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Volumn 10, Issue 2, 2003, Pages 99-107

An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ESTROGEN; HEMOGLOBIN; HEMOGLOBIN F; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; SUPEROXIDE; VASCULAR CELL ADHESION MOLECULE 1;

EID: 0037372314     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200303000-00001     Document Type: Review
Times cited : (132)

References (111)
  • 1
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylchotine
    • Furchgott RF, Zawadzki JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylchotine. Nature 1980, 288:373-376.
    • (1980) Nature , vol.288 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 2
    • 0023518452 scopus 로고
    • Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical
    • Ignarro LJ, Byrns RE, Buga GM, et al.: Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res 1987, 61:866-879.
    • (1987) Circ Res , vol.61 , pp. 866-879
    • Ignarro, L.J.1    Byrns, R.E.2    Buga, G.M.3
  • 3
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, et al.: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A 1987, 84:9265-9269.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3
  • 4
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biologic activity of endothelium-derived relaxing factor
    • Palmer RM, Ferrige AG, Moncada S: Nitric oxide release accounts for the biologic activity of endothelium-derived relaxing factor. Nature 1987, 327:524-526.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 5
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer RM, Ashton DS, Moncada S: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988, 333:664-666.
    • (1988) Nature , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 6
    • 0027161713 scopus 로고
    • Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension
    • Panza JA, Casino PR, Kilcoyne CM, et al.: Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993, 87:1468-1474.
    • (1993) Circulation , vol.87 , pp. 1468-1474
    • Panza, J.A.1    Casino, P.R.2    Kilcoyne, C.M.3
  • 7
    • 0023028215 scopus 로고
    • Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
    • Ludmer PL, Selwyn AP, Shook TL, et al.: Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986, 315:1046-1051.
    • (1986) N Engl J Med , vol.315 , pp. 1046-1051
    • Ludmer, P.L.1    Selwyn, A.P.2    Shook, T.L.3
  • 8
    • 0028969847 scopus 로고
    • Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary atherosclerosis
    • Quyyumi AA, Dakak N, Andrews NP, et al.: Nitric oxide activity in the human coronary circulation: impact of risk factors for coronary atherosclerosis. J Clin Invest 1995, 95:1747-1755.
    • (1995) J Clin Invest , vol.95 , pp. 1747-1755
    • Quyyumi, A.A.1    Dakak, N.2    Andrews, N.P.3
  • 9
    • 0034307274 scopus 로고    scopus 로고
    • Activated monocytes in sickle cell disease: Potential role in the activation of vascular endothelium and vasoocclusion
    • Belcher JD, Marker PH, Weber JP, et al.: Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vasoocclusion. Blood 2000, 96:2451-2459.
    • (2000) Blood , vol.96 , pp. 2451-2459
    • Belcher, J.D.1    Marker, P.H.2    Weber, J.P.3
  • 10
    • 0033624253 scopus 로고    scopus 로고
    • Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    • Kaul DK, Hebbel RP: Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. J Clin Invest 2000, 106:411-420. •• This study demonstrated increased inflammation (increased adherent and extravasated leukocytes mediated through P-selectin) after hypoxia plus reoxygenation in transgenic sickle cell mice, consistent with ischemia-reperfusion pathophysiology in vaso-occlusive crisis.
    • (2000) J Clin Invest , vol.106 , pp. 411-420
    • Kaul, D.K.1    Hebbel, R.P.2
  • 11
    • 0034235705 scopus 로고    scopus 로고
    • Reperfusion injury pathophysiology in sickle transgenic mice
    • Osarogiagbon UR, Choong S, Belcher JD, et al.: Reperfusion injury pathophysiology in sickle transgenic mice. Blood 2000, 96:314-320.
    • (2000) Blood , vol.96 , pp. 314-320
    • Osarogiagbon, U.R.1    Choong, S.2    Belcher, J.D.3
  • 12
    • 0036217313 scopus 로고    scopus 로고
    • Renal pathology in hemizygous sickle cell mice
    • Diwan BA, Gladwin MT, Noguchi CT, et al.: Renal pathology in hemizygous sickle cell mice. Toxicol Pathol 2002, 30:254-262.
    • (2002) Toxicol Pathol , vol.30 , pp. 254-262
    • Diwan, B.A.1    Gladwin, M.T.2    Noguchi, C.T.3
  • 13
    • 0035544703 scopus 로고    scopus 로고
    • Pathophysiology of a sickle cell trait mouse model: Human alpha(beta)(S) transgenes with one mouse beta-globin allele
    • Noguchi CT, Gladwin M, Diwan B, et al.: Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. Blood Cells Mol Dis 2001, 27:971-977.
    • (2001) Blood Cells Mol Dis , vol.27 , pp. 971-977
    • Noguchi, C.T.1    Gladwin, M.2    Diwan, B.3
  • 14
    • 0033921542 scopus 로고    scopus 로고
    • Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse
    • Kaul DK, Liu XD, Fabry ME, et al.: Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse. Am J Physiol Heart Circ Physiol 2000, 278:H1799-H1806.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Kaul, D.K.1    Liu, X.D.2    Fabry, M.E.3
  • 15
    • 0033637285 scopus 로고    scopus 로고
    • Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease
    • Nath KA, Shah V, Haggard JJ, et al.: Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease. Am J Physiol Regul Integr Comp Physiol 2000, 279:R1949-R1955.
