxidant status in patients of sickle cell anaemia
    • Titus J., Suresh C., Gupta M., and Parekh N. Pro-oxidant and anti-oxidant status in patients of sickle cell anaemia. Indian J. Clin. Biochem. 19 (2004) 168-172
    • (2004) Indian J. Clin. Biochem. , vol.19 , pp. 168-172
    • Titus, J.1    Suresh, C.2    Gupta, M.3    Parekh, N.4
  • 184
  • 185
    • 0020510926 scopus 로고
    • Impaired pentose phosphate shunt function in sickle cell disease: a potential mechanism for increased Heinz body formation and membrane lipid peroxidation
    • Lachant N.A., Davidson W.D., and Tanaka K.R. Impaired pentose phosphate shunt function in sickle cell disease: a potential mechanism for increased Heinz body formation and membrane lipid peroxidation. Am. J. Hematol. 15 (1983) 1-13
    • (1983) Am. J. Hematol. , vol.15 , pp. 1-13
    • Lachant, N.A.1    Davidson, W.D.2    Tanaka, K.R.3
  • 186
    • 0029025475 scopus 로고
    • Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
    • Charache S., Terrin M.L., Moore R.D., Dover G.J., Barton F.B., Eckert S.V., McMahon R.P., and Bonds D.R. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N. Engl. J. Med. 332 (1995) 1317-1322
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1317-1322
    • Charache, S.1    Terrin, M.L.2    Moore, R.D.3    Dover, G.J.4    Barton, F.B.5    Eckert, S.V.6    McMahon, R.P.7    Bonds, D.R.8
  • 188
    • 0034728917 scopus 로고    scopus 로고
    • Pathogenesis and treatment of acute chest syndrome of sickle-cell anaemia
    • Gladwin M.T., and Rodgers G.P. Pathogenesis and treatment of acute chest syndrome of sickle-cell anaemia. Lancet 355 (2000) 1476-1478
    • (2000) Lancet , vol.355 , pp. 1476-1478
    • Gladwin, M.T.1    Rodgers, G.P.2
  • 189
    • 0036330307 scopus 로고    scopus 로고
    • Hydroxyurea treatment of sickle cell anemia in hospital-based practices
    • Ferguson R.P., Arun A., Carter C., Walker S.D., and Castro O. Hydroxyurea treatment of sickle cell anemia in hospital-based practices. Am. J. Hematol. 70 (2002) 326-328
    • (2002) Am. J. Hematol. , vol.70 , pp. 326-328
    • Ferguson, R.P.1    Arun, A.2    Carter, C.3    Walker, S.D.4    Castro, O.5
  • 192
    • 18244422547 scopus 로고    scopus 로고
    • Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
    • Moore R.D., Charache S., Terrin M.L., Barton F.B., and Ballas S.K. Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Am. J. Hematol. 64 (2000) 26-31
    • (2000) Am. J. Hematol. , vol.64 , pp. 26-31
    • Moore, R.D.1    Charache, S.2    Terrin, M.L.3    Barton, F.B.4    Ballas, S.K.5
  • 193
    • 20044371448 scopus 로고    scopus 로고
    • Hydroxyurea therapy for sickle cell disease in community-based practices: a survey of Florida and North Carolina hematologists/oncologists
    • Zumberg M.S., Reddy S., Boyette R.L., Schwartz R.J., Konrad T.R., and Lottenberg R. Hydroxyurea therapy for sickle cell disease in community-based practices: a survey of Florida and North Carolina hematologists/oncologists. Am. J. Hematol. 79 (2005) 107-113
    • (2005) Am. J. Hematol. , vol.79 , pp. 107-113
    • Zumberg, M.S.1    Reddy, S.2    Boyette, R.L.3    Schwartz, R.J.4    Konrad, T.R.5    Lottenberg, R.6
  • 194
    • 41549087189 scopus 로고    scopus 로고
    • National Toxicology Program-Center for the Evaluation of Risks to Human Reproduction U. S. D. o. H. a. H. S. White Paper on Hydroxyurea Risk:Benefit Oct 2007. In: NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea, 2007.
    • National Toxicology Program-Center for the Evaluation of Risks to Human Reproduction U. S. D. o. H. a. H. S. White Paper on Hydroxyurea Risk:Benefit Oct 2007. In: NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea, 2007.
