Hypexia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice

Journal of Clinical Investigation

Volumn 106, Issue 3, 2000, Pages 411-420

  Kaul, D K ^a   Hebbel, R P ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL OCCLUSION; CONTROLLED STUDY; HYPOXIA; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; LEUKOCYTE MIGRATION; NONHUMAN; PRIORITY JOURNAL; REOXYGENATION; REPERFUSION INJURY; SHEAR RATE; SICKLE CELL ANEMIA; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM; ANIMAL; BLOOD; C57BL MOUSE; CELL ADHESION; CELL MOTION; DISEASE MODEL; HEMODYNAMICS; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NEUTROPHIL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; OXIDIZING AGENT; PADGEM PROTEIN;

ANEMIA, SICKLE CELL; ANIMALS; ANTIBODIES, MONOCLONAL; CELL ADHESION; CELL MOVEMENT; DISEASE MODELS, ANIMAL; E-SELECTIN; HEMODYNAMIC PROCESSES; HUMANS; INFLAMMATION; LEUKOCYTE COUNT; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; NEUTROPHILS; OXIDANTS; P-SELECTIN; REPERFUSION INJURY;

EID: 0033624253     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9225     Document Type: Article

References (58)

1. Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology
2. The pathophysiology of vascular obstruction in the sickle syndromes
3. Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: Relevance to ischemic heart disease
4. Ischemia-reperfusion: Mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease
5. Endothelial cell and vascular damage in the sickle cell disorders
6. Increased circulating endothelial cells in sickle cell crisis
7. Circulating activated endothelial cells in sickle cell anemia
8. Abnormal vascular function following ischemia-reperfusion injury
9. Tissue factor expression by endothelial cells in sickle cell anemia
10. Sickle cell anemia as a possible state of enhanced anti-apoptotic tone: Survival effect of vascular endothelial growth factor on circulating and unanchored endothelial cells
11. Leukocyte counts in children with sickle cell disease. Comparative values in the steady state, vasoocclusive crisis, and bacterial infection
12. An unusual pattern of neutrophil kinetics in sickle cell anemia
13. Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell disease
14. Elevated soluble adhesion molecules in sickle hemoglobinopathy patients during the steady state and crisis
15. Sickle cell acute chest syndrome: Pathogenesis and rationale for treatment
16. Platelet-activating factor in plasma of patients with sickle ceil disease in steady state
17. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial ceil conditioned medium induces oxidant stress leading to transendothelial migration of monocytes
18. Bacterial infection and sickle cell anemia. An analysis of 250 infections in 166 patients and a review of the literature
19. Case report: Vaso-occlusive crisis associated neutrophil dysfunction in patients with sickle cell disease
20. Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle
21. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons
22. Neutrophil elastase and oxygen radicals: Synergism in lung injury after hindlimb ischemia
23. Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear
24. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion
25. Selectins
26. Leukocyte-endothelial adhesion molecules
27. Selectin-carbohydrate interactions during inflammation and metastasis
28. Two-step model of leukocyte-endothelial cell interaction in inflammation: Distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo
29. High expression of human beta S- and alpha-globins in transgenic mice: Hemoglobin composition and hematological consequences
30. High expression of human beta S- and alpha-globins in transgenic mice: Erythrocyte abnormalities, organ damage, and the effect of hypoxia
31. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy
32. In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse
33. Rheologic and hemodynamic characteristics of red cells of mouse, rat and human
34. The correlation of photometric signals derived from in vivo red blood cell flow in microvessels
35. Erythrocyte velocity measurement in microvessels by a two-slit photometric method
36. On-line volume flow rate and velocity profile measurement for blood in microvessels
37. In vivo and in vitro measurements of red cell velocity under epifluorescence microscopy
38. In vivo measurements of 'apparent viscosity' and microvessel hematocrit in the mesentery of the cat
39. 2 in cultured endothelial cells
40. Microvascular responses to inhibition of nitric oxide production. Role of active oxidants
41. A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123
42. Mechanisms of cell injury in rat mesentery and cremaster muscle
43. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
44. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
45. Reperfusion injury pathophysiology in sickle transgenic mice
46. Leukocyte-endothelium adhesion: Microhemodynamics in mesentery of the cat
47. Role of leukocyte-endothelium adhesion in affecting recovery from ischemic episodes
48. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion
49. Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart
50. An absolute requirement for P-selectin in ischemia/reperfusion-induced leukocyte recruitment in cremaster muscle
51. Gene-targeted mice in leukocyte adhesion research
52. Therapeutic modulation of vascular endothelial cell activation state as therapy for sickle ceil disease
53. Peroxynitrite formation and apoptosis in transgenic sickle ceil mouse kidneys
54. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1
55. Sequential contribution of L- and P-selectin to leukocyte rolling in vivo
56. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease
57. Alpha 4 beta 1-integrin expression on sickle reticulocytes: Vascular cell adhesion molecule-1-dependent binding to endothelium