    • (2000) Am J Physiol Regul Integr Comp Physiol , vol.279
    • Nath, K.A.1    Shah, V.2    Haggard, J.J.3
  • 16
    • 0035909930 scopus 로고    scopus 로고
    • Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
    • Asian M, Ryan TM, Adler B, et al.: Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci USA 2001, 98:15215-15220. •• This study shows that levels of superoxide-generating xanthine oxidase on the lumenal surface of the vasculature are elevated in transgenic sickle cell mice and in the plasma of patients with sickle cell disease. Because superoxide reacts with and inactivates NO at diffusion-limited rates, their observation may explain the endothelial dysfunction observed in these mice. They showed that a superoxide scavenger rescues vasoresponse.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15215-15220
    • Asian, M.1    Ryan, T.M.2    Adler, B.3
  • 17
    • 0013373192 scopus 로고    scopus 로고
    • Spontaneous stroke and increased erythrocyte adhesion in transgenic knockout sickle cell mice
    • Punzalan RC, Holzman S, Trost BA et al.: Spontaneous stroke and increased erythrocyte adhesion in transgenic knockout sickle cell mice. Blood 1999, 94:419A.
    • (1999) Blood , vol.94
    • Punzalan, R.C.1    Holzman, S.2    Trost, B.A.3
  • 18
    • 0028801145 scopus 로고
    • The metabolites of nitric oxide in sickle-cell disease
    • Rees DC, Cervi P, Grimwade D, et al.: The metabolites of nitric oxide in sickle-cell disease. Br J Haematol 1995, 91:834-837.
    • (1995) Br J Haematol , vol.91 , pp. 834-837
    • Rees, D.C.1    Cervi, P.2    Grimwade, D.3
  • 19
    • 0034533319 scopus 로고    scopus 로고
    • Arginine therapy: A novel strategy to induce nitric oxide production in sickle cell disease
    • Morris CR, Kuypers FA, Larkin S, et al.: Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol 2000, 111:498-500.
    • (2000) Br J Haematol , vol.111 , pp. 498-500
    • Morris, C.R.1    Kuypers, F.A.2    Larkin, S.3
  • 20
    • 0034321784 scopus 로고    scopus 로고
    • Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome
    • Morris CR, Kuypers FA, Larkin S, et al.: Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Pediatr Hematol Oncol 2000, 22:515-520.
    • (2000) J Pediatr Hematol Oncol , vol.22 , pp. 515-520
    • Morris, C.R.1    Kuypers, F.A.2    Larkin, S.3
  • 21
    • 0033198521 scopus 로고    scopus 로고
    • Sickle cell acute chest syndrome: Pathogenesis and rationale for treatment
    • -) vary inversely with plasma soluble VCAM-1 levels in patients with sickle cell disease with acute chest syndrome, suggesting that reduced NO bioavailability contributes to the acute chest syndrome.
    • (1999) Blood , vol.94 , pp. 1555-1560
    • Stuart, M.J.1    Setty, B.N.2
  • 22
    • 0025598375 scopus 로고
    • Nitrogen metabolism in sickle cell anemia: Free amino acids in plasma and urine
    • Enwonwu CO, Xu XX, Turner E: Nitrogen metabolism in sickle cell anemia: free amino acids in plasma and urine. Am J Med Sci 1990, 300:366-371.
    • (1990) Am J Med Sci , vol.300 , pp. 366-371
    • Enwonwu, C.O.1    Xu, X.X.2    Turner, E.3
  • 23
    • 0013376461 scopus 로고    scopus 로고
    • Divergent nitric oxide bioavailability in men and women with sickle cell anemia
    • in press
    • Gladwin MT, Schechter AN, Ognibene FP et al.: Divergent nitric oxide bioavailability in men and women with sickle cell anemia. Circulation 2002, in press. •• See [24•].
    • (2002) Circulation
    • Gladwin, M.T.1    Schechter, A.N.2    Ognibene, F.P.3
  • 24
    • 0035869387 scopus 로고    scopus 로고
    • Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation
    • Belhassen L, Pelle G, Sediame S, et al.: Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation. Blood 2001, 97:1584-1589. • These two studies [23••,24•] are complementary and consistent and show an increased response of forearm blood flow in patients with sickle cell disease to infusions of acetylcholine; however, Gladwin et al. [23••] show that these responses are different between males and females. In male patients with sickle cell disease, NO-dependent vasodilation was blunted.
    • (2001) Blood , vol.97 , pp. 1584-1589
    • Belhassen, L.1    Pelle, G.2    Sediame, S.3
  • 25
    • 0035895323 scopus 로고    scopus 로고
    • The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17ss-estradiol
    • Walker HA, Dean TS, Sanders TA, et al.: The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17ss-estradiol. Circulation 2001, 103:258-262.
    • (2001) Circulation , vol.103 , pp. 258-262
    • Walker, H.A.1    Dean, T.S.2    Sanders, T.A.3
  • 26
    • 0001412940 scopus 로고    scopus 로고
    • Vascular effects of estrogen and vitamin E therapies in postmenopausal women
    • Koh KK, Blum A, Hathaway L, et al.: Vascular effects of estrogen and vitamin E therapies in postmenopausal women. Circulation 1999, 100:1851-1857.
    • (1999) Circulation , vol.100 , pp. 1851-1857
    • Koh, K.K.1    Blum, A.2    Hathaway, L.3
  • 27
    • 0030664730 scopus 로고    scopus 로고
    • The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women
    • Guetta V, Quyyumi AA, Prasad A, et al.: The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women. Circulation 1997, 96:2795-2801.
    • (1997) Circulation , vol.96 , pp. 2795-2801
    • Guetta, V.1    Quyyumi, A.A.2    Prasad, A.3
  • 28
    • 0030989927 scopus 로고    scopus 로고
    • Effect of estrogen on isoforms of nitric oxide synthase: Possible mechanism of anti-atherosclerotic effect of estrogen
    • Hayashi T, Yamada K, Esaki T, et al.: Effect of estrogen on isoforms of nitric oxide synthase: possible mechanism of anti-atherosclerotic effect of estrogen. Gerontology 1997, 43:24-34.
    • (1997) Gerontology , vol.43 , pp. 24-34
    • Hayashi, T.1    Yamada, K.2    Esaki, T.3
  • 29
    • 0028849299 scopus 로고
    • Gender differences in atherosclerosis: Possible role of nitric oxide
    • Hayashi T, Fukuto JM, Ignarro LJ, et al.: Gender differences in atherosclerosis: possible role of nitric oxide. J Cardiovasc Pharmacol 1995, 26:792-802.