  • 195
    • 0032873984 scopus 로고    scopus 로고
    • Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy
    • Saleh A.W., Hillen H.F., and Duits A.J. Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy. Acta Haematol. 102 (1999) 31-37
    • (1999) Acta Haematol. , vol.102 , pp. 31-37
    • Saleh, A.W.1    Hillen, H.F.2    Duits, A.J.3
  • 196
    • 3342982985 scopus 로고    scopus 로고
    • Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea
    • Conran N., Fattori A., Saad S.T., and Costa F.F. Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea. Am. J. Hematol. 76 (2004) 343-347
    • (2004) Am. J. Hematol. , vol.76 , pp. 343-347
    • Conran, N.1    Fattori, A.2    Saad, S.T.3    Costa, F.F.4
  • 197
    • 34047202625 scopus 로고    scopus 로고
    • Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity
    • Cokic V.P., Beleslin-Cokic B.B., Noguchi C.T., and Schechter A.N. Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity. Nitric Oxide 16 (2007) 371-378
    • (2007) Nitric Oxide , vol.16 , pp. 371-378
    • Cokic, V.P.1    Beleslin-Cokic, B.B.2    Noguchi, C.T.3    Schechter, A.N.4
  • 199
    • 3042554283 scopus 로고    scopus 로고
    • Catalase-mediated nitric oxide formation from hydroxyurea
    • Huang J., Kim-Shapiro D.B., and King S.B. Catalase-mediated nitric oxide formation from hydroxyurea. J. Med. Chem. 47 (2004) 3495-3501
    • (2004) J. Med. Chem. , vol.47 , pp. 3495-3501
    • Huang, J.1    Kim-Shapiro, D.B.2    King, S.B.3
  • 200
    • 4043163356 scopus 로고    scopus 로고
    • Nitric oxide production from hydroxyurea
    • King S.B. Nitric oxide production from hydroxyurea. Free Radic. Biol. Med. 37 (2004) 737-744
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 737-744
    • King, S.B.1
  • 201
    • 0029944579 scopus 로고    scopus 로고
    • Hydroxyurea reacts with heme proteins to generate nitric oxide
    • Pacelli R., Taira J., Cook J.A., Wink D.A., and Krishna M.C. Hydroxyurea reacts with heme proteins to generate nitric oxide. Lancet 347 (1996) 900
    • (1996) Lancet , vol.347 , pp. 900
    • Pacelli, R.1    Taira, J.2    Cook, J.A.3    Wink, D.A.4    Krishna, M.C.5
  • 205
    • 0032977037 scopus 로고    scopus 로고
    • Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea
    • Glover R.E., Ivy E.D., Orringer E.P., Maeda H., and Mason R.P. Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea. Mol. Pharmacol. 55 (1999) 1006-1010
    • (1999) Mol. Pharmacol. , vol.55 , pp. 1006-1010
    • Glover, R.E.1    Ivy, E.D.2    Orringer, E.P.3    Maeda, H.4    Mason, R.P.5
  • 206
    • 0034466430 scopus 로고    scopus 로고
    • Nitric oxide metabolites in sickle cell anemia patients after oral administration of hydroxyurea, hemoglobinopathy
    • Nahavandi M., Wyche M.Q., Perlin E., Tavakkoli F., and Castro O. Nitric oxide metabolites in sickle cell anemia patients after oral administration of hydroxyurea, hemoglobinopathy. Hematology 5 (2000) 335-339
    • (2000) Hematology , vol.5 , pp. 335-339
    • Nahavandi, M.1    Wyche, M.Q.2    Perlin, E.3    Tavakkoli, F.4    Castro, O.5
  • 207
    • 34247470728 scopus 로고    scopus 로고
    • Pulmonary hypertension in sickle cell disease: relevance to children
    • Kato G.J., Onyekwere O.C., and Gladwin M.T. Pulmonary hypertension in sickle cell disease: relevance to children. Pediatr. Hematol. Oncol. 24 (2007) 159-170
    • (2007) Pediatr. Hematol. Oncol. , vol.24 , pp. 159-170
    • Kato, G.J.1    Onyekwere, O.C.2    Gladwin, M.T.3
  • 208
    • 27644533273 scopus 로고    scopus 로고
    • Enalapril and hydroxyurea therapy for children with sickle nephropathy
    • Fitzhugh C.D., Wigfall D.R., and Ware R.E. Enalapril and hydroxyurea therapy for children with sickle nephropathy. Pediatr. Blood Cancer 45 (2005) 982-985
    • (2005) Pediatr. Blood Cancer , vol.45 , pp. 982-985
    • Fitzhugh, C.D.1    Wigfall, D.R.2    Ware, R.E.3
  • 211
