ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  Meng, Wei ^b   Ma, Jianya ^b   Ayata, Cenk ^b   Hara, Hideaki ^b   Huang, Paul L ^b   Fishman, Mark C ^b   Moskowitz, Michael A ^a  

^a Stroke and Neurovascular Regulation Laboratory   (United States)

^b NONE

Author keywords

cerebral circulation; mutant mice

Indexed keywords

ACETYLCHOLINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TETRODOTOXIN;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; BRAIN CIRCULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; GENE DELETION; MALE; MOUSE; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; VASODILATATION;

EID: 33750730317     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.3.h1145     Document Type: Article

References (35)

1. Arneric, S. P., M. A. Honing, T. A. Milner, S. Greco, C. Iadecola, and D. J. Reis. Neuronal and endothelial sites of acetylcholine synthesis and release associated with microvessels in rat cerebral cortex: ultrastructural and neurochemical studies. Brain Res. 454: 11-13, 1988
2. Bredt, D. S., and S. H. Snyder. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA 87: 682-685, 1990.
3. Cole, A. E., and R. A. Nicoll. Characterization of a slow cholinergic post-synaptic potential recorded in vitro from rat hippocampal pyramidal cells. J. Physiol. Lond. 352: 173-188, 1984.
4. Dalkara, T., K. Irikura, Z. Huang, N. Panahian, and M. A. Moskowitz. Cerebrovascular responses under controlled physiological conditions in the anesthetized mouse. J. Cereb. Blood Flow Metab. 15:631-638, 1995.
5. Dauphin, F., P. Lamcombe, R. Sercombe, E. Hamel, and J. Seylaz. Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms. Brain Res. 553: 75-83, 1991.
6. Faraci, F. M. Endothelium-derived vasoactive factors and regulation of the cerebral circulation. Neurosurgery 33: 648-659, 1993.
7. Faraci, F. M., and K. R. Breese. Nitric oxide mediates vasodilation in response to activation of N-methyl-D-aspartate receptors in brain. Circ. Res. 72: 476-480, 1993.
8. Garland, C. J., F. Plane, B. K. Kemp, and T. M. Cocks. Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol. Sci. 16: 23-30, 1995.
9. Gonzales, C., and C. Estrada. Nitric oxide mediates the neurogenic vasodilation of bovine cerebral arteries. J. Cereb. Blood Flow Metab. 11: 366-370, 1991.
10. Hara, H., P. L. Huang, N. Panahian, M. C. Fishman, and M. A. Moskowitz. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab. 16: 605-611, 1996
11. Huang, P. L., T. M. Dawson, D. S. Bredt, S. H. Snyder, and M. C. Fishman. Targeted disruption of neuronal nitric oxide synthase gene. Cell 75: 1273-1286, 1993.
12. Huang, P. L., Z. Huang, H. Moshimo, K. D. Bloch, M. A. Moskowitz, J. S. Bevan, and M. C. Fishman. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature Lond. 377: 239-242, 1995.
13. Huang, Z., P. L. Huang, N. Panahian, T. Dalkara, M. C. Fishman, and M. A. Moskowitz. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science Wash. DC 265: 1883-1885, 1994.
14. Irikura, K., P. L. Huang, J. Ma, W. S. Lee, T. Dalkara, M. C. Fishman, T. M. Dawson, S. H. Snyder, and M. A. Moskowitz. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc. Natl. Acad. Sci. USA 92: 6823-6827, 1995.
15. Irikura, K., K. I. Maynard, and M. A. Moskowitz. Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation. J. Cereb. Blood Flow Metab. 14: 45-48, 1994.
16. Lee, T. J., and S. J. Sarwinsky. Nitric oxidergic neurogenic vasodilation in the porcine basilar artery. Blood Vessels 28: 407-412, 1991.
