Haptoglobin polymorphisms and iron homeostasis in health and in disease

Clinica Chimica Acta

Volumn 345, Issue 1-2, 2004, Pages 35-42

  Van Vlierberghe, H ^a   Langlois, M ^b   Delanghe, J ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b General Hospital St Jan   (Belgium)

Author keywords

Haptoglobin; Hemochromatosis; Iron

Indexed keywords

HAPTOGLOBIN; IRON; PLASMA PROTEIN;

ANGIOGENESIS; ATHEROSCLEROSIS; BACTERIOSTASIS; CARDIOVASCULAR DISEASE; DISEASE COURSE; HEALTH; HEMOCHROMATOSIS; HEMOLYSIS; HOMEOSTASIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; INFECTION; IRON METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; REVIEW; RISK FACTOR;

DISEASE; DISEASE PROGRESSION; HAPTOGLOBINS; HEALTH; HOMEOSTASIS; HUMANS; IRON; POLYMORPHISM, GENETIC;

EID: 2942542718     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2004.03.016     Document Type: Review

References (60)

1. Langlois M.R., Delanghe J.R. Biological and clinical significance of haptoglobin polymorphism in humans. Clin. Chem. 42:1996;1589-1600
2. Giblett E.R. The haptoglobin system. Ser. Haematol. 1:1968;3-20
3. Bowman B.H. Haptoglobin. Bowman B.H. Hepatic Plasma Proteins. 1993;159-167 Academic Press, San Diego
4. Schultze H.E., Heremans J.F., et al. Molecular Biology of Human Proteins. Nature and Metabolism of Extracellular Proteins. vol. 1:1966;384-402 Elsevier, Amsterdam
5. Lange V. Der Haptoglobin Polymorphismus-nicht nur eine genetische Markierungshilfe. (Review) Anthropol. Anz. 50:1992;281-302
6. Smithies O. Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem. J. 61:1955;629-641
7. Thomas L., Fateh-Moghadam A., Guder W.G., Hofmann W., Reiber H., Lammers M. Proteindiagnostik. 1991;92-93 Behringwerke, Frankfurt a.M
8. Raynes J.G., Eagling S., McAdam K.P. Acute-phase protein synthesis in human hepatoma cells: differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin-1 and interleukin-6. Clin. Exp. Immunol. 83:1991;488-491
9. Thomas L. Haptoglobin/hämopexin. Thomas L. Labor und Diagnose. 4th ed. 1992;813-820 Medizinische Verlagsgesellschaft, Marburg
10. Louagie H.K., Brouwer J.T., Delanghe J.R., De Buyzere M.L., Leroux-Roels G.G. Haptoglobin polymorphism and chronic hepatitis C. J. Hepatol. 25:1996;10-14
11. Okazaki T., Yangisawa Y., Nagai T. Analysis of the affinity of each haptoglobin polymer for hemoglobin by two-dimensional affinity chromatography electrophoresis. Clin. Chim. Acta. 258:1997;137-144
12. Garby L., Noyes W.D. Studies on hemoglobin metabolism: I. The kinetic properties of the plasma hemoglobin pool in normal man. J. Clin. Invest. 38:1959;1479-1483
13. Delanghe J.R., Langlois M.R. Hemopexin: a review of biological aspects and the role in laboratory medicine. Clin. Chim. Acta. 312:2001;13-23
14. Javid J. The effect of haptoglobin-polymer size on hemoglobin binding capacity. Vox Sang. 10:1965;320-325
15. Delanghe J.R., Allcock K., Langlois M.R., Claeys L., De Buyzere M.L. Fast determination of haptoglobin phenotype and calculation of hemoglobin-binding capacity using high pressure gel permeation chromatography. Clin. Chim. Acta. 291:2000;43-51
16. Sadrzadeh S.M.H., Graf E., Panter S.S., Hallaway P.E., Eaton J.W. Hemoglobin - a biologic Fenton reagent. J. Biol. Chem. 259:1984;14354-14356
17. Gutteridge J.M.C. Lipid peroxidation and antioxidants as biomarker of tissue damage. Clin. Chem. 41:1995;1819-1828
18. Gutteridge J.M.C. The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochim. Biophys. Acta. 917:1987;219-223
19. Miller Y., Altamentova S., Shaklai N. Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry. 36:1997;12189-12198
20. Lim S.K., Kim H., Lim S.K., bin Ali A., Lim Y.K., Wang Y., et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood. 92:1998;1870-1877