    • 0027982886 scopus 로고
    • Variable degrees of suppression of hemoglobin S synthesis in subjects with hemoglobin SS disease on a long-term transfusion regimen
    • Zinkham W.H., Seidler A.J., and Kickler T.S. Variable degrees of suppression of hemoglobin S synthesis in subjects with hemoglobin SS disease on a long-term transfusion regimen. J. Pediatr. 124 (1994) 215-219
    • (1994) J. Pediatr. , vol.124 , pp. 215-219
    • Zinkham, W.H.1    Seidler, A.J.2    Kickler, T.S.3
  • 212
    • 0032952492 scopus 로고    scopus 로고
    • Serum transferrin receptor as a marker of erythropoiesis suppression in patients on chronic transfusion
    • Tancabelic J., Sheth S., Paik M., and Piomelli S. Serum transferrin receptor as a marker of erythropoiesis suppression in patients on chronic transfusion. Am. J. Hematol. 60 (1999) 121-125
    • (1999) Am. J. Hematol. , vol.60 , pp. 121-125
    • Tancabelic, J.1    Sheth, S.2    Paik, M.3    Piomelli, S.4
  • 214
    • 33846707289 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation for sickle cell disease: state of the art
    • Krishnamurti L. Hematopoietic cell transplantation for sickle cell disease: state of the art. Expert Opin. Biol. Ther. 7 (2007) 161-172
    • (2007) Expert Opin. Biol. Ther. , vol.7 , pp. 161-172
    • Krishnamurti, L.1
  • 215
    • 0030054553 scopus 로고    scopus 로고
    • Bone marrow transplantation in sickle cell anemia-the dilemma of choice
    • Platt O.S., and Guinan E.C. Bone marrow transplantation in sickle cell anemia-the dilemma of choice. N. Engl. J. Med. 335 (1996) 426-428
    • (1996) N. Engl. J. Med. , vol.335 , pp. 426-428
    • Platt, O.S.1    Guinan, E.C.2
  • 216
    • 0037371369 scopus 로고    scopus 로고
    • Decreased exhaled nitric oxide in sickle cell disease: relationship with chronic lung involvement
    • Girgis R.E., Qureshi M.A., Abrams J., and Swerdlow P. Decreased exhaled nitric oxide in sickle cell disease: relationship with chronic lung involvement. Am. J. Hematol. 72 (2003) 177-184
    • (2003) Am. J. Hematol. , vol.72 , pp. 177-184
    • Girgis, R.E.1    Qureshi, M.A.2    Abrams, J.3    Swerdlow, P.4
  • 217
    • 0037372314 scopus 로고    scopus 로고
    • An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy
    • Reiter C.D., and Gladwin M.T. An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy. Curr. Opin. Hematol. 10 (2003) 99-107
    • (2003) Curr. Opin. Hematol. , vol.10 , pp. 99-107
    • Reiter, C.D.1    Gladwin, M.T.2
  • 219
    • 33748133932 scopus 로고    scopus 로고
    • Inhaled nitric oxide for treatment of sickle cell stroke
    • Montero-Huerta P., Hess D.R., and Head C.A. Inhaled nitric oxide for treatment of sickle cell stroke. Anesthesiology 105 (2006) 619-621
    • (2006) Anesthesiology , vol.105 , pp. 619-621
    • Montero-Huerta, P.1    Hess, D.R.2    Head, C.A.3
  • 220
    • 0030669447 scopus 로고    scopus 로고
    • Inhaled nitric oxide in sickle cell disease with acute chest syndrome
    • Atz A.M., and Wessel D.L. Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology 87 (1997) 988-990
    • (1997) Anesthesiology , vol.87 , pp. 988-990
    • Atz, A.M.1    Wessel, D.L.2
  • 221
    • 0032738619 scopus 로고    scopus 로고
    • Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent
    • Sullivan K.J., Goodwin S.R., Evangelist J., Moore R.D., and Mehta P. Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. Crit. Care Med. 27 (1999) 2563-2568
    • (1999) Crit. Care Med. , vol.27 , pp. 2563-2568
    • Sullivan, K.J.1    Goodwin, S.R.2    Evangelist, J.3    Moore, R.D.4    Mehta, P.5
  • 222
    • 0042860078 scopus 로고    scopus 로고
    • Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide
    • Zuzak K.J., Gladwin M.T., Cannon III R.O., and Levin I.W. Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide. Am. J. Physiol., Heart Circ. Physiol. 285 (2003) H1183-H1189