17. Lin, Y., and J. W. Phillis. Muscarinic agonist-mediated induction of long term potentiation in rat cortex Brain Res. 551: 342-345, 1991.
18. Luiten, P. G., R. P. Gaykemia, J. Traber, and D. G. Spenceer Jr. Cortical projection patterns of magnocellular basal nucleus subdivisions as revealed by anterogradely transported Phaseolus vulgaris leucoagglutinin. Brain Res. 413: 229-250, 1987.
19. Luscher, T. F. Heterogeneity of endothelial dysfunction in hypertension. Eur. Heart J. 13, Suppl. D: 50-55, 1992.
20. Ma, J., C. Ayata, P. L. Huang, M. C. Fishman, and M. A. Moskowitz. Regional cerebral blood flow responses to vibrissal stimulation in mice lacking neuronal NOS gene expression. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1085-H1090, 1996.
21. Marks, G. S., J. F. Brien, K. Nakatsu, and B. E. McLaughlin. Does carbon monoxide have a physiological function? Trends Pharmacol. Sci. 12: 185-188, 1991.
22. 2+ influx. J. Neurosci. 16: 1702-1709, 1996.
23. McCormick, D. A., and D. A. Prince. Two types of muscarinic response to acetylcholine in mammalian cortical neurons. Proc. Natl. Acad. Sci. USA 82: 6344-6348, 1985.
24. Meng, W., D. M. Colonna, J. R. Tobin, and D. W. Busija. Nitric oxide and prostaglandins interact to mediate arteriolar dilation during cortical spreading depression. Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H176-H181, 1995.
25. Moro, V., J. Badaut, V. Springhetti, L. Edvisson, J. Seylaz, and F. Lasbennes. Regional study of the co-localization of neuronal nitric oxide synthase with muscarinic receptors in the rat cerebral cortex. Neuroscience 69: 797-805, 1995.
26. Moro, V., K. Kacem, V. Springhetti, J. Seylaz, and F. Lasbennes. Microvessels isolated from brain: localization of muscarinic sites by radioligand binding and immunofluorescent techniques. J. Cereb. Blood Flow Metab. 15: 1082-1092, 1995.
27. Panahian, N., T. Yoshida, P. L. Huang, E. T. Hedley-Whyte, T. Dalkara, M. C. Fishman, and M. A. Moskowitz. Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase. Neuroscience. 72: 343-354, 1996.
28. Raszkiewicz, J., D. G. Linville, J. F. J. Kerwin, F. Wagenaar, and S. P. Arneric. Nitric oxide synthase is critical in mediating basal forebrain regulation of cortical cerebral circulation. J. Neurosci. Res. 33: 129-135, 1992.
29. Rosenblum, W. I. Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles. Stroke 17: 494-497, 1986.
30. Toda, N., and T. Okamura. Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebral arterial muscle. Biochem. Biophys. Res. Commun. 170: 308-313, 1990.
31. Toda, N., J. Zhang, K. Ayajiki, and T. Okamura. Mechanisms underlying endothelium dependent relaxation by acetylcholinein canine retinal and cerebral arteries. J. Pharmacol. Exp. Ther 274: 1507-1512, 1995.
32. Wei, E. P., R. Kukreja, and H. A. Kontos. Effects in cats of inhibition of nitric oxide synthesis on cerebral vasodilation and endothelium-derived relaxing factor from acetylcholine. Stroke 23: 1623-1629, 1992.
33. Zakhary, R., S. P. Gaine, J. L. Dinerman, M. Ruat, N. A. Flavahan, and S. H. Snyder. Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc. Natl. Acad. Sci. USA 93: 795-798, 1996.
34. Zhang, F., S. Xu, and C. Iadecola. Role of nitric oxide and acetylcholine in neocortical hyperemia elicited by basal forebrain stimulation: evidence for an involvement of endothelial nitric oxide. Neuroscience 69: 1195-1204, 1995.
35. Zilles, K., H. Schroder, U. Schroder, E. Horvath, L. Werner, P. G. Luiten, A. Maelicke, and A. D. Strosberg. Distribution of cholinergic receptors in the rat and human neocortex. Exper. Suppl. Basel 57: 212-218, 1989.