Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease

Circulation

Volumn 115, Issue 12, 2007, Pages 1551-1562

  Raghavachari, Nalini ^a,b   Xu, Xiuli ^a,b   Harris, Amy ^b   Villagra, Jose ^a,b   Logun, Carolea ^b   Barb, Jennifer ^c   Solomon, Michael A ^a,b   Suffredini, Anthony F ^b   Danner, Robert L ^b   Kato, Gregory ^a,b   Munson, Peter J ^c   Morris Jr , Sidney M ^d   Gladwin, Mark T ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Enzymes; Genes; Metabolism; Platelets; Polymerase chain reaction; Signal transduction; Thrombolysis

Indexed keywords

ARGINASE; ARGININE; MESSENGER RNA; POLYAMINE; RNA; THROMBOCYTE ENZYME; TRANSCRIPTOME;

ADULT; AMINO ACID METABOLISM; APHERESIS; ARTICLE; BIOASSAY; CELL TYPE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FEASIBILITY STUDY; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE PROBE; GENETIC DATABASE; HOMEOSTASIS; HUMAN; HUMAN CELL; MALE; NEGRO; OXIDATION REDUCTION REACTION; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; VALIDATION STUDY;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ANEMIA, SICKLE CELL; ARGINASE; ARGININE; BLOOD PLATELETS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NITRIC OXIDE; NUCLEIC ACID AMPLIFICATION TECHNIQUES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYAMINES; TRANSCRIPTION, GENETIC;

EID: 34247533748     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.658641     Document Type: Article

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