    • (2003) Am. J. Physiol., Heart Circ. Physiol. , vol.285
    • Zuzak, K.J.1    Gladwin, M.T.2    Cannon III, R.O.3    Levin, I.W.4
  • 223
    • 0037420269 scopus 로고    scopus 로고
    • Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease
    • Weiner D.L., Hibberd P.L., Betit P., Cooper A.B., Botelho C.A., and Brugnara C. Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA 289 (2003) 1136-1142
    • (2003) JAMA , vol.289 , pp. 1136-1142
    • Weiner, D.L.1    Hibberd, P.L.2    Betit, P.3    Cooper, A.B.4    Botelho, C.A.5    Brugnara, C.6
  • 224
    • 0030982849 scopus 로고    scopus 로고
    • Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury
    • Bloomfield G.L., Holloway S., Ridings P.C., Fisher B.J., Blocher C.R., Sholley M., Bunch T., Sugerman H.J., and Fowler A.A. Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury. Crit. Care Med. 25 (1997) 584-593
    • (1997) Crit. Care Med. , vol.25 , pp. 584-593
    • Bloomfield, G.L.1    Holloway, S.2    Ridings, P.C.3    Fisher, B.J.4    Blocher, C.R.5    Sholley, M.6    Bunch, T.7    Sugerman, H.J.8    Fowler, A.A.9
  • 225
    • 0031975630 scopus 로고    scopus 로고
    • Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group
    • Dellinger R.P., Zimmerman J.L., Taylor R.W., Straube R.C., Hauser D.L., Criner G.J., Davis Jr. K., Hyers T.M., and Papadakos P. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit. Care Med. 26 (1998) 15-23
    • (1998) Crit. Care Med. , vol.26 , pp. 15-23
    • Dellinger, R.P.1    Zimmerman, J.L.2    Taylor, R.W.3    Straube, R.C.4    Hauser, D.L.5    Criner, G.J.6    Davis Jr., K.7    Hyers, T.M.8    Papadakos, P.9
  • 226
    • 0029792742 scopus 로고    scopus 로고
    • Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs
    • Guidot D.M., Hybertson B.M., Kitlowski R.P., and Repine J.E. Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs. Am. J. Physiol. 271 (1996) L225-L229
    • (1996) Am. J. Physiol. , vol.271
    • Guidot, D.M.1    Hybertson, B.M.2    Kitlowski, R.P.3    Repine, J.E.4
  • 231
    • 0026680709 scopus 로고
    • Iron release and membrane damage in erythrocytes exposed to oxidizing agents, phenylhydrazine, divicine and isouramil
    • Ferrali M., Signorini C., Ciccoli L., and Comporti M. Iron release and membrane damage in erythrocytes exposed to oxidizing agents, phenylhydrazine, divicine and isouramil. Biochem. J. 285 Pt 1 (1992) 295-301
    • (1992) Biochem. J. , vol.285 , Issue.PART 1 , pp. 295-301
    • Ferrali, M.1    Signorini, C.2    Ciccoli, L.3    Comporti, M.4
  • 232
    • 0029097965 scopus 로고
    • Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo
    • Shalev O., Repka T., Goldfarb A., Grinberg L., Abrahamov A., Olivieri N.F., Rachmilewitz E.A., and Hebbel R.P. Deferiprone (L1) chelates pathologic iron deposits from membranes of intact thalassemic and sickle red blood cells both in vitro and in vivo. Blood 86 (1995) 2008-2013
    • (1995) Blood , vol.86 , pp. 2008-2013
    • Shalev, O.1    Repka, T.2    Goldfarb, A.3    Grinberg, L.4    Abrahamov, A.5    Olivieri, N.F.6    Rachmilewitz, E.A.7    Hebbel, R.P.8
  • 236
    • 0035199811 scopus 로고    scopus 로고
    • Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research
    • Bolli R. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. J. Mol. Cell. Cardiol. 33 (2001) 1897-1918
    • (2001) J. Mol. Cell. Cardiol. , vol.33 , pp. 1897-1918
    • Bolli, R.1
  • 237
    • 0037304475 scopus 로고    scopus 로고
    • The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart
    • Bell R.M., Maddock H.L., and Yellon D.M. The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart. Cardiovasc. Res. 57 (2003) 405-415
    • (2003) Cardiovasc. Res. , vol.57 , pp. 405-415
    • Bell, R.M.1    Maddock, H.L.2    Yellon, D.M.3
  • 238
    • 29444432915 scopus 로고    scopus 로고
    • The ubiquitous role of nitric oxide in cardioprotection
