Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy

Acta Haematologica

Volumn 102, Issue 1, 1999, Pages 31-37

  Saleh Jr , Alexander W ^a   Hillen, H F P ^c   Duits, A J ^a,b  

^a St Elisabeth Hospital Willemstad   (Netherlands Antilles)

^b Red Cross Bloodbank Curacao   (Netherlands Antilles)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Fibronectin; Hemoglobin F; Hydroxyurea; Interleukin 6 receptor ; Interleukin 8; L selectin, soluble; Myeloperoxidase; Sickle cell anemia; Vascular adhesion molecule 1, soluble

Indexed keywords

FIBRONECTIN; HEMOGLOBIN F; HYDROXYUREA; INTERLEUKIN 6; INTERLEUKIN 8; L SELECTIN; MYELOPEROXIDASE; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CELL ADHESION; CELL COUNT; CELL PROLIFERATION; CLINICAL ARTICLE; ERYTHROCYTE ADHESIVENESS; FEMALE; HUMAN; LEUKOCYTOSIS; MALE; NEUTROPHIL; PATIENT MONITORING; PRIORITY JOURNAL; SICKLE CELL ANEMIA; THROMBOCYTE; VASCULAR ENDOTHELIUM;

ADOLESCENT; ADULT; AGED; ANEMIA, SICKLE CELL; ANTISICKLING AGENTS; BLOOD PLATELETS; ENDOTHELIUM, VASCULAR; FEMALE; FIBRONECTINS; HUMANS; HYDROXYUREA; INTERLEUKIN-8; L-SELECTIN; MALE; MIDDLE AGED; NEUTROPHILS; PEROXIDASE; RECEPTORS, INTERLEUKIN-6; SOLUBILITY; VASCULAR CELL ADHESION MOLECULE-1; VON WILLEBRAND FACTOR;

EID: 0032873984     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000040964     Document Type: Article

References (27)

1. Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, McMahon RP, Bonds DR, Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia: Effect of hydroxyurea on the frequency of painfull crises in sickle cell anemia. N Engl J Med 1995;332: 1317-1322.
2. Vichinsky EP, Lubin BH: A cautionary note regarding hydroxyurea in sickle cell disease. Blood 1994;83:1124-1128.
3. Saleh AW, Velvis H, Hillen HFP, Gu L-H, Huisman THJ: Hydroxyurea therapy in sickle cell anemia patients in Curaçao, The Netherlands Antilles. Acta Haematol 1997;98:125-129.
4. Adragna NC, Fonseca P, Lauf PK: Hydroxy-urea affects cell morphology, cation transport, and red blood cell adhesion in cultured vascular endothelial cells. Blood 1994;83:553-560.
5. Swerlick RA, Eckman JR, Kumar A, Jeitler M, Wick TM: Reliculocytes from patients with sickle cell anemia express the a4b1-integrin complex and bind to TNF-a stimulated endothelial cells via a VCAM-1-a4b1 dependent mechanism. Blood 1993;82:1891-1899.
6. Kaul DK, Fabry ME, Nagel RL: Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: Pathophysiological implications. Proc Natl Acad Sci USA 1989;86:3356-3360.
7. Juneja HS: Pathophysiology and management of sickle cell pain crisis. Lancet 1995;346: 1408-1411.
8. Vordermeier S, Singh S, Biggerstaff J, Harrison P, Grech H, Pearson TC, Dumonde DC, Brown KA: Red blood cells from patients with sickle cell disease exhibit an increased adherence to cultured endothelium pretreated with tumor necrosis factor (TNF). Br J Haematol 1992;81:591-597.
9. Antonucci R, Walker R, Herion J, Orringer E: Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets. Am J Hematol 1990;34:44-48.
10. Fadlon E, Vordemeier S, Pearson TC, Mire-Sluis AR, Dumonde DC, Phillips J, Fishlock K, Alun Brown K: Blood polymorphonuclear leucocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD 64. Blood 1998;91: 266-274.
11. Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, Kinney TR: Pain in sickle cell disease. Rates and risk factors. N Engl J Med 1991;325:11-16.35.
12. Kasschau MR, Barabino GA, Bridges KR, Golan DE: Adhesion of sickle neutrophils and erythrocytes to fibronectin. Blood 1996;87: 771-780.
13. Wautier JL, Pintigny D, Wautier MP, Paton RC, Galacteros F, Passa P, Caen JP: Fibrinogen, a modulator of erythrocyte adhesion to vascular endothelium. J Lab Clin Med 1983; 101:911-918.
14. Wick TM, Moake JL, Udden MM, McIntire LV: Unusually large von Willebrand factor multimers preferentially promote young sickle and nonsickle erythrocyte adhesion to endothelial cells. Am J Hematol 1993;42:284-292.
15. Brittain HA, Eckman JR, Swerlick RA, Howard RJ, Wick TM: Thrombospondin from activated platelets promotes sickle erythrocyte adherence Io human microvascular endothelium under physiologic flow: A potential role for platelet activation in sickle cell vaso-occlusion. Blood 1993;81:2137-2143.
16. Natarajan M, McIntire LV, Udden M. Moake J: Adhesion of sickle cells and damage to IL-1 stimulated endothelial cells under flow conditions in vitro (abstract). Ann Biomed Eng 1994; 22:26a.
17. Oppenheim JJ, Zachariae COC, Mukaida N, Matsushima K.: Properties of the novel proinflammatory supergene 'intercrine' cytokine family. Annu Rev Immunol 1991;9:617-648.
18. Darbonne WC, Rice GC, Mohler MA, Apple T, Hebert CA, Valente AJ, Baker JB: Red blood cells are a sink for interleukin-8, a leucocyte chemotaxin. J Clin Invest 1991;88:1362.
19. Solovey A, Yi Lin BS, Browne P, Choong S, Wayner E, Hebbel RP: Circulating activated endothelial cells in sickle cell anemia. N Engl J Med 1997;337:1584-1590.
20. Duits AJ, Pieters RC, Saleh AW, van Rosmalen E, Katerberg H, Berend K, Rojer RA: Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vaso-occlusive crisis. Clin Immunol Immunopathol 1996;81:96-98.
21. Ballas SK, Dover GJ, Charache S: Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo. Am J Hematol 1989;32:104-111.
22. Styles LA, Lubin B, Vichinsky E, Lawrence S, Hua M, Test S, Kuypers F: Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea. Blood 1997;89:2554-2559.
23. Bisse E, Wieland H: High performance liquid chromatographic separation of human haemoglobins: Simultaneous quantitation of foetal and glycated haemoglobins. J Chromatogr 1988;434:95-110.
24. Saleh AW, Duits AJ, Gerbers A, de Vries C, Hillen HFP: Cytokines and soluble adhesion molecules in sickle cell anemia patients during hydroxyurea therapy. Acta Haematol 1998; 100:26-31.
25. Berliner N, Hsing A, Graubert T, Sigurdsson F, Zain M, Bruno E, Hoffman R: Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression. Blood 1995; 85:799-803.
26. Harlan JM, Schwartz BR, Reidy MA, Schwartz SM, Ochs HD, Harker LA: Activated neutrophils disrupt endothelial monolayer integrity by an oxygen radical-independent mechanism. Lab Invest 1985;52:141-150.
27. Schnog JJ, Lard LR, Rojer RA, van der Dijs FP, Muskiet FA, Duits AJ: New concepts in assessing sickle cell disease severity. Am J Hematol 1998;58:61-66.