    • (1995) J Cardiovasc Pharmacol , vol.26 , pp. 792-802
    • Hayashi, T.1    Fukuto, J.M.2    Ignarro, L.J.3
  • 30
    • 0026437582 scopus 로고
    • Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: Implications for atherosclerosis
    • Hayashi T, Fukuto JM, Ignarro LJ, et al.: Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A 1992, 89:11259-11263.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11259-11263
    • Hayashi, T.1    Fukuto, J.M.2    Ignarro, L.J.3
  • 31
    • 0028229893 scopus 로고
    • Induction of calcium-dependent nitric oxide synthases by sex hormones
    • Weiner CP, Lizasoain I, Baylin SA, et al.: Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci U S A 1994, 91:5212-5216.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 5212-5216
    • Weiner, C.P.1    Lizasoain, I.2    Baylin, S.A.3
  • 32
    • 0028322326 scopus 로고
    • Sex differences in endothelial function in normal and hypercholesterolaemic subjects
    • Chowienczyk PJ, Watts GF, Cockcroft JR, et al.: Sex differences in endothelial function in normal and hypercholesterolaemic subjects. Lancet 1994, 344:305-306.
    • (1994) Lancet , vol.344 , pp. 305-306
    • Chowienczyk, P.J.1    Watts, G.F.2    Cockcroft, J.R.3
  • 33
    • 0027930853 scopus 로고
    • Acute vascular effects of estrogen in postmenopausal women
    • Gilligan DM, Badar DM, Panza JA, et al.: Acute vascular effects of estrogen in postmenopausal women. Circulation 1994, 90:786-791.
    • (1994) Circulation , vol.90 , pp. 786-791
    • Gilligan, D.M.1    Badar, D.M.2    Panza, J.A.3
  • 34
    • 0027958761 scopus 로고
    • Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women
    • Sack MN, Rader DJ, Cannon RO III: Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 1994, 343:269-270.
    • (1994) Lancet , vol.343 , pp. 269-270
    • Sack, M.N.1    Rader, D.J.2    Cannon R.O. III3
  • 35
    • 0028291736 scopus 로고
    • Mortality in sickle cell disease: Life expectancy and risk factors for early death
    • Platt OS, Brambilla DJ, Rosse WF, et al.: Mortality in sickle cell disease: life expectancy and risk factors for early death. N Engl J Med 1994, 330:1639-1644.
    • (1994) N Engl J Med , vol.330 , pp. 1639-1644
    • Platt, O.S.1    Brambilla, D.J.2    Rosse, W.F.3
  • 36
    • 0023180585 scopus 로고
    • The painful crisis of homozygous sickle cell disease: A study of the risk factors
    • Baum KF, Dunn DT, Maude GH, et al.: The painful crisis of homozygous sickle cell disease: a study of the risk factors. Arch Intern Med 1987, 147:1231-1234.
    • (1987) Arch Intern Med , vol.147 , pp. 1231-1234
    • Baum, K.F.1    Dunn, D.T.2    Maude, G.H.3
  • 37
    • 0025770390 scopus 로고
    • Pain in sickle cell disease: Rates and risk factors
    • Platt OS, Thorington BD, Brambilla DJ, et al.: Pain in sickle cell disease: rates and risk factors. N Engl J Med 1991, 325:11-16.
    • (1991) N Engl J Med , vol.325 , pp. 11-16
    • Platt, O.S.1    Thorington, B.D.2    Brambilla, D.J.3
  • 38
    • 0028897283 scopus 로고
    • An analysis of fetal hemoglobin variation in sickle cell disease: The relative contributions of the X-linked factor, beta-globin haplotypes, alpha-globin gene number, gender, and age
    • Chang YC, Smith KD, Moore RD, et al.: An analysis of fetal hemoglobin variation in sickle cell disease: the relative contributions of the X-linked factor, beta-globin haplotypes, alpha-globin gene number, gender, and age. Blood 1995, 85:1111-1117.
    • (1995) Blood , vol.85 , pp. 1111-1117
    • Chang, Y.C.1    Smith, K.D.2    Moore, R.D.3
  • 39
    • 0026708201 scopus 로고
    • Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2
    • Dover GJ, Smith KD, Chang YC, et al.: Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2. Blood 1992, 80:816-824.
    • (1992) Blood , vol.80 , pp. 816-824
    • Dover, G.J.1    Smith, K.D.2    Chang, Y.C.3
  • 40
    • 0028934536 scopus 로고
    • Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia
    • Steinberg MH, Hsu H, Nagel RL, et al.: Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia. Am J Hematol 1995, 48:175-181.
    • (1995) Am J Hematol , vol.48 , pp. 175-181
    • Steinberg, M.H.1    Hsu, H.2    Nagel, R.L.3
  • 41
    • 0035852675 scopus 로고    scopus 로고
    • Mechanism for fetal globin gene expression: Role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway
    • Ikuta T, Ausenda S, Cappellini MD: Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway. Proc Natl Acad Sci U S A 2001, 98:1847-1852. •• The NO-soluble guanylyl cyclase-cyclic GMP-MAP kinase pathway in the human erythroleukemic cell line K562 mediates fetal hemoglobin induction by butyrate.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1847-1852
    • Ikuta, T.1    Ausenda, S.2    Cappellini, M.D.3
  • 42
    • 0013325401 scopus 로고    scopus 로고
    • Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase
    • in press
    • Cokic VP, Smith RD, Beleslin-Cokic BB, et al.: Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J Clin Invest 2002, in press.