    • Jones S.P., and Bolli R. The ubiquitous role of nitric oxide in cardioprotection. J. Mol. Cell. Cardiol. 40 (2006) 16-23
    • (2006) J. Mol. Cell. Cardiol. , vol.40 , pp. 16-23
    • Jones, S.P.1    Bolli, R.2
  • 240
    • 34250776600 scopus 로고    scopus 로고
    • Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
    • Dezfulian C., Raat N., Shiva S., and Gladwin M.T. Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc. Res. 75 (2007) 327-338
    • (2007) Cardiovasc. Res. , vol.75 , pp. 327-338
    • Dezfulian, C.1    Raat, N.2    Shiva, S.3    Gladwin, M.T.4
  • 241
    • 23944440347 scopus 로고    scopus 로고
    • Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury
    • Lu P., Liu F., Yao Z., Wang C.Y., Chen D.D., Tian Y., Zhang J.H., and Wu Y.H. Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury. Hepatobiliary Pancreat. Dis. Int. 4 (2005) 350-355
    • (2005) Hepatobiliary Pancreat. Dis. Int. , vol.4 , pp. 350-355
    • Lu, P.1    Liu, F.2    Yao, Z.3    Wang, C.Y.4    Chen, D.D.5    Tian, Y.6    Zhang, J.H.7    Wu, Y.H.8
  • 242
    • 4544378255 scopus 로고    scopus 로고
    • Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    • Webb A., Bond R., McLean P., Uppal R., Benjamin N., and Ahluwalia A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13683-13688
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13683-13688
    • Webb, A.1    Bond, R.2    McLean, P.3    Uppal, R.4    Benjamin, N.5    Ahluwalia, A.6
  • 244
    • 33750934803 scopus 로고    scopus 로고
    • Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury
    • Jung K.H., Chu K., Ko S.Y., Lee S.T., Sinn D.I., Park D.K., Kim J.M., Song E.C., Kim M., and Roh J.K. Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury. Stroke 37 (2006) 2744-2750
    • (2006) Stroke , vol.37 , pp. 2744-2750
    • Jung, K.H.1    Chu, K.2    Ko, S.Y.3    Lee, S.T.4    Sinn, D.I.5    Park, D.K.6    Kim, J.M.7    Song, E.C.8    Kim, M.9    Roh, J.K.10
  • 248
    • 0028170690 scopus 로고
    • N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase
    • Boucher J.L., Custot J., Vadon S., Delaforge M., Lepoivre M., Tenu J.P., Yapo A., and Mansuy D. N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. Biochem. Biophys. Res. Commun. 203 (1994) 1614-1621
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 1614-1621
    • Boucher, J.L.1    Custot, J.2    Vadon, S.3    Delaforge, M.4    Lepoivre, M.5    Tenu, J.P.6    Yapo, A.7    Mansuy, D.8
  • 250
    • 0032555182 scopus 로고    scopus 로고
    • Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine
    • Moali C., Boucher J.L., Sari M.A., Stuehr D.J., and Mansuy D. Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. Biochemistry 37 (1998) 10453-10460
    • (1998) Biochemistry , vol.37 , pp. 10453-10460
    • Moali, C.1    Boucher, J.L.2    Sari, M.A.3    Stuehr, D.J.4    Mansuy, D.5
  • 251
    • 34447536457 scopus 로고    scopus 로고
    • Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
    • Schmidt T.S., and Alp N.J. Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin. Sci. (Lond.) 113 (2007) 47-63
    • (2007) Clin. Sci. (Lond.) , vol.113 , pp. 47-63
    • Schmidt, T.S.1    Alp, N.J.2
  • 252
    • 28844494992 scopus 로고    scopus 로고
    • Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4
    • Hasegawa H., Sawabe K., Nakanishi N., and Wakasugi O.K. Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4. Mol. Genet. Metab. 86 Suppl 1 (2005) S2-S10
    • (2005) Mol. Genet. Metab. , vol.86 , Issue.SUPPL. 1
    • Hasegawa, H.1    Sawabe, K.2    Nakanishi, N.3    Wakasugi, O.K.4
  • 254
    • 41549130997 scopus 로고    scopus 로고
    • Clinical trials in sickle cell disease: adopting the combination chemotherapy paradigm
    • Steinberg M.H. Clinical trials in sickle cell disease: adopting the combination chemotherapy paradigm. Am. J. Hematol. (2007)
    • (2007) Am. J. Hematol.