21. Lim Y.K., Jenner A., Ali A.B., Wang Y., Hsu S.I., Chong S.M., et al. Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis. Kidney Int. 58:2000;1033-1044
22. Panter S.S., Sadrzadeh S.M.H., Hallaway P.E., Haines J.L., Andersen V.E., Eaton J.W. Hypohaptoglobinemia associated with familial epilepsy. J. Exp. Med. 161:1985;748-754
23. Kristiansen M., Graversen J.H., Jacobsen C., Sonne O., Hoffman H.-J., Lax S.K.A., et al. Identification of the haemoglobin scavenger receptor. (Letter) Nature. 409:2001;198-201
24. Langlois M.R., Martin M.-E., Boelaert J.R., Beaumont C., Taes Y.E., De Buyzere M.L., et al. The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males. Clin. Chem. 46:2000;1619-1625
25. Cozzi A., Corsi B., Levi S., Santambrogio P., Biasiotto G., Arosio P. Analysis of the biological functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin. Blood. 103:2004;2377-2383
26. Klausner R.D., Rouault T.A., Harford J.B. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell. 72:1993;19-28
27. Hentze M., Kühn L.C. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 93:1996;8175-8182
28. Ponka P., Beaumont C., Richardson D.R. Function and regulation of transferrin and ferritin. Semin. Hematol. 35:1998;35-54
29. El Ghmati S.M., Van Hoeyveld E.M., Van Strijp J.A.G., Ceuppens J.L., Stevens E.A.M. Identification of haptoglobin as an alternative ligand for CD11b/CD18. J. Immunol. 156:1996;2542-2552
30. Wagner L., Gessl A., Baumgartner Parzer S., Base W., Waldhäusl W., Pasternack M.S. Haptoglobin phenotyping by newly developed monoclonal antibodies. Demonstration of haptoglobin uptake into peripheral blood neutrophils and monocytes. J. Immunol. 156:1996;1989-1996
31. Berkova N., Gilbert C., Goupil S., Yan J., Korobko V., Naccache P.H. TNF-induced haptoglobin release from human neutrophils: pivotal role of the TNF p55 receptor. J. Immunol. 162:1999;6226-6232
32. Maes M., Cooreman W., Delanghe J., Scharpé S., Wauters A., Neels H., et al. Components of biological variation in plasma haptoglobin: relationships to plasma fibrinogen and immune variables, including interleukin-6 and its receptor. Clin. Chim. Acta. 239:1995;23-35
33. Langlois M.R., Delanghe J.R., Philippé J., Ouyang J., Bernard D., De Buyzere M.L., et al. Distribution of lymphocyte subsets in bone marrow and peripheral blood is associated with haptoglobin type. Binding of haptoglobin to the B-cell lectin CD22. Eur. J. Clin. Chem. Clin. Biochem. 35:1997;199-205
34. Hanasaki K., Powell L.D., Varki A. Binding of human plasma sialoglycoproteins by the B-cell specific lectin CD22. Selective recognition of immunoglobulin A and haptoglobin. J. Biol. Chem. 270:1995;7543-7550
35. Köhler W., Prokop O. Relationship between haptoglobin and Streptococcus pyogenes T4 antigens. (Letter) Nature. 271:1978;373
36. Prokop O., Köhler W. Haptoglobins act similar to antibodies. Zent.bl. Gynakol. 101:1979;1111-1116
37. Gordeuk V.R., McLaren G., Samowitz W. Etiologies, consequences, and treatment of iron overload. Crit. Rev. Clin. Lab. Sci. 31:1994;89-133
38. Van Vlierberghe H., Langlois M., Delanghe J., Horsmans Y., Michielsen P., Henrion J., et al. Haptoglobin phenotype 2-2 overrepresentation in Cys282Tyr hemochromatotic patients. J. Hepatol. 35:2001;707-711
39. Carter K., Bowen D.J., McCune A., Worwood M. Haptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemohromatosis: phenotype and genotype analysis. Br. J. Haematol. 22:2003;326-332
40. Beutler E., Gelbart T., Lee P. Haptoglobin polymorphism and iron homeostasis. Clin. Chem. 48:2002;2232-2235