    • (2002) J Clin Invest
    • Cokic, V.P.1    Smith, R.D.2    Beleslin-Cokic, B.B.3
  • 43
    • 79960970882 scopus 로고    scopus 로고
    • Impact of HbF and gender on mean survival time of NY1KO sickle transgenic mice expressing exclusively human hemoglobins
    • Fabry ME, Witt WM, Suzuka SM: Impact of HbF and gender on mean survival time of NY1KO sickle transgenic mice expressing exclusively human hemoglobins [abstract]. Blood 2001, 98:750a.
    • (2001) Blood , vol.98
    • Fabry, M.E.1    Witt, W.M.2    Suzuka, S.M.3
  • 44
    • 0036908599 scopus 로고    scopus 로고
    • Cell-free hemoglobin limits nitric oxide bioavailability in sickle cell disease
    • Reiter CD, Wang X, Tanus-Santos JE, et al.: Cell-free hemoglobin limits nitric oxide bioavailability in sickle cell disease. Nat Med 2002, 8:1383-1389. •• This investigation demonstrates that chronic intravascular hemolysis, leading to elevated levels of cell-free hemoglobin, eliminates NO bioavailability. Inhaled NO as a therapy inactivates cell-free hemoglobin in the pulmonary vasculature, which increases NO bioavailability in the periphery.
    • (2002) Nat Med , vol.8 , pp. 1383-1389
    • Reiter, C.D.1    Wang, X.2    Tanus-Santos, J.E.3
  • 45
    • 0002732412 scopus 로고
    • The rate of uptake of carbon monoxide and of nitric oxide by normal human erythrocytes and experimentally produced spherocytes
    • Carlsen E, Comroe JH: The rate of uptake of carbon monoxide and of nitric oxide by normal human erythrocytes and experimentally produced spherocytes. J Gen Physiol 1958, 42:83-107.
    • (1958) J Gen Physiol , vol.42 , pp. 83-107
    • Carlsen, E.1    Comroe, J.H.2
  • 46
    • 0032563283 scopus 로고    scopus 로고
    • Diffusion-limited reaction of free nitric oxide with erythrocytes
    • Liu X, Miller MJ, Joshi MS, et al.: Diffusion-limited reaction of free nitric oxide with erythrocytes. J Biol Chem 1998, 273:18709-18713.
    • (1998) J Biol Chem , vol.273 , pp. 18709-18713
    • Liu, X.1    Miller, M.J.2    Joshi, M.S.3
  • 47
    • 0031425115 scopus 로고    scopus 로고
    • A tutorial on the diffusibility and reactivity of free nitric oxide
    • Lancaster JR Jr: A tutorial on the diffusibility and reactivity of free nitric oxide. Nitric Oxide 1997, 1:18-30.
    • (1997) Nitric Oxide , vol.1 , pp. 18-30
    • Lancaster J.R., Jr.1
  • 48
    • 33750814148 scopus 로고    scopus 로고
    • Effective diffusion distance of nitric oxide in the microcirculation
    • Vaughn MW, Kuo L, Liao JC: Effective diffusion distance of nitric oxide in the microcirculation. Am J Physiol 1998, 274:H1705-H1714.
    • (1998) Am J Physiol , vol.274
    • Vaughn, M.W.1    Kuo, L.2    Liao, J.C.3
  • 49
    • 0034723187 scopus 로고    scopus 로고
    • Erythrocytes possess an intrinsic barrier to nitric oxide consumption
    • Vaughn MW, Huang KT, Kuo L, et al.: Erythrocytes possess an intrinsic barrier to nitric oxide consumption. J Biol Chem 2000, 275:2342-2348.
    • (2000) J Biol Chem , vol.275 , pp. 2342-2348
    • Vaughn, M.W.1    Huang, K.T.2    Kuo, L.3
  • 50
    • 0035949654 scopus 로고    scopus 로고
    • Modulation of nitric oxide bioavailability by erythrocytes
    • Huang KT, Han TH, Hyduke DR, et al.: Modulation of nitric oxide bioavailability by erythrocytes. Proc Natl Acad Sci U S A 2001, 98:11771-11776.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 11771-11776
    • Huang, K.T.1    Han, T.H.2    Hyduke, D.R.3
  • 51
    • 0018742687 scopus 로고
    • The rate of oxygen uptake by human red blood cells
    • Coin JT, Olson JS: The rate of oxygen uptake by human red blood cells. J Biol Chem 1979, 254:1178-1190.
    • (1979) J Biol Chem , vol.254 , pp. 1178-1190
    • Coin, J.T.1    Olson, J.S.2
  • 52
    • 0032538124 scopus 로고    scopus 로고
    • Diffusion of nitric oxide and scavenging by blood in the vasculature
    • Butler AR, Megson IL, Wright PG: Diffusion of nitric oxide and scavenging by blood in the vasculature. Biochim Biophys Acta 1998, 1425:168-176.
    • (1998) Biochim Biophys Acta , vol.1425 , pp. 168-176
    • Butler, A.R.1    Megson, I.L.2    Wright, P.G.3
  • 53
    • 0033587678 scopus 로고    scopus 로고
    • Intravascular flow decreases erythrocyte consumption of nitric oxide
    • Liao JC, Hein TW, Vaughn MW, et al.: Intravascular flow decreases erythrocyte consumption of nitric oxide. Proc Natl Acad Sci U S A 1999, 96:8757-8761.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8757-8761
    • Liao, J.C.1    Hein, T.W.2    Vaughn, M.W.3
  • 54
    • 0025930739 scopus 로고
    • Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide
    • Pohl U, Lamontagne D: Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide. Basic Res Cardiol 1991, 86:97-105.
    • (1991) Basic Res Cardiol , vol.86 , pp. 97-105
    • Pohl, U.1    Lamontagne, D.2
  • 55
    • 0027251288 scopus 로고
    • Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin
    • Hess JR, MacDonald VW, Brinkley WW: Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 1993, 74:1769-1778.
    • (1993) J Appl Physiol , vol.74 , pp. 1769-1778
    • Hess, J.R.1    MacDonald, V.W.2    Brinkley, W.W.3
  • 56
    • 0029131674 scopus 로고
    • Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions
    • Lee R, Neya K, Svizzero TA, et al.: Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions. J Appl Physiol 1995, 79:236-242.