    • Steinberg, M.H.1
  • 255
    • 0034191994 scopus 로고    scopus 로고
    • Sickle cell anemia: a potential nutritional approach for a molecular disease
    • Ohnishi S.T., Ohnishi T., and Ogunmola G.B. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition 16 (2000) 330-338
    • (2000) Nutrition , vol.16 , pp. 330-338
    • Ohnishi, S.T.1    Ohnishi, T.2    Ogunmola, G.B.3
  • 256
    • 0033636562 scopus 로고    scopus 로고
    • Progress in understanding the mechanisms of action of 5-aminosalicylic acid
    • MacDermott R.P. Progress in understanding the mechanisms of action of 5-aminosalicylic acid. Am. J. Gastroenterol. 95 (2000) 3343-3345
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 3343-3345
    • MacDermott, R.P.1
  • 258
    • 0032533627 scopus 로고    scopus 로고
    • Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes
    • Sultana C., Shen Y., Rattan V., Johnson C., and Kalra V.K. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes. Blood 92 (1998) 3924-3935
    • (1998) Blood , vol.92 , pp. 3924-3935
    • Sultana, C.1    Shen, Y.2    Rattan, V.3    Johnson, C.4    Kalra, V.K.5
  • 260
    • 0035793576 scopus 로고    scopus 로고
    • Peroxynitrite: toxic or protective in the heart?
    • Ferdinandy P., and Schulz R. Peroxynitrite: toxic or protective in the heart?. Circ. Res. 88 (2001) E12-E13
    • (2001) Circ. Res. , vol.88
    • Ferdinandy, P.1    Schulz, R.2
  • 261
    • 0031015688 scopus 로고    scopus 로고
    • Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
    • Yasmin W., Strynadka K.D., and Schulz R. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc. Res. 33 (1997) 422-432
    • (1997) Cardiovasc. Res. , vol.33 , pp. 422-432
    • Yasmin, W.1    Strynadka, K.D.2    Schulz, R.3
  • 262
    • 0035132563 scopus 로고    scopus 로고
    • Improved cerebrovascular patency following therapy in patients with sickle cell disease: initial results in 4 patients who received HLA-identical hematopoietic stem cell allografts
    • Steen R.G., Helton K.J., Horwitz E.M., Benaim E., Thompson S., Bowman L.C., Krance R., Wang W.C., and Cunningham J.M. Improved cerebrovascular patency following therapy in patients with sickle cell disease: initial results in 4 patients who received HLA-identical hematopoietic stem cell allografts. Ann. Neurol. 49 (2001) 222-229
    • (2001) Ann. Neurol. , vol.49 , pp. 222-229
    • Steen, R.G.1    Helton, K.J.2    Horwitz, E.M.3    Benaim, E.4    Thompson, S.5    Bowman, L.C.6    Krance, R.7    Wang, W.C.8    Cunningham, J.M.9
  • 263
    • 0037101989 scopus 로고    scopus 로고
    • Sildenafil relieves priapism in patients with sickle cell disease
    • Bialecki E.S., and Bridges K.R. Sildenafil relieves priapism in patients with sickle cell disease. Am. J. Med. 113 (2002) 252
    • (2002) Am. J. Med. , vol.113 , pp. 252
    • Bialecki, E.S.1    Bridges, K.R.2
  • 266
    • 33646849221 scopus 로고    scopus 로고
    • Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism
    • Burnett A.L., Bivalacqua T.J., Champion H.C., and Musicki B. Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. Urology 67 (2006) 1043-1048
    • (2006) Urology , vol.67 , pp. 1043-1048
    • Burnett, A.L.1    Bivalacqua, T.J.2    Champion, H.C.3    Musicki, B.4
  • 267