41. Delanghe J., de Hemptinne B., Vandenbussche H., Troisi R., Decruyenaere J. Donor organ haptoglobin phenotype determines outcome in liver transplantation following hepatitis. [Abstract] Clin. Chem. 44(Suppl.):1998;A159
42. Kasvosve I., Gordeuk V.R., Delanghe J.R., Gomo Z.A., Gangaidzo I.T., Khumalo H., et al. Iron status in black persons is not influenced by haptoglobin polymorphism. Clin. Chem. Lab. Med. 40:2002;810-813
43. Tuomainen T.P., Punnonen K., Nyyssönen K., Salonen J.T. Association between body iron stores and the risk of acute myocardial infarction in men. Circulation. 97:1998;1461-1466
44. Delanghe J., Duprez D., De Buyzere M., Bergez B., Callens B., Leroux-Roels G., et al. Haptoglobin polymorphism and complications in established essential hypertension. J. Hypertens. 11:1993;861-867
45. Delanghe J., Cambier B., Langlois M., De Buyzere M., Neels H., De Bacquer D., et al. Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery. Atherosclerosis. 132:1997;215-219
46. Delanghe J., Langlois M., Duprez D., De Buyzere M., Clement D. Haptoglobin polymorphism and peripheral arterial occlusive disease. Atherosclerosis. 145:1999;287-292
47. Chapelle J.P., Albert A., Smeets J.P., Heusghem C., Kulbertus H.E. Effect of the haptoglobin phenotype on the size of a myocardial infarct. N. Engl. J. Med. 307:1982;457-463
48. Nakhoul F.M., Marsh S., Hochberg I., Leibu R., Miller B.P., Levy A.P. Haptoglobin genotype as a risk factor for diabetic retinopathy. J. Am. Med. Assoc. 284:2000;1244-1245
49. Levy A.P., Roguin A., Hochberg I., Herer P., Marsh S., Nakhoul F.M., et al. Haptoglobin phenotype and vascular complications in patients with diabetes. N. Engl. J. Med. 343:2000;969-970
50. Roguin A., Koch W., Kastrati A., Schomig A., Levy A.P. Haptoglobin genotype is predictive of major adverse cardiac events in the 1-year period after percutaneous transluminal coronary angioplasty in individuals with diabetes. Diabetes Care. 26:2003;2628-2631
51. Asleh R., Marsh S., Shilkrut M., Binah O., Guetta J., Lejbkowicz F., et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ. Res. 92:2003;1193-1200
52. Eaton J.W., Brandt P., Mahoney J.R., Lee J.T. Haptoglobin: a natural bacteriostat. Science. 215:1982;691-693
53. Lettinga K.D., Delanghe J.R., Prins J., Langlois M.R., Speelman P., Reitsman P., et al., Haptoglobin polymorphism influences severity of Legionnaires' Disease independently of iron status. Abstract poster 698, ICAAC, 2002
54. Kasvosve I., Gomo Z.A.R., Mvundura E., Moyo V.M., Saungweme T., Khumalo H., et al. Haptoglobin polymorphism and mortality in patients with tuberculosis. Int. J. Tuberc. Lung Dis. 4:2000;758-764
55. Delanghe J.R., Langlois M.R., Boelaert J.R., Van Acker J., Van Wanzeele F., van der Groen G., et al. Haptoglobin polymorphism, iron metabolism, and mortality in HIV infection. AIDS. 12:1998;1027-1032
56. de Monye C., Karcher D.S., Boelaert J.R., Gordeuk V.R. Bone marrow macrophage iron grade and survival of HIV-seropositive patients. AIDS. 13:1999;375-380
57. Gordeuk V.R., Delanghe J., Langlois M., Boelaert J.R. Iron status and the outcome of HIV infection: an overview. J. Clin. Virol. 20:2001;109-113
58. Quaye I.K., Brandful J., Ekuban F.A., Gyan B., Ankrach N.A. Haptoglobin polymorphism in human immunodeficiency virus infection: Hp0 phenotype limits depletion of CD4 cell counts in HIV-1 seropositive individuals. J. Infect. Dis. 181:2000;1483-1485
59. Quaye I.K., Ekuban F.A., Brandful J.A., Gyan B.A., Akanmori B.D., Ankrach N.A. Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: decreased risk for Hp0 individuals. Hum. Hered. 50:2000;382-383
60. Beutler E., Felitte V.J., Koziol J.A., Ho N.J., Gelbart T. Penetrance of 845G→A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet. 359:2002;211-218