    • (1995) J Appl Physiol , vol.79 , pp. 236-242
    • Lee, R.1    Neya, K.2    Svizzero, T.A.3
  • 57
    • 0001517449 scopus 로고    scopus 로고
    • Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes
    • de Figueiredo LF, Mathru M, Solanki D, et al.: Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes. J Trauma 1997, 42:847-856.
    • (1997) J Trauma , vol.42 , pp. 847-856
    • De Figueiredo, L.F.1    Mathru, M.2    Solanki, D.3
  • 58
    • 0022459918 scopus 로고
    • Coronary constrictor effect of stroma-free hemoglobin solutions
    • Vogel WM, Dennis RC, Cassidy G, et al.: Coronary constrictor effect of stroma-free hemoglobin solutions. Am J Physiol 1986, 251:H413-H420.
    • (1986) Am J Physiol , vol.251
    • Vogel, W.M.1    Dennis, R.C.2    Cassidy, G.3
  • 59
    • 0029862605 scopus 로고    scopus 로고
    • Regional blood flow alterations after bovine fumaryl beta beta-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition
    • Ulatowski JA, Nishikawa T, Matheson-Urbaitis B, et al.: Regional blood flow alterations after bovine fumaryl beta beta-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition. Crit Care Med 1996, 24:558-565.
    • (1996) Crit Care Med , vol.24 , pp. 558-565
    • Ulatowski, J.A.1    Nishikawa, T.2    Matheson-Urbaitis, B.3
  • 60
    • 0029156744 scopus 로고
    • The effects of recombinant human hemoglobin on esophageal motor functions in humans
    • Murray JA, Ledlow A, Launspach J, et al.: The effects of recombinant human hemoglobin on esophageal motor functions in humans. Gastroenterology 1995, 109:1241-1248.
    • (1995) Gastroenterology , vol.109 , pp. 1241-1248
    • Murray, J.A.1    Ledlow, A.2    Launspach, J.3
  • 61
    • 0033579126 scopus 로고    scopus 로고
    • Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: A randomized controlled efficacy trial
    • Sloan EP, Koenigsberg M, Gens D, et al.: Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. JAMA 1999, 282:1857-1864.
    • (1999) JAMA , vol.282 , pp. 1857-1864
    • Sloan, E.P.1    Koenigsberg, M.2    Gens, D.3
  • 62
    • 0000413016 scopus 로고
    • The metabolism of hemoglobin and bile pigment in hemolytic disease
    • Crosby WH: The metabolism of hemoglobin and bile pigment in hemolytic disease. Am J Med 1955, 18:112-122.
    • (1955) Am J Med , vol.18 , pp. 112-122
    • Crosby, W.H.1
  • 63
    • 0015106182 scopus 로고
    • Plasma hemoglobin and hemoglobin fractions in sickle cell crisis
    • Naumann HN, Diggs LW, Barreras L, et al.: Plasma hemoglobin and hemoglobin fractions in sickle cell crisis. Am J Clin Pathol 1971, 56:137-147.
    • (1971) Am J Clin Pathol , vol.56 , pp. 137-147
    • Naumann, H.N.1    Diggs, L.W.2    Barreras, L.3
  • 64
    • 0022982483 scopus 로고
    • Acute chest syndrome in children with sickle cell disease: A retrospective analysis of 100 hospitalized cases
    • Sprinkle RH, Cole T, Smith S, et al.: Acute chest syndrome in children with sickle cell disease: a retrospective analysis of 100 hospitalized cases. Am J Pediatr Hematol Oncol 1986, 8:105-110.
    • (1986) Am J Pediatr Hematol Oncol , vol.8 , pp. 105-110
    • Sprinkle, R.H.1    Cole, T.2    Smith, S.3
  • 65
    • 0023488843 scopus 로고
    • Identification of an inducible endothelial-leukocyte adhesion molecule
    • Bevilacqua MP, Pober JS, Mendrick DL, et al.: Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A 1987, 84:9238-9242.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9238-9242
    • Bevilacqua, M.P.1    Pober, J.S.2    Mendrick, D.L.3
  • 66
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer TA: Adhesion receptors of the immune system. Nature 1990, 346:425-434.
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 67
    • 0025896795 scopus 로고
    • Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
    • Cybulsky MI, Gimbrone MA Jr: Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991, 251:788-791.
    • (1991) Science , vol.251 , pp. 788-791
    • Cybulsky, M.I.1    Gimbrone M.A., Jr.2
  • 68
    • 0035010184 scopus 로고    scopus 로고
    • A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    • Cybulsky MI, Iiyama K, Li H, et al.: A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001, 107:1255-1262.
    • (2001) J Clin Invest , vol.107 , pp. 1255-1262
    • Cybulsky, M.I.1    Iiyama, K.2    Li, H.3
  • 69
    • 0028894111 scopus 로고
    • Sickle reticulocytes adhere to VCAM-1
    • Gee BE, Platt OS: Sickle reticulocytes adhere to VCAM-1. Blood 1995, 85:268-274.
    • (1995) Blood , vol.85 , pp. 268-274
    • Gee, B.E.1    Platt, O.S.2
  • 70
    • 0027184968 scopus 로고
    • Alpha 4 beta 1-integrin expression on sickle reticulocytes: Vascular cell adhesion molecule-1-dependent binding to endothelium
    • Swerlick RA, Eckman JR, Kumar A, et al.: Alpha 4 beta 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood 1993, 82:1891-1899.
    • (1993) Blood , vol.82 , pp. 1891-1899
    • Swerlick, R.A.1    Eckman, J.R.2    Kumar, A.3
  • 71
    • 0029973833 scopus 로고    scopus 로고
    • Adhesion of sickle red blood cells and damage to interleukin-1 beta stimulated endothelial cells under flow in vitro
    • Natarajan M, Udden MM, McIntire LV: Adhesion of sickle red blood cells and damage to interleukin-1 beta stimulated endothelial cells under flow in vitro. Blood 1996, 87:4845-4852.