    • 1542720652 scopus 로고    scopus 로고
    • Ferrario C.; ABdelhamed A. I.; Moore M. AII antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartan
    • Ferrario C.; ABdelhamed A. I.; Moore M. AII antagonists in hypertension, heart failure, and diabetic nephropathy: focus on losartan. Curr. Med. Res. Opin. 20 (2004) 279-293
    • (2004) Curr. Med. Res. Opin. , vol.20 , pp. 279-293
  • 270
    • 0036802402 scopus 로고    scopus 로고
    • Pulmonary hypertension in sickle cell hemoglobinopathy: a clinicopathologic study of 20 cases
    • Haque A.K., Gokhale S., Rampy B.A., Adegboyega P., Duarte A., and Saldana M.J. Pulmonary hypertension in sickle cell hemoglobinopathy: a clinicopathologic study of 20 cases. Hum. Pathol. 33 (2002) 1037-1043
    • (2002) Hum. Pathol. , vol.33 , pp. 1037-1043
    • Haque, A.K.1    Gokhale, S.2    Rampy, B.A.3    Adegboyega, P.4    Duarte, A.5    Saldana, M.J.6
  • 271
    • 0036095651 scopus 로고    scopus 로고
    • Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes
    • Aessopos A., Farmakis D., and Loukopoulos D. Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes. Blood 99 (2002) 30-35
    • (2002) Blood , vol.99 , pp. 30-35
    • Aessopos, A.1    Farmakis, D.2    Loukopoulos, D.3
  • 272
    • 0025528264 scopus 로고
    • Vascular lesions in the central nervous system in sickle cell disease (neuropathology)
    • Koshy M., Thomas C., and Goodwin J. Vascular lesions in the central nervous system in sickle cell disease (neuropathology). J. Assoc. Acad. Minor Phys. 1 (1990) 71-78
    • (1990) J. Assoc. Acad. Minor Phys. , vol.1 , pp. 71-78
    • Koshy, M.1    Thomas, C.2    Goodwin, J.3
  • 273
    • 0025740501 scopus 로고
    • Intracranial aneurysms in sickle-cell anemia: clinical features and pathogenesis
    • Oyesiku N.M., Barrow D.L., Eckman J.R., Tindall S.C., and Colohan A.R. Intracranial aneurysms in sickle-cell anemia: clinical features and pathogenesis. J. Neurosurg. 75 (1991) 356-363
    • (1991) J. Neurosurg. , vol.75 , pp. 356-363
    • Oyesiku, N.M.1    Barrow, D.L.2    Eckman, J.R.3    Tindall, S.C.4    Colohan, A.R.5
  • 277
    • 27644445541 scopus 로고    scopus 로고
    • Incidence and natural history of proliferative sickle cell retinopathy: observations from a cohort study
    • Downes S.M., Hambleton I.R., Chuang E.L., Lois N., Serjeant G.R., and Bird A.C. Incidence and natural history of proliferative sickle cell retinopathy: observations from a cohort study. Ophthalmology 112 (2005) 1869-1875
    • (2005) Ophthalmology , vol.112 , pp. 1869-1875
    • Downes, S.M.1    Hambleton, I.R.2    Chuang, E.L.3    Lois, N.4    Serjeant, G.R.5    Bird, A.C.6
  • 278
    • 0031977392 scopus 로고    scopus 로고
    • Intracranial aneurysms and sickle cell anemia: multiplicity and propensity for the vertebrobasilar territory
    • discussion 977-978
    • Preul M.C., Cendes F., Just N., and Mohr G. Intracranial aneurysms and sickle cell anemia: multiplicity and propensity for the vertebrobasilar territory. Neurosurgery 42 (1998) 971-977 discussion 977-978
    • (1998) Neurosurgery , vol.42 , pp. 971-977
    • Preul, M.C.1    Cendes, F.2    Just, N.3    Mohr, G.4
  • 279
    • 0033819662 scopus 로고    scopus 로고
    • Management of multiple intracranial aneurysms: neuroanesthetic considerations of sickle cell disease
