Hydroxyurea reacts with heme proteins to generate nitric oxide [6]

Lancet

Volumn 347, Issue 9005, 1996, Pages 900-

  Pacelli, R ^a   Taira, J ^a   Cook, J A ^a   Wink, D A ^a   Krishna, M C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HEMOPROTEIN; HYDROGEN PEROXIDE; HYDROXYUREA; MYOGLOBIN; NITRIC OXIDE;

ELECTRON SPIN RESONANCE; HUMAN; LETTER; PRIORITY JOURNAL; SICKLE CELL ANEMIA;

EID: 0029944579     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)91378-1     Document Type: Letter

References (5)

1. Jw Yarbro Mechanism of action of hydroxyurea Semin Oncol 19 1992 1 10
2. S. Charache Ml Terrin Rd Moore Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia N Engl J Med 332 1995 1317 1322
3. Gp Rodgers Gj Dover N. Uyesaca Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea N Engl J Med 322 1990 1037 1045
4. K. Stolze N. Nohl Reactions of reducing xenobiotics with oxymyoglobin. Formation of metmyoglobin, ferrymyoglobin and free radicals: an electron spin resonance and chemiluminescence study Biochem Pharmacol 49 1995 1261 1267
5. T. Akaike M. Yoshida Y. Miyamoto Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction Biochemistry 32 1993 827 832