    • (1996) Blood , vol.87 , pp. 4845-4852
    • Natarajan, M.1    Udden, M.M.2    McIntire, L.V.3
  • 72
    • 0029817660 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: Potential role in sickle cell disease
    • Setty BN, Stuart MJ: Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood 1996, 88:2311-2320.
    • (1996) Blood , vol.88 , pp. 2311-2320
    • Setty, B.N.1    Stuart, M.J.2
  • 73
    • 0005991370 scopus 로고    scopus 로고
    • Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis
    • Duits AJ, Pieters RC, Saleh AW, et al.: Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis. Clin Immunol Immunopathol 1996, 81:96-98.
    • (1996) Clin Immunol Immunopathol , vol.81 , pp. 96-98
    • Duits, A.J.1    Pieters, R.C.2    Saleh, A.W.3
  • 74
    • 0034658663 scopus 로고    scopus 로고
    • Perfusion with sickle erythrocytes upregulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells
    • Shiu YT, Udden MM, McIntire LV: Perfusion with sickle erythrocytes upregulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells. Blood 2000, 95:3232-3241.
    • (2000) Blood , vol.95 , pp. 3232-3241
    • Shiu, Y.T.1    Udden, M.M.2    McIntire, L.V.3
  • 75
    • 0036175090 scopus 로고    scopus 로고
    • Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease
    • Gladwin MT, Shelhamer JH, Ognibene FP, et al.: Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease. Br J Haematol 2002, 116:436-444.
    • (2002) Br J Haematol , vol.116 , pp. 436-444
    • Gladwin, M.T.1    Shelhamer, J.H.2    Ognibene, F.P.3
  • 76
    • 0029159779 scopus 로고
    • Nitric oxide decreases cytokine-induced endothelial activation: Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
    • De Caterina R, Libby P, Peng HB, et al.: Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995, 96:60-68.
    • (1995) J Clin Invest , vol.96 , pp. 60-68
    • De Caterina, R.1    Libby, P.2    Peng, H.B.3
  • 77
    • 0029817660 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: Potential role in sickle cell disease
    • Setty BN, Stuart MJ: Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood 1996, 88:2311-2320.
    • (1996) Blood , vol.88 , pp. 2311-2320
    • Setty, B.N.1    Stuart, M.J.2
  • 78
    • 0030669447 scopus 로고    scopus 로고
    • Inhaled nitric oxide in sickle cell disease with acute chest syndrome
    • Atz AM, Wessel DL: Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology 1997, 87:988-990.
    • (1997) Anesthesiology , vol.87 , pp. 988-990
    • Atz, A.M.1    Wessel, D.L.2
  • 79
    • 0032738619 scopus 로고    scopus 로고
    • Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent
    • Sullivan KJ, Goodwin SR, Evangelist J, et al.: Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. Crit Care Med 1999, 27:2563-2568.
    • (1999) Crit Care Med , vol.27 , pp. 2563-2568
    • Sullivan, K.J.1    Goodwin, S.R.2    Evangelist, J.3
  • 80
    • 0028111967 scopus 로고
    • Pulmonary hypertension in sickle cell disease
    • Sutton LL, Castro O, Cross DJ, et al.: Pulmonary hypertension in sickle cell disease. Am J Cardiol 1994, 74:626-628.
    • (1994) Am J Cardiol , vol.74 , pp. 626-628
    • Sutton, L.L.1    Castro, O.2    Cross, D.J.3
  • 81
    • 0035665831 scopus 로고    scopus 로고
    • Pulmonary complications of sickle cell anemia: A need for increased recognition, treatment, and research
    • Minter KR, Gladwin MT: Pulmonary complications of sickle cell anemia: a need for increased recognition, treatment, and research. Am J Respir Crit Care Med 2001, 164:2016-2019.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 2016-2019
    • Minter, K.R.1    Gladwin, M.T.2
  • 82
    • 0037152092 scopus 로고    scopus 로고
    • Sildenafil for treatment of lung fibrosis and pulmonary hypertension: A randomised controlled trial
    • Ghofrani HA, Wiedemann R, Rose F, et al.: Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 2002, 360:895-900. •• This study demonstrates that the oral phosphodiesterase 5 inhibitor, sildenafil (Viagra; Pfizer US Pharmaceutical Group, New York, NY), is a selective pulmonary vasodilator, reducing pulmonary artery pressures and increasing oxygenation in patients with pulmonary hypertension secondary to lung fibrosis. Similar effects could be anticipated in patients with secondary pulmonary hypertension secondary to sickle cell disease.
    • (2002) Lancet , vol.360 , pp. 895-900
    • Ghofrani, H.A.1    Wiedemann, R.2    Rose, F.3
  • 83
    • 0037106989 scopus 로고    scopus 로고
    • Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension
    • Lepore J, Maroo A, Pereira NL, et al.: Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol 2002, 90:677.
    • (2002) Am J Cardiol , vol.90 , pp. 677
    • Lepore, J.1    Maroo, A.2    Pereira, N.L.3
  • 84
    • 0013425554 scopus 로고    scopus 로고
    • Pulmonary hypertension in sickle cell disease: Cardiac catheterization results and survival
    • Castro OL, Hoque M, Brown BD: Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival. Blood 2002, 3:3. •• Report on pulmonary pressures from right heart catheterization in patients with sickle cell anemia. This study reveals a 2-year median survival in patients with secondary pulmonary hypertension.
    • (2002) Blood , vol.3 , pp. 3
    • Castro, O.L.1    Hoque, M.2    Brown, B.D.3
  • 85
    • 0037103214 scopus 로고    scopus 로고
    • Long-term treatment with sildenafil in a thalassemic patient with pulmonary hypertension
    • Littera R, La Nasa G, Derchi G, et al.: Long-term treatment with sildenafil in a thalassemic patient with pulmonary hypertension. Blood 2002, 100:1516-1517.