    • Firth P.G., and Peterfreund R.A. Management of multiple intracranial aneurysms: neuroanesthetic considerations of sickle cell disease. J. Neurosurg. Anesthesiol. 12 (2000) 366-371
    • (2000) J. Neurosurg. Anesthesiol. , vol.12 , pp. 366-371
    • Firth, P.G.1    Peterfreund, R.A.2
  • 280
    • 34248589909 scopus 로고    scopus 로고
    • Therapy insight: stroke risk and its management in patients with sickle cell disease
    • Kirkham F.J. Therapy insight: stroke risk and its management in patients with sickle cell disease. Nat. Clin. Pract. Neurol. 3 (2007) 264-278
    • (2007) Nat. Clin. Pract. Neurol. , vol.3 , pp. 264-278
    • Kirkham, F.J.1
  • 281
    • 0242290075 scopus 로고    scopus 로고
    • Brain injury in children with sickle cell disease: prevalence and etiology
    • Steen R.G., Xiong X., Langston J.W., and Helton K.J. Brain injury in children with sickle cell disease: prevalence and etiology. Ann. Neurol. 54 (2003) 564-572
    • (2003) Ann. Neurol. , vol.54 , pp. 564-572
    • Steen, R.G.1    Xiong, X.2    Langston, J.W.3    Helton, K.J.4
  • 282
    • 0035312965 scopus 로고    scopus 로고
    • Modulation of endothelial cell activation in sickle cell disease: a pilot study
    • Solovey A.A., Solovey A.N., Harkness J., and Hebbel R.P. Modulation of endothelial cell activation in sickle cell disease: a pilot study. Blood 97 (2001) 1937-1941
    • (2001) Blood , vol.97 , pp. 1937-1941
    • Solovey, A.A.1    Solovey, A.N.2    Harkness, J.3    Hebbel, R.P.4
  • 283
    • 0036624892 scopus 로고    scopus 로고
    • Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study
    • Cheung A.T., Chen P.C., Larkin E.C., Duong P.L., Ramanujam S., Tablin F., and Wun T. Microvascular abnormalities in sickle cell disease: a computer-assisted intravital microscopy study. Blood 99 (2002) 3999-4005
    • (2002) Blood , vol.99 , pp. 3999-4005
    • Cheung, A.T.1    Chen, P.C.2    Larkin, E.C.3    Duong, P.L.4    Ramanujam, S.5    Tablin, F.6    Wun, T.7
  • 285
    • 0034047487 scopus 로고    scopus 로고
    • Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease
    • Wigfall D.R., Ware R.E., Burchinal M.R., Kinney T.R., and Foreman J.W. Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease. J. Pediatr. 136 (2000) 749-753
    • (2000) J. Pediatr. , vol.136 , pp. 749-753
    • Wigfall, D.R.1    Ware, R.E.2    Burchinal, M.R.3    Kinney, T.R.4    Foreman, J.W.5
  • 286
    • 0026162028 scopus 로고
    • The glomerulopathy of homozygous sickle hemoglobin (SS) disease: morphology and pathogenesis
    • Bhathena D.B., and Sondheimer J.H. The glomerulopathy of homozygous sickle hemoglobin (SS) disease: morphology and pathogenesis. J. Am. Soc. Nephrol. 1 (1991) 1241-1252
    • (1991) J. Am. Soc. Nephrol. , vol.1 , pp. 1241-1252
    • Bhathena, D.B.1    Sondheimer, J.H.2
  • 289
    • 1042288323 scopus 로고    scopus 로고
    • The intriguing contribution of white blood cells to sickle cell disease-a red cell disorder
    • Okpala I. The intriguing contribution of white blood cells to sickle cell disease-a red cell disorder. Blood Rev. 18 (2004) 65-73
    • (2004) Blood Rev. , vol.18 , pp. 65-73
    • Okpala, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.