Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts

Cardiovascular Research

Volumn 33, Issue 2, 1997, Pages 422-432

  Yasmin, Wahida ^a   Strynadka, Ken D ^a   Schulz, Richard ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

free radical scavenger; free radicals; myocardial ischemia; nitric oxide; peroxynitrite; rat, heart; reperfusion

Indexed keywords

CATALASE; DITYROSINE; N ACETYL S NITROSOPENICILLAMINE; N(G) METHYLARGININE; PEROXYNITRITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PENICILLAMINE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; S-NITROSO-N-ACETYLPENICILLAMINE; VASODILATOR AGENTS;

EID: 0031015688     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(96)00254-4     Document Type: Article

References (49)

1. Bolli R. Mechanism of myocardial 'stunning'. Circulation 1990;82:723-738.
2. Marban E. Myocardial stunning and hibernation: the physiology behind the colloquialisms. Circulation 1991;83:681-688.
3. Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB. Demonstration of free radical generation in 'stunned' myocardium of intact dogs with the use of the spin trap α-phenyl n-tert-butyl nitrone. J Clin Invest 1988;82:476-485.
4. Garlick PB, Davies MJ, Hearse DJ, Slater TF. Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy. Circ Res 1987;61:757-760.
5. Schulz R, Triggle CR. Role of nitric oxide in vascular smooth muscle and cardiac muscle function. Trends Pharmacol Sci 1994;15:255-259.
6. Lamas S, Marsden PA, Li GK, Tempst P, Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci USA 1992;89:6348-6352.
7. 2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992;105:575-580.
8. Balligand J-L, Kobjik L, Han X, et al. Nitric oxide-dependent parasympathetic signalling is due to activation of constitutive endothelial (Type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 1995;270:14582-14586.
9. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-2012.
10. Brady AJB, Warren JB, Poole-Wilson PA, Williams TJ, Harding SE. Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol 1993;265:H176-H182.
11. Shah AM, Lewis MJ. Modulation of myocardial contraction by endocardial and coronary vascular endothelium. Trends Cardiovasc Med 1993;3:98-103.
12. Balligand JL, Kelly RA, Marsden PA, Smith TW, Michel T. Control of cardiac muscle function by an endogenous nitric oxide signalling system. Proc Natl Acad Sci USA 1993;90:347-351.
13. Schulz R, Panas DL, Catena R, Moncada S, Olley PM, Lopaschuk GD. The role of nitric oxide in cardiac depression induced by interleukin-1β and tumour necrosis factor-a. Br J Pharmacol 1995;114:27-34.
14. Depré C, Hue L. Cyclic GMP in the perfused rat heart: effect of ischemia, anoxia and nitric oxide synthase inhibitor. FEBS Lett 1994;345:241-245.
15. Zweier JL, Wang P, Kuppusamy P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem 1995;270:304-307.
16. Node K, Kitakaze M, Kosaka H, et al. Plasma nitric oxide end products are increased in the ischemic canine heart. Biochem Biophys Res Commun 1995;211:370-374.
17. Schulz R, Wambolt R. Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischemia-reperfusion injury. Cardiovasc Res 1995;30:432-439.
18. G-nitro-L-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heart. J Mol Cell Cardiol 1995;27:419-426.
19. Depré C, Vanoverschelde J-L, Goudemant J-F, Mottet I, Hue L. Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart. Circulation 1995;92:1911-1918.
20. Zweier JL, Wang P, Samouillov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nature Med 1995;1:804-809.
21. Woolfson RG, Patel VC, Neild VC, Yellon DM. Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism. Circulation 1995;91:1545-1551.
22. Patel VC, Yellon DM, Singh KJ, Neild GH, Woolfson RG. Inhibition of nitric oxide limits infarct size in the in situ rabbit heart. Biochem Biophys Res Commun 1993;194:234-238.
23. Siegfried MR, Erhardt J, Rider T, Ma X-L, Lefer AM. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther 1992;260:668-675.
24. Weyrich AS, Ma X-L, Lefer A. The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation 1992;86:279-288.
25. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-1624.
26. Pryor W, Squadrito GL. The chemistry of peroxynitrite: from the reaction of nitric oxide and superoxide. Am J Physiol 1995;L699-L722.
27. Moro MA, Darley-Usmar VM, Goodwin DA, et al. Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci USA 1994;91:6702-6706.
28. Rubbo H, Radi R, Trujillos M, et al. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J Biol Chem 1994;269:26066-26075.
29. Villa LM, Salas E, Darley-Usmar VM, Radomski MW, Moncada S. Peroxynitrite induces both vasodilation and impaired vascular relaxation in the isolated perfused rat heart. Proc Natl Acad Sci USA 1994;91:12383-12387.
30. Wink DA, Hanbauer I, Krishna MC, DeGraff W, Gamson J, Mitchell JB. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc Natl Acad Sci USA 1994;90:9813-9817.
31. Van der Vliet A, O'Neill A, Halliwell B, Cross CE, Kaur H. Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite. FEBS Lett 1994;339:89-92.
32. Heinecke JW, Li W, Daenke III HL, Goldstein JA. Dityrosine, a specific marker of oxidation is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages. J Biol Chem 1993;268:4069-4077.
33. Giulivi C, Davies KJA. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19S) proteasome. J Biol Chem 1993;286:8752-8759.
34. Liu S, Beckman JS, Ku DD. Peroxynitrite, a product of superoxide and nitric oxide produces coronary vasorelaxation in dogs. J Pharmacol Exp Ther 1994;268:1114-1121.
35. Schulz R, Dodge KL, Lopaschuk GD, Clanachan A. Peroxynitrite impairs contractile function by decreasing cardiac efficiency. Am J Physiol 1997 (in press).
36. Nava E, Palmer RMJ, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet 1991;338:1555-1557.
37. Kelm M, Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res 1990;66:1561-1575.
38. Bates TE, Loesch A, Burnstock G, Clark JB. Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation. Biochem Biophys Res Commun 1996;218:40-44.
39. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem J 1973;134:707-716.
40. G-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res 1993;72:387-395.
41. Rees DD, Palmer RMJ, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990;101:746-752.
42. Omar BA, Flores SC, McCord JM. Superoxide dismutase: pharmacological developments and applications. Adv Pharmacol 1992;23:109-161.
43. Faulkner KM, Liochev SI, Fridovich I. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J Biol Chem 1994;269:23471-23476.
44. Yasmin W, Szabó C, Schulz R. Cell permeable superoxide dismutase mimetic protects from myocardial ischemia-reperfusion. Can J Cardiol 1996;12:114E(Abstract).
45. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651-4655.
46. van der Vliet A, Eiserich JP, O'Neill CA, Halliwell B, Cross CE. Tyrosine modification by reactive nitrogen species: a closer look. Arch Biochem Biophys 1995;319:341-349.
47. Nakashima S, Tohmatsu T, Hattori H, Okano Y, Nozawa Y. Inhibitory action of cyclic GMP on secretion, polyphosphoinositide and calcium mobilization in thrombin-stimulated human platelets. Biochem Biophys Res Commun 1986;135:1099-1104.
48. Hattler BG, Gorcsan J, Shah N, et al. A potential role for nitric oxide in myocardial stunning. J Cardiac Surg 1994;9:425-429.
49. Matheis G, Sherman MP, Buckberg GD, Haybron DM, Young HH, Ignarro LJ. Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol 1992;262:H616-H620.