    • (2002) Blood , vol.100 , pp. 1516-1517
    • Littera, R.1    La Nasa, G.2    Derchi, G.3
  • 86
    • 0031975630 scopus 로고    scopus 로고
    • Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: Results of a randomized phase II trial
    • Inhaled Nitric Oxide in ARDS Study Group
    • Dellinger RP, Zimmerman JL, Taylor RW, et al.: Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 1998, 26:15-23.
    • (1998) Crit Care Med , vol.26 , pp. 15-23
    • Dellinger, R.P.1    Zimmerman, J.L.2    Taylor, R.W.3
  • 87
    • 0029792742 scopus 로고    scopus 로고
    • Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs
    • Guidot DM, Hybertson BM, Kitlowski RP, et al.: Inhaled NO prevents IL-1-induced neutrophil accumulation and associated acute edema in isolated rat lungs. Am J Physiol 1996, 271:L225-L229.
    • (1996) Am J Physiol , vol.271
    • Guidot, D.M.1    Hybertson, B.M.2    Kitlowski, R.P.3
  • 88
    • 0030982849 scopus 로고    scopus 로고
    • Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury
    • Bloomfield GL, Holloway S, Ridings PC, et al.: Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury. Crit Care Med 1997, 25:584-593.
    • (1997) Crit Care Med , vol.25 , pp. 584-593
    • Bloomfield, G.L.1    Holloway, S.2    Ridings, P.C.3
  • 89
    • 0032102218 scopus 로고    scopus 로고
    • Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds
    • Fox-Robichaud A, Payne D, Hasan SU, et al.: Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest 1998, 101:2497-2505.
    • (1998) J Clin Invest , vol.101 , pp. 2497-2505
    • Fox-Robichaud, A.1    Payne, D.2    Hasan, S.U.3
  • 90
    • 0034954199 scopus 로고    scopus 로고
    • Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery
    • Cannon RO III, Sehechter AN, Panza JA, et al.: Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest 2001, 108:279-287. •• This study has shown the surprising result that inhaled NO, or an inhaled NO metabolite, can systemically vasodilate during regional NO synthase blockade or during exercise.
    • (2001) J Clin Invest , vol.108 , pp. 279-287
    • Cannon R.O. III1    Sehechter, A.N.2    Panza, J.A.3
  • 92
    • 0037082452 scopus 로고    scopus 로고
    • Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity
    • Romero JR, Suzuka SM, Nagel RL, et al.: Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity. Blood 2002, 99:1103-1108. •• Dietary supplementation with arginine for up to 11 months reduces red blood cell density in a transgenic sickle cell mouse model.
    • (2002) Blood , vol.99 , pp. 1103-1108
    • Romero, J.R.1    Suzuka, S.M.2    Nagel, R.L.3
  • 93
    • 79960971715 scopus 로고    scopus 로고
    • Inhaled nitric oxide has a protective effect in hypoxic transgenic sickle cell mice (SAD): Evidences of modulation of ischemic lung injury
    • De Franceshi L, Baron A, Scarpa A, et al.: Inhaled nitric oxide has a protective effect in hypoxic transgenic sickle cell mice (SAD): evidences of modulation of ischemic lung injury. Blood 2001 (suppl):3125.
    • (2001) Blood , Issue.SUPPL. , pp. 3125
    • De Franceshi, L.1    Baron, A.2    Scarpa, A.3
  • 94
    • 0030982523 scopus 로고    scopus 로고
    • Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo
    • Head CA, Brugnara C, Martinez-Ruiz R, et al.: Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest 1997, 100:1193-1198.
    • (1997) J Clin Invest , vol.100 , pp. 1193-1198
    • Head, C.A.1    Brugnara, C.2    Martinez-Ruiz, R.3
  • 95
    • 0034989750 scopus 로고    scopus 로고
    • Inhaled nitric oxide improves survival rates during hypoxia in a sickle cell (SAD) mouse model
    • Martinez-Ruiz R, Montero-Huerta P, Hriomi J, et al.: Inhaled nitric oxide improves survival rates during hypoxia in a sickle cell (SAD) mouse model. Anesthesiology 2001, 94:1113-1118.
    • (2001) Anesthesiology , vol.94 , pp. 1113-1118
    • Martinez-Ruiz, R.1    Montero-Huerta, P.2    Hriomi, J.3
  • 96
    • 0030931379 scopus 로고    scopus 로고
    • NO therapy?
    • Schechter AN: NO therapy? [editorial]. J Clin Invest 1997, 100:955-956.
    • (1997) J Clin Invest , vol.100 , pp. 955-956
    • Schechter, A.N.1
  • 97
    • 0033836250 scopus 로고    scopus 로고
    • Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport
    • Hrinczenko BW, Alayash AI, Wink DA, et al.: Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport. Br J Haematol 2000, 110:412-419.
    • (2000) Br J Haematol , vol.110 , pp. 412-419
    • Hrinczenko, B.W.1    Alayash, A.I.2    Wink, D.A.3
  • 98
    • 0032696892 scopus 로고    scopus 로고
    • Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity
    • Gladwin MT, Schechter AN, Shelhamer JH, et al.: Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. J Clin Invest 1999, 104:937-945.
    • (1999) J Clin Invest , vol.104 , pp. 937-945
    • Gladwin, M.T.1    Schechter, A.N.2    Shelhamer, J.H.3
  • 99
    • 0034901883 scopus 로고    scopus 로고
    • Nitric oxide transport on sickle cell hemoglobin: Where does it bind?
    • Gladwin MT, Ognibene FP, Shelhamer JH, et al.: Nitric oxide transport on sickle cell hemoglobin: where does it bind? Free Radic Res 2001, 35:175-180.
    • (2001) Free Radic Res , vol.35 , pp. 175-180
    • Gladwin, M.T.1    Ognibene, F.P.2    Shelhamer, J.H.3
  • 100
    • 18544386402 scopus 로고    scopus 로고
    • Effects of iron nitrosylation on sickle cell hemoglobin solubility
    • Xu X, Lockamy VL, Chen K, et al.: Effects of iron nitrosylation on sickle cell hemoglobin solubility. J Biol Chem 2002, 277:36787-36792. • This study demonstrated that NO-heme ligation of hemoglobin S has minimal effects on polymerization, requiring substantial modification for effect.
    • (2002) J Biol Chem , vol.277 , pp. 36787-36792
    • Xu, X.1    Lockamy, V.L.2    Chen, K.3
  • 101
    • 0033609913 scopus 로고    scopus 로고
    • Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin
    • Bonaventura C, Ferruzzi G, Tesh S, et al.: Effects of S-nitrosation on oxygen binding by normal and sickle cell hemoglobin. J Biol Chem 1999, 274:24742-24748.
    • (1999) J Biol Chem , vol.274 , pp. 24742-24748
    • Bonaventura, C.1    Ferruzzi, G.2    Tesh, S.3
  • 102
    • 0021710345 scopus 로고
    • Inhibition of erythrocyte sickling by thiol reagents
    • Garel MC, Domenget C, Galacteros F, et al.: Inhibition of erythrocyte sickling by thiol reagents. Mol Pharmacol 1984, 26:559-565.
    • (1984) Mol Pharmacol , vol.26 , pp. 559-565
    • Garel, M.C.1    Domenget, C.2    Galacteros, F.3
  • 103
    • 0022828370 scopus 로고
    • Covalent binding of glutathione to hemoglobin, I: Inhibition of hemoglobin S polymerization
    • Garel MC, Domenget C, Caburi-Martin J, et al.: Covalent binding of glutathione to hemoglobin, I: inhibition of hemoglobin S polymerization. J Biol Chem 1986, 261:14704-14709.
    • (1986) J Biol Chem , vol.261 , pp. 14704-14709
    • Garel, M.C.1    Domenget, C.2    Caburi-Martin, J.3
  • 104
    • 0034730133 scopus 로고    scopus 로고
    • Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation
    • Gladwin MT, Ognibene FP, Pannell LK, et al.: Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc Natl Acad Sci U S A 2000, 97:9943-9948.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9943-9948
    • Gladwin, M.T.1    Ognibene, F.P.2    Pannell, L.K.3
  • 105
    • 0029025475 scopus 로고
    • Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia: Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
    • Charache S, Terrin ML, Moore RD, et al.: Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia: Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med 1995, 332:1317-1322.
    • (1995) N Engl J Med , vol.332 , pp. 1317-1322
    • Charache, S.1    Terrin, M.L.2    Moore, R.D.3
  • 106
    • 0029944579 scopus 로고    scopus 로고
    • Hydroxyurea reacts with heme proteins to generate nitric oxide
    • Pacelli R, Taira J, Cook JA, et al.: Hydroxyurea reacts with heme proteins to generate nitric oxide [letter]. Lancet 1996, 347:900.
    • (1996) Lancet , vol.347 , pp. 900
    • Pacelli, R.1    Taira, J.2    Cook, J.A.3
  • 107
    • 0032510287 scopus 로고    scopus 로고
    • Time resolved absorption study of the reaction of hydroxyurea with sickle cell hemoglobin
    • Kim-Shapiro DB, King SB, Bonifant CL, et al.: Time resolved absorption study of the reaction of hydroxyurea with sickle cell hemoglobin. Biochim Biophys Acta 1998, 1380:64-74.
    • (1998) Biochim Biophys Acta , vol.1380 , pp. 64-74
    • Kim-Shapiro, D.B.1    King, S.B.2    Bonifant, C.L.3
  • 108
    • 0032774330 scopus 로고    scopus 로고
    • The reaction of deoxy-sickle cell hemoglobin with hydroxyurea
    • Kim-Shapiro DB, King SB, Shields H, et al.: The reaction of deoxy-sickle cell hemoglobin with hydroxyurea. Biochim Biophys Acta 1999, 1428:381-387.
    • (1999) Biochim Biophys Acta , vol.1428 , pp. 381-387
    • Kim-Shapiro, D.B.1    King, S.B.2    Shields, H.3
  • 109
    • 0033951829 scopus 로고    scopus 로고
    • The reactions of myoglobin, normal adult hemoglobin, sickle cell hemoglobin and hemin with hydroxyurea
    • Rupon JW, Domingo SR, Smith SV, et al.: The reactions of myoglobin, normal adult hemoglobin, sickle cell hemoglobin and hemin with hydroxyurea. Biophys Chem 2000, 84:1-11.
    • (2000) Biophys Chem , vol.84 , pp. 1-11
    • Rupon, J.W.1    Domingo, S.R.2    Smith, S.V.3
  • 110
    • 0032977037 scopus 로고    scopus 로고
    • Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea
    • Glover RE, Ivy ED, Orringer EP, et al.: Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea. Mol Pharmacol 1999, 55:1006-1010.
    • (1999) Mol Pharmacol , vol.55 , pp. 1006-1010
    • Glover, R.E.1    Ivy, E.D.2    Orringer, E.P.3
  • 111
    • 0034466430 scopus 로고    scopus 로고
    • Nitric oxide metabolites in sickle cell anemia patients after oral administration of hydroxyurea; hemoglobinopathy
    • Nahavandi M, Wycke MQ, Perlin E, et al.: Nitric oxide metabolites in sickle cell anemia patients after oral administration of hydroxyurea; hemoglobinopathy. Hematology 2000, 5:335-339.
    • (2000) Hematology , vol.5 , pp. 335-339
    • Nahavandi, M.1    Wycke, M.Q.2    Perlin